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1. 发明公开

US20240115772A1 Antimicrobial Coatings 审中-公开
公开(公告)号：US20240115772A1
公开(公告)日：2024-04-11
申请号：US18389597
申请日：2023-12-19
申请人： MicroVention, Inc.
发明人： Gregory M. Cruise , Steve Plotkin , Petr Vasek
IPC分类号： A61L29/08 , A61L29/04 , A61L29/06 , A61L29/16 , A61M25/00
CPC分类号： A61L29/085 , A61L29/043 , A61L29/044 , A61L29/06 , A61L29/16 , A61M25/0017 , A61L2300/104 , A61L2300/114 , A61L2300/254 , A61L2300/406 , A61L2420/08
摘要： Described are coatings for medical devices and methods of forming same.

2. 发明申请

US20180207323A1 MEDICAL PRODUCTS AND METHODS CONFIGURED FOR CONTROLLED RELEASE OF NITRIC OXIDE 审中-公开
公开(公告)号：US20180207323A1
公开(公告)日：2018-07-26
申请号：US15876190
申请日：2018-01-21
申请人： BIOCREDE INC.
发明人： Hao CHEN , Kevin RENEHAN , Kwun Yin HO , Alexander WOLF
IPC分类号： A61L29/16 , A61L29/04 , A61L29/06 , A61L31/16 , A61L31/04 , A61L31/06
CPC分类号： A61L29/16 , A61K9/7084 , A61L15/42 , A61L15/44 , A61L15/46 , A61L29/041 , A61L29/043 , A61L29/06 , A61L29/14 , A61L31/042 , A61L31/046 , A61L31/06 , A61L31/14 , A61L31/16 , A61L2300/114 , A61L2300/404 , A61L2300/42 , A61L2400/18 , A61L2420/02
摘要： The disclosure concerns various medical devices implemented to provide a nitric oxide rich environment for anti-microbial or anti-thrombogenic benefits. The medical device generally includes a nitric oxide donor material that is contained within a sealed cavity, and a transport medium that defines and captivates the entirety of the cavity, wherein the transport medium is permeable to both water and nitric oxide. As the nitric oxide donor material becomes saturated with water from the surrounding tissue or fluids, nitric oxide is chemically released, and the resulting nitric oxide is communicated through the transport medium to a treatment site for anti-microbial and anti-thrombogenic benefits.

3. 发明授权

US09750847B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities 有权
公开(公告)号：US09750847B2
公开(公告)日：2017-09-05
申请号：US14922369
申请日：2015-10-26
申请人： Nanyang Technological University
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61L27/34 , A61L27/52 , A61L31/04 , A61K8/04 , A61K31/14 , A61K8/73 , A61Q19/00 , A61L27/54 , A61L31/16 , A61L27/20 , A61L29/04 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , G02B1/04
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes. In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.

4. 发明授权

US09220584B2 Treatment of diabetic patients with a stent and locally administered adjunctive therapy 有权
标题翻译：用支架治疗糖尿病患者和局部给药辅助治疗
公开(公告)号：US09220584B2
公开(公告)日：2015-12-29
申请号：US13435645
申请日：2012-03-30
申请人： Syed F. A. Hossainy
发明人： Syed F. A. Hossainy
IPC分类号： A61F2/06 , A61F2/00 , A61F2/958
CPC分类号： A61F2/958 , A61F2/00 , A61F2/844 , A61F2/915 , A61F2250/0067 , A61L29/043 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/204 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2400/10 , A61M25/007 , A61M25/10 , A61M2025/105
摘要： Embodiments of the present invention include methods of treating, preventing, and/or ameliorating a vascular disease and/or disorder in a diabetic or pre-diabetic patient. The methods include implanting a stent in a vascular region in a diabetic or pre-diabetic patient, and prior to and/or during the implantation procedure, delivering a lubricant formulation to the vascular region. The stent may be a bare metal stent, or a drug eluting stent, such as a metal stent with a coating including a drug, such as everolimus or sirolimus.
摘要翻译：本发明的实施方案包括治疗，预防和/或改善糖尿病或前期糖尿病患者的血管疾病和/或病症的方法。所述方法包括将支架植入糖尿病患者或糖尿病前患者的血管区域，以及在植入术前和/或期间，将润滑剂制剂输送到血管区域。支架可以是裸金属支架或药物洗脱支架，例如具有包括药物的涂层的金属支架，例如依维莫司或西罗莫司。

5. 发明申请

US20150224236A1 COMPOSITIONS AND METHODS FOR DELIVERING AN AGENT TO A WOUND 有权
标题翻译：用于将代理商送达的组合物和方法
公开(公告)号：US20150224236A1
公开(公告)日：2015-08-13
申请号：US14618722
申请日：2015-02-10
申请人： University of Memphis Research Foundation
发明人： Warren O. Haggard , Scott P. Noel , Joel D. Bumgardner
IPC分类号： A61L31/16 , A61L31/14 , A61L31/04 , A61L15/28 , A61L15/44
CPC分类号： A61K47/36 , A61K9/0024 , A61K9/7007 , A61K31/00 , A61K31/7036 , A61K38/14 , A61L15/28 , A61L15/44 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/042 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/232 , A61L2300/25 , A61L2300/406 , C08B37/003 , C08J5/18 , C08J2305/08 , C08L5/08 , A61K2300/00
摘要： The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
摘要翻译：本发明提供了具有壳聚糖的组合物以及使用这些组合物将生物活性剂局部递送至开放性骨折，复合伤口或其它感染部位的方法。有利地，壳聚糖组合物的降解和药物洗脱曲线可以根据特定患者在护理点（例如在手术套件，诊所，医师办公室或其他临床环境中）的需要进行调整。

6. 发明授权

US08993540B2 Compositions and methods for delivering an agent to a wound 有权
标题翻译：将药剂递送至伤口的组合物和方法
公开(公告)号：US08993540B2
公开(公告)日：2015-03-31
申请号：US13256585
申请日：2010-03-16
申请人： Warren O. Haggard , Scott P. Noel , Joel D. Bumgardner
发明人： Warren O. Haggard , Scott P. Noel , Joel D. Bumgardner
IPC分类号： A61K31/715 , A61P31/04 , A61P31/12 , A61P17/02 , C07H1/00 , A61K47/36 , A61K31/00 , A61L15/28 , A61L27/20 , A61L27/58 , A61L31/04 , C08B37/08 , C08L5/08 , A61K9/00 , A61K9/70
CPC分类号： A61K47/36 , A61K9/0024 , A61K9/7007 , A61K31/00 , A61K31/7036 , A61K38/14 , A61L15/28 , A61L15/44 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/042 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/232 , A61L2300/25 , A61L2300/406 , C08B37/003 , C08J5/18 , C08J2305/08 , C08L5/08 , A61K2300/00
摘要： The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
摘要翻译：本发明提供了具有壳聚糖的组合物以及使用这些组合物将生物活性剂局部递送至开放性骨折，复合伤口或其它感染部位的方法。有利地，壳聚糖组合物的降解和药物洗脱曲线可以根据特定患者在护理点（例如在手术套件，诊所，医师办公室或其他临床环境中）的需要进行调整。

7. 发明申请

US20130190245A1 Light Activated Composite Tissue Adhesives 审中-公开
标题翻译：光活性复合组织粘合剂
公开(公告)号：US20130190245A1
公开(公告)日：2013-07-25
申请号：US12943771
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61L24/00
CPC分类号： A61L24/001 , A61L24/102 , A61L29/043 , Y10S514/801 , C08L89/06
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin.
摘要翻译：应用含有核黄素的光活化胶原蛋白复合材料层作为由细菌引起的感染病变的治疗，作为外科手术的结果。这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。胶原蛋白复合物和组织之间的强烈交联结果。此外，消除伤口中类似的根除病原体的暴露导致无菌伤口。在其它实例中，复合膜可以替代地含有lumichrome或lumiflavin。

8. 发明申请

US20120251607A1 ANTIMICROBIAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND USES THEREOF 失效
标题翻译：抗微生物组合物，其制备方法及其用途
公开(公告)号：US20120251607A1
公开(公告)日：2012-10-04
申请号：US13077005
申请日：2011-03-31
申请人： Daniel J. Coady , Kazuki Fukushima , James L. Hedrick , Yi Yan Yang
发明人： Daniel J. Coady , Kazuki Fukushima , James L. Hedrick , Yi Yan Yang
IPC分类号： A01N25/04 , A01P1/00 , A61K9/14 , A61P31/04 , A01N47/06 , A61K31/78
CPC分类号： A61K31/78 , A01N33/12 , A61K31/77 , A61K47/34 , A61L15/26 , A61L15/28 , A61L15/46 , A61L17/10 , A61L17/12 , A61L29/043 , A61L29/06 , A61L31/10 , A61L2300/40 , Y02A50/473 , A01N25/10 , A01N2300/00 , C08L71/02 , C08L67/04
摘要： A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.
摘要翻译：物质组合物包含包含聚碳酸酯链片段的阳离子聚合物，所述聚碳酸酯链片段包含包含含有季胺基团的侧链部分的重复单元; 和包含聚酯链段和聚（环氧烷）链段的无电荷聚合物; 其中i）阳离子聚合物和非带电聚合物是两亲性的和生物相容的，ii）阳离子聚合物和非带电聚合物通过在水中的非共价相互作用形成混合络合物，和iii）混合络合物是更有效的当使用其他相同条件进行测试时，与单体阳离子聚合物和非带电聚合物相比，抗微生物剂对抗至少革兰氏阴性微生物。

9. 发明申请

US20120208802A1 Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin 有权
标题翻译：包含牛磺酰胺衍生物和生物可接受的盐和酸的抗微生物锁定溶液，加入少量肝素
公开(公告)号：US20120208802A1
公开(公告)日：2012-08-16
申请号：US13199605
申请日：2011-09-02
申请人： Frank R. Prosl
发明人： Frank R. Prosl
IPC分类号： A01N43/88 , A01P1/00
CPC分类号： A61L29/16 , A01N25/02 , A01N43/88 , A61K31/18 , A61K31/185 , A61K31/727 , A61L29/00 , A61L29/043 , A61L2300/204 , A61L2300/406 , A61K2300/00
摘要： The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising: (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.
摘要翻译：本发明涉及在血管插入患者之后抑制或预防感染并防止通畅并发症，包括向该装置施用药学有效量的组合物，其包含：（A）至少一种牛磺酰胺衍生物，（B）至少一种选自生物可接受的酸及其生物可接受的盐的化合物; 和（C）低浓度的肝素。

10. 发明申请

US20110159067A1 HYDROPHOBIC POLYSACCHARIDES WITH PENDENT GROUPS HAVING TERMINAL REACTIVE FUNCTIONALITIES AND MEDICAL USES THEREOF 失效
标题翻译：具有终端反应功能及其医疗用途的具有相关组的疏水性多糖
公开(公告)号：US20110159067A1
公开(公告)日：2011-06-30
申请号：US12982214
申请日：2010-12-30
申请人： Emily R. Rolfes Meyering
发明人： Emily R. Rolfes Meyering
IPC分类号： A61F13/00 , C07H1/00
CPC分类号： C07H13/04 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/148 , A61L31/042 , A61L31/148
摘要： Hydrophobic α(1→4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic α(1→4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译：描述了可用于制备可植入或可注射医疗用品的疏水性α（1→4）吡喃葡萄糖聚合物。疏水性α（1→4）吡喃葡萄糖聚合物包括具有烃基和末端胺或羟基的侧基。可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够在体内降解。还描述了包括和能够在体内释放生物活性剂的基质。

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