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1. 发明授权

US12037420B2 Dextran-poly alpha-1,3-glucan graft copolymers and synthesis methods thereof 有权
公开(公告)号：US12037420B2
公开(公告)日：2024-07-16
申请号：US17412880
申请日：2021-08-26
申请人： NUTRITION & BIOSCIENCES USA 4, INC.
发明人： Natnael Behabtu , Samuel David Arthur
IPC分类号： C08B37/02 , C12P19/08
CPC分类号： C08B37/0021 , C12P19/08
摘要： Compositions are disclosed herein comprising a graft copolymer having (i) a backbone comprising dextran with a molecular weight of at least about 100000 Daltons, and poly alpha-1,3-glucan side chains comprising at least about 95% alpha-1,3-glucosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in absorbent materials.

2. 发明授权

US11932890B2 Alpha-1,3-glucan graft copolymers 有权
公开(公告)号：US11932890B2
公开(公告)日：2024-03-19
申请号：US17406386
申请日：2021-08-19
申请人： NUTRITION & BIOSCIENCES USA 4, INC.
发明人： Rong Guan , James Joshua Ohane , Nikita Iltchenko , Yefim Brun , Brian McCauley , Laurie A. Howe , Yougen Li
IPC分类号： C08B37/00 , C08B37/02 , C08J5/18 , C08L5/02 , C11D3/37 , C12P19/08 , C12P19/18
CPC分类号： C12P19/08 , C08B37/0009 , C08B37/0021 , C08J5/18 , C08L5/02 , C11D3/3707 , C12P19/18 , C08J2305/00 , C08J2305/02
摘要： Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.

3. 发明申请

US20170198323A1 ENZYMATIC SYNTHESIS OF SOLUBLE GLUCAN FIBER 审中-公开
公开(公告)号：US20170198323A1
公开(公告)日：2017-07-13
申请号：US15313285
申请日：2015-05-22
申请人： E I DU PONT DE NEMOURS AND COMPANY
发明人： Qiong Cheng , Robert Dicosimo , Arthur Ouwehand , Zheng You , Mark S. Payne , Jahnavi Chandra Prasad
IPC分类号： C12P19/18 , A61K31/702 , A61K8/60 , A61Q19/00 , A23G1/40 , A23K20/10 , A23G9/34 , A23L2/52 , A23L7/139 , A23L27/30 , A23L33/10 , A23L33/21 , C07H3/06 , A23G3/42
CPC分类号： C12P19/18 , A23G1/40 , A23G3/42 , A23G9/34 , A23K20/10 , A23L2/52 , A23L2/60 , A23L5/00 , A23L7/00 , A23L7/139 , A23L9/00 , A23L21/00 , A23L27/30 , A23L29/30 , A23L29/37 , A23L33/10 , A23L33/105 , A23L33/115 , A23L33/125 , A23L33/17 , A23L33/18 , A23L33/21 , A23V2002/00 , A61K8/60 , A61K8/73 , A61K31/702 , A61K31/716 , A61K45/06 , A61K2800/10 , A61K2800/85 , A61Q19/00 , C07H3/06 , C08B37/0009 , C08L5/00 , C12P19/04 , C12P19/08 , C12Y204/01005 , C12Y301/01059 , C12Y302/01011 , C12Y302/01059 , A61K2300/00
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

4. 发明授权

US09399765B2 Construction of new variants of dextransucrase DSR-S by genetic engineering 有权
公开(公告)号：US09399765B2
公开(公告)日：2016-07-26
申请号：US14798518
申请日：2015-07-14
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE RECHERCHE AGRONOMIQUE , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
发明人： Pierre F. Monsan , Magali Remaud-Simeon , Gabrielle Potocki-Veronese , Claire Moulis
IPC分类号： C07H21/04 , C08B37/02 , C13K5/00 , C12N9/10 , C12N9/24 , C12N9/46 , C12P21/06 , C12P19/34 , C12P19/12 , C12P19/04 , C12P19/08 , C07K1/00 , C07H3/06 , C12P19/18
CPC分类号： C12N9/1051 , C07H3/06 , C07K2319/35 , C08B37/0021 , C12P19/04 , C12P19/08 , C12P19/12 , C12P19/18 , C12Y204/01005 , Y02P20/52
摘要： The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or their specificity in the synthesis of the α-1,6 bonds. The present invention relates to nucleic acid sequences of truncated or mutated dextransucrases, vectors containing the nucleic acid sequences and host cells transformed by sequences encoding truncated or mutated dextransucrases. In another aspect, the invention concerns a method for producing, in a recombinant manner, truncated or mutated dextransucrases which conserve their enzymatic activity or which conserve their specificity in the synthesis of α-1,6 bonds and can produce, from saccharose, dextrans with high molar mass and modified rheological properties compared with the properties of dextran obtained with the native enzyme and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and isomalto-oligosaccharides of the invention can be used namely as texturing agents or as prebiotics.

5. 发明申请

US20150004140A1 COMPOSITIONS AND METHODS FOR MAKING ALPHA-(1,2)-BRANCHED ALPHA-(1,6) OLIGODEXTRANS 有权
标题翻译：制备ALPHA-（1,2） - 联合阿尔法 - （1,6）OLIGODEXTRANS的组合物和方法
公开(公告)号：US20150004140A1
公开(公告)日：2015-01-01
申请号：US14329549
申请日：2014-07-11
申请人： Tate & Lyle Ingredients France SAS
发明人： Thierry NAEYE , Alexandra Eilnerhand , Michel Lopez , Susan M. Potter , Magali Remaud-Siméon , Pierre Frédéric Emmanuel Monsan
IPC分类号： C08B37/02 , A23L1/30 , C12P19/18 , C12P19/08 , A61K31/721 , A61K35/74
CPC分类号： C08B37/0021 , A23L33/10 , A23L33/21 , A23V2002/00 , A61K31/702 , A61K31/721 , A61K31/733 , A61K35/741 , A61K45/06 , A61K2035/115 , C07B37/00 , C08L5/02 , C08L2203/02 , C08L2205/02 , C08L2205/025 , C12P19/08 , C12P19/18 , A61K2300/00 , A23V2200/3202
摘要： Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial indigestibility in the subject. Methods for improving the health of a subject comprise administering the composition to a subject in an amount effective to improve gut health, or to prevent or treat a gastrointestinal disorder, a cholesterol-related disorder, diabetes, or obesity. Methods for making oligodextrans having controlled size and controlled degree of branching comprise providing alpha-(1,6) oligodextrans having an average molecular weight between 0.5 and 100 kDa and introducing at least 10% alpha-(1,2)-osidic side chains onto the alpha-(1,6) oligodextrans.
摘要翻译：用于改善受试者健康的组合物包括α-（1,2） - 支链的α-（1,6）寡聚葡聚糖，优选具有约10kDa至70kDa的平均分子量，约10％至50％的α- （1,2） - 苷侧链，并且在受试者中具有至少部分难消化性。用于改善受试者健康的方法包括以有效改善肠道健康的量或预防或治疗胃肠道疾病，胆固醇相关病症，糖尿病或肥胖症的方式向受试者施用该组合物。制备具有受控大小和受控支化程度的寡聚葡聚糖的方法包括提供平均分子量为0.5至100kDa的α-（1,6）寡聚葡聚糖，并将至少10％的α-（1,2） - 苷侧链引入 α-（1,6）寡聚葡聚糖。

6. 发明申请

US20130052300A1 FAT REPLACERS AND FILLING MATERIALS 审中-公开
标题翻译：脂肪替代物和填充材料
公开(公告)号：US20130052300A1
公开(公告)日：2013-02-28
申请号：US13696113
申请日：2011-05-04
申请人： Els Ginette Alexander Dendooven , Van Sau Nguyen , Lutgart Van-Nieuwenhuyze , Ronny Leontina Marcel Vercauteren
发明人： Els Ginette Alexander Dendooven , Van Sau Nguyen , Lutgart Van-Nieuwenhuyze , Ronny Leontina Marcel Vercauteren
IPC分类号： A23L1/09 , A23L1/307
CPC分类号： A23L29/273 , A21D2/181 , A23L33/10 , A23L33/20 , A23L33/21 , A23V2002/00 , C08B37/0021 , C12P19/08 , C12P19/18 , C12Y204/01005 , A23V2200/124 , A23V2250/28 , A23V2250/5042
摘要： The present invention relates generally to fat replacers and their use in various food products. Aspects of the disclosure are particularly directed to oligodextran-based fat replacers that are lower in calories, heat stable, and increase fiber. They can either be used alone or in combination with other additives to decrease the fat content while maintaining good organoleptic properties.
摘要翻译：本发明一般涉及脂肪替代物及其在各种食品中的用途。本公开的方面特别涉及低聚糖基脂肪替代物，其更低的热量，热稳定性和增加纤维。它们可以单独使用或与其他添加剂组合使用，以降低脂肪含量，同时保持良好的感官特性。

7. 发明申请

US20110129879A1 Hybrid Genes and Enzymes of Glucanase and Dextransucrase and Processes for Preparing Isomalto-Oligosaccharides or Dextran Using the Same 有权
标题翻译：葡聚糖酶和葡聚糖蔗糖酶的杂交基因和酶及其制备异麦芽低聚糖或葡聚糖的方法
公开(公告)号：US20110129879A1
公开(公告)日：2011-06-02
申请号：US12063678
申请日：2007-04-28
申请人： Do Man Kim , Mi Young Seo
发明人： Do Man Kim , Mi Young Seo
IPC分类号： C12P19/18 , C07H21/04 , C12N9/10
CPC分类号： C12N9/244 , C07K2319/00 , C12N9/1051 , C12P19/08 , C12P19/18 , C12Y204/01005 , C12Y302/01006
摘要： Disclosed are hybrid genes of glucanase and dextransucrase, recombinant vectors comprising said hybrid genes, microorganisms which are transformed with said recombinant vectors, hybrid enzymes which are expressed from said hybrid genes, and processes for preparing isomalto-oligosaccharides or dextran using said microorganisms or enzymes. Expensive isomalto-oligosaccharides and low molecular weight dextran for clinical use can be produced simply and effectively from cheap substrate-sucrose, using a single bacterial strain or enzyme.
摘要翻译：公开了葡聚糖酶和葡聚糖蔗糖酶的杂交基因，包含所述杂交基因的重组载体，用所述重组载体转化的微生物，从所述杂交基因表达的杂合酶，以及使用所述微生物或酶制备异麦芽寡聚糖或葡聚糖的方法。昂贵的异麦芽寡糖和临床使用的低分子量葡聚糖可以使用单一细菌菌株或酶，从廉价的底物蔗糖中简单有效地制备。

8. 发明授权

US07897373B2 Construction of new variants of dextransucrase DSR-S by genetic engineering 有权
标题翻译：通过基因工程构建葡聚糖蔗糖酯酶DSR-S的新变体
公开(公告)号：US07897373B2
公开(公告)日：2011-03-01
申请号：US12223744
申请日：2007-02-08
申请人： Pierre F. Monsan , Magali Remaud-Simeon , Gabrielle Potocki-Veronese , Claire Moulis
发明人： Pierre F. Monsan , Magali Remaud-Simeon , Gabrielle Potocki-Veronese , Claire Moulis
IPC分类号： C12N9/24 , C07H21/04
CPC分类号： C12N9/1051 , C07H3/06 , C07K2319/35 , C08B37/0021 , C12P19/04 , C12P19/08 , C12P19/12 , C12P19/18 , C12Y204/01005 , Y02P20/52
摘要： The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or their specificity in the synthesis of the α-1,6 bonds. The present invention relates to nucleic acid sequences of truncated or mutated dextransucrases, vectors containing the nucleic acid sequences and host cells transformed by sequences encoding truncated or mutated dextransucrases. In another aspect, the invention concerns a method for producing, in a recombinant manner, truncated or mutated dextransucrases which conserve their enzymatic activity or which conserve their specificity in the synthesis of α-1,6 bonds and can produce, from saccharose, dextrans with high molar mass and modified rheological properties compared with the properties of dextran obtained with the native enzyme and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and isomalto-oligosaccharides of the invention can be used namely as texturing agents or as prebiotics.
摘要翻译：本发明涉及一种在保护酶活性或其合成α-1,6键的特异性的同时生产截短或突变的葡聚糖蔗糖酶的重组方法。本发明涉及截短或突变的葡聚糖蔗糖酶的核酸序列，含有核酸序列的载体和由编码截短或突变的葡聚糖蔗糖酶的序列转化的宿主细胞。另一方面，本发明涉及一种以重组方式生产截短或突变的葡聚糖蔗糖酯的方法，其保留其酶活性或在合成α-1,6键时保护其特异性，并可从蔗糖，葡萄糖，与用天然酶和具有受控摩尔质量的异麦芽低聚糖和葡聚糖获得的葡聚糖的性质相比，具有高的摩尔质量和改进的流变学性质。本发明的葡聚糖和异麦芽低聚糖可以用作变形剂或益生元。

9. 发明申请

US20060014861A1 Compositions and methods relating to an adhesive composition 审中-公开
标题翻译：与粘合剂组合物有关的组合物和方法
公开(公告)号：US20060014861A1
公开(公告)日：2006-01-19
申请号：US11149981
申请日：2005-06-09
申请人： Gill Geesey , Anthony Haag
发明人： Gill Geesey , Anthony Haag
IPC分类号： A61K9/16 , C04B37/00
CPC分类号： C09D105/02 , C12P19/08
摘要： The present invention is an adhesive composition including a biopolymer and methods of making and using the composition. The biopolymer in the composition can, in some instances, be a polysaccharide. The composition can also include a surfactant. In some embodiments, the polysaccharide is treated to reduce its hydrophilicity to improve moisture resistance of the adhesive bond.
摘要翻译：本发明是包含生物聚合物的粘合剂组合物和制备和使用该组合物的方法。在一些情况下，组合物中的生物聚合物可以是多糖。组合物还可以包括表面活性剂。在一些实施方案中，处理多糖以降低其亲水性以改善粘合剂粘合的耐湿性。

10. 发明授权

US06004800A Leuconostoc strains for biosynthesis of dextran 失效
标题翻译：用于生物合成葡聚糖的明串珠菌属菌株
公开(公告)号：US06004800A
公开(公告)日：1999-12-21
申请号：US87643
申请日：1998-05-29
申请人： Jurg Aebischer , Nicola D'Amico , Dominique De Maleprade , Kurt Eyer , Corinne Lesens , Jean-Richard Neeser , Roberto Reniero , Daniel Schmid
发明人： Jurg Aebischer , Nicola D'Amico , Dominique De Maleprade , Kurt Eyer , Corinne Lesens , Jean-Richard Neeser , Roberto Reniero , Daniel Schmid
IPC分类号： A23C9/127 , A23C9/12 , A23C9/123 , A23G9/32 , A23G9/44 , A23G9/52 , A23L29/00 , A23L29/269 , A61K8/66 , A61K8/72 , A61K8/73 , A61K8/98 , A61K8/99 , A61Q19/00 , C08B37/02 , C12N1/20 , C12N9/10 , C12P19/04 , C12P19/08 , C12R1/01
CPC分类号： A61Q19/00 , A23C9/1216 , A23C9/1236 , A23L29/06 , A23L29/065 , A23L29/273 , A61K8/73 , A61K8/99 , C12N9/1051 , C12P19/08 , C12Y204/01005 , A23C2220/206 , A61K2800/85
摘要： Strains of Leuconostoc mesenteroides ssp. cremoris which provide, upon culturing, dextran, and the strains include deposited strains CNCM I-1692 and CNCM I-1693.
摘要翻译：肠系膜菌肠炎菌菌株在培养时提供葡聚糖和菌株的cremoris包括沉积菌株CNCM I-1692和CNCM I-1693。

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