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1. 发明申请

US20130295019A1 LIGANDS AND METHODS FOR LABELING BIOMOLECULES IN VIVO 有权
标题翻译：用于标记体内生物分子的配体和方法
公开(公告)号：US20130295019A1
公开(公告)日：2013-11-07
申请号：US13813163
申请日：2011-08-05
申请人： Peng Wu , David Soriano del Amo , Wei Wang , Florence L. Marlow
发明人： Peng Wu , David Soriano del Amo , Wei Wang , Florence L. Marlow
IPC分类号： C07D249/04 , A61K49/00
CPC分类号： C07D249/04 , A61K49/0052 , G01N33/533 , G01N33/582
摘要： Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.
摘要翻译：公开了三（三唑基甲基）胺配体，以及用于在受试者或生活系统中标记和/或成像感兴趣的生物分子的试剂盒和方法。

2. 发明授权

US09809560B2 Ligands and methods for labeling biomolecules in vivo 有权
公开(公告)号：US09809560B2
公开(公告)日：2017-11-07
申请号：US13813163
申请日：2011-08-05
申请人： Peng Wu , David Soriano del Amo , Wei Wang , Florence L. Marlow
发明人： Peng Wu , David Soriano del Amo , Wei Wang , Florence L. Marlow
IPC分类号： C07D249/00 , C07D249/04 , G01N33/533 , G01N33/58 , A61K49/00
CPC分类号： C07D249/04 , A61K49/0052 , G01N33/533 , G01N33/582
摘要： Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.

3. 发明授权

US09081501B2 Multi-petascale highly efficient parallel supercomputer 有权
标题翻译：多千兆高效并行超级计算机
公开(公告)号：US09081501B2
公开(公告)日：2015-07-14
申请号：US13004007
申请日：2011-01-10
申请人： Sameh Asaad , Ralph E. Bellofatto , Michael A. Blocksome , Matthias A. Blumrich , Peter Boyle , Jose R. Brunheroto , Dong Chen , Chen-Yong Cher , George L. Chiu , Norman Christ , Paul W. Coteus , Kristan D. Davis , Gabor J. Dozsa , Alexandre E. Eichenberger , Noel A. Eisley , Matthew R. Ellavsky , Kahn C. Evans , Bruce M. Fleischer , Thomas W. Fox , Alan Gara , Mark E. Giampapa , Thomas M. Gooding , Michael K. Gschwind , John A. Gunnels , Shawn A. Hall , Rudolf A. Haring , Philip Heidelberger , Todd A. Inglett , Brant L. Knudson , Gerard V. Kopcsay , Sameer Kumar , Amith R. Mamidala , James A. Marcella , Mark G. Megerian , Douglas R. Miller , Samuel J. Miller , Adam J. Muff , Michael B. Mundy , John K. O'Brien , Kathryn M. O'Brien , Martin Ohmacht , Jeffrey J. Parker , Ruth J. Poole , Joseph D. Ratterman , Valentina Salapura , David L. Satterfield , Robert M. Senger , Brian Smith , Burkhard Steinmacher-Burow , William M. Stockdell , Craig B. Stunkel , Krishnan Sugavanam , Yutaka Sugawara , Todd E. Takken , Barry M. Trager , James L. Van Oosten , Charles D. Wait , Robert E. Walkup , Alfred T. Watson , Robert W. Wisniewski , Peng Wu
发明人： Sameh Asaad , Ralph E. Bellofatto , Michael A. Blocksome , Matthias A. Blumrich , Peter Boyle , Jose R. Brunheroto , Dong Chen , Chen-Yong Cher , George L. Chiu , Norman Christ , Paul W. Coteus , Kristan D. Davis , Gabor J. Dozsa , Alexandre E. Eichenberger , Noel A. Eisley , Matthew R. Ellavsky , Kahn C. Evans , Bruce M. Fleischer , Thomas W. Fox , Alan Gara , Mark E. Giampapa , Thomas M. Gooding , Michael K. Gschwind , John A. Gunnels , Shawn A. Hall , Rudolf A. Haring , Philip Heidelberger , Todd A. Inglett , Brant L. Knudson , Gerard V. Kopcsay , Sameer Kumar , Amith R. Mamidala , James A. Marcella , Mark G. Megerian , Douglas R. Miller , Samuel J. Miller , Adam J. Muff , Michael B. Mundy , John K. O'Brien , Kathryn M. O'Brien , Martin Ohmacht , Jeffrey J. Parker , Ruth J. Poole , Joseph D. Ratterman , Valentina Salapura , David L. Satterfield , Robert M. Senger , Brian Smith , Burkhard Steinmacher-Burow , William M. Stockdell , Craig B. Stunkel , Krishnan Sugavanam , Yutaka Sugawara , Todd E. Takken , Barry M. Trager , James L. Van Oosten , Charles D. Wait , Robert E. Walkup , Alfred T. Watson , Robert W. Wisniewski , Peng Wu
IPC分类号： G06F15/173 , G06F9/06 , G06F15/76
CPC分类号： G06F13/287 , G06F9/06 , G06F9/3004 , G06F9/30047 , G06F9/3885 , G06F12/0811 , G06F12/0831 , G06F12/0862 , G06F12/0864 , G06F12/1027 , G06F15/17381 , G06F15/17387 , G06F15/76 , G06F15/8069 , G06F2212/1016 , G06F2212/602 , G06F2212/6022 , G06F2212/6024 , G06F2212/6032 , Y02D10/13 , Y02D10/14
摘要： A Multi-Petascale Highly Efficient Parallel Supercomputer of 100 petaOPS-scale computing, at decreased cost, power and footprint, and that allows for a maximum packaging density of processing nodes from an interconnect point of view. The Supercomputer exploits technological advances in VLSI that enables a computing model where many processors can be integrated into a single Application Specific Integrated Circuit (ASIC). Each ASIC computing node comprises a system-on-chip ASIC utilizing four or more processors integrated into one die, with each having full access to all system resources and enabling adaptive partitioning of the processors to functions such as compute or messaging I/O on an application by application basis, and preferably, enable adaptive partitioning of functions in accordance with various algorithmic phases within an application, or if I/O or other processors are underutilized, then can participate in computation or communication nodes are interconnected by a five dimensional torus network with DMA that optimally maximize the throughput of packet communications between nodes and minimize latency.
摘要翻译：具有100 petaOPS规模计算的多Petascale高效并行超级计算机，其成本，功耗和占地面积都在降低，并且允许从互连角度来看处理节点的最大封装密度。超级计算机利用了VLSI的技术进步，实现了许多处理器可以集成到单个专用集成电路（ASIC）中的计算模型。每个ASIC计算节点包括利用集成到一个管芯中的四个或更多个处理器的片上系统ASIC，每个处理器具有对所有系统资源的完全访问，并且使得处理器能够对诸如计算或消息传递I / O 并且优选地，根据应用内的各种算法阶段实现功能的自适应分割，或者如果I / O或其他处理器未被充分利用，则可以参与计算或通信节点通过五维环面网络互连使用DMA来最大限度地最大化节点之间的分组通信的吞吐量并最小化等待时间。

4. 发明授权

US08549498B2 Integration of trace selection and trace profiling in dynamic optimizers 有权
标题翻译：在动态优化器中集成跟踪选择和跟踪分析
公开(公告)号：US08549498B2
公开(公告)日：2013-10-01
申请号：US13215747
申请日：2011-08-23
申请人： Hiroshige Hayashizaki , Hiroshi Inoue , Peng Wu
发明人： Hiroshige Hayashizaki , Hiroshi Inoue , Peng Wu
IPC分类号： G06F9/45
CPC分类号： G06F11/3612
摘要： Integrated trace selection and profiling in dynamic optimizers may include selecting a trace head based on profile of basic blocks that are executed. The basic blocks executed from the trace head may be recorded as a trace. The trace may be added to a trace nursery in non-compiled state. The trace may be interpreted and profiled until the trace matures. Under a profiling mode, path sensitive runtime information such as values, types, targets of call-sites, and exit frequencies can be collected. The trace may be moved out of the nursery to a compilation queue in response to determining that the trace has matured based on an execution count of the profiled trace.
摘要翻译：动态优化器中的集成跟踪选择和分析可能包括基于执行的基本块的轮廓选择跟踪头。从跟踪头执行的基本块可以记录为跟踪。踪迹可以添加到非编译状态的跟踪托儿所。跟踪可能被解释和分析，直到跟踪成熟。在分析模式下，可以收集路径敏感的运行时信息，如值，类型，呼叫站点目标和退出频率。响应于确定跟踪已经基于分析跟踪的执行计数而成熟，跟踪可以移出苗圃到编译队列。

5. 发明授权

US08423979B2 Code generation for complex arithmetic reduction for architectures lacking cross data-path support 有权
标题翻译：针对缺乏跨数据路径支持的架构的复杂算术减少的代码生成
公开(公告)号：US08423979B2
公开(公告)日：2013-04-16
申请号：US11548851
申请日：2006-10-12
申请人： Roch Georges Archambault , Alexandre E. Eichenberger , Amy Kai-Ting Wang , Peng Wu , Peng P. Zhao
发明人： Roch Georges Archambault , Alexandre E. Eichenberger , Amy Kai-Ting Wang , Peng Wu , Peng P. Zhao
IPC分类号： G06F9/45
CPC分类号： G06F8/445 , G06F8/45
摘要： A computer implemented method, apparatus, and computer usable program code for compiling source code for performing a complex operation followed by a complex reduction operation. A method is determined for generating executable code for performing the complex operation and the complex reduction operation. Executable code is generated for computing sub-products, reducing the sub-products to intermediate results, and summing the intermediate results to generate a final result in response to a determination that a reduced single instruction multiple data method is appropriate.
摘要翻译：一种计算机实现的方法，装置和计算机可用程序代码，用于编译用于执行复杂操作的复杂缩减操作的源代码。确定用于生成用于执行复杂操作和复合缩减操作的可执行代码的方法。生成用于计算子产品的可执行代码，将子产品减少到中间结果，并且对中间结果求和以响应于减少的单指令多数据方法的确定而产生最终结果。

6. 发明申请

US20130086567A1 Execution trace trunction 有权
标题翻译：执行跟踪功能
公开(公告)号：US20130086567A1
公开(公告)日：2013-04-04
申请号：US13249250
申请日：2011-09-30
申请人： Hiroshi Inoue , Hiroshige Hayashizaki , Peng Wu
发明人： Hiroshi Inoue , Hiroshige Hayashizaki , Peng Wu
IPC分类号： G06F9/45
CPC分类号： G06F8/443 , G06F11/3636
摘要： An execution trace of building blocks of computer code includes a head building block at which the execution trace starts, and a tail building block at which the execution trace ends. The building blocks are executable in a sequence from the head building block to the tail building block. The execution trace is truncated at a particular building block of the execution trace, which becomes the tail building block. The particular building block can correspond to a head building block of an additional execution trace, and/or to a loop header building block of a loop within the execution trace and at which the loop is entered. The execution trace is a compilation unit on which basis a trace-based compiler computer program generates an executable version of the code at least by compiling these units.
摘要翻译：计算机代码的构建块的执行跟踪包括执行跟踪开始的头构建块和执行跟踪结束的尾部构建块。构建块可以从头部构造块到尾部构造块的顺序执行。执行跟踪在执行跟踪的特定构建块处被截断，这将成为尾部构建块。特定构建块可以对应于附加执行跟踪的头部构造块，和/或对应于执行跟踪内的循环的循环头部构造块，并且进入循环。执行跟踪是一个编译单元，在该基础上，基于跟踪的编译器计算机程序至少通过编译这些单元来生成代码的可执行版本。

7. 发明申请

US20130013899A1 Using Hardware Transaction Primitives for Implementing Non-Transactional Escape Actions Inside Transactions 审中-公开
标题翻译：使用硬件事务原语在事务内部实现非事务性转义操作
公开(公告)号：US20130013899A1
公开(公告)日：2013-01-10
申请号：US13176833
申请日：2011-07-06
申请人： Christopher M. Barton , Harold W. Cain, III , Bradly G. Frey , Hung Q. Le , Maged M. Michael , Raul E. Silvera , Derek E. Williams , Michael Wong , Peng Wu
发明人： Christopher M. Barton , Harold W. Cain, III , Bradly G. Frey , Hung Q. Le , Maged M. Michael , Raul E. Silvera , Derek E. Williams , Michael Wong , Peng Wu
IPC分类号： G06F9/30
CPC分类号： G06F9/466
摘要： Mechanisms are provided for performing escape actions within transactions. These mechanisms execute a transaction comprising a transactional section and an escape action. The transactional section is comprised of one or more instructions that are to be executed in an atomic manner as part of the transaction. The escape action is comprised of one or more instructions to be executed in a non-transactional manner. These mechanisms further populate at least one actions list data structure, associated with a thread of the data processing system that is executing the transaction, with one or more actions associated with the escape action. Moreover, these mechanisms execute one or more actions in the actions list data structure based upon whether the transaction commits successfully or is aborted.
摘要翻译：提供了在事务中执行转义操作的机制。这些机制执行包括事务部分和转义动作的事务。事务部分由作为事务的一部分以原子方式执行的一个或多个指令组成。转义动作由以非事务方式执行的一个或多个指令组成。这些机制进一步填充与执行交易的数据处理系统的线程相关联的至少一个动作列表数据结构，其中一个或多个动作与转义动作相关联。此外，这些机制基于事务提交成功还是中止，在动作列表数据结构中执行一个或多个动作。

8. 发明申请

US20120316413A1 MEASUREMENT APPARATUS 审中-公开
标题翻译：测量装置
公开(公告)号：US20120316413A1
公开(公告)日：2012-12-13
申请号：US13514471
申请日：2011-01-18
申请人： Shuhai Liu , Feng Xu , Weihu Wang , Peng Wu , Yanqing Zhang
发明人： Shuhai Liu , Feng Xu , Weihu Wang , Peng Wu , Yanqing Zhang
IPC分类号： A61B5/00 , A61B5/0402 , A61B5/02 , A61B5/01 , A61B5/0408 , A61B5/145
CPC分类号： A61B5/04 , A61B5/0002 , A61B5/02 , A61B5/6898
摘要： Disclosed is a measurement apparatus that includes a main body, a signal processing module disposed inside the main body, a first data communication interface coupled with the signal processing module, and a signal collection module coupled with the signal processing module; the signal collection module functions to measure the physiological parameter signal and output the physiological parameter signal to the signal processing module; the signal processing module functions to process the physiological parameter signal to generate the physiological parameter data, and output the physiological parameter data to the terminal device via the first data communication interface, such that the terminal device can display the physiological parameter data. The user can directly conduct the physiological parameter measurement using the measurement apparatus according to the present invention without any specialized measurement equipment.
摘要翻译：本发明公开了一种测量装置，包括主体，设置在主体内部的信号处理模块，与信号处理模块耦合的第一数据通信接口以及与信号处理模块耦合的信号采集模块; 信号采集模块用于测量生理参数信号并将生理参数信号输出到信号处理模块; 所述信号处理模块用于处理所述生理参数信号以产生所述生理参数数据，并且经由所述第一数据通信接口将所述生理参数数据输出到所述终端设备，使得所述终端设备可以显示所述生理参数数据。用户可以使用根据本发明的测量装置直接进行生理参数测量而没有任何专门的测量设备。

9. 发明申请

US20120109715A1 VISUALIZING VISITATION PATTERNS AT SITES OF A COMMERCIAL FACILITY 审中-公开
标题翻译：可视化商业场所的访客模式
公开(公告)号：US20120109715A1
公开(公告)日：2012-05-03
申请号：US12916310
申请日：2010-10-29
申请人： Peng Wu , Hui Chao , Daniel R. Tretter
发明人： Peng Wu , Hui Chao , Daniel R. Tretter
IPC分类号： G06Q10/00
CPC分类号： G06Q30/0201 , G06Q30/0204
摘要： Sensor data characterizing detected physical presence characteristics of customers visiting respective sites distributed about a commercial facility is obtained. Visitation patterns of different demographic groups of the customers to the sites are determined. A graphic visualization of one or more of the visitation patterns is generated.
摘要翻译：获得表征检测到访问分布在商业设施附近的各个站点的客户的物理存在特性的传感器数据。确定了不同人口群体对该地点的访问模式。生成一个或多个访问模式的图形可视化。

10. 发明授权

US08097701B2 Aldehyde tags, uses thereof in site-specific protein modification 有权
标题翻译：醛标签，其在位点特异性蛋白质修饰中的用途
公开(公告)号：US08097701B2
公开(公告)日：2012-01-17
申请号：US13163565
申请日：2011-06-17
申请人： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
发明人： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
IPC分类号： C07K1/00 , C07K16/00 , A61L33/00
CPC分类号： C07K16/00 , A61K38/1825 , A61K38/215 , A61K38/37 , A61K38/45 , A61K39/00 , C07K1/006 , C07K1/1072 , C07K1/13 , C07K14/00 , C07K14/35 , C07K14/565 , C07K16/46 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/622 , C12N9/13 , C12N9/96 , C12P21/00 , C12P21/005 , C12Y208/02
摘要： The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
摘要翻译：本发明的特征在于通过掺入醛标记蛋白的位点特异性修饰的组合物和方法。通过甲酰甘氨酸生成酶（FGE）的作用，在醛标记的硫酸酯酶基序上进行酶促修饰产生甲酰甘氨酸（FGly）残基。 FGly残基的醛部分可以用作化学处理，用于将目标部分的位点特异性连接到多肽。

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