专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08704158B2 Fluorescence standard, and the use thereof 有权
标题翻译：荧光标准及其用途
公开(公告)号：US08704158B2
公开(公告)日：2014-04-22
申请号：US12937009
申请日：2009-04-17
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
IPC分类号： G01D18/00 , G01J1/58 , G01N21/00 , C12M1/34
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescence standards are corundum, fluorite, turquoise, amber, zircon, zoisite, iolite or cordierite, spinel, topaz, calcium fluorite, sphalerite or zincblende, calcite or calcspar, apatite, scheelite or calcium tungstate, willemite, feldspars, sodalite, a uranium mineral, a mineral containing Al3+, and in particular ruby and sapphire.
摘要翻译：本发明涉及荧光标准，特别是用于校准光学检测器的荧光标准。根据本发明，荧光矿物或矿物质的混合物用作荧光标准。荧光矿物可以是天然存在的矿物质或合成产生的矿物质。用作荧光标准的优选的荧光矿物是刚玉，萤石，绿松石，琥珀，锆石，堇青石，石英或堇青石，尖晶石，黄玉，萤石，闪锌矿或闪锌矿，方解石或钙质，磷灰石，白钨矿或钨酸钙，硅锌矿，长石，钠盐，铀矿物质，含有Al3 +的矿物，特别是红宝石和蓝宝石。

2. 发明申请

US20110076687A1 FLUORESCENCE STANDARD, AND THE USE THEREOF 有权
标题翻译：荧光标准及其使用
公开(公告)号：US20110076687A1
公开(公告)日：2011-03-31
申请号：US12937009
申请日：2009-04-17
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
IPC分类号： G01J1/10 , G01N21/64 , C12Q1/68 , C12Q1/04 , C12M1/34 , G01N23/00
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescence standards are corundum, fluorite, turquoise, amber, zircon, zoisite, iolite or cordierite, spinel, topaz, calcium fluorite, sphalerite or zincblende, calcite or calcspar, apatite, scheelite or calcium tungstate, willemite, feldspars, sodalite, a uranium mineral, a mineral containing Al3+, and in particular ruby and sapphire.
摘要翻译：本发明涉及荧光标准，特别是用于校准光学检测器的荧光标准。根据本发明，荧光矿物或矿物质的混合物用作荧光标准。荧光矿物可以是天然存在的矿物质或合成产生的矿物质。用作荧光标准的优选的荧光矿物是刚玉，萤石，绿松石，琥珀，锆石，堇青石，石英或堇青石，尖晶石，黄玉，萤石，闪锌矿或闪锌矿，方解石或钙质，磷灰石，白钨矿或钨酸钙，硅锌矿，长石，钠盐，铀矿物质，含有Al3 +的矿物，特别是红宝石和蓝宝石。

3. 发明授权

US08563326B2 Sample holder and method of using the same 失效
标题翻译：样品夹持器及其使用方法
公开(公告)号：US08563326B2
公开(公告)日：2013-10-22
申请号：US12933832
申请日：2009-03-31
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
IPC分类号： G01N33/53
CPC分类号： G01N21/03 , B01L3/50857 , B01L3/5088 , B01L2200/142 , B01L2300/04 , B01L2300/0822 , B01L2300/0861 , B01L2300/161 , G01N21/25 , G01N21/278 , G01N21/64 , G01N21/76 , G01N35/00029 , G01N2021/0325 , G01N2021/0346 , G01N2021/035 , G02B21/34
摘要： A sample holder, such as a microscope slide, is provided in the form of a card-shaped substrate or plate, preferably for use in an analytical reader. The sample holder comprises at least one hole, preferably a plurality of holes, for receiving a sample to be analyzed. The at least one hole extends completely through the substrate and is sized such that the sample is held within the at least one hole by means of the surface tension of the sample against the force of gravity. Optionally the substrate comprises a first upper substrate and a second lower substrate that together embed a porous membrane. As a further option the sample holder comprises a first cover attached to the top side of the first upper substrate and/or a second cover attached to the bottom side of the second lower substrate. Moreover a method for using such a sample holder in an analytical reader is provided, comprising the steps of: filling the at least one hole of the sample holder with a sample and reagent mixture; inserting the sample holder in the analytical reader; and analyzing the sample and reagent mixture in the at least one hole of the sample holder with the analytical reader.
摘要翻译：样品架（例如显微镜载玻片）以卡形基板或板的形式提供，优选用于分析读取器。样品架包括用于接收待分析样品的至少一个孔，优选多个孔。所述至少一个孔完全延伸穿过基底，并且其尺寸设计成使得样品通过样品的表面张力抵抗重力而保持在至少一个孔内。可选地，基底包括一起嵌入多孔膜的第一上基底和第二下基底。作为另一选择，样品架包括附接到第一上基板的顶侧的第一盖和/或附接到第二下基板的底侧的第二盖。此外，提供了一种在分析读取器中使用这种样品保持器的方法，包括以下步骤：用样品和试剂混合物填充样品架的至少一个孔; 将样品架插入分析读数器; 并用分析读取器分析样品架的至少一个孔中的样品和试剂混合物。

4. 发明授权

US08202479B1 Light collection system 有权
标题翻译：集光系统
公开(公告)号：US08202479B1
公开(公告)日：2012-06-19
申请号：US11270263
申请日：2005-11-09
申请人： Dar Bahatt , Konrad Faulstich
发明人： Dar Bahatt , Konrad Faulstich
IPC分类号： C12M1/34
CPC分类号： C12Q1/66 , G01N21/6428 , G01N21/645 , G01N21/66 , G01N21/763 , G01N33/581 , G01N2021/6439 , G01N2021/6469
摘要： The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.
摘要翻译：本教导提供了用于生物材料的检测单元和用于检测生物材料的方法，所述生物材料包括与包含生物材料的内部空间光学耦合的感光材料，以避免光学部件或外部光源。

5. 发明申请

US20080241838A1 METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸的方法和系统
公开(公告)号：US20080241838A1
公开(公告)日：2008-10-02
申请号：US11965837
申请日：2007-12-28
申请人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
发明人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6823 , C12Q1/6825 , C12Q2531/113 , C12Q2521/307 , C12Q2525/204 , C12Q2565/607 , C12Q2561/109 , C12Q2565/519
摘要： Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved.
摘要翻译：描述了用于检测样品中靶核酸的方法和试剂盒。在一些实施方案中，待分析的样品包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测的第二区标记，扩增杂交引物的聚合酶和包含核酸酶活性的酶，其可以切割杂交的杂交探针，从而释放标记的探针片段。在一些实施方案中，然后可以将样品与包含可以与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。这些捕获探针比完整的杂交探针更容易与探针片段结合。然后可以在支撑表面上检测标签。以这种方式，可以实现探针片段与完整杂交探针之间的改善的区别。

6. 发明申请

US20070212695A1 Compositions, methods, and kits for selective amplification of nucleic acids 审中-公开
标题翻译：用于选择性扩增核酸的组合物，方法和试剂盒
公开(公告)号：US20070212695A1
公开(公告)日：2007-09-13
申请号：US11331599
申请日：2006-01-12
申请人： Vissarion Aivazachvili , Konrad Faulstich , Tony Tran
发明人： Vissarion Aivazachvili , Konrad Faulstich , Tony Tran
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6827 , C12Q1/6844 , C12Q1/6853 , Y02A50/54 , C12Q2525/307 , C12Q2531/125 , C12Q2525/117 , C12Q2561/125 , C12Q2537/143
摘要： The current teachings are directed to compositions, methods, and kits for selectively amplifying and for detecting target sequences. In some embodiments, a circularizable probe and/or a probe pair are disclosed for selectively amplifying target sequences. Methods for selectively amplifying target sequences are also disclosed, as are methods for detecting selectively amplified target sequences. Certain embodiments of the disclosed methods comprise a circularizable probe, a probe pair, comprising a first probe and a second probe, or both. In certain embodiments, a multiplicity of different circularizable probes, a multiplicity of different probe sets, or a multiplicity of different circularizable probes and a multiplicity of different probe sets are provided to selectively amplify or to detect a multiplicity of different target sequences, typically in a multiplex reaction. According to certain disclosed methods, surrogates of the target sequences are selectively amplified, including without limitation ligated probes, first amplification products, second amplification products, or combinations thereof. In some embodiments, selectively amplified target sequences or their surrogates are detected, directly or indirectly, indicating the presence of the corresponding target sequence. Kits to facilitate the performance of the disclosed methods are also provided.
摘要翻译：目前的教导涉及用于选择性扩增和检测靶序列的组合物，方法和试剂盒。在一些实施方案中，公开了可圆化探针和/或探针对，用于选择性扩增靶序列。还公开了选择性扩增靶序列的方法，以及用于检测选择性扩增的靶序列的方法。所公开方法的某些实施方案包括可圆化的探针，包括第一探针和第二探针的探针对，或两者。在某些实施方案中，提供多个不同的可圆化探针，多个不同的探针组或多个不同的可环化探针和多个不同的探针组，以选择性地扩增或检测多种不同靶序列，通常在多重反应。根据某些公开的方法，选择性扩增靶序列的替代物，包括但不限于连接的探针，第一扩增产物，第二扩增产物或其组合。在一些实施方案中，直接或间接检测选择性扩增的靶序列或其替代物，表明存在相应的靶序列。还提供了用于促进所公开方法的性能的套件。

7. 发明授权

US08147770B2 Microfluidic device including a dissolvable structure for flow control 有权
标题翻译：微流体装置包括用于流量控制的可溶解结构
公开(公告)号：US08147770B2
公开(公告)日：2012-04-03
申请号：US12954519
申请日：2010-11-24
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
IPC分类号： B01D11/04 , B01L3/00 , B01L3/02 , G01N1/10
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

8. 发明申请

US20110126913A1 Device Including A Dissolvable Structure For Flow Control 有权
标题翻译：包括流量控制可溶解结构的装置
公开(公告)号：US20110126913A1
公开(公告)日：2011-06-02
申请号：US12954519
申请日：2010-11-24
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
IPC分类号： F16K31/64 , F16K51/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解的屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

9. 发明申请

US20110014617A1 Methods and Systems for Detecting Nucleic Acids 审中-公开
标题翻译：检测核酸的方法和系统
公开(公告)号：US20110014617A1
公开(公告)日：2011-01-20
申请号：US12816006
申请日：2010-06-15
申请人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
发明人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6823 , C12Q1/6825 , C12Q2531/113 , C12Q2521/307 , C12Q2525/204 , C12Q2565/607 , C12Q2561/109 , C12Q2565/519
摘要： Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved.
摘要翻译：描述了用于检测样品中靶核酸的方法和试剂盒。在一些实施方案中，待分析的样品包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测的第二区标记，扩增杂交引物的聚合酶和包含核酸酶活性的酶，其可以切割杂交的杂交探针，从而释放标记的探针片段。在一些实施方案中，然后可以将样品与包含可以与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。这些捕获探针比完整的杂交探针更容易与探针片段结合。然后可以在支撑表面上检测标签。以这种方式，可以实现探针片段与完整杂交探针之间的改善的区别。

10. 发明授权

US06627416B1 5′-modified nucleotides and the application thereof in molecular biology and medicine 失效
标题翻译： 5'-修饰的核苷酸及其在分子生物学和医学中的应用
公开(公告)号：US06627416B1
公开(公告)日：2003-09-30
申请号：US09646890
申请日：2001-01-10
申请人： Konrad Faulstich , Wilhelm Ansorge
发明人： Konrad Faulstich , Wilhelm Ansorge
IPC分类号： C12Q168
CPC分类号： C12Q1/6869 , C12Q2527/119 , C12Q2527/101 , C12Q2525/113
摘要： The invention relates to 5′-modified nucleotides and to nucleic acids which contain these nucleotides. Processes for incorporating the 5′-modified nucleotides into nucleic acids, and the subsequent site-specific cleavage of the nucleic acids at the 5′-modified monomer building blocks, are also disclosed. These processes can be employed for nucleic acid sequencing, for generating nucleic acid libraries, for detecting mutations, for preparing support-bound nucleic acids and for pharmaceutical purposes.
摘要翻译：本发明涉及5'-修饰的核苷酸和含有这些核苷酸的核酸。还公开了将5'-修饰的核苷酸并入核酸的方法，以及随后的5'-修饰的单体结构单元上的核酸的位点特异性切割。这些方法可用于核酸测序，产生核酸文库，检测突变，制备载体结合核酸和用于制药目的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式