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1. 发明申请

US20180252630A1 HYDROGEL PARTICLES WITH TUNABLE OPTICAL PROPERTIES 审中-公开
公开(公告)号：US20180252630A1
公开(公告)日：2018-09-06
申请号：US15895307
申请日：2018-02-13
申请人： SLINGSHOT BIOSCIENCES
发明人： Jeffrey KIM , Oliver LIU , Jeremy AGRESTI , Anh Tuan NGUYEN
IPC分类号： G01N15/10 , G01N15/14 , G01N21/64
CPC分类号： G01N15/1012 , G01N15/14 , G01N21/6428 , G01N2015/1006 , G01N2015/1018 , G01N2015/1415 , G01N2015/149 , G01N2021/6439
摘要： The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.

2. 发明申请

US20170248500A1 DETERMINATION OF ANALYTES IN A SAMPLE MATRIX BY SOLVENT EXTRACTION 审中-公开
公开(公告)号：US20170248500A1
公开(公告)日：2017-08-31
申请号：US15515794
申请日：2014-10-20
申请人： FOSS ANALYTICAL A/S
发明人： Claus HOLM , Malin DAHL , Christer Zoffman BISGAARD
IPC分类号： G01N1/40 , G01N1/34 , G01N30/60 , B01D11/02
CPC分类号： G01N1/40 , A23L5/23 , B01D11/02 , B01D11/0203 , G01N1/34 , G01N1/4055 , G01N15/1012 , G01N15/1459 , G01N30/60 , G01N33/543 , G01N33/569 , G01N2001/2893 , G01N2001/4061 , G01N2015/1006 , G01N2015/1018 , G01N2030/009 , G01N2030/062
摘要： Determination of Analytes in a Sample Matrix by Solvent Extraction A method for the assay of one or more analytes in a sample matrix comprising the steps of: performing analyte extraction on the sample matrix, said analyte extraction comprising combining the sample matrix with a solvent for an extraction period which is less than that required for reaching equilibrium; and separating the analyte containing solvent from the sample matrix; next measuring a level of analyte present in the separated solvent; and then applying in a computer a calibration by which is established a mathematical relationship between levels of analyte extracted from each of a plurality of reference samples by means of the process employed above in the extraction for the sample matrix and a reference value of the levels of analyte for each reference sample to thereby derive a measure of the level of analyte in the sample matrix. Specifically a method to determine the amount of mycotoxins in cereal grain, especially OTA (ochratoxin A) and DON (deoxynivalenol) by mixing with a solvent comprising water alcohol mixture, with 20-40% ethanol by volume.

3. 发明申请

US20170212136A1 PROCESS FOR ENSURING CONSISTENCY AND REPRODUCIBILITY OF A DIAGNOSTIC OR RESEARCH METHOD 审中-公开
公开(公告)号：US20170212136A1
公开(公告)日：2017-07-27
申请号：US15225651
申请日：2016-08-01
申请人： Nodality, Inc.
发明人： Norman Purvis , Santosh Putta , Matt Westfall , David Rosen , David Spellmeyer , Jason Ptacek
IPC分类号： G01N33/96 , G01N15/10
CPC分类号： G01N33/96 , C12Q1/025 , G01N15/1012 , G01N33/5005 , G01N33/68 , G01N2015/1006 , G01N2015/1018 , G01N2496/80 , G01N2560/00 , H01J49/0009
摘要： A method is disclosed in which control processes are used to maintain consistency across a research or diagnostic series of steps. Some embodiments of the processes include the use of fresh or lyophilized cell lines, beads, surface or other markers. The use of quality control processes is intended to monitor data from the underlying methods in order to detect unacceptable variations and to allow for exclusion or normalization. Overlapping control processes allows for tighter control and for redundancy in the monitoring.

4. 发明授权

US09618442B2 Multiple flow channel particle analysis system 有权
公开(公告)号：US09618442B2
公开(公告)日：2017-04-11
申请号：US14739812
申请日：2015-06-15
申请人： CYTONOME/ST, LLC
发明人： Johnathan Charles Sharpe , Emanuel Tito Mendes Machado , Blair D. Morad , Rudolf Hulspas , Donald Francis Perrault, Jr.
IPC分类号： G01N21/00 , G01N15/14 , G01N15/10 , G01N21/53 , G01N21/64
CPC分类号： G01N15/1484 , G01N15/1012 , G01N15/1056 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N21/64 , G01N2015/1018 , G01N2015/1075 , G01N2015/1402 , G01N2015/149
摘要： A microfluidic multiple channel particle analysis system which allows particles from a plurality of particle sources to be independently simultaneously entrained in a corresponding plurality of fluid streams for analysis and sorting into particle subpopulations based upon one or more particle characteristics.

5. 发明申请

US20160282253A1 NANOPARTICLES FOR SELF REFERENCING CALIBRATION 审中-公开
标题翻译：自我参考校准的纳米技术
公开(公告)号：US20160282253A1
公开(公告)日：2016-09-29
申请号：US15032960
申请日：2014-10-28
申请人： TRUSTEES OF BOSTON UNIVERSITY
发明人： Selim M. UNLU , George DAABOUL , Margo R. MONROE , Carlos LOPEZ , Ahmet TUYSUZOGLU
IPC分类号： G01N15/10 , G02B21/06 , G02B21/02 , G01N33/543 , G02B7/09 , G01N15/14 , C12Q1/68 , G02B21/34 , G02B21/36
CPC分类号： G01N15/1012 , B82Y15/00 , C12Q1/6837 , G01N15/1434 , G01N33/54366 , G01N2015/1018 , G01N2015/1087 , G01N2015/1454 , G02B7/09 , G02B21/02 , G02B21/06 , G02B21/244 , G02B21/34 , G02B21/365 , Y10S977/954
摘要： Systems and methods for high-throughput processing of assay plates include a calibration nanoparticle to facilitate automated focusing of the imaging system. An assay plate includes a base layer, a transparent layer in contact with the base layer, and at least one calibration nanoparticle having a pre-defined size immobilized on the assay plate surface. The assay plate surface can be functionalized to selectively bind to biological targets. The assay plate can be used in an imaging system for high-throughput autofocus and biological target detection.
摘要翻译：用于测定板的高通量处理的系统和方法包括用于促进成像系统的自动聚焦的校准纳米颗粒。测定板包括基底层，与基底层接触的透明层，以及固定在测定板表面上的至少一种具有预定义尺寸的校准纳米颗粒。测定板表面可以官能化以选择性地结合生物靶标。测定板可用于成像系统中，用于高通量自动对焦和生物目标检测。

6. 发明授权

US09068915B2 Method and system for calibrating a flow cytometer 有权
标题翻译：用于校准流式细胞仪的方法和系统
公开(公告)号：US09068915B2
公开(公告)日：2015-06-30
申请号：US13779701
申请日：2013-02-27
申请人： OJK Consulting Ltd
发明人： Oliver Kenyon
IPC分类号： G01N15/14 , G01N31/00 , G01N15/10
CPC分类号： G01N15/1459 , G01N15/1012 , G01N2015/1018
摘要： A method and system for calibrating a flow cytometer to a refractive index X, the method comprising: analyzing a first mixture of particles in the cytometer and recording the results produced, wherein the first mixture comprises particles having refractive index X, wherein the particles of refractive index X have a plurality of different sizes; analyzing a second mixture of particles in the cytometer and recording the results produced, wherein the second mixture comprises particles having refractive index Y, wherein refractive index Y does not equal refractive index X, and wherein the particles of refractive index Y have a plurality of different sizes, wherein there is at least a partial overlap between the particle sizes in the first and second mixtures, and wherein the size of at least one particle of the second mixture is known; and using the results produced by the first and second mixture to calibrate the cytometer to refractive index X.
摘要翻译：一种用于将流式细胞仪校准为折射率X的方法和系统，所述方法包括：分析细胞仪中的第一颗粒混合物并记录产生的结果，其中第一混合物包含具有折射率X的颗粒，其中折射率索引X具有多个不同的大小; 分析细胞仪中的第二颗粒混合物并记录产生的结果，其中第二混合物包含具有折射率Y的颗粒，其中折射率Y不等于折射率X，并且其中折射率Y的颗粒具有多个不同的尺寸，其中在第一和第二混合物中的颗粒尺寸之间至少存在部分重叠，并且其中第二混合物的至少一个颗粒的尺寸是已知的; 并使用由第一和第二混合物产生的结果将细胞仪校准为折射率X.

7. 发明申请

US20140343869A1 PARTICLE PROCESSING SYSTEMS AND METHODS FOR NORMALIZATION/CALIBRATION OF SAME 审中-公开
标题翻译：颗粒加工系统及其正规化/校准方法
公开(公告)号：US20140343869A1
公开(公告)日：2014-11-20
申请号：US14281353
申请日：2014-05-19
申请人： CYTONOME/ST, LLC
发明人： Johnathan Charles Sharpe , Emanuel Tito Mendes Machado , Rudolf Hulspas
IPC分类号： G01N15/14
CPC分类号： G01N15/1484 , G01N15/1012 , G01N15/1056 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N21/64 , G01N2015/1018 , G01N2015/1075 , G01N2015/1402 , G01N2015/149
摘要： Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.
摘要翻译：本文公开了系统，方法和非暂时性存储介质，用于调整表示在颗粒处理系统的流动路径中流动的粒子的粒子特性的粒子检测系统的输出。更具体地，可以处理输出并生成校准的粒子特性的输出。在其它实施方案中，使用一种或多种校准颗粒。因此，可以相对于标准比较代表在粒子处理系统的流路中流动的一个或多个校准粒子的粒子特性的粒子检查系统的输出，并且可以基于将输出与标准进行比较。

8. 发明申请

US20140077100A1 MICROORGANISM DETECTING APPARATUS CALIBRATION METHOD AND MICROORGANISM DETECTING APPARATUS CALIBRATION KIT 审中-公开
标题翻译：微生物检测装置校准方法和微生物检测装置校准工具包
公开(公告)号：US20140077100A1
公开(公告)日：2014-03-20
申请号：US14026272
申请日：2013-09-13
申请人： Azbil Corporation
发明人： Norio HASEGAWA
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , G01N15/1012 , G01N15/1459 , G01N21/274 , G01N21/278 , G01N21/645 , G01N2015/0046 , G01N2015/0065 , G01N2015/1018 , Y10T428/2982
摘要： A method for calibrating a microorganism detecting apparatus includes drawing into the microorganism detecting apparatus polystyrene particles with a weight-average molecular weight of no less than 250,000 and no more than 850,000 that, when exposed to light, produce a fluorescence of an intensity that is substantially identical to an intensity of fluorescence produced by a microorganism. The polystyrene particles are exposed to light from a light source of the microorganism detecting apparatus. A fluorescence detector of the microorganism detecting apparatus detects the fluorescence produced by a polystyrene particle. The microorganism detecting apparatus is calibrated based on a detected intensity of the fluorescence.
摘要翻译：微生物检测装置的校准方法包括将重均分子量为250,000以上且850,000以下的微生物检测装置的聚苯乙烯粒子进行拉伸，当暴露于光时，产生强度基本上为与微生物产生的荧光强度相同。聚苯乙烯颗粒暴露于来自微生物检测装置的光源的光。微生物检测装置的荧光检测器检测由聚苯乙烯颗粒产生的荧光。基于检测到的荧光强度校准微生物检测装置。

9. 发明申请

US20130242296A1 METHOD AND SYSTEM FOR CALIBRATING A FLOW CYTOMETER 有权
标题翻译：用于校准流量计的方法和系统
公开(公告)号：US20130242296A1
公开(公告)日：2013-09-19
申请号：US13779701
申请日：2013-02-27
申请人： OJK CONSULTING LTD
发明人： Oliver KENYON
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , G01N15/1012 , G01N2015/1018
摘要： A method and system for calibrating a flow cytometer to a refractive index X, the method comprising: analysing a first mixture of particles in the cytometer and recording the results produced, wherein the first mixture comprises particles having refractive index X, wherein the particles of refractive index X have a plurality of different sizes; analysing a second mixture of particles in the cytometer and recording the results produced, wherein the second mixture comprises particles having refractive index Y, wherein refractive index Y does not equal refractive index X, and wherein the particles of refractive index Y have a plurality of different sizes, wherein there is at least a partial overlap between the particle sizes in the first and second mixtures, and wherein the size of at least one particle of the second mixture is known; and using the results produced by the first and second mixture to calibrate the cytometer to refractive index X.
摘要翻译：一种用于将流式细胞仪校准为折射率X的方法和系统，所述方法包括：分析细胞仪中的第一颗粒混合物并记录产生的结果，其中第一混合物包含具有折射率X的颗粒，其中折射率索引X具有多个不同的大小; 分析细胞仪中的第二颗粒混合物并记录产生的结果，其中第二混合物包含具有折射率Y的颗粒，其中折射率Y不等于折射率X，并且其中折射率Y的颗粒具有多个不同的尺寸，其中在第一和第二混合物中的颗粒尺寸之间至少存在部分重叠，并且其中第二混合物的至少一个颗粒的尺寸是已知的; 并使用由第一和第二混合物产生的结果将细胞仪校准为折射率X.

10. 发明授权

US08171777B2 Systems, storage mediums, and methods for identifying particles in flow 有权
标题翻译：系统，存储介质和用于识别流量中的颗粒的方法
公开(公告)号：US08171777B2
公开(公告)日：2012-05-08
申请号：US12212219
申请日：2008-09-17
申请人： Adam Richard Schilffarth
发明人： Adam Richard Schilffarth
IPC分类号： G01N15/10 , G01N15/14 , G01N21/05 , G01N21/64
CPC分类号： G01N15/1429 , G01N15/0205 , G01N15/1012 , G01N15/1031 , G01N15/1425 , G01N15/1427 , G01N15/1459 , G01N2015/025 , G01N2015/1018 , G01N2015/1438 , G01N2015/1477
摘要： Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.
摘要翻译：提供了用于将在流式细胞仪中从多个询问区产生的脉冲相关联的特定颗粒流过流式细胞仪的方法，存储介质和系统。方法，存储介质和系统的实施方案包括用于使用具有独特标记的校准颗粒来校准流式细胞仪的结构，以确定流过流式细胞仪的颗粒的飞行时间。基于计算出的与流式细胞仪的收集器对应的询问区域的飞行时间和相对位置，方法，存储介质和系统可进一步包括用于将其它信号脉冲与一个或多个不同粒子集合的粒子相关联的配置。

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