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    • 8. 发明授权
    • Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies
    • 肿瘤成像和光谱学方法以及抗肿瘤药物疗法疗效的测定
    • US08078262B2
    • 2011-12-13
    • US10474977
    • 2002-04-15
    • John C MurphyJerry R. WilliamsRobert Osiander
    • John C MurphyJerry R. WilliamsRobert Osiander
    • A61B6/00
    • A61B5/415A61B5/015A61B5/416A61B5/418
    • The present invention relates to methods of passive infrared imaging and dynamic infrared imaging of a tumor or lesion (“DIR”) where multiple images are taken before, during and after heating or cooling the tumor or lesion. Patterns of intensity of infrared emission in the infrared image(s) are related to the level of vascularity or metabolic activity of the tumor or lesion, and are used to identify size and shape of the tumor or lesion. The patterns can also be used to determine whether Kaposi's sarcoma lesions, skin cancer lesions and melanomas are active or inactive. Changes in the patterns of infrared emission determined by comparing images taken before, during and after the onset of drug or radiation therapy, are used to assess efficacy of the therapy. The methods can also be used to study tissue affected by angiogenic diseases.
    • 本发明涉及在加热或冷却肿瘤或病变之前,期间和之后摄取多个图像的肿瘤或病变(“DIR”)的被动红外成像和动态红外成像方法。 红外图像中红外发射强度的模式与肿瘤或病变的血管分布或代谢活动水平有关,用于鉴定肿瘤或病变的大小和形状。 这些模式也可用于确定卡波西肉瘤病变,皮肤癌病变和黑素瘤是否活跃或无活性。 通过比较在药物或放射治疗之前,期间和之后拍摄的图像确定的红外发射模式的变化用于评估治疗的疗效。 该方法也可用于研究受血管生成疾病影响的组织。
    • 9. 发明授权
    • Thermal interface and switch using carbon nanotube arrays
    • 使用碳纳米管阵列的热界面和开关
    • US07416019B2
    • 2008-08-26
    • US10916730
    • 2004-08-11
    • Robert OsianderJennifer L. Sample
    • Robert OsianderJennifer L. Sample
    • F28F27/00
    • B82Y30/00B82Y40/00C01B32/162C01B2202/02C01B2202/08C01B2202/34C01B2202/36F28F13/00F28F2013/006F28F2013/008F28F2255/20H01L23/373H01L2924/0002Y10S977/734Y10S977/742Y10S977/939Y10T428/265Y10T428/30H01L2924/00
    • Thermal interfaces and methods include an array of carbon nanotubes aligned substantively perpendicularly from a substrate. One method includes arranging metal catalyst particles with a particular ligand on a fluid surface of a Langmuir-Blodgett trough. This forms uniformly spaced particles with spacing based on the particular ligand. The uniformly spaced metal catalyst particles are deposited on a substrate and carbon nanotubes are grown on the particles using chemical vapor deposition. A thermal interface can be produced with a carbon nanotube packing ratio greater than fifty percent and used in a thermal switch or other device. In some methods, commercially available nanotubes are condensed on a substrate using carbon nanotubes with terminal carboxylic acids in solution and an amine monolayer on the substrate. Pretreatment of the nanotubes in a switch by applying heavy pressure between two surfaces results in good thermal conductivity between those surfaces at smaller operating pressures.
    • 热界面和方法包括从衬底基本垂直排列的碳纳米管阵列。 一种方法包括在Langmuir-Blodgett槽的流体表面上布置具有特定配体的金属催化剂颗粒。 这形成基于特定配体的间隔均匀间隔的颗粒。 将均匀间隔的金属催化剂颗粒沉积在基底上,并且使用化学气相沉积在颗粒上生长碳纳米管。 可以生产具有大于百分之五十的碳纳米管填充比的热界面,并用于热开关或其他装置中。 在一些方法中,使用具有末端羧酸的碳纳米管和基材上​​的胺单层将市售的纳米管冷凝在基材上。 通过在两个表面之间施加重压来在开关中预处理纳米管导致在较小的操作压力下这些表面之间的良好导热性。