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1. 发明申请

US20060035948A1 Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20060035948A1
公开(公告)日：2006-02-16
申请号：US10510835
申请日：2003-04-10
申请人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho -Won Seo , Hwa-Sup Shin
发明人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho -Won Seo , Hwa-Sup Shin
IPC分类号： A61K31/41 , C07D405/02
CPC分类号： C07D405/12
摘要： The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
摘要翻译：本发明涉及用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物。本发明的化合物可用于保护神经细胞和脑损伤; 抗氧化; 抑制NO产生; 保护心脏抑制血管发生; 保护肾脏，心脏和组织等保护器官，并在主要心血管手术中保护器官。

2. 发明授权

US07414068B2 Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07414068B2
公开(公告)日：2008-08-19
申请号：US10510835
申请日：2003-04-10
申请人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho-Won Seo , Hwa-Sup Shin
发明人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho-Won Seo , Hwa-Sup Shin
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D405/12
摘要： The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
摘要翻译：本发明涉及用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物。本发明的化合物可用于保护神经细胞和脑损伤; 抗氧化; 抑制NO产生; 保护心脏抑制血管发生; 保护肾脏，心脏和组织等保护器官，并在主要心血管手术中保护器官。

3. 发明授权

US06323238B1 Benzopyranyl guanidine derivatives, process for preparation thereof, and pharmaceutical compositions containing them 失效
标题翻译：苯并吡喃基胍衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06323238B1
公开(公告)日：2001-11-27
申请号：US09693082
申请日：2000-10-20
申请人： Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Nak-Jeong Kim , Jee Hee Suh , Young Sook Park , Sun Kyung Hwang , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , In Sun Cho , Miae Namgoong , Dongsoo Jang
发明人： Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Nak-Jeong Kim , Jee Hee Suh , Young Sook Park , Sun Kyung Hwang , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , In Sun Cho , Miae Namgoong , Dongsoo Jang
IPC分类号： C07D31174
CPC分类号： C07D407/04 , A61K31/155 , A61K31/352 , C07D311/68
摘要： The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. Wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification.
摘要翻译：本发明涉及式1的新型苯并吡喃基胍衍生物，其制备方法和苯并吡喃基胍衍生物的药物用途。本发明的苯并吡喃基胍衍生物可用于保护心脏，神经元细胞或脑损伤，保存器官，苯并吡喃基胍衍生物在药理学上可用于抑制NO产生，抑制脂质过氧化，血管生成或再狭窄。其中R1 ，R2，R3，R4，R5，R6，n和*各自在说明书中定义。

4. 发明授权

US06413983B1 Benzopyranyl heterocycle derivatives, process for preparation thereof, and pharmaceutical compositions containing them 失效
标题翻译：苯并吡喃基杂环衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06413983B1
公开(公告)日：2002-07-02
申请号：US09724029
申请日：2000-11-28
申请人： Sung-Eun Yoo , Sun Kyung Lee , Kyu Yang Yi , Nak Jeong Kim , Jee Hee Suh , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , Dongha Lee , Insun Cho , Miae Namgung , Dongsoo Jang
发明人： Sung-Eun Yoo , Sun Kyung Lee , Kyu Yang Yi , Nak Jeong Kim , Jee Hee Suh , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , Dongha Lee , Insun Cho , Miae Namgung , Dongsoo Jang
IPC分类号： A01N4342
CPC分类号： C07D498/14 , C07D405/04
摘要： The present invention relates to novel benzopyranyl heterocycle derivatives of the formula 1, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from “ischemia-reperfusion” injury, treatment for diseases related to it and suppressing lipid peroxidation. Wherein R1, R2, R3, R4, n and * are each defined in specification.
摘要翻译：本发明涉及式1的新型苯并吡喃基杂环衍生物，其制备方法和苯并吡喃基杂环衍生物的药物用途。本发明的苯并吡喃基杂环衍生物可用于保护心脏，脑，视网膜和神经元细胞免受“缺血再灌注”损伤，治疗与之相关的疾病和抑制脂质过氧化作用。其中R1，R2，R3，R4，n 和*各自在规范中定义。

5. 发明授权

US07420060B2 Benzopyran derivatives substituted with a thioxobenzoxazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them 失效
标题翻译：被噻吩并恶唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，它们的制剂和含有它们的药物组合物
公开(公告)号：US07420060B2
公开(公告)日：2008-09-02
申请号：US10558111
申请日：2004-05-28
申请人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
发明人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
IPC分类号： C07D263/58
CPC分类号： C07D413/04
摘要： The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in , have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.
摘要翻译：本发明涉及用硫代苯并恶唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有上述作为有效成分的药物组合物用<式1>所示的噻吩并恶唑衍生物取代的苯并吡喃衍生物具有在体内和体外保护心脏免于缺血 - 再灌注的功能，使得含有本发明的噻唑并苯并恶唑衍生物或其可药用盐取代的苯并吡喃衍生物的药物组合物作为有效成分可以有效地用于保护组织受缺血再灌注的影响，例如保护心脏，神经细胞，脑，视网膜细胞，储存器官等，以及治疗由局部缺血 - 再灌注引起的疾病。

6. 发明授权

US07309793B2 Benzopyran derivatives substituted with a benzimidazole derivative, pharmaceutically acceptable salts therof, their preparations and pharmaceutical compositions containing them 失效
标题翻译：被苯并咪唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，其制剂和含有它们的药物组合物
公开(公告)号：US07309793B2
公开(公告)日：2007-12-18
申请号：US10558020
申请日：2004-05-28
申请人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
发明人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
IPC分类号： C07D235/26 , C07D235/28 , C07D235/30
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.
摘要翻译：本发明涉及用苯并咪唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有它们的药物组合物。由式（1）表示的苯并咪唑衍生物取代的苯并吡喃衍生物具有保护心脏免于缺血再灌注而无副作用如血管舒张的功能，因此含有苯并咪唑衍生物或其药学上可接受的盐取代的苯并吡喃衍生物的药物组合物作为有效成分的本发明可以有效地用于保护受缺血再灌注影响的组织，例如用于保护心脏，神经细胞，脑，视网膜细胞，储存器官等，并用于治疗疾病由缺血再灌注引起。

7. 发明申请

US20060293376A1 Benzopyran derivatives substituted with a benzimidazole derviative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them 失效
标题翻译：被苯并咪唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，其制剂和含有它们的药物组合物
公开(公告)号：US20060293376A1
公开(公告)日：2006-12-28
申请号：US10558020
申请日：2004-05-28
申请人： Hong Lim , Dong Lee , San Kim , Sung-Eun Yoo , Kyu Yi , Sun Lee , Jee Suh , Nak Kim , Sun Hwang , Tae Kim , Byung Lee , Ho-Won Seo
发明人： Hong Lim , Dong Lee , San Kim , Sung-Eun Yoo , Kyu Yi , Sun Lee , Jee Suh , Nak Kim , Sun Hwang , Tae Kim , Byung Lee , Ho-Won Seo
IPC分类号： A61K31/4184 , C07D405/04
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.
摘要翻译：本发明涉及被苯并咪唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有它们的药物组合物。由式（1）表示的苯并咪唑衍生物取代的苯并吡喃衍生物具有保护心脏免于缺血再灌注而无副作用如血管舒张的功能，因此含有苯并咪唑衍生物或其药学上可接受的盐取代的苯并吡喃衍生物的药物组合物作为有效成分的本发明可以有效地用于保护受缺血再灌注影响的组织，例如用于保护心脏，神经细胞，脑，视网膜细胞，储存器官等，并用于治疗疾病由缺血再灌注引起。

8. 发明授权

US06469209B1 Acrylate-type fungicide 失效
标题翻译：丙烯酸酯类杀菌剂
公开(公告)号：US06469209B1
公开(公告)日：2002-10-22
申请号：US10009701
申请日：2001-12-14
申请人： Hong Lim , Bong Jin Chung , Jong Sang Chung , In Young Choi , Dae Jong Park , Chang Il Hwang
发明人： Hong Lim , Bong Jin Chung , Jong Sang Chung , In Young Choi , Dae Jong Park , Chang Il Hwang
IPC分类号： C07C23309
CPC分类号： A01N37/50
摘要： The present invention relates to novel acrylate-type N-methyl E-2-(2-methylphenyl)oxymethyl)-6-methylphenyl-glyoxylamide O-methyl oxime represented by formula (1), its preparation method and its use as fungicides. The compound of the present invention has not only stronger fungicidal effect on plant pathogens at low concentrations but also broader fungicidal spectrum than the conventional fungicides. Especially, because the compound has excellent systemic and curative effect as well as no toxicity, it can be used as an efficacious agricultural fungicide. In addition, the compound of the present invention can be useful as environmental-friendly fungicide capable of causing less environmental pollution fungicide due to its strong fungicidal effect at low concentrations.
摘要翻译：本发明涉及由式（1）表示的新型丙烯酸酯型N-甲基E-2-（2-甲基苯基）氧甲基）-6-甲基苯基 - 乙醛酰胺O-甲基肟，其制备方法及其作为杀真菌剂的用途。本发明的化合物不仅具有比常规杀真菌剂在低浓度下对植物病原体更强的杀真菌作用，而且具有更广泛的杀真菌作用。特别是因为该化合物具有优异的全身和治疗效果以及无毒性，因此可用作有效的农药杀菌剂。此外，本发明的化合物由于其在低浓度下具有强烈的杀真菌作用，因此可用作能够减少环境污染杀真菌剂的环保杀真菌剂。

9. 发明申请

US20060055029A1 Integrated heatspreader for use in wire bonded ball grid array semiconductor packages 有权
标题翻译：集成式散热器，适用于线栅球栅阵列半导体封装
公开(公告)号：US20060055029A1
公开(公告)日：2006-03-16
申请号：US10939082
申请日：2004-09-10
申请人： Maurice Othieno , Hong Lim , Qwai Low
发明人： Maurice Othieno , Hong Lim , Qwai Low
IPC分类号： H01L23/34
CPC分类号： H01L23/3735 , H01L23/3677 , H01L24/48 , H01L24/73 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/73265 , H01L2924/00014 , H01L2924/14 , H01L2924/15311 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： The present invention is directed toward systems, packages, and methods for providing improved thermal performance in such packages and systems. Embodiments of the invention include a semiconductor integrated circuit (IC) package having a substrate with a heat spreader mounted on the substrate. An IC die is mounted to the heat spreader such that the heat spreader lies in between the die and the substrate. The invention is also directed to a heat spreader plate useable in a semiconductor package. The heat spreader plate comprises a plate comprised of thermally conductive material suitable for attachment to a packaging substrate wherein the plate includes openings for exposing electrical bonding surfaces of a packaging substrate when the heater spreader plate is mounted on the packaging substrate. Such openings enable wirebonding between the exposed electrical bonding surfaces of the substrate and an integrated circuit die to complete construction of a package including the heatspreader.
摘要翻译：本发明涉及用于在这种包装和系统中提供改进的热性能的系统，包装和方法。本发明的实施例包括具有安装在基板上的散热器的基板的半导体集成电路（IC）封装。 IC散热器安装在散热器上，使得散热器位于模具和基板之间。本发明还涉及可用于半导体封装的散热板。散热板包括由适于附接到包装基板的导热材料构成的板，其中，当加热器散布板安装在包装基板上时，该板包括用于暴露包装基板的电接合表面的开口。这种开口使得能够在基板的暴露的电接合表面和集成电路管芯之间进行引线接合，以完成包括散热器的封装的构造。

10. 发明申请

US20050281011A1 Heat spreader in integrated circuit package 有权
标题翻译：散热器集成电路封装
公开(公告)号：US20050281011A1
公开(公告)日：2005-12-22
申请号：US10873387
申请日：2004-06-22
申请人： Hong Lim , Maurice Othieno , Qwai Low
发明人： Hong Lim , Maurice Othieno , Qwai Low
IPC分类号： H01L23/31 , H01L23/433 , H05K1/18
CPC分类号： H01L23/4334 , H01L23/3128 , H01L24/48 , H01L24/73 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2924/00014 , H01L2924/14 , H01L2924/15311 , H01L2924/16152 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： An integrated circuit (IC) package comprises a package substrate, an IC die mounted on the package substrate, a wire bond electrically connecting the IC die and the package substrate, and a heat spreader mounted on the package substrate. The heat spreader comprises a hole through a portion thereof. The IC die and the wire bond are disposed substantially between the heat spreader and the package substrate.
摘要翻译：集成电路（IC）封装包括封装基板，安装在封装基板上的IC管芯，将IC芯片与封装基板电连接的引线键合件和安装在封装基板上的散热器。散热器包括穿过其一部分的孔。 IC芯片和引线接合件基本上设置在散热器和封装衬底之间。

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