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1. 发明授权

US06413983B1 Benzopyranyl heterocycle derivatives, process for preparation thereof, and pharmaceutical compositions containing them 失效
标题翻译：苯并吡喃基杂环衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06413983B1
公开(公告)日：2002-07-02
申请号：US09724029
申请日：2000-11-28
申请人： Sung-Eun Yoo , Sun Kyung Lee , Kyu Yang Yi , Nak Jeong Kim , Jee Hee Suh , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , Dongha Lee , Insun Cho , Miae Namgung , Dongsoo Jang
发明人： Sung-Eun Yoo , Sun Kyung Lee , Kyu Yang Yi , Nak Jeong Kim , Jee Hee Suh , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , Dongha Lee , Insun Cho , Miae Namgung , Dongsoo Jang
IPC分类号： A01N4342
CPC分类号： C07D498/14 , C07D405/04
摘要： The present invention relates to novel benzopyranyl heterocycle derivatives of the formula 1, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from “ischemia-reperfusion” injury, treatment for diseases related to it and suppressing lipid peroxidation. Wherein R1, R2, R3, R4, n and * are each defined in specification.
摘要翻译：本发明涉及式1的新型苯并吡喃基杂环衍生物，其制备方法和苯并吡喃基杂环衍生物的药物用途。本发明的苯并吡喃基杂环衍生物可用于保护心脏，脑，视网膜和神经元细胞免受“缺血再灌注”损伤，治疗与之相关的疾病和抑制脂质过氧化作用。其中R1，R2，R3，R4，n 和*各自在规范中定义。

2. 发明授权

US06323238B1 Benzopyranyl guanidine derivatives, process for preparation thereof, and pharmaceutical compositions containing them 失效
标题翻译：苯并吡喃基胍衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06323238B1
公开(公告)日：2001-11-27
申请号：US09693082
申请日：2000-10-20
申请人： Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Nak-Jeong Kim , Jee Hee Suh , Young Sook Park , Sun Kyung Hwang , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , In Sun Cho , Miae Namgoong , Dongsoo Jang
发明人： Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Nak-Jeong Kim , Jee Hee Suh , Young Sook Park , Sun Kyung Hwang , Hwa Sup Shin , Byung Ho Lee , Ho Won Seo , Hong Lim , Sun-Ok Kim , In Sun Cho , Miae Namgoong , Dongsoo Jang
IPC分类号： C07D31174
CPC分类号： C07D407/04 , A61K31/155 , A61K31/352 , C07D311/68
摘要： The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. Wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification.
摘要翻译：本发明涉及式1的新型苯并吡喃基胍衍生物，其制备方法和苯并吡喃基胍衍生物的药物用途。本发明的苯并吡喃基胍衍生物可用于保护心脏，神经元细胞或脑损伤，保存器官，苯并吡喃基胍衍生物在药理学上可用于抑制NO产生，抑制脂质过氧化，血管生成或再狭窄。其中R1 ，R2，R3，R4，R5，R6，n和*各自在说明书中定义。

3. 发明授权

US07420060B2 Benzopyran derivatives substituted with a thioxobenzoxazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them 失效
标题翻译：被噻吩并恶唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，它们的制剂和含有它们的药物组合物
公开(公告)号：US07420060B2
公开(公告)日：2008-09-02
申请号：US10558111
申请日：2004-05-28
申请人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
发明人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
IPC分类号： C07D263/58
CPC分类号： C07D413/04
摘要： The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in , have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.
摘要翻译：本发明涉及用硫代苯并恶唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有上述作为有效成分的药物组合物用<式1>所示的噻吩并恶唑衍生物取代的苯并吡喃衍生物具有在体内和体外保护心脏免于缺血 - 再灌注的功能，使得含有本发明的噻唑并苯并恶唑衍生物或其可药用盐取代的苯并吡喃衍生物的药物组合物作为有效成分可以有效地用于保护组织受缺血再灌注的影响，例如保护心脏，神经细胞，脑，视网膜细胞，储存器官等，以及治疗由局部缺血 - 再灌注引起的疾病。

4. 发明授权

US07309793B2 Benzopyran derivatives substituted with a benzimidazole derivative, pharmaceutically acceptable salts therof, their preparations and pharmaceutical compositions containing them 失效
标题翻译：被苯并咪唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，其制剂和含有它们的药物组合物
公开(公告)号：US07309793B2
公开(公告)日：2007-12-18
申请号：US10558020
申请日：2004-05-28
申请人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
发明人： Hong Lim , Dong Ha Lee , Sun Ok Kim , Sung-Eun Yoo , Kyu Yang Yi , Sun Kyung Lee , Jee Hee Suh , Nak Jeong Kim , Sun Kyung Hwang , Tae Mi Kim , Byung Ho Lee , Ho-Won Seo
IPC分类号： C07D235/26 , C07D235/28 , C07D235/30
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.
摘要翻译：本发明涉及用苯并咪唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有它们的药物组合物。由式（1）表示的苯并咪唑衍生物取代的苯并吡喃衍生物具有保护心脏免于缺血再灌注而无副作用如血管舒张的功能，因此含有苯并咪唑衍生物或其药学上可接受的盐取代的苯并吡喃衍生物的药物组合物作为有效成分的本发明可以有效地用于保护受缺血再灌注影响的组织，例如用于保护心脏，神经细胞，脑，视网膜细胞，储存器官等，并用于治疗疾病由缺血再灌注引起。

5. 发明授权

US07351843B2 Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them 失效
标题翻译：呋喃羰基胍衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07351843B2
公开(公告)日：2008-04-01
申请号：US10581799
申请日：2004-12-24
申请人： Kyu Yang Yi , Sun Kyung Lee , Nak Jeong Kim , Jee Hee Suh , Soon Hee Hwang , Byung Ho Lee , Ho Won Seo , Sun Kyung Hwang , Sung Eun Yoo , Kyung Hee Lee
发明人： Kyu Yang Yi , Sun Kyung Lee , Nak Jeong Kim , Jee Hee Suh , Soon Hee Hwang , Byung Ho Lee , Ho Won Seo , Sun Kyung Hwang , Sung Eun Yoo , Kyung Hee Lee
IPC分类号： C07D307/02 , A61K31/34 , A01N43/08
CPC分类号： C07D307/68
摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
摘要翻译：本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等

6. 发明申请

US20100145054A1 IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 失效
标题翻译：具有芳基哌啶取代基的咪唑衍生物，其制备方法和含有其的药物组合物
公开(公告)号：US20100145054A1
公开(公告)日：2010-06-10
申请号：US12599005
申请日：2008-05-13
申请人： Jee Hee Suh , Kyu Yang YI , Nack Jeong KIM , Sung Eun Yoo , Kwang-Seok Oh , Hyae Gyeong Cheon , Mija Ahn , Byung Ho Lee , Won Hoon Jung , Sang Dal Rhee
发明人： Jee Hee Suh , Kyu Yang YI , Nack Jeong KIM , Sung Eun Yoo , Kwang-Seok Oh , Hyae Gyeong Cheon , Mija Ahn , Byung Ho Lee , Won Hoon Jung , Sang Dal Rhee
IPC分类号： C07D471/04 , C07D401/02
CPC分类号： C07D235/18 , C07D401/14 , C07D471/04
摘要： The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
摘要翻译：本发明涉及一种具有式（I）的芳基哌啶取代基及其制备方法的新型咪唑衍生物，以及含有所述咪唑衍生物作为预防或治疗MCH（黑色素浓缩激素）相关疾病

7. 发明授权

US08198307B2 Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same 失效
标题翻译：具有芳基哌啶取代基的咪唑衍生物，其制备方法和含有其的药物组合物
公开(公告)号：US08198307B2
公开(公告)日：2012-06-12
申请号：US12599005
申请日：2008-05-13
申请人： Jee Hee Suh , Kyu Yang Yi , Nack Jeong Kim , Sung Eun Yoo , Kwang-Seok Oh , Hyae Gyeong Cheon , Mija Ahn , Byung Ho Lee , Won Hoon Jung , Sang Dal Rhee
发明人： Jee Hee Suh , Kyu Yang Yi , Nack Jeong Kim , Sung Eun Yoo , Kwang-Seok Oh , Hyae Gyeong Cheon , Mija Ahn , Byung Ho Lee , Won Hoon Jung , Sang Dal Rhee
IPC分类号： C07D471/04 , C07D417/14 , C07D413/14 , C07D409/14 , C07D405/14 , C07D403/14 , C07D403/06 , A61K31/4545 , A61K31/454
CPC分类号： C07D235/18 , C07D401/14 , C07D471/04
摘要： The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
摘要翻译：本发明涉及一种具有式（I）的芳基哌啶取代基及其制备方法的新型咪唑衍生物，以及含有所述咪唑衍生物作为预防或治疗MCH（黑色素浓缩激素）相关疾病

8. 发明申请

US20080215149A1 Lightweight Silicone Implant and Manufacturing Method Thereof 审中-公开
标题翻译：轻质硅胶植入物及其制造方法
公开(公告)号：US20080215149A1
公开(公告)日：2008-09-04
申请号：US11848120
申请日：2007-08-30
申请人： Eun Hyun Bae , Byung Ho Lee
发明人： Eun Hyun Bae , Byung Ho Lee
IPC分类号： A61F2/02
CPC分类号： A61F2/12 , A61F2/0059 , A61F2/02
摘要： Disclosed herein are a lightweight silicone implant which is manufactured by filling a foamed silicone sponge and/or vacant silicone capsules in a silicone bag or a cohesive gel bag and sealing the bag, and a method for manufacturing the same.
摘要翻译：本文公开了一种轻质硅树脂植入物，其通过在硅树脂袋或粘性凝胶袋中填充泡沫硅氧烷海绵和/或空的硅酮胶囊并密封袋而制造，及其制造方法。

9. 发明申请

US20080229738A1 Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment 有权
标题翻译：液压回路，用于在重型设备行驶期间防止铲斗与斗环分离
公开(公告)号：US20080229738A1
公开(公告)日：2008-09-25
申请号：US12075590
申请日：2008-03-12
申请人： Byung Ho Lee
发明人： Byung Ho Lee
IPC分类号： F15B13/01
CPC分类号： E02F9/2239 , F15B2211/20576 , F15B2211/30505 , F15B2211/3116 , F15B2211/329 , F15B2211/40515 , F15B2211/41518 , F15B2211/41554 , F15B2211/428 , F15B2211/45 , F15B2211/7142 , F15B2211/781
摘要： A hydraulic circuit is provided, which can prevent the bucket from being separated from the bucket rest by preventing a change of stroke of a boom cylinder or an arm cylinder during long traveling of wheel type heavy equipment, and can secure safety since it is not required for an operator to adjust the position of a working device like boom and arm. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port formed to connect with a large chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port formed to connect with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During long traveling of the heavy equipment, a very small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.
摘要翻译：提供了一种液压回路，其可以通过在轮式重型设备的长时间行驶期间防止动臂缸或手臂缸的行程改变来防止铲斗与斗架分离，并且可以确保安全性，因为不需要用于操作者调节工作装置如吊杆和手臂的位置。液压回路包括第一和第二液压泵，动臂缸，臂缸，悬臂汇流逻辑阀，形成为与动臂缸的大腔连接的壳体中的第一端口，其中用于动臂缸的阀芯为可移动地安装有形成为与壳体中的液压箱连接的第二端口，以及形成在壳体和位于第一端口和第二端口之间的动臂缸的线轴的陆部的第一孔口。在重型设备的长时间行进中，从第二液压泵供给到动臂缸的大腔的非常少量的液压流体通过第一孔排入液压缸，以防止动臂缸的行程改变。

10. 发明授权

US08104276B2 Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment 有权
标题翻译：液压回路，用于在重型设备行驶期间防止铲斗与斗环分离
公开(公告)号：US08104276B2
公开(公告)日：2012-01-31
申请号：US12075590
申请日：2008-03-12
申请人： Byung Ho Lee
发明人： Byung Ho Lee
IPC分类号： F16D31/02
CPC分类号： E02F9/2239 , F15B2211/20576 , F15B2211/30505 , F15B2211/3116 , F15B2211/329 , F15B2211/40515 , F15B2211/41518 , F15B2211/41554 , F15B2211/428 , F15B2211/45 , F15B2211/7142 , F15B2211/781
摘要： A hydraulic circuit for preventing a change of stroke of a boom cylinder or an arm cylinder during transportation. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port connected with a chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port connected with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During transportation, a small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.
摘要翻译：一种液压回路，用于防止在运输过程中动臂缸或手臂缸的行程变化。液压回路包括第一和第二液压泵，起重臂液压缸，悬臂气缸，起重臂汇合逻辑阀，与动臂缸的腔室连接的壳体中的第一端口，其中用于悬臂液压缸的阀芯可移动地安装，与所述壳体中的液压箱连接的第二端口，以及形成在所述壳体和位于所述第一端口和所述第二端口之间的所述悬臂缸的所述线轴的台架部分之间的第一孔。在运输过程中，从第二液压泵供给到动臂缸的大腔的少量液压油通过第一孔排入液压缸，以防止动臂缸的行程改变。

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