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    • 5. 发明申请
    • SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS
    • 用作病毒序列代理的微生物和脂质体的系统和方法
    • US20100069814A1
    • 2010-03-18
    • US12211748
    • 2008-09-16
    • Anthony V. BorgiaJohn Perry
    • Anthony V. BorgiaJohn Perry
    • A61M37/00A61K9/12A61K9/127
    • A61K9/127A61K47/6911A61K47/6925
    • A system and method of utilizing microbubbles and liposomes as viral sequestering agents. Microbubbles and liposomes having polyanions and conjugation systems are injected into the bloodstream of a subject human or animal. The microbubbles and/or liposomes attract virus particles including envelope viruses. After the microbubbles and/or liposomes have circulated in the blood for a pre-established time period, the microbubbles and/or liposomes along with attached virus particles are separated from the blood of the subject by passing the blood over or through a substrate or using a centrifuge. The substrate includes a conjugation system which has an affinity for the polyanions of the microbubbles and/or liposomes. As the microbubbles and/or liposomes and attached virus particles are removed from the blood, the viral titer of the subject is lowered. The microbubbles and/or liposomes may also be mixed with blood and filtered outside of the subject such that the microbubbles and/or liposomes are never in the bloodstream of the subject.
    • 利用微泡和脂质体作为病毒螯合剂的系统和方法。 具有聚阴离子和缀合系统的微泡和脂质体被注射到受试者人或动物的血流中。 微泡和/或脂质体吸引病毒颗粒,包括包膜病毒。 在微泡和/或脂质体在血液中循环预先确定的时间段之后,将微泡和/或脂质体连同附着的病毒颗粒通过使血液通过或通过底物或使用 离心机 底物包括对微泡和/或脂质体的聚阴离子具有亲和力的共轭体系。 当从血液中除去微泡和/或脂质体和附着的病毒颗粒时,受试者的病毒滴度降低。 微泡和/或脂质体也可以与血液混合并在受试者之外过滤,使得微泡和/或脂质体永远不在受试者的血液中。
    • 10. 发明申请
    • Roof and wall covering with improved corner construction
    • 屋顶和墙壁覆盖物,改善角落结构
    • US20060059830A1
    • 2006-03-23
    • US10912707
    • 2004-08-05
    • John Perry
    • John Perry
    • E04D1/00
    • E04D1/3402E04D1/30E04D2001/305E04F13/0864
    • A wall covering for a pair of wall surfaces that form a corner. The wall covering includes (1) plurality of wall panels each having a plurality of horizontal tiers of simulated building elements and (2) a plurality of corner moldings each having a single tier of building elements. The corner moldings each have mounting flanges and an interlock and alignment pin that facilitate adjustable positioning of the corner molding with a selected tier of building elements of an adjacent wall panel. The corner molding mounting flanges and building elements further define relatively deep wall panel receiving pockets for positively retaining the side of an adjacent wall panel and forming a water barrier.
    • 用于形成角落的一对墙壁的墙壁。 墙壁覆盖物包括(1)多个墙板,每个壁板具有多个水平层的模拟建筑构件,以及(2)多个角落模制件,每个具有单层建筑构件。 角落模具各自具有安装凸缘和互锁和对准销,其有助于角部模具与相邻壁板的选定层的构建元件的可调定位。 角落模制安装法兰和建筑元件进一步限定相对较深的壁板接收袋,用于积极地保持相邻壁板的侧面并形成防水屏障。