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1. 发明申请

US20100069814A1 SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS 审中-公开
标题翻译：用作病毒序列代理的微生物和脂质体的系统和方法
公开(公告)号：US20100069814A1
公开(公告)日：2010-03-18
申请号：US12211748
申请日：2008-09-16
申请人： Anthony V. Borgia , John Perry
发明人： Anthony V. Borgia , John Perry
IPC分类号： A61M37/00 , A61K9/12 , A61K9/127
CPC分类号： A61K9/127 , A61K47/6911 , A61K47/6925
摘要： A system and method of utilizing microbubbles and liposomes as viral sequestering agents. Microbubbles and liposomes having polyanions and conjugation systems are injected into the bloodstream of a subject human or animal. The microbubbles and/or liposomes attract virus particles including envelope viruses. After the microbubbles and/or liposomes have circulated in the blood for a pre-established time period, the microbubbles and/or liposomes along with attached virus particles are separated from the blood of the subject by passing the blood over or through a substrate or using a centrifuge. The substrate includes a conjugation system which has an affinity for the polyanions of the microbubbles and/or liposomes. As the microbubbles and/or liposomes and attached virus particles are removed from the blood, the viral titer of the subject is lowered. The microbubbles and/or liposomes may also be mixed with blood and filtered outside of the subject such that the microbubbles and/or liposomes are never in the bloodstream of the subject.
摘要翻译：利用微泡和脂质体作为病毒螯合剂的系统和方法。具有聚阴离子和缀合系统的微泡和脂质体被注射到受试者人或动物的血流中。微泡和/或脂质体吸引病毒颗粒，包括包膜病毒。在微泡和/或脂质体在血液中循环预先确定的时间段之后，将微泡和/或脂质体连同附着的病毒颗粒通过使血液通过或通过底物或使用离心机底物包括对微泡和/或脂质体的聚阴离子具有亲和力的共轭体系。当从血液中除去微泡和/或脂质体和附着的病毒颗粒时，受试者的病毒滴度降低。微泡和/或脂质体也可以与血液混合并在受试者之外过滤，使得微泡和/或脂质体永远不在受试者的血液中。

2. 发明申请

US20090112208A1 EXTERNAL BONE SCREW SYSTEM AND METHOD OF USE FOR FRACTURES, FUSIONS OR OSTEOTOMIES 审中-公开
标题翻译：外骨螺钉系统及其用于骨折，融合或手术的方法
公开(公告)号：US20090112208A1
公开(公告)日：2009-04-30
申请号：US11924566
申请日：2007-10-25
申请人： Anthony V. Borgia , Axel A. Weller
发明人： Anthony V. Borgia , Axel A. Weller
IPC分类号： A61B17/00 , A61B17/04 , A61B17/58
CPC分类号： A61B17/171 , A61B17/16 , A61B17/1615 , A61B17/8605 , A61B17/8635 , A61B17/8685 , A61B2090/035
摘要： A bone screw system is disclosed. The bone screw system allows a bone screw to be inserted into a bone via a guide set with a plurality of pins. After the bone screw is inserted, a head portion of an extension member attached to the bone screw remains external to the wound such that the bone screw can be tightened later without re-opening the wound. The bone screw system is applicable to bone fractures, bone fusions, Osteomonies and other bone connectivity procedures. After healing, the bone screw may be left in the patient by removing an upper portion or the screw may be removed with additional incisions and a local anesthetic.
摘要翻译：公开了骨螺钉系统。骨螺钉系统允许骨螺钉通过具有多个销的引导装置插入骨中。在插入骨螺钉之后，附接到骨螺钉的延伸构件的头部部分保持在伤口的外部，使得可以稍后拧紧骨螺钉而不重新打开伤口。骨螺钉系统适用于骨折，骨融合，骨质疏松等骨连接手术。愈合后，骨头螺钉可能通过去除上部部分留在患者身上，或者可以用附加的切口和局部麻醉剂去除螺钉。

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