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1. 发明授权

US08883437B2 Nitroreductase enzymatic substrates 有权
标题翻译：硝基还原酶酶底物
公开(公告)号：US08883437B2
公开(公告)日：2014-11-11
申请号：US13387295
申请日：2010-07-29
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/26 , C12Q1/04 , C07D263/56 , C07D209/20 , C07D277/62
CPC分类号： C12Q1/26 , C12Q1/04
摘要： The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
摘要翻译：本发明涉及式（I）化合物作为酶底物用于检测硝基还原酶活性的用途，其中：W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; X是NR，CZ5Z6，S或O，R是H，烷基，芳烷基，芳基，链烷酸或烷基磺酸，Z5和Z6是烷基; Y是N或N + R，R是烷基，芳烷基，芳基，链烷酸或烷基磺酸; Z 1，Z 2，Z 3和Z 4独立地是H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括磺酰基或羧基酰胺或其酯。

2. 发明申请

US20120122137A1 Novel Nitroreductase Enzymatic Substrates 有权
标题翻译：新型硝基还原酶酶底物
公开(公告)号：US20120122137A1
公开(公告)日：2012-05-17
申请号：US13387295
申请日：2010-07-29
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/26 , C07D209/20 , C07D263/56 , C07D209/12 , C07D235/06 , C07D277/64
CPC分类号： C12Q1/26 , C12Q1/04
摘要： The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonie, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
摘要翻译：本发明涉及式（I）化合物作为酶底物用于检测硝基还原酶活性的用途，其中：W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; X是NR，CZ5Z6，S或O，R是H，烷基，芳烷基，芳基，链烷酸或烷基磺酸，Z5和Z6是烷基; Y是N或N + R，R是烷基，芳烷基，芳基，链烷酸或烷基磺酸; Z 1，Z 2，Z 3和Z 4独立地是H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括磺酰基或羧基酰胺或其酯。

3. 发明授权

US08535902B2 Peptidase substrates 有权
标题翻译：肽酶底物
公开(公告)号：US08535902B2
公开(公告)日：2013-09-17
申请号：US13386750
申请日：2010-07-27
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07K4/00 , C07D213/00
CPC分类号： C12Q1/37 , C12Q1/04
摘要： The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下式（I）的化合物用于检测肽酶活性和/或pH变化的用途：根据该化合物：Y1是肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; X是NR，CZ5Z6，S或O，R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基，Z5和Z6是烷基; Y是N或N + R，R是烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3和Z 4独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

4. 发明申请

US20120129203A1 Novel Peptidase Substrates 有权
标题翻译：新型肽酶底物
公开(公告)号：US20120129203A1
公开(公告)日：2012-05-24
申请号：US13386750
申请日：2010-07-27
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07K5/062 , C07K5/083
CPC分类号： C12Q1/37 , C12Q1/04
摘要： The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下式（I）的化合物用于检测肽酶活性和/或pH变化的用途：根据该化合物：Y1是肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; X是NR，CZ5Z6，S或O，R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基，Z5和Z6是烷基; Y是N或N + R，R是烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3和Z 4独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

5. 发明申请

US20120122135A1 Novel Peptidase Substrates 有权
标题翻译：新型肽酶底物
公开(公告)号：US20120122135A1
公开(公告)日：2012-05-17
申请号：US13386760
申请日：2010-07-28
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07K5/083 , G01N21/80 , C07D215/12
CPC分类号： G01N33/84 , C12Q1/04 , C12Q1/37
摘要： The present invention relates to the use of a compound of the following formula (I), as an enzyme substrate for the detection of a peptidase activity or as a pH indicator: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U is N or N+R and V is CZ6N or N+R or else V is N or N+R and U is CZ6; R is H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3, Z4 and Z5 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下述式（I）化合物作为检测肽酶活性的酶底物或作为pH指示剂的用途：其中：Y1为肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U是N或N + R，V是CZ6N或N + R，或者V是N或N + R，U是CZ6; R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3，Z 4和Z 5独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

6. 发明授权

US08592175B2 Nitroreductase enzymatic substrates 有权
标题翻译：硝基还原酶酶底物
公开(公告)号：US08592175B2
公开(公告)日：2013-11-26
申请号：US13387280
申请日：2010-07-29
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/26 , C07K4/00 , C07D215/18
CPC分类号： C12Q1/26 , C12Q1/04
摘要： The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U is N or N+R and V is CZ6N or N+R or V is N or N+R and U is CZ6, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z1, Z2, Z3, Z4, Z5 and Z6 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
摘要翻译：本发明涉及式（I）化合物作为酶底物用于检测硝基还原酶活性的用途，其中：W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U是N或N + R，V是CZ6N或N + R或V是N或N + R，U是CZ6，R是H，烷基，芳烷基，芳基，链烷基或烷基磺酸; 并且Z 1，Z 2，Z 3，Z 4，Z 5和Z 6独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括磺酰基或羧基酰胺或其酯，和盐的相同。

7. 发明授权

US08592174B2 Peptidase substrates 有权
标题翻译：肽酶底物
公开(公告)号：US08592174B2
公开(公告)日：2013-11-26
申请号：US13386760
申请日：2010-07-28
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07D231/00 , A61K38/06
CPC分类号： G01N33/84 , C12Q1/04 , C12Q1/37
摘要： The present invention relates to the use of a compound of the following formula (I), as an enzyme substrate for the detection of a peptidase activity or as a pH indicator: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U is N or N+R and V is CZ6N or N+R or else V is N or N+R and U is CZ6; R is H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3, Z4 and Z5 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下述式（I）化合物作为检测肽酶活性的酶底物或作为pH指示剂的用途：其中：Y1为肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U是N或N + R，V是CZ6N或N + R，或者V是N或N + R，U是CZ6; R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3，Z 4和Z 5独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

8. 发明申请

US20120129204A1 NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES 有权
标题翻译：新型硝酸酯酶底物
公开(公告)号：US20120129204A1
公开(公告)日：2012-05-24
申请号：US13387280
申请日：2010-07-29
申请人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Olivier Fabrega , Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/26 , C07D215/12
CPC分类号： C12Q1/26 , C12Q1/04
摘要： The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U is N or N+R and V is CZ6 N or N+R or V is N or N+R and U is CZ6, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z1, Z2, Z3, Z4, Z5 and Z6 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
摘要翻译：本发明涉及式（I）化合物作为酶底物用于检测硝基还原酶活性的用途，其中：W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U是N或N + R，V是CZ6N或N + R或V是N或N + R，U是CZ6，R是H，烷基，芳烷基，芳基，链烷基或烷基磺酸; 并且Z 1，Z 2，Z 3，Z 4，Z 5和Z 6独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括磺酰基或羧基酰胺或其酯，和盐的相同。

9. 发明申请

US20120122134A1 Novel Peptidase Substrates 有权
标题翻译：新型肽酶底物
公开(公告)号：US20120122134A1
公开(公告)日：2012-05-17
申请号：US13386578
申请日：2010-07-28
申请人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07D221/00 , C07K17/02
CPC分类号： C12Q1/37 , C12Q1/04 , G01N33/84
摘要： The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U and V are N, N+R or CZ4, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下式（I）的化合物用于检测肽酶活性和/或pH变化的用途：根据该化合物：Y1是肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U和V是N，N + R或CZ4，R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3和Z 4独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

10. 发明授权

US08535903B2 Nitroreductase enzymatic substrates 有权
标题翻译：硝基还原酶酶底物
公开(公告)号：US08535903B2
公开(公告)日：2013-09-17
申请号：US13387636
申请日：2010-07-29
申请人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/04 , C07D211/72
CPC分类号： C12Q1/26 , C12Q1/04
摘要： The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity or as an enzymatic substrate for the detection of a nitroreductase activity and indicator of pH, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U and V are N, N+R, CZ4, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, preferably if U is CZ4, V is N or N+R and, if V is CZ4, U is N or N+R; and Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
摘要翻译：本发明涉及具有式（I）化合物作为酶底物的用途，用于检测硝基还原酶活性或用作检测硝基还原酶活性和pH指示剂的酶底物，其中：W1，W2，W3和 W4独立地是H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U和V是N，N + R，CZ4，R是H，烷基，芳烷基，芳基，链烷酸或烷基磺酸，优选如果U是CZ4，V是N或N + R，并且如果V是CZ4，则U是N或 N + R; 并且Z 1，Z 2，Z 3和Z 4独立地是H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括磺酰基或羧基酰胺或其酯相同。

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