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1. 发明申请

US20050120949A1 Apparatus and method for spotting a substrate 失效
标题翻译：用于点样衬底的装置和方法
公开(公告)号：US20050120949A1
公开(公告)日：2005-06-09
申请号：US11038334
申请日：2005-01-18
申请人： Charles Vann , Zbigniew Bryning
发明人： Charles Vann , Zbigniew Bryning
IPC分类号： G01N37/00 , B01J19/00 , B01L3/02 , C40B60/14 , G01N35/00 , G01N35/10 , B05C3/00
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01L3/0251 , B01L3/0262 , B01L2300/0819 , B01L2300/0838 , B01L2400/028 , B01L2400/0406 , C40B60/14 , G01N35/1016 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , G01N2035/1069 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongated fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
摘要翻译：本发明提供了一种将少量体积的选定液体（例如生物样品或试剂）分配到基底上的方法和装置。该装置包括适于容纳液体的管。细长纤维设置在管内用于在升高和降低位置之间的轴向移动。当纤维在其升高和降低位置之间移动或摆动时，可以在衬底上的选定位置处形成液体斑点。该装置易于适用于具有大量单个斑点的微阵列的生产。

2. 发明申请

US20070148050A1 APPARATUS AND METHOD FOR SPOTTING A SUBSTRATE 审中-公开
标题翻译：装置和方法用于分选基板
公开(公告)号：US20070148050A1
公开(公告)日：2007-06-28
申请号：US11683794
申请日：2007-03-08
申请人： Charles Vann , Zbigniew Bryning
发明人： Charles Vann , Zbigniew Bryning
IPC分类号： B01L3/02
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01L3/0251 , B01L3/0262 , B01L2300/0819 , B01L2300/0838 , B01L2400/028 , B01L2400/0406 , C40B60/14 , G01N35/1016 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , G01N2035/1069 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongated fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
摘要翻译：本发明提供了一种将少量体积的选定液体（例如生物样品或试剂）分配到基底上的方法和装置。该装置包括适于容纳液体的管。细长纤维设置在管内用于在升高和降低位置之间的轴向移动。当纤维在其升高和降低位置之间移动或摆动时，可以在衬底上的选定位置处形成液体斑点。该装置易于适用于具有大量单个斑点的微阵列的生产。

3. 发明申请

US20060102477A1 Electrowetting dispensing devices and related methods 审中-公开
公开(公告)号：US20060102477A1
公开(公告)日：2006-05-18
申请号：US11213355
申请日：2005-08-26
申请人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
发明人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
IPC分类号： C07K1/26
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.

4. 发明申请

US20050130318A1 Bead dispensing system 有权
公开(公告)号：US20050130318A1
公开(公告)日：2005-06-16
申请号：US10990714
申请日：2004-11-16
申请人： Charles Vann , Dennis Lehto
发明人： Charles Vann , Dennis Lehto
IPC分类号： G01N33/53 , B01J19/00 , B01L3/02 , B01L99/00 , C40B40/06 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/10 , G01N37/00 , B01L3/00
CPC分类号： G01N35/1065 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00549 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/0065 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , B01L3/021 , B01L3/0289 , B01L3/563 , B01L2200/021 , B01L2200/0647 , B01L2200/0657 , B01L2200/143 , B01L2300/0654 , B01L2300/0864 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B82Y30/00 , C40B40/06 , C40B60/14 , C40B70/00 , G01N35/10 , G01N2035/00574 , Y10T436/11 , Y10T436/255 , Y10T436/2575
摘要： A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as a vacuum, magnetic, and/or electrostatic force, is operable at each projection end region to attract and retain one bead. The projection array can be aligned with an array of bead-receiving regions of a substrate, e.g., an array of spaced-apart wells of a micro-plate or card. In one embodiment, a plurality of reagent-carrying beads are picked up, retained at respective projection end regions, and moved to a location over a multi-well plate. The beads are then released in a fashion permitting each bead to land in a respective well. The system of the invention is particularly useful for fabricating arrays of reagents.

5. 发明申请

US20050208543A1 Phosphor particle coded beads 有权
标题翻译：荧光粉颗粒编码珠
公开(公告)号：US20050208543A1
公开(公告)日：2005-09-22
申请号：US11031983
申请日：2005-01-06
申请人： Charles Vann , Charles Connell , Aldrich Lau , Meng Taing , Steven Menchen
发明人： Charles Vann , Charles Connell , Aldrich Lau , Meng Taing , Steven Menchen
IPC分类号： C12Q1/68 , C40B20/04 , C40B70/00 , G01N33/53 , G01N33/533 , G01N33/543 , G01N33/58
CPC分类号： B82Y5/00 , C12Q2563/155 , G01N33/54346 , G01N33/587
摘要： Beads coded with phosphor particles and methods of making and using them are provided.
摘要翻译：提供用磷光体颗粒编码的珠子，并制作和使用它们的方法。

6. 发明申请

US20050118589A1 Digital array 审中-公开
标题翻译：数字阵列
公开(公告)号：US20050118589A1
公开(公告)日：2005-06-02
申请号：US10496300
申请日：2002-11-21
申请人： Charles Vann , Kai Lao , Mark Reed
发明人： Charles Vann , Kai Lao , Mark Reed
IPC分类号： G01N33/53 , A61K20060101 , C07H21/02 , C12N9/22 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.
摘要翻译：本发明涉及用于检测样品中靶标的方法和组合物。

7. 发明申请

US20050026209A1 Optical fiber bundle for detecting binding of chemical species 审中-公开
标题翻译：用于检测化学物质结合的光纤束
公开(公告)号：US20050026209A1
公开(公告)日：2005-02-03
申请号：US10932608
申请日：2004-09-01
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/64 , G01N21/77 , C12Q1/68
CPC分类号： G01N21/7703 , B01J19/0046 , B01J2219/00326 , B01J2219/0043 , B01J2219/00495 , B01J2219/00515 , B01J2219/00524 , B01J2219/00572 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00657 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01L3/5023 , B01L3/5085 , B82Y30/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/6452 , G01N21/648 , G01N2201/0833
摘要： The system includes a bundle of elongate optical fibers, multiple probes, a well, a light source and a detector. The optical fibers each have a first end remote from a second end. Each of the multiple probes is attached to one of the optical fibers within a predetermined section between each of the optical fiber's first and second ends. The well is configured to hold a solution comprising a target and to receive at least the predetermined section of each of the optical fibers. The light source is configured to direct light into the first end of each of the optical fibers. Finally, the detector is configured to detect light emitted by the binding of the target to at least one of the multiple probes. In some embodiments, there are multiple bundles and multiple wells.
摘要翻译：该系统包括一束细长的光纤，多个探针，阱，光源和检测器。光纤各自具有远离第二端的第一端。多个探针中的每一个在每个光纤的第一和第二端之间的预定部分内附接到光纤中的一个。井被配置为保持包括目标的解决方案并且接收每个光纤的至少预定部分。光源被配置为将光引导到每个光纤的第一端。最后，检测器被配置为检测由目标物与至少一个多个探针的结合发射的光。在一些实施例中，存在多个束和多个孔。

8. 发明申请

US20070141605A1 Portable preparation, analysis, and detection apparatus for nucleic acid processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20070141605A1
公开(公告)日：2007-06-21
申请号：US11602149
申请日：2006-11-20
申请人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
发明人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

9. 发明申请

US20070031977A1 Portable genomic analyzer 审中-公开
标题翻译：便携式基因组分析仪
公开(公告)号：US20070031977A1
公开(公告)日：2007-02-08
申请号：US11453340
申请日：2006-06-14
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： G01N1/00
CPC分类号： B01L3/502753 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2300/0681 , B01L2400/0409 , B01L2400/0421 , G01N2021/6439 , Y10T436/25
摘要： An apparatus for identifying a target portion of a sample. In some embodiments, the sample can be substantially purified and/or amplified in a test chamber. In some embodiments, the sample can be provided in an amount so that amplification is not necessary. The apparatus generally comprises a test chamber having an input region for receiving a sample and an analysis region. A sample chamber can be defined by at least a portion of the test chamber. A separation mechanism can separate a target portion of the sample from the sample and an analysis chamber can aid in analyzing at least the target portion of the sample.
摘要翻译：一种用于识别样本的目标部分的装置。在一些实施方案中，样品可以在测试室中基本上纯化和/或扩增。在一些实施方案中，可以提供一定量的样品，使得不需要扩增。该装置通常包括具有用于接收样品的输入区域和分析区域的测试室。样品室可以由测试室的至少一部分限定。分离机构可以将样品的目标部分与样品分离，并且分析室可以帮助分析至少样品的目标部分。

10. 发明申请

US20060228734A1 Fluid processing device with captured reagent beads 审中-公开
标题翻译：具有捕获试剂珠的流体处理装置
公开(公告)号：US20060228734A1
公开(公告)日：2006-10-12
申请号：US11378559
申请日：2006-03-17
申请人： Charles Vann , Umberto Ulmanella
发明人： Charles Vann , Umberto Ulmanella
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/50851 , B01L2200/0642 , B01L2200/0668 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/087 , B01L2400/0406 , B01L2400/0487 , B01L2400/0655 , B01L2400/0677 , G01N21/6452 , G01N33/54386 , G01N2021/0325 , G01N2021/6482
摘要： A fluid processing device, method and system are provided. The fluid processing device can comprise: a substrate; a plurality of reaction regions disposed in or on the substrate; at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and a plurality of reagent-releasing beads. Each reagent-releasing bead can be positioned in a respective one of the reaction regions. Each bead can comprise one or more reaction components for an assay. Each of the reagent-releasing beads can have a minimum dimension that is greater than the maximum dimension of the channel cross-section.
摘要翻译：提供流体处理装置，方法和系统。流体处理装置可以包括：基板; 设置在所述基板中或所述基板上的多个反应区域; 至少一个通道，其互连所述多个反应区域，所述至少一个通道具有包括最大尺寸的横截面积; 和多个试剂释放珠。每个试剂释放珠可以位于相应的一个反应区域中。每个珠可以包含用于测定的一种或多种反应成分。每个试剂释放珠可以具有大于通道横截面的最大尺寸的最小尺寸。

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