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1. 发明申请

US20160023179A1 MICRODEVICE ARRAYS FORMED BY MAGNETIC ASSEMBLY 审中-公开
标题翻译： MICRODEVICE阵列由磁性组件形成
公开(公告)号：US20160023179A1
公开(公告)日：2016-01-28
申请号：US14875514
申请日：2015-10-05
申请人： ARRAYOMICS, INC.
发明人： Christopher D. Herold , David Rothwarf , Bao Nguyen
IPC分类号： B01J19/00 , G06K19/06
CPC分类号： B01J19/0046 , B01J2219/00497 , B01J2219/00549 , B01J2219/00563 , B01J2219/00585 , B01J2219/00655 , B01J2219/00709 , C40B40/00 , C40B50/00 , G01N33/54326 , G01N33/54366 , G06K19/06187
摘要： Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.
摘要翻译：包含预定的磁化优选轴的微器件设置在具有谨慎区域的阵列中。在磁场的影响下，微器件可以具有至少十二个离散取向，并且可以有利地在适当位置上翻翻。可以以支持至少102,103,106甚至1010或更多选择的编码空间的方式对微器件进行编码，并且可以包括一个或多个化学反应位点。这些区域可以由长条和短条定义，其中微型设备跨越长条之间的间隙，较短的条测量小于这种间隙的60％。还提供了优选实施例以产生用于基于磁性组件的排列的微加工微型器件。

2. 发明申请

US20150126412A1 SYSTEMS FOR FILLING A SAMPLE ARRAY BY DROPLET DRAGGING 审中-公开
标题翻译：通过DROPLET DRAGGING填充样品阵列的系统
公开(公告)号：US20150126412A1
公开(公告)日：2015-05-07
申请号：US14301325
申请日：2014-06-10
申请人： Massachusetts Institute of Technology
发明人： Ian Hunter , Colin J.H. Brenan
IPC分类号： B01J19/00 , G01N35/10
CPC分类号： B01J19/0046 , B01F13/0071 , B01F13/0084 , B01J2219/00313 , B01J2219/00317 , B01J2219/00351 , B01J2219/00533 , B01J2219/00536 , B01J2219/00549 , B01J2219/00585 , B01J2219/00599 , B01L3/5025 , B01L3/5085 , B01L3/50857 , B01L2200/0642 , C12Q1/34 , C40B60/14 , C40B70/00 , G01N21/75 , G01N35/00069 , G01N35/1002 , G01N2035/00237 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.
摘要翻译：一种用于装载多个不同样本容器的方法和阵列填充系统，所述样本容器包括整体结构。每个容器的特征在于亲水表面，并且容器由疏水表面分开。该系统具有能够保持液体并适于运动的液体转移装置，以通过将液体拖过疏水表面而使保持在液体转移装置中的液体与阵列的连续容器顺序连通。

3. 发明申请

US20150087543A1 Device, Array, And Methods For Disease Detection And Analysis 有权
标题翻译：设备，阵列和疾病检测和分析方法
公开(公告)号：US20150087543A1
公开(公告)日：2015-03-26
申请号：US14465796
申请日：2014-08-21
申请人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
发明人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译：提供耦合到捕获分子的装置和阵列。具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。

4. 发明授权

US08577621B2 Biopolymer array reading 有权
标题翻译：生物聚合物阵列读数
公开(公告)号：US08577621B2
公开(公告)日：2013-11-05
申请号：US13289822
申请日：2011-11-04
申请人： Charles David Troup , Herbert F. Cattell
发明人： Charles David Troup , Herbert F. Cattell
IPC分类号： G01N33/48 , C12M1/00
CPC分类号： G06F19/20 , B01J2219/00549 , B01J2219/00565 , B01J2219/00659 , B01J2219/00668 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.
摘要翻译：用于处理生物聚合物阵列的方法和用于执行该方法的装置和计算机程序产品。该方法可以包括从与该阵列相关联的标签读取每个生物聚合物阵列的不同阵列标识符。读取至少一些生物聚合物阵列，并将每个读取阵列的结果保存在与该阵列的读取标识符相链接的存储器中。接收不同的通信地址和每个的阵列标识符的选择。对于至少一些阵列，每个的保存结果与使用标识符的不同通信地址之一进行匹配，并将保存的结果发送给匹配的不同通信地址。还提供了从读取生物聚合物阵列处理数据的方法。

5. 发明申请

US20130090260A1 Multiplexed Assay Using Spectrally-Encoded Solid Support Matrices 审中-公开
标题翻译：使用频谱编码固体支持矩阵的多路复用测试
公开(公告)号：US20130090260A1
公开(公告)日：2013-04-11
申请号：US13708778
申请日：2012-12-07
申请人： Michael P. Nova , Andrew E. Senyei
发明人： Michael P. Nova , Andrew E. Senyei
IPC分类号： C40B30/04 , C40B60/08
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix particle with a substrate adapted for attachment and/or synthesis of molecules. A spectrally-encoded identifier embodied in a photochemical medium is embedded or encased within the substrate to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions, and then placed within the path of an optical detector adapted to read the spectrally-encoded identifier and measure biochemical activity on each support matrix particle. The measured biochemical activity is associated with the unique identity of the support matrix particle and, hence, with the molecule attached to the particle.
摘要翻译：在多重测定中，多个分子的每个分子连接到具有适于附着和/或合成分子的底物的载体基质颗粒上。在光化学介质中实施的经光谱编码的标识符被嵌入或封装在衬底内以唯一地识别附着于衬底的分子。分子暴露于一个或多个处理条件，然后放置在适于读取频谱编码的标识符的光学检测器的路径内，并测量每个支持矩阵粒子上的生化活性。测量的生物化学活性与支持基质颗粒的独特特性相关联，因此与附着于颗粒的分子相关。

6. 发明授权

US07935659B2 Multiplexed assays using encoded solid supports 失效
标题翻译：使用编码的固体支持物的多重测定
公开(公告)号：US07935659B2
公开(公告)日：2011-05-03
申请号：US11011452
申请日：2004-12-14
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
IPC分类号： C40B50/16 , C40B50/18
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

7. 发明授权

US07917304B2 Spotter provided with spot pattern encryption function and detection device coping with spot pattern encryption 有权
标题翻译： Spotter提供斑点图案加密功能和应对斑点图案加密的检测设备
公开(公告)号：US07917304B2
公开(公告)日：2011-03-29
申请号：US11528603
申请日：2006-09-28
申请人： Tohru Ishibashi
发明人： Tohru Ishibashi
IPC分类号： G06F19/00 , G06F15/00 , C07H21/04
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00527 , B01J2219/00542 , B01J2219/00549 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00704 , B01J2219/00722 , B01L3/545 , B01L2300/021 , B01L2300/0636 , C12Q1/6837 , C40B40/06 , C40B50/14 , G01N35/1074 , G01N2035/00158 , C12Q2565/513
摘要： Plural probes spotted on a probe immobilization substrate are arranged such that the probes cannot be specified by a third party easily. When the plural probes are spotted on the probe immobilization substrate, a position where each probe is spotted is changed for each probe immobilization substrate to be prepared, whereby types of probes to be arranged in respective spot addresses are encrypted. The preset invention provides a spotter, a dispensing device to be used for the spotter, a probe immobilization substrate that is prepared using the spotter, and a detection device that decodes encrypted positions where the respective probes are spotted.
摘要翻译：在探针固定基板上点出的多个探针被布置成使得探针不能容易地由第三方指定。当多个探针被点在探针固定基底上时，针对要制备的每个探针固定基底改变每个探针被点样的位置，由此将要布置在各个点地址中的探针类型被加密。本发明提供了一种检测器，用于检测器的分配装置，使用该检测器准备的探针固定基板，以及检测装置，其对各个探针被点样的加密位置进行解码。

8. 发明授权

US07811768B2 Microdevice containing photorecognizable coding patterns and methods of using and producing the same 有权
标题翻译：包含光可识别编码模式的微器件及其使用和生产方法
公开(公告)号：US07811768B2
公开(公告)日：2010-10-12
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
CPC分类号： B82Y5/00 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06037 , G06K19/06046 , G06K19/06131 , G06K19/06178 , G06K19/06196
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.
摘要翻译：本发明一般涉及部分或分子分析，分离，检测和操作以及文库合成领域。特别地，本发明提供了一种微型器件，该微型器件包括：a）衬底; 和b）在基底上的可识别的编码图案。优选地，微器件不包括阳极化金属表面层。还提供了用于分离，检测和操作部分以及使用微器件合成文库的方法和试剂盒。本发明还提供二维光学编码器及其用途。

9. 发明授权

US07718419B2 Microdevices having a preferential axis of magnetization and uses thereof 有权
标题翻译：具有优先磁化轴的微器件及其用途
公开(公告)号：US07718419B2
公开(公告)日：2010-05-18
申请号：US11841935
申请日：2007-08-20
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译：本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。特别地，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。

10. 发明授权

US07682837B2 Devices and methods to form a randomly ordered array of magnetic beads and uses thereof 有权
标题翻译：用于形成随机排列的磁珠阵列的装置和方法及其用途
公开(公告)号：US07682837B2
公开(公告)日：2010-03-23
申请号：US09923752
申请日：2001-08-07
申请人： Maneesh Jain , Robert L. White , Lester A. Roberts
发明人： Maneesh Jain , Robert L. White , Lester A. Roberts
IPC分类号： G01N33/551 , C12Q1/00
CPC分类号： C12Q1/6837 , B01J2219/00274 , B01J2219/00542 , B01J2219/00549 , B01J2219/00563 , B01J2219/00655 , B03C1/035 , G01N35/0098 , G01N2035/00574 , Y10S428/90 , Y10T428/24355 , C12Q2563/143 , C12Q2563/107
摘要： The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.
摘要翻译：本发明包括用于形成磁性颗粒的随机阵列的装置和方法，使用这些装置和方法形成的阵列，以及使用阵列的方法。本发明提供一种具有磁畴的组件（芯片），其产生能够固定诸如市售磁珠的磁性颗粒的局部磁场。探针或传感器分子可以耦合到珠粒，然后将其分散在组件上，形成随机顺序阵列。阵列可用于分析样本，目标和/或样本和目标之间的相互作用。本发明特别用于诸如高通量基因分型和其它基于核酸杂交的测定之类的过程中。

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