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1. 发明申请

US20070141605A1 Portable preparation, analysis, and detection apparatus for nucleic acid processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20070141605A1
公开(公告)日：2007-06-21
申请号：US11602149
申请日：2006-11-20
申请人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
发明人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

2. 发明申请

US20090321259A1 Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20090321259A1
公开(公告)日：2009-12-31
申请号：US12433201
申请日：2009-04-30
申请人： Charles S. Vann , Michael Greenstein , yuh-Min Chiang
发明人： Charles S. Vann , Michael Greenstein , yuh-Min Chiang
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

3. 发明申请

US20110177562A1 Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20110177562A1
公开(公告)日：2011-07-21
申请号：US12973190
申请日：2010-12-20
申请人： Charles S. Vann , Michael Greenstein , Yuh-Min Chiang
发明人： Charles S. Vann , Michael Greenstein , Yuh-Min Chiang
IPC分类号： C12P19/34 , G01N27/447
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

4. 发明授权

US07514046B2 Methods and systems for processing microscale devices for reuse 有权
标题翻译：用于处理微量元件进行再利用的方法和系统
公开(公告)号：US07514046B2
公开(公告)日：2009-04-07
申请号：US10861784
申请日：2004-06-04
申请人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
发明人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
IPC分类号： B01L1/00
CPC分类号： B01L9/527 , B01L3/5027 , B01L3/502715 , B01L99/00 , B01L2300/022 , B01L2300/024 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.
摘要翻译：本发明提供用于冲洗，洗涤和引发微型装置以重新使用的方法和系统。洗涤和引发方法包括从歧管流动的溶液冲洗微流体芯片的阱和微通道。系统包括适于密封并将溶液或气体流入芯片井的歧管。设备包括具有数据存储模块的微流体设备，以跟踪微型设备的再处理状态。

5. 发明授权

US07344894B2 Thermal regulation of fluidic samples within a diagnostic cartridge 有权
标题翻译：诊断墨盒内流体样品的热调节
公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译：使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量，例如电阻式，感应型和珀耳帖式加热器，或外部加热。微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。

6. 发明授权

US07341861B2 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
标题翻译：非核糖体肽合成酶和相关生物合成基因
公开(公告)号：US07341861B2
公开(公告)日：2008-03-11
申请号：US11357566
申请日：2006-02-17
申请人： John A. Hucul , Nathan Magarvey , Michael Greenstein
发明人： John A. Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/93 , C07K2319/00
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
摘要翻译：本发明描述了来自吸水链霉菌的新型非核糖体肽合成酶和相关生物合成基因的鉴定。本发明还提供从这些合成酶和相关基因产生新型化合物如抗生素的方法。

7. 发明授权

US07195907B2 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
标题翻译：非核糖体肽合成酶和相关生物合成基因
公开(公告)号：US07195907B2
公开(公告)日：2007-03-27
申请号：US10746795
申请日：2003-12-23
申请人： John A. Hucul , Nathan Magarvey , Michael Greenstein
发明人： John A. Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C07K14/36
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
摘要翻译：本发明描述了来自吸水链霉菌的新型非核糖体肽合成酶和相关生物合成基因的鉴定。本发明还提供从这些合成酶和相关基因产生新型化合物如抗生素的方法。

8. 发明申请

US20060165559A1 Automated system for handling microfluidic devices 有权
公开(公告)号：US20060165559A1
公开(公告)日：2006-07-27
申请号：US11133943
申请日：2005-05-20
申请人： Michael Greenstein , Colin Kennedy , James Mikkelsen
发明人： Michael Greenstein , Colin Kennedy , James Mikkelsen
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0819 , G01N21/05 , G01N21/11 , G01N21/13 , G01N35/04 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

9. 发明授权

US06964860B2 Glycopeptide antibiotics 有权
标题翻译：糖肽抗生素
公开(公告)号：US06964860B2
公开(公告)日：2005-11-15
申请号：US10131847
申请日：2002-04-25
申请人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
发明人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
IPC分类号： C07H15/203 , C07H19/04 , C07K9/00 , C12P19/28 , C12P17/16 , A61K38/12 , A61K38/16
CPC分类号： C07H15/203 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
摘要翻译：本发明提供下式的化合物其中R 1，R 2，R 3，R 4，R 4， R 5，R 6a，R 6b，R 6c，R 6d，R SUP， > 6e和R＆lt; 7＆gt;在本说明书中定义。这些化合物可用作抗生素。

10. 发明授权

US06364890B1 Extraction and transportation of blood for analysis 有权
标题翻译：提取和运输血液进行分析
公开(公告)号：US06364890B1
公开(公告)日：2002-04-02
申请号：US09614318
申请日：2000-07-12
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B1732
CPC分类号： A61B5/15144 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.
摘要翻译：一种用于通过穿刺从患者皮肤取样血液的装置。该装置包括用于切割皮肤的一个或多个刺血针和用于从穿刺伤口输送血液的导流板单元。板单元具有用于将流体传导到一个或多个目标位置的一个或多个通道。优选地，存在用于传导第一部分流体的第一通道，所述第一部分流体包含更多的来自穿刺伤口的最初发射的流体（初始流体）和用于传导含有较少初始流体的第二部分流体的第二通道从穿刺伤口。通过毛细血管力将血液吸入通道。该装置可用于以相对简单的程序来刺激皮肤并获得代表性的血液样品。

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