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1. 发明申请

US20080006202A1 COMPRESSIBLE TRANSPARENT SEALING FOR OPEN MICROPLATES 审中-公开
标题翻译：用于开放式麦克风的可靠透明密封
公开(公告)号：US20080006202A1
公开(公告)日：2008-01-10
申请号：US11768369
申请日：2007-06-26
申请人： Kirk Hirano , James Nurse , Albert Carrillo , Mike Lu , Adrian Fawcett
发明人： Kirk Hirano , James Nurse , Albert Carrillo , Mike Lu , Adrian Fawcett
IPC分类号： B65B7/28
CPC分类号： G01N35/028 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L2200/0605 , B01L2200/0642 , B01L2200/142 , B01L2300/041 , B01L2300/044 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0864 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0406 , B01L2400/0487 , G01N2035/00287
摘要： An apparatus for sealing a microplate, wherein the apparatus comprises a microplate having a first surface and an opposing second surface. A plurality of wells is formed in the first surface of the microplate, wherein each of the plurality of wells is sized to receive an assay therein. A sealing cover is disposed over the microplate adjacent the plurality of wells and is compliant to accommodate variations between the sealing cover and the microplate and/or distribute loads evenly therebetween.
摘要翻译：一种用于密封微板的装置，其中所述装置包括具有第一表面和相对的第二表面的微板。在微量培养板的第一表面中形成多个孔，其中多个孔中的每一个的大小适于在其中接受测定。密封盖设置在与多个孔相邻的微孔板上方，并且符合以适应密封盖和微孔板之间的变化和/或在它们之间均匀分布载荷。

2. 发明授权

US5263111A Optical waveguide structures and formation methods 失效
标题翻译：光波导结构及其形成方法
公开(公告)号：US5263111A
公开(公告)日：1993-11-16
申请号：US841956
申请日：1992-02-26
申请人： James Nurse , John P. Arrington
发明人： James Nurse , John P. Arrington
IPC分类号： G02B6/12 , G02B6/13 , G02B6/28 , G02B6/30 , G02B6/42 , G02B6/00 , G02B6/36
CPC分类号： G02B6/13 , G02B6/12002 , G02B6/2817 , G02B6/30 , G02B6/42 , G02B2006/12076 , G02B2006/12102 , G02B2006/12104
摘要： A method is provided for forming an optical waveguide structure upon a substrate in accordance with the steps of: (a) forming a layer of base coat material upon the substrate, (b) forming a layer of cladding material having a predetermined refractive index upon the base coat layer, (c) applying a channel waveguide pattern defining structure to the layer of cladding material, (d) applying a patterning agent to transfer the pattern of the channel waveguide pattern defining structure to a predetermined depth or depths into the cladding material layer to define a waveguide trench pattern, (e) removing any remaining residue of channel waveguide pattern defining structure, (f) forming a thick coat layer of waveguide material having a higher refractive index than the cladding material onto the cladding material and into the waveguide trench pattern, (g) planarizing the waveguide material substantially to the plane of a topmost surface of the cladding material in order to reduce the thickness of the thick coat layer, and (h) forming a layer of additional cladding material to encapsulate the waveguide material in the waveguide trench pattern. An out-of-plane mirror can be used to couple two different layers together optically. A lens element can be used for collimating light reflected by the out-of-plane mirror.
摘要翻译：提供了一种根据以下步骤在基板上形成光波导结构的方法：（a）在所述基板上形成底涂层材料层，（b）在所述基板上形成具有预定折射率的包层材料层底涂层，（c）将限定结构的通道波导图案施加到包层材料层，（d）施加图案化剂以将沟道波导图案限定结构的图案转移到预定深度或深度进入包层材料层限定波导沟槽图案，（e）去除沟道波导图案限定结构的任何剩余残留物，（f）在包层材料上形成具有比包覆材料更高的折射率的波导材料的厚涂层，并且进入波导沟槽图案，（g）将波导材料基本上平行化到包层材料的最上表面的平面，以便减小厚度并且（h）形成附加的包覆材料层以将波导材料封装在波导沟槽图案中。平面镜可用于将两个不同的层耦合在一起。透镜元件可用于准直由平面外反射镜反射的光。

3. 发明授权

US08163150B2 Electrowetting dispensing devices and related methods 有权
标题翻译：电动滴胶装置及相关方法
公开(公告)号：US08163150B2
公开(公告)日：2012-04-24
申请号：US12709402
申请日：2010-02-19
申请人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
发明人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
IPC分类号： G01N27/447 , G01N1/16
CPC分类号： G01N27/44743 , B01J4/008 , B01J2219/00315 , B01J2219/0036 , B01J2219/00418 , B01J2219/00653 , B01L3/0241 , B01L3/0268 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/02 , B01L2400/0409 , B01L2400/0427
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.
摘要翻译：用于分配用于生物分析的液体的方法可以包括通过电润湿定位待分配的液体。定位可以包括使液体与多个预定位置对准。该方法还可以包括通过分别与预定位置对准的多个开口分配来自多个预定位置的对准的液体。分配可以经由电润湿。

4. 发明申请

US20070062583A1 Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other 有权
标题翻译：使与第二流体接触的第一流体的离散体积彼此不混溶的装置和方法
公开(公告)号：US20070062583A1
公开(公告)日：2007-03-22
申请号：US11508044
申请日：2006-08-22
申请人： David Cox , Willy Wiyatno , Mark Oldham , James Nurse , Douglas Greiner , Sam Woo , Richard Reel , Dennis Lehto , Linda Lee , Janusz Wojtowicz
发明人： David Cox , Willy Wiyatno , Mark Oldham , James Nurse , Douglas Greiner , Sam Woo , Richard Reel , Dennis Lehto , Linda Lee , Janusz Wojtowicz
IPC分类号： G01N1/28 , G01N1/14
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内产生与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括一种装置，该装置包括至少一个导管，其操作地连接到一个或多个泵，用于提供通过与离散体积的流体不混溶的流体彼此分离的离散体积，例如水不混溶流体 - 油分离体积。

5. 发明申请

US20110123985A1 COLUMN ENRICHMENT OF PCR BEADS COMPRISING TETHERED AMPLICONS 审中-公开
标题翻译：包含四核苷酸的PCR珠的柱增殖
公开(公告)号：US20110123985A1
公开(公告)日：2011-05-26
申请号：US12756589
申请日：2010-04-08
申请人： Aldrich N. K. LAU , Achim KARGER , Patrick KINNEY , James NURSE , Aftab KEVAL , Douglas GREINER , Carmen GJERSTAD
发明人： Aldrich N. K. LAU , Achim KARGER , Patrick KINNEY , James NURSE , Aftab KEVAL , Douglas GREINER , Carmen GJERSTAD
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： B01F3/0807 , B01F7/161 , B01F7/22 , B01F2215/0422 , B01F2215/0431 , B01F2215/0481
摘要： An enrichment module and method are provided for enriching a population of templated beads and separating them from non-templated beads. The method can include hybridizing a templated bead with an enrichment bead to form a complex, trapping the complex in a filtration medium, washing non-templated beads through the filtration medium while retaining the complex, and then eluting the templated bead from the complex. The module can include a column for enrichment and filtration material exhibiting desired size-exclusion properties.
摘要翻译：提供了一种富集模块和方法，用于富集模板珠群并将其与非模板珠分离。该方法可以包括将模板珠与富集珠杂交以形成复合物，将复合物捕获在过滤介质中，通过过滤介质洗涤非模板珠，同时保留复合物，然后从络合物洗脱模板珠。该模块可以包括用于富集和过滤材料的柱，其具有期望的尺寸排阻性质。

6. 发明申请

US20080000892A1 HEATED COVER METHODS AND TECHNOLOGY 审中-公开
标题翻译：加热覆盖方法和技术
公开(公告)号：US20080000892A1
公开(公告)日：2008-01-03
申请号：US11768377
申请日：2007-06-26
申请人： Kirk Hirano , Jason Babcoke , Albert Carrillo , Douwe Haga , Pin Kao , Patrick Kinney , James Nurse
发明人： Kirk Hirano , Jason Babcoke , Albert Carrillo , Douwe Haga , Pin Kao , Patrick Kinney , James Nurse
IPC分类号： H05B3/20
CPC分类号： B01L7/52 , B01L3/50851 , B01L3/50853 , B01L3/50857 , B01L7/00 , B01L2200/0605 , B01L2200/0642 , B01L2300/0654 , B01L2300/0829 , B01L2300/1816 , B01L2300/1838 , B01L2300/1861 , B01L2300/1872 , F28F13/00 , F28F2013/001 , G01N21/0332 , G01N21/6452 , G01N2201/062 , H05B3/84 , H05B6/02 , H05B6/105
摘要： A heating apparatus comprising a support base and a microplate having a first surface and an opposing second surface. The microplate is positioned adjacent the support base and comprises a plurality of wells formed in the first surface thereof. Each of the plurality of wells is sized to receive an assay therein. A sapphire crystalline transparent window is positioned adjacent the microplate opposing the support base. A heating device heats the transparent window in response to a control system.
摘要翻译：一种加热设备，包括支撑基座和具有第一表面和相对的第二表面的微孔板。微孔板位于支撑基底附近并且包括在其第一表面中形成的多个阱。多个孔中的每一个的大小适于在其中接受测定。蓝宝石结晶透明窗口位于与支撑基座相对的微孔板附近。加热装置响应于控制系统加热透明窗口。

7. 发明申请

US20060102477A1 Electrowetting dispensing devices and related methods 审中-公开
公开(公告)号：US20060102477A1
公开(公告)日：2006-05-18
申请号：US11213355
申请日：2005-08-26
申请人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
发明人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
IPC分类号： C07K1/26
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.

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