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1. 发明申请

US20070141605A1 Portable preparation, analysis, and detection apparatus for nucleic acid processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20070141605A1
公开(公告)日：2007-06-21
申请号：US11602149
申请日：2006-11-20
申请人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
发明人： Charles Vann , Michael Greenstein , Yuh-Min Chiang
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

2. 发明申请

US20070031977A1 Portable genomic analyzer 审中-公开
标题翻译：便携式基因组分析仪
公开(公告)号：US20070031977A1
公开(公告)日：2007-02-08
申请号：US11453340
申请日：2006-06-14
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： G01N1/00
CPC分类号： B01L3/502753 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2300/0681 , B01L2400/0409 , B01L2400/0421 , G01N2021/6439 , Y10T436/25
摘要： An apparatus for identifying a target portion of a sample. In some embodiments, the sample can be substantially purified and/or amplified in a test chamber. In some embodiments, the sample can be provided in an amount so that amplification is not necessary. The apparatus generally comprises a test chamber having an input region for receiving a sample and an analysis region. A sample chamber can be defined by at least a portion of the test chamber. A separation mechanism can separate a target portion of the sample from the sample and an analysis chamber can aid in analyzing at least the target portion of the sample.
摘要翻译：一种用于识别样本的目标部分的装置。在一些实施方案中，样品可以在测试室中基本上纯化和/或扩增。在一些实施方案中，可以提供一定量的样品，使得不需要扩增。该装置通常包括具有用于接收样品的输入区域和分析区域的测试室。样品室可以由测试室的至少一部分限定。分离机构可以将样品的目标部分与样品分离，并且分析室可以帮助分析至少样品的目标部分。

3. 发明申请

US20060228734A1 Fluid processing device with captured reagent beads 审中-公开
标题翻译：具有捕获试剂珠的流体处理装置
公开(公告)号：US20060228734A1
公开(公告)日：2006-10-12
申请号：US11378559
申请日：2006-03-17
申请人： Charles Vann , Umberto Ulmanella
发明人： Charles Vann , Umberto Ulmanella
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/50851 , B01L2200/0642 , B01L2200/0668 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/087 , B01L2400/0406 , B01L2400/0487 , B01L2400/0655 , B01L2400/0677 , G01N21/6452 , G01N33/54386 , G01N2021/0325 , G01N2021/6482
摘要： A fluid processing device, method and system are provided. The fluid processing device can comprise: a substrate; a plurality of reaction regions disposed in or on the substrate; at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and a plurality of reagent-releasing beads. Each reagent-releasing bead can be positioned in a respective one of the reaction regions. Each bead can comprise one or more reaction components for an assay. Each of the reagent-releasing beads can have a minimum dimension that is greater than the maximum dimension of the channel cross-section.
摘要翻译：提供流体处理装置，方法和系统。流体处理装置可以包括：基板; 设置在所述基板中或所述基板上的多个反应区域; 至少一个通道，其互连所述多个反应区域，所述至少一个通道具有包括最大尺寸的横截面积; 和多个试剂释放珠。每个试剂释放珠可以位于相应的一个反应区域中。每个珠可以包含用于测定的一种或多种反应成分。每个试剂释放珠可以具有大于通道横截面的最大尺寸的最小尺寸。

4. 发明申请

US20050013734A1 Matrix storage and retrieval system 审中-公开
标题翻译：矩阵存储和检索系统
公开(公告)号：US20050013734A1
公开(公告)日：2005-01-20
申请号：US10488437
申请日：2002-09-09
申请人： Charles Vann , David Cox , Dennis Lehto
发明人： Charles Vann , David Cox , Dennis Lehto
IPC分类号： A61J3/00 , A61J3/06 , A61J3/07 , B01J19/00 , B01L9/00 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： B01J19/0046 , B01J2219/00274 , B01J2219/00306 , B01J2219/00308 , B01J2219/0031 , B01J2219/00322 , B01J2219/00333 , B01J2219/00351 , B01J2219/00409 , B01J2219/00459 , B01J2219/00461 , B01J2219/00463 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00547 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01L3/0289 , B01L9/523 , B01L2200/0657 , B01L2300/0829 , B01L2400/0633 , B01L2400/0655 , C40B60/14 , C40B70/00 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/1002 , G01N2035/00158 , G01N2035/00752 , G01N2035/042 , G01N2035/0425 , G01N2035/1041 , Y10T436/11 , Y10T436/2575
摘要： A system for storing and dispensing a plurality of vessels (54). The system includes an array of storage silos (44) or passages operable to store the plurality of vessels (54) where the storage silos have a dispensing end and a reloading end. A retrieval robot (22) is positioned adjacent to the dispensing end of the array of storage silos and is operable to retrieve at least one vessel (54) from at least one silo (44) in the array of storage silos. A reload robot (26) is positioned adjacent the reload end of the army of storage silos (44) and is operable to reload at least one vessel (54) into at least one silo (44) in said array of storage silos (44).
摘要翻译：一种用于存储和分配多个容器（54）的系统。该系统包括一组存储筒仓（44）或可操作以存储多个容器（54）的通道，其中存储筒仓具有分配端和重新加载端。检索机器人（22）被定位成与存储筒仓阵列的分配端相邻，并且可操作以从存储筒仓阵列中的至少一个筒仓（44）收回至少一个容器（54）。重新装载机器人（26）位于储存仓（44）的军队的重新加载端附近，并且可操作以将至少一个容器（54）重新装载到所述存储筒仓阵列（44）中的至少一个筒仓（44）中，。

5. 发明授权

US08163150B2 Electrowetting dispensing devices and related methods 有权
标题翻译：电动滴胶装置及相关方法
公开(公告)号：US08163150B2
公开(公告)日：2012-04-24
申请号：US12709402
申请日：2010-02-19
申请人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
发明人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
IPC分类号： G01N27/447 , G01N1/16
CPC分类号： G01N27/44743 , B01J4/008 , B01J2219/00315 , B01J2219/0036 , B01J2219/00418 , B01J2219/00653 , B01L3/0241 , B01L3/0268 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/02 , B01L2400/0409 , B01L2400/0427
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.
摘要翻译：用于分配用于生物分析的液体的方法可以包括通过电润湿定位待分配的液体。定位可以包括使液体与多个预定位置对准。该方法还可以包括通过分别与预定位置对准的多个开口分配来自多个预定位置的对准的液体。分配可以经由电润湿。

6. 发明申请

US20110136677A1 METHODS OF BEAD MANIPULATION AND FORMING BEAD ARRAYS 有权
标题翻译：珠子操纵和形成珠粒阵列的方法
公开(公告)号：US20110136677A1
公开(公告)日：2011-06-09
申请号：US12872333
申请日：2010-08-31
申请人： Mark OLDHAM , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
发明人： Mark OLDHAM , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
IPC分类号： C40B20/08 , C40B50/00 , C40B30/00 , B05D5/00 , B05D7/24
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.
摘要翻译：根据各种实施方案，提供了一种方法，其包括用洗涤溶液洗涤基底上的DNA包被的珠粒阵列以从基底去除堆叠的珠粒。洗涤溶液可以在载体中包括惰性固体珠。 DNA包被的珠可以具有平均直径，并且洗涤溶液中的固体珠的平均直径可以是DNA包被的珠的直径的至少两倍。洗涤可以形成脱落的DNA包被的珠粒和单层DNA包被的珠粒。在一些实施方案中，用于形成阵列的第一珠粒与包含分子量约350Da或更低的PEG的聚（乙二醇）（PEG）溶液接触。在一些实施例中，用于形成珠阵列的滑块被提供为用于对其进行成像的系统。

7. 发明申请

US20060210434A1 Matrix storage and dispensing system 有权
公开(公告)号：US20060210434A1
公开(公告)日：2006-09-21
申请号：US11436296
申请日：2006-05-18
申请人： Charles Vann , David Cox
发明人： Charles Vann , David Cox
IPC分类号： G01N33/00
CPC分类号： B01J19/0046 , B01J2219/00274 , B01J2219/00306 , B01J2219/00308 , B01J2219/0031 , B01J2219/00322 , B01J2219/00333 , B01J2219/00351 , B01J2219/00409 , B01J2219/00459 , B01J2219/00461 , B01J2219/00463 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00547 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01L3/0289 , B01L9/523 , B01L2200/0657 , B01L2300/0829 , B01L2400/0633 , B01L2400/0655 , C40B60/14 , C40B70/00 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/1002 , G01N2035/00158 , G01N2035/00752 , G01N2035/042 , G01N2035/0425 , G01N2035/1041 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.

8. 发明申请

US20060166347A1 Sample preparation devices and methods 审中-公开
标题翻译：样品制备装置和方法
公开(公告)号：US20060166347A1
公开(公告)日：2006-07-27
申请号：US11342012
申请日：2006-01-27
申请人： Konrad Faulstich , John Van Camp , Charles Vann
发明人： Konrad Faulstich , John Van Camp , Charles Vann
IPC分类号： C12N1/06
CPC分类号： C12N1/066 , B01L3/502 , B01L2300/0681 , B01L2400/0478 , B01L2400/0605 , C12N1/06 , G01N2001/4088
摘要： A method and device for preparing biological samples includes lysing the microorganisms, and collecting a desired biological material.
摘要翻译：用于制备生物样品的方法和装置包括裂解微生物并收集所需的生物材料。

9. 发明申请

US20060063159A1 Post-synthesis processing system for supported oligonucleotides, and method 审中-公开
标题翻译：支持寡核苷酸的后合成处理系统及方法
公开(公告)号：US20060063159A1
公开(公告)日：2006-03-23
申请号：US10946718
申请日：2004-09-22
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： C40B40/08 , C40B60/04
CPC分类号： C12Q1/6806 , B01J19/0046 , B01J2219/00454 , B01J2219/00468 , B01J2219/005 , B01J2219/00542 , B01J2219/00592 , B01J2219/00596 , B01J2219/00691 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B50/14 , C40B70/00
摘要： A system is provided that can include: a plurality of retainment regions, where each retainment region is adapted to retain a respective type of an oligonucleotide supported on a respective support; a mixture retainment region; a handling device; a control unit adapted to control the handling device; and a separating unit adapted to simultaneously separate different supported oligonucleotides from their respective supports. A method is provided that can include: pooling together a plurality of supported oligonucleotides to form a mixture; and simultaneously separating the oligonucleotides of the supported oligonucleotides in the mixture from their supports. A method for facilitating genetic analysis is also provided and can include: receiving from a user a request for one or more genetic analysis assays; formulating each assay; and providing to the user the one or more assay; wherein the formulating can include pooling together into a mixture retainment region a plurality of different supported oligonucleotides and simultaneously separating the different oligonucleotides from their respective supports.
摘要翻译：提供了一种系统，其可以包括：多个保留区域，其中每个保留区域适于保留支撑在相应载体上的相应类型的寡核苷酸; 混合物保留区域; 处理装置; 适于控制所述处理装置的控制单元; 以及分离单元，其适于将不同的支持的寡核苷酸与其各自的载体同时分离。提供了一种可以包括：将多个所支持的寡核苷酸汇集在一起以形成混合物的方法; 并同时将载体中寡核苷酸的寡核苷酸与其载体分离。还提供了促进遗传分析的方法，并且可以包括：从用户接收对一种或多种遗传分析测定的请求; 制定每个测定; 并向用户提供一个或多个测定; 其中所述配制可以包括将多个不同的负载寡核苷酸汇合在一起成为混合物保留区域，并同时将不同的寡核苷酸与其各自的载体分离。

10. 发明申请

US20050042651A1 Integrated optics fiber array 失效
标题翻译：集成光纤阵列
公开(公告)号：US20050042651A1
公开(公告)日：2005-02-24
申请号：US10877113
申请日：2004-06-24
申请人： Charles Vann , Tim Geiser , Andrew Blasband
发明人： Charles Vann , Tim Geiser , Andrew Blasband
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/64 , G01N21/77 , C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00326 , B01J2219/0043 , B01J2219/00495 , B01J2219/00515 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00657 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01L3/5023 , B82Y30/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/648 , G01N21/7703 , G01N2021/6484
摘要： The device for detecting the binding of two chemical species includes a first plate having a base, multiple optical fibers and a second plate. The base has multiple grooves formed therein. The multiple optical fibers are each disposed within a corresponding one of the multiple grooves. The second plate has multiple channels formed therein. The first plate and the second plate are configured to be placed adjacent to one another such that each the optical fiber is exposed to and traverses the multiple channels.
摘要翻译：用于检测两种化学物质的结合的装置包括具有基底，多根光纤和第二板的第一板。底座上形成有多个凹槽。多个光纤各自设置在多个槽中的对应的一个中。第二板具有形成在其中的多个通道。第一板和第二板被配置为彼此相邻放置，使得每个光纤被暴露并穿过多个通道。

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