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1. 发明授权

US07283696B2 Microfluidic control for waveguide optical switches, variable attenuators, and other optical devices 有权
标题翻译：用于波导光开关，可变衰减器和其他光学器件的微流控制
公开(公告)号：US07283696B2
公开(公告)日：2007-10-16
申请号：US11289188
申请日：2005-11-28
申请人： Anthony J. Ticknor , John T. Kenney , Giacomo Vacca , Dudley A. Saville , Ken G. Purchase
发明人： Anthony J. Ticknor , John T. Kenney , Giacomo Vacca , Dudley A. Saville , Ken G. Purchase
IPC分类号： G02B6/10
CPC分类号： G02B26/005 , B01F13/0059 , B01F13/0076 , B01J2219/00274 , B01L3/50273 , B01L2300/0816 , B01L2400/0427 , B01L2400/086 , F04B19/006 , G02B6/3536 , G02B6/3538 , G02B6/3546 , G02B6/355 , G02B6/3552 , G02B6/3568 , G02B6/357 , G02B6/3574 , G02B6/3576 , G02B6/358 , G02B6/3594
摘要： Devices utilize elements carried by a fluid in a microchannel to switch, attenuate, shutter, filter, or phase shift optical signals. In certain embodiments, a microchannel carries a gaseous or liquid slug that interacts with at least a portion of the optical power of an optical signal traveling through a waveguide. The microchannel may form part of the cladding of the waveguide, part of the core and the cladding, or part of the core only. The microchannel may also have ends or may be configured as a loop or continuous channel. The fluid devices may be self-latching or may be semi-latching. The fluid in the microchannel is moved using e.g., e.g., electrocapillarity, differential-pressure electrocapillarity, electrowetting, continuous electrowetting, electrophoresis, electroosmosis, dielectrophoresis, electro-hydrodynamic electrohydrodynamic pumping, magneto-hydrodynamic magnetohydrodynamic pumping, thermocapillarity, thermal expansion, dielectric pumping, and/or variable dielectric pumping.
摘要翻译：设备利用由微通道中的流体承载的元件来切换，衰减，快门，滤波或相移光信号。在某些实施例中，微通道携带气体或液体块，其与穿过波导的光信号的光功率的至少一部分相互作用。微通道可以形成波导的包层的一部分，芯部的一部分和包层，或仅部分芯部。微通道还可以具有端部或者可以被配置为环路或连续通道。流体装置可以是自锁的或可以是半锁定的。微通道中的流体例如使用电毛细管力，差压电毛细管力，电润湿，连续电润湿，电泳，电渗，介电电泳，电流动力学电流动力学泵浦，磁流体动力学磁流体动力学泵浦，热吸收，热膨胀，介电泵送，和/或可变电介质泵浦。

2. 发明授权

US07016560B2 Microfluidic control for waveguide optical switches, variable attenuators, and other optical devices 失效
公开(公告)号：US07016560B2
公开(公告)日：2006-03-21
申请号：US10085885
申请日：2002-02-27
申请人： Anthony J. Ticknor , John T. Kenney , Giacomo Vacca , Dudley A. Saville , Ken G. Purchase
发明人： Anthony J. Ticknor , John T. Kenney , Giacomo Vacca , Dudley A. Saville , Ken G. Purchase
IPC分类号： G02B6/35 , G02B6/26
CPC分类号： B01F13/0076 , B01F13/0059 , B01L3/50273 , B01L3/502784 , B01L2300/0816 , B01L2400/0427 , B01L2400/0448 , F04B19/006 , G02B6/3538 , G02B6/3546 , G02B6/355 , G02B6/3568 , G02B6/3574 , G02B6/3576 , G02B6/358 , G02B26/005
摘要： Devices utilize elements carried by a fluid in a microchannel toswitch, attenuate, shutter, filter, or phase shift optical signals. In certain embodiments, a microchannel carries a gaseous or liquid slug that interacts with at least a portion of the optical power of an optical signal traveling through a waveguide. The microchannel may form part of the cladding of the waveguide, part of the core and the cladding, or part of the core only. The microchannel may also have ends or may be configured as a loop or continuous channel. The fluid devices may be self-latching or may be semi-latching. The fluid in the microchannel is moved using e.g., e.g., electrocapillarity, differential-pressure electrocapillarity, electrowetting, continuous electrowetting, electrophoresis, electroosmosis, dielectrophoresis, electro-hydrodynamic electrohydrodynamic pumping, magneto-hydrodynamic magnetohydrodynamic pumping, thermocapillarity, thermal expansion, dielectric pumping, and/or variable dielectric pumping.

3. 发明授权

US06949176B2 Microfluidic control using dielectric pumping 有权
标题翻译：微流控制采用介质抽吸
公开(公告)号：US06949176B2
公开(公告)日：2005-09-27
申请号：US10087264
申请日：2002-02-28
申请人： Giacomo Vacca , John T. Kenney , Dudley A. Saville
发明人： Giacomo Vacca , John T. Kenney , Dudley A. Saville
IPC分类号： B01F13/00 , B01L3/00 , F04B19/00 , G02B6/35 , G02B26/02 , G01N27/26 , G02B6/26 , G02B6/42
CPC分类号： G02B26/005 , B01F13/0059 , B01F13/0076 , B01J2219/00274 , B01L3/50273 , B01L2300/0816 , B01L2400/0427 , B01L2400/086 , F04B19/006 , G02B6/3536 , G02B6/3538 , G02B6/3546 , G02B6/355 , G02B6/3552 , G02B6/3568 , G02B6/357 , G02B6/3574 , G02B6/3576 , G02B6/358 , G02B6/3594
摘要： Devices and methods utilizing dielectric pumping and variable dielectric pumping to move fluids through microchannels. Two fluids having dissimilar dielectric constants form an interface that is positioned between two electrodes in order to move the interface and therefore the fluids. Dielectric pumping and variable dielectric pumping may be used to move fluids in miniaturized analytical packages containing microchannels in which forces created by surface tension predominate over the gravitational force.
摘要翻译：利用电介质泵浦和可变介质泵浦来移动流体通过微通道的装置和方法。具有不同介电常数的两种流体形成位于两个电极之间的界面，以便移动界面并因此移动流体。电介质泵浦和可变电介质泵送可以用于在包含微通道的微型分析包中移动流体，其中由表面张力产生的力主要超过重力。

4. 发明授权

US09091624B2 White blood cell analysis system and method 有权
标题翻译：白细胞分析系统及方法
公开(公告)号：US09091624B2
公开(公告)日：2015-07-28
申请号：US13456729
申请日：2012-04-26
申请人： Jiong Wu , Giacomo Vacca
发明人： Jiong Wu , Giacomo Vacca
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1434 , G01N15/1459 , G01N21/6428 , G01N33/49 , G01N2015/008 , G01N2015/1006 , G01N2015/1477 , G01N2015/1488 , G01N2021/6439
摘要： Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder WBC reagent(s), suitable for assays of samples containing fragile WBCs. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye, which corresponds in emission spectrum to an excitation source of a hematology instrument; (b) using a fluorescence trigger to screen the blood sample for WBCs; and (c) using measurements of (1) axial light loss, (2) intermediate angle scatter, (3) 90° polarized side scatter, (4) 90° depolarized side scatter, and (5) fluorescence emission to perform a differentiation analysis.
摘要翻译：用于分析血液样品的系统和方法，更具体来说用于进行白细胞（WBC）差异分析。系统和方法通过荧光染色和荧光触发策略筛选WBC。因此，基本上消除了来自未分解的红细胞（RBC）和裂解的RBC的片段的干扰。这些系统和方法还可以开发出相对温和的WBC试剂，适用于含有脆弱WBC的样品的测定。在一个实施方案中，系统和方法包括：（a）用发射光谱对应于血液学仪器的激发源的专用细胞膜可渗透荧光染料染色血液样品; （b）使用荧光触发来筛选白细胞的血样; 和（c）使用（1）轴向光损失，（2）中角散射，（3）90°偏振侧散射，（4）90°去极化侧散射的测量，和（5）荧光发射来进行微分分析。

5. 发明授权

US08911669B2 Method for flagging a sample 有权
标题翻译：标记样品的方法
公开(公告)号：US08911669B2
公开(公告)日：2014-12-16
申请号：US12546552
申请日：2009-08-24
申请人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
IPC分类号： G01N33/00 , G01N31/00 , G01N15/14 , G01N15/10 , G01N15/00
CPC分类号： G01N33/4915 , G01N15/1429 , G01N15/1459 , G01N33/492 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/2575
摘要： A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
摘要翻译：提供血液分析仪。在某些实施方案中，血液分析仪包括：a）流动池; b）用于将光引导到流动池的光源; c）多个检测器，用于检测通过流通池的血细胞的多个光学特性; 和d）数据分析工作站被编程为：i。列举通过流动池的测试血液细胞; 和ii。标记含有裂解抗性红细胞或脆弱白细胞的血液样品。

6. 发明授权

US08906308B2 Method for determining volume and hemoglobin content of individual red blood cells 有权
标题翻译：测定个体红细胞体积和血红蛋白含量的方法
公开(公告)号：US08906308B2
公开(公告)日：2014-12-09
申请号：US12657218
申请日：2010-01-15
申请人： Martin Krockenberger , Diana G. Garrett , Giacomo Vacca
发明人： Martin Krockenberger , Diana G. Garrett , Giacomo Vacca
IPC分类号： G01N33/00 , G01N31/00 , G01N15/14 , G01N33/49 , G01N15/00
CPC分类号： G01N15/06 , G01N15/0656 , G01N15/1459 , G01N15/147 , G01N33/4915 , G01N33/492 , G01N33/721 , G01N2015/0065 , G01N2015/0073 , G01N2015/0687 , G01N2015/0693 , G01N2333/805 , Y10T436/101666
摘要： A method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method.
摘要翻译：一种用于测定含有红细胞群的样品中各个红细胞的体积或血红蛋白含量的方法。该方法可以在血液分析仪上进行。还提供了用于执行该方法的血液分析仪和包含用于执行该方法的程序的计算机可读介质。

7. 发明申请

US20120282600A1 Basophil Analysis System and Method 有权
标题翻译：嗜碱粒细胞分析系统和方法
公开(公告)号：US20120282600A1
公开(公告)日：2012-11-08
申请号：US13456744
申请日：2012-04-26
申请人： Jiong Wu , Giacomo Vacca , Michael R. Buhl
发明人： Jiong Wu , Giacomo Vacca , Michael R. Buhl
IPC分类号： C12M1/42 , G01N21/64
CPC分类号： G01N15/1434 , G01N15/1459 , G01N21/6428 , G01N33/49 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , G01N2015/1486 , G01N2015/1488 , G01N2021/6439
摘要： Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements.
摘要翻译：本文提供了用于分析血液样品的系统和方法，并且更具体地用于进行嗜碱性粒细胞分析。在一个实施方案中，系统和方法包括：（a）用专用细胞膜可渗透荧光染料染色血液样品; 然后（b）使用光散射和荧光发射的测量来区分嗜碱性粒细胞与其他WBC亚种群。在一个实施方案中，系统和方法包括基于光散射和荧光测量的组合进行血液样品的嗜碱性粒细胞聚类分析。

8. 发明申请

US20120270306A1 METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 失效
标题翻译：方法和设备，用于快速计算和识别流动流中的生物颗粒
公开(公告)号：US20120270306A1
公开(公告)日：2012-10-25
申请号：US13448216
申请日：2012-04-16
申请人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
发明人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
IPC分类号： C12M1/42
CPC分类号： G01N15/1434 , G01N1/38 , G01N15/1425 , G01N15/1459 , G01N2015/0065 , G01N2015/1402 , G01N2015/1447 , G01N2015/1486
摘要： A method for increasing the throughput and/or the precision of a flow cytometer, or a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer. The system and method includes utilizing the technique of laser rastering in combination with a lysis-free single-dilution method.
摘要翻译：一种用于增加流式细胞仪的流量和/或精度的方法，或使用流式细胞仪的血液分析仪，并进一步降低这种细胞仪或分析仪的复杂性。该系统和方法包括利用激光扫描技术与无裂解单稀释法结合使用。

9. 发明申请

US20080158561A1 METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 失效
标题翻译：方法和设备，用于快速计算和识别流动流中的生物颗粒
公开(公告)号：US20080158561A1
公开(公告)日：2008-07-03
申请号：US11934277
申请日：2007-11-02
申请人： Giacomo Vacca , Norman R. Goldblatt , Michael W. Yee
发明人： Giacomo Vacca , Norman R. Goldblatt , Michael W. Yee
IPC分类号： G01N21/00
CPC分类号： G01N15/0205 , G01N15/0227 , G01N15/1459 , G01N15/1463 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2015/1493
摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, by utilizing the technique of laser rastering. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flow cell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.
摘要翻译：通过利用激光扫描技术提高流式细胞仪或使用流式细胞仪的血液分析仪的生产量，精度或精度以及吞吐量的方法。激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

10. 发明授权

US07804594B2 Method and apparatus for rapidly counting and identifying biological particles in a flow stream 失效
标题翻译：用于在流动流中快速计数和识别生物颗粒的方法和装置
公开(公告)号：US07804594B2
公开(公告)日：2010-09-28
申请号：US11934277
申请日：2007-11-02
申请人： Giacomo Vacca , Norman R. Goldblatt , Michael W. Yee
发明人： Giacomo Vacca , Norman R. Goldblatt , Michael W. Yee
IPC分类号： G01N21/00
CPC分类号： G01N15/0205 , G01N15/0227 , G01N15/1459 , G01N15/1463 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2015/1493
摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, by utilizing the technique of laser rastering. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flow cell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.
摘要翻译：通过利用激光扫描技术提高流式细胞仪或使用流式细胞仪的血液分析仪的生产量，精度或精度以及吞吐量的方法。激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

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