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1. 发明申请

US20120270306A1 METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 失效
标题翻译：方法和设备，用于快速计算和识别流动流中的生物颗粒
公开(公告)号：US20120270306A1
公开(公告)日：2012-10-25
申请号：US13448216
申请日：2012-04-16
申请人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
发明人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
IPC分类号： C12M1/42
CPC分类号： G01N15/1434 , G01N1/38 , G01N15/1425 , G01N15/1459 , G01N2015/0065 , G01N2015/1402 , G01N2015/1447 , G01N2015/1486
摘要： A method for increasing the throughput and/or the precision of a flow cytometer, or a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer. The system and method includes utilizing the technique of laser rastering in combination with a lysis-free single-dilution method.
摘要翻译：一种用于增加流式细胞仪的流量和/或精度的方法，或使用流式细胞仪的血液分析仪，并进一步降低这种细胞仪或分析仪的复杂性。该系统和方法包括利用激光扫描技术与无裂解单稀释法结合使用。

2. 发明授权

US08400632B2 Method and apparatus for rapidly counting and identifying biological particles in a flow stream 失效
标题翻译：用于在流动流中快速计数和识别生物颗粒的方法和装置
公开(公告)号：US08400632B2
公开(公告)日：2013-03-19
申请号：US13448216
申请日：2012-04-16
申请人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
发明人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
IPC分类号： G01N21/00
CPC分类号： G01N15/1434 , G01N1/38 , G01N15/1425 , G01N15/1459 , G01N2015/0065 , G01N2015/1402 , G01N2015/1447 , G01N2015/1486
摘要： A method for increasing the throughput and/or the precision of a flow cytometer, or a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer. The system and method includes utilizing the technique of laser rastering in combination with a lysis-free single-dilution method.
摘要翻译：一种用于增加流式细胞仪的流量和/或精度的方法，或使用流式细胞仪的血液分析仪，并进一步降低这种细胞仪或分析仪的复杂性。该系统和方法包括利用激光扫描技术与无裂解单稀释法结合使用。

3. 发明授权

US08159670B2 Method and apparatus for rapidly counting and identifying biological particles in a flow stream 失效
标题翻译：用于在流动流中快速计数和识别生物颗粒的方法和装置
公开(公告)号：US08159670B2
公开(公告)日：2012-04-17
申请号：US12262431
申请日：2008-10-31
申请人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
发明人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
IPC分类号： G01N21/00
CPC分类号： G01N15/1434 , G01N1/38 , G01N15/1425 , G01N15/1459 , G01N2015/0065 , G01N2015/1402 , G01N2015/1447 , G01N2015/1486
摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.
摘要翻译：一种用于增加流式细胞仪或使用流式细胞仪的血液分析仪的吞吐量或精度或精度或者吞吐量的方法，并且为了进一步降低这种细胞仪或分析仪的复杂性，通过利用激光扫描技术与无裂解单稀释法结合使用。激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。无裂解的单次稀释法包括使用单次等分试样，单次无裂解试剂溶液，单一稀释液和通过测量装置的所述稀释液单次进行样品上的所有流式细胞仪测量。适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

4. 发明申请

US20090142765A1 METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 失效
标题翻译：方法和设备，用于快速计算和识别流动流中的生物颗粒
公开(公告)号：US20090142765A1
公开(公告)日：2009-06-04
申请号：US12262431
申请日：2008-10-31
申请人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
发明人： Giacomo Vacca , Richard G. Kendall , Norman R. Goldblatt , Michael W. Yee , Mahesh R. Junnarkar
IPC分类号： G01N21/75 , C12Q1/68
CPC分类号： G01N15/1434 , G01N1/38 , G01N15/1425 , G01N15/1459 , G01N2015/0065 , G01N2015/1402 , G01N2015/1447 , G01N2015/1486
摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.
摘要翻译：一种用于增加流式细胞仪或使用流式细胞仪的血液分析仪的吞吐量或精度或精度或者吞吐量的方法，并且为了进一步降低这种细胞仪或分析仪的复杂性，通过利用激光扫描技术与无裂解单稀释法结合使用。激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。无裂解的单次稀释法包括使用单次等分试样，单次无裂解试剂溶液，单一稀释液和通过测量装置的所述稀释液单次进行样品上的所有流式细胞仪测量。适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

5. 发明授权

US07317517B2 Birefringence profiler 失效
标题翻译：双折射分析仪
公开(公告)号：US07317517B2
公开(公告)日：2008-01-08
申请号：US10631538
申请日：2003-07-31
申请人： Mahesh R. Junnarkar , Bidhan P. Chaudhuri
发明人： Mahesh R. Junnarkar , Bidhan P. Chaudhuri
IPC分类号： G01N21/00
CPC分类号： G01M11/35
摘要： A waveguide under test can be exposed to a light signal whose polarization rotates between the vertical and horizontal polarizations. The intensity detected at a photodetector can be separated into AC and DC components. The AC components may be utilized to derive a characteristics which is indicative of birefringence of the waveguide. If the light signal is scanned over the waveguide under test, a measure of the birefringence at each position along the waveguide may be determined.
摘要翻译：受测试的波导可以暴露于其垂直和水平极化之间偏振旋转的光信号。在光电检测器处检测的强度可以分为AC和DC分量。可以使用AC分量来导出指示波导的双折射的特性。如果光信号在被测波导上扫描，则可以确定沿着波导的每个位置处的双折射的测量。

6. 发明授权

US06898347B2 Monitoring power in optical networks 失效
标题翻译：监控光网络中的功率
公开(公告)号：US06898347B2
公开(公告)日：2005-05-24
申请号：US10448759
申请日：2003-05-30
申请人： Mahesh R. Junnarkar , Anirban Bandyopadhyay
发明人： Mahesh R. Junnarkar , Anirban Bandyopadhyay
IPC分类号： G02B6/42 , G02B6/26
CPC分类号： G02B6/42 , G02B6/4206 , G02B6/4214
摘要： An optical network may include a detector for detecting the power of each of a plurality of channels of a wavelength division multiplexed optical signal in one embodiment of the present invention. Each channel may be conveyed to an interface underneath a detector by way of a core formed in the substrate. The interface may include a trench with one side surface angled to form a reflector to reflect light upwardly to be detected by the detector. The trench may be filled with a convex microlens.
摘要翻译：在本发明的一个实施例中，光网络可以包括用于检测波分复用光信号的多个信道中的每一个的功率的检测器。每个通道可以通过形成在基板中的芯体传送到检测器下面的界面。界面可以包括具有一个侧表面成角度以形成反射器的沟槽，以将光向上反射以由检测器检测。沟槽可以填充凸起的微透镜。

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