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1. 发明申请

US20060256343A1 Methods, systems and computer program products for characterizing structures based on interferometric phase data 有权
公开(公告)号：US20060256343A1
公开(公告)日：2006-11-16
申请号：US11337166
申请日：2006-01-20
申请人： Michael Choma , Joseph Izatt , Audrey Ellerbee , Marinko Sarunic
发明人： Michael Choma , Joseph Izatt , Audrey Ellerbee , Marinko Sarunic
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02004 , G01B9/0203 , G01B9/02044 , G01B9/02057 , G01B9/02083 , G01B9/02091 , G01J3/2823 , G01J3/453 , G01N21/39 , G01N2021/1787
摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.

2. 发明申请

US20060232783A1 Methods and systems for reducing complex conjugat ambiguity in interferometric data 有权
标题翻译：用于降低干涉测量数据中复杂的共轭模糊度的方法和系统
公开(公告)号：US20060232783A1
公开(公告)日：2006-10-19
申请号：US11336652
申请日：2006-01-20
申请人： Michael Choma , Joseph Izatt , Anjul Davis
发明人： Michael Choma , Joseph Izatt , Anjul Davis
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02069 , G01B9/02078 , G01B9/02091
摘要： A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.
摘要翻译：在光学相干断层扫描（OCT）干涉图中可以解决复共轭模糊度。参考光信号沿着参考路径传播。样品光信号撞击样品反射器。参考光信号相对于采样光信号被偏移，从而分离OCT干涉图的复共轭分量的正位移和负位移。

3. 发明申请

US20050036150A1 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US20050036150A1
公开(公告)日：2005-02-17
申请号：US10765010
申请日：2004-01-26
申请人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
发明人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

4. 发明授权

US06200266B1 Method and apparatus for ultrasound imaging using acoustic impedance reconstruction 失效
标题翻译：使用声阻抗重建的超声成像方法和装置
公开(公告)号：US06200266B1
公开(公告)日：2001-03-13
申请号：US09282215
申请日：1999-03-31
申请人： Nima Shokrollahi , William Tobocman , Sanford Roth , Joseph Izatt
发明人： Nima Shokrollahi , William Tobocman , Sanford Roth , Joseph Izatt
IPC分类号： A61B800
CPC分类号： G01S7/52061 , A61B8/0858 , A61B8/13 , G01S7/52036 , G01S7/52046 , G01S7/52069 , G01S15/8993
摘要： An ultrasound imaging system employs acoustic impedance reconstruction to produce high-resolution images of anatomical structures, which are virtually free of speckle. Determination of the acoustic impedance profile involves prefiltering of the incident ultrasound signal and the ultrasound signal reflected from the specimen to be imaged. A time domain window function is applied to both the incident and reflected signals, and an N-point FFT is computed for both the digitized incident and reflected signals to obtain the incident and reflected spectrums. A complex division of the reflected spectrum by the incident spectrum is performed to obtain the transfer function. A window function having a sharp, low-frequency cutoff is applied to the transfer function prior to performing an inverse FFT to obtain the estimated impulse response. The acoustic impedance of individual A-scans is calculated from the impulse response using the plane wave Born approximation, involving integration and exponentiation of the estimated impulse response. By mechanically or electronically scanning the transducer along a line, a series of A-scan acoustic impedance profiles are calculated and used to produce a two-dimensional, grey-scale B-scan image.
摘要翻译：超声成像系统采用声阻抗重建来产生解剖结构的高分辨率图像，其实质上不含斑点。声阻抗曲线的确定涉及入射超声信号的预滤波和从待成像的样本反射的超声信号。时域窗函数被应用于入射和反射信号，并且为数字入射和反射信号计算N点FFT以获得入射和反射光谱。进行入射光谱的反射光谱的复分割以获得传递函数。在执行逆FFT之前将具有尖锐的低频截止的窗函数应用于传递函数以获得估计的脉冲响应。使用平面波Born近似从脉冲响应计算各个A扫描的声阻抗，涉及估计的脉冲响应的积分和取幂。通过沿着一条线机械地或电子地扫描换能器，计算一系列A扫描声阻抗曲线并用于产生二维灰度B扫描图像。

5. 发明申请

US20080106696A1 OPTICAL COHERENCE IMAGING SYSTEMS HAVING A MECHANISM FOR SHIFTING FOCUS AND SCANNING MODALITY AND RELATED ADAPTERS 有权
标题翻译：具有移动聚焦和扫描模式的机构的光学相干成像系统及相关适配器
公开(公告)号：US20080106696A1
公开(公告)日：2008-05-08
申请号：US11930865
申请日：2007-10-31
申请人： Eric Buckland , Joseph Izatt , Seungbum Woo , Michael Sullivan
发明人： Eric Buckland , Joseph Izatt , Seungbum Woo , Michael Sullivan
IPC分类号： A61B3/18 , A61B3/14
CPC分类号： A61B3/102 , A61B3/12
摘要： Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein.
摘要翻译：本发明的一些实施例提供用于后置成像系统的适配器。适配器包括被配置为使后部成像系统适合作为前成像系统操作的镜片组。本文还提供了相关的光学相干断层扫描系统和前置成像系统。

6. 发明申请

US20070086017A1 Imaging Systems Using Unpolarized Light And Related Methods And Controllers 有权
标题翻译：使用非偏振光和相关方法和控制器的成像系统
公开(公告)号：US20070086017A1
公开(公告)日：2007-04-19
申请号：US11539275
申请日：2006-10-06
申请人： Eric Buckland , John Marciante , Joseph Izatt , William Brown
发明人： Eric Buckland , John Marciante , Joseph Izatt , William Brown
IPC分类号： G01B9/02 , G01J3/45 , G01B11/02
CPC分类号： G01N21/45 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01B9/02004 , G01B9/02027 , G01B9/02044 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/23 , G01N2021/1787
摘要： Optical imaging systems are provided including a light source and a depolarizer. The light source is provided in a source arm of the optical imaging system. A depolarizer is coupled to the light source in the source arm of the optical imaging system and is configured to substantially depolarize the light from the light source. Related methods and controllers are also provided.
摘要翻译：提供了包括光源和消偏振器的光学成像系统。光源设置在光学成像系统的源臂中。去偏振器耦合到光学成像系统的源极臂中的光源，并且被配置为基本上使来自光源的光去极化。还提供了相关方法和控制器。

7. 发明申请

US20070258094A1 Methods, systems and computer program products for optical coherence tomography (OCT) using automatic dispersion compensation 有权
标题翻译：用于光学相干断层扫描（OCT）的方法，系统和计算机程序产品，使用自动色散补偿
公开(公告)号：US20070258094A1
公开(公告)日：2007-11-08
申请号：US11796399
申请日：2007-04-27
申请人： Joseph Izatt , Eric Buckland , William Brown
发明人： Joseph Izatt , Eric Buckland , William Brown
IPC分类号： G01J3/45 , G01B11/02 , G01B9/02
CPC分类号： G01B9/02091 , G01B9/02044 , G01B9/02083 , G01N21/4795
摘要： Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated. The acquired raw spectral data and the postulated trial spectral phase data are assembled into trial complex spectrum data. Trial A-scan data is computed by performing an inverse Fourier transform on the trial complex spectrum data and determining the magnitude of a result.
摘要翻译：提供了用于在光学相干断层扫描（OCT）系统中生成软件色散补偿参数的方法，系统和计算机程序产品。对于样品上的给定横向位置和给定的参考反射，获取原始光谱干涉图数据。假设对应于获取的光谱干涉图数据的每个波数样本的试验光谱相位。将获得的原始光谱数据和假设的试验光谱相位数据组装成试验复数谱数据。通过对试验复谱数据进行傅里叶逆变换并确定结果的大小来计算试验A-扫描数据。

8. 发明申请

US20070081166A1 Portable Optical Coherence Tomography (OCT) Devices and Related Systems 有权
标题翻译：便携式光学相干断层扫描（OCT）设备和相关系统
公开(公告)号：US20070081166A1
公开(公告)日：2007-04-12
申请号：US11535663
申请日：2006-09-27
申请人： William Brown , Eric Buckland , Joseph Izatt
发明人： William Brown , Eric Buckland , Joseph Izatt
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： A61B3/14 , A61B3/1005 , A61B3/102 , A61B3/1208 , A61B3/1225 , A61B3/125 , G01B9/02028 , G01B9/0205 , G01B9/02057 , G01B9/02089 , G01B9/02091 , G01B2290/25 , G01B2290/35 , G01N21/4795
摘要： Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
摘要翻译：提供了包括配置成扫描至少两个方向的至少一个反射镜的便携式光学相干断层摄影（OCT）装置。便携式OCT设备被配置为向样本提供便携式接口，该样本可以与样品对准而不重新定位样品。还提供了相关系统。

9. 发明申请

US20070024868A1 INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY... 有权
标题翻译：用于光学相干域反射测量的干涉仪
公开(公告)号：US20070024868A1
公开(公告)日：2007-02-01
申请号：US11470079
申请日：2006-09-05
申请人： Joseph Izatt , Andrew Rollins
发明人： Joseph Izatt , Andrew Rollins
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation-source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学检测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

10. 发明申请

US20070024856A1 Optical coherence imaging systems having a reduced effective linewidth and methods of using the same 有权
标题翻译：具有降低的有效线宽的光学相干成像系统及其使用方法
公开(公告)号：US20070024856A1
公开(公告)日：2007-02-01
申请号：US11495226
申请日：2006-07-28
申请人： Joseph Izatt , Eric Buckland , William Brown
发明人： Joseph Izatt , Eric Buckland , William Brown
IPC分类号： G01J3/45 , G01B9/02 , G01B11/02
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01B9/02004 , G01B9/02007 , G01B9/02008 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Frequency domain optical coherence imaging systems have an optical source, an optical detector and an optical transmission path between the optical source and the optical detector. The optical transmission path between the optical source and the optical detector reduces an effective linewidth of the imaging system. The optical source may be a broadband source and the optical transmission path may include a periodic optical filter.
摘要翻译：频域光学相干成像系统在光源和光学检测器之间具有光源，光学检测器和光传输路径。光源和光学检测器之间的光传输路径降低了成像系统的有效线宽。光源可以是宽带源，并且光传输路径可以包括周期性滤光器。

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