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    • 3. 发明授权
    • Method of preparation of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine
    • 4-羟基-1,2,2,6,6-五甲基哌啶的制备方法
    • US5910591A
    • 1999-06-08
    • US953517
    • 1997-10-17
    • Masaaki Yasuda
    • Masaaki Yasuda
    • C07D211/46C07D211/44
    • C07D211/46
    • The present invention relates to a method for preparing 4-hydroxy-1,2,2,6,6-pentamethylpiperidine comprising the following steps:(i) reacting 4-hydroxy-2,2,6,6-tetramethylpiperidine with at least one compound selected from the group consisting of formaldehyde, paraformaldehyde and trioxane, optionally in the presence of formic acid;(ii) neutralizing the reaction product of step (i) by adding a base thereto; and(iii) after the neutralization, separating the crude product from the aqueous layer and crystallizing and filtering the crude product to thereby obtain crystals of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine with a water content of 3% by weight or less. The present invention also relates to a method for preparing 4-hydroxy-1,2,2,6,6-pentamethylpiperidine, comprising reacting 4-hydroxy-2,2,6,6-tetramethylpiperidine with at least one compound selected from the group consisting of formaldehyde, paraformaldehyde and trioxane, optionally in the presence of formic acid added in an amount smaller than that of 4-hydroxy-2,2,6,6-tetramethylpiperidine in terms of mole.
    • 本发明涉及一种制备4-羟基-1,2,2,6,6-五甲基哌啶的方法,包括以下步骤:(i)使4-羟基-2,2,6,6-四甲基哌啶与至少一种 选自甲醛,多聚甲醛和三恶烷的化合物,任选在甲酸存在下; (ii)通过向其中加入碱来中和步骤(i)的反应产物; 和(iii)中和后,将粗产物与水层分离并使粗产物结晶并过滤,从而得到水含量为3%的4-羟基-1,2,2,6,6-五甲基哌啶晶体, 以下。 本发明还涉及一种制备4-羟基-1,2,2,6,6-五甲基哌啶的方法,包括使4-羟基-2,2,6,6-四甲基哌啶与至少一种选自下组的化合物 由甲醛,多聚甲醛和三恶烷组成,任选在甲酸的存在下加入的量小于4-羟基-2,2,6,6-四甲基哌啶的摩尔量。