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1. 发明授权

US06436659B1 Biological indicator for sterilization processes with double buffer system 有权
标题翻译：双缓冲系统灭菌过程的生物指标
公开(公告)号：US06436659B1
公开(公告)日：2002-08-20
申请号：US09699728
申请日：2000-10-27
申请人： Henry K. Hui , Leslie A. Feldman , Richard A. Gorham
发明人： Henry K. Hui , Leslie A. Feldman , Richard A. Gorham
IPC分类号： C12Q122
CPC分类号： C12Q1/22 , A61L2/28 , G01N31/226
摘要： A method and an apparatus for preventing reversion of the color of an indicator dye in a biological indicator is disclosed. The indicator dye changes color if viable microorganisms are present after sterilization, because acidic byproducts are formed when the microorganisms metabolize the growth medium. It has been found that the dye can change color back to the original color after the completion of the sterilization due to leaching or diffusion of basic impurities into the growth medium. The method and the apparatus employ a dual buffer system with one buffer which operates at high pH to moderate pH fluctuations at the start of the sterilization and a second buffer which operates at low pH to minimize pH fluctuations after the sterilization is complete. Less high pH buffer than low pH buffer is used in order to maximize the speed and sensitivity of the biological indicator.
摘要翻译：公开了一种用于防止生物指示剂中指示剂染料的颜色反转的方法和装置。如果活菌在灭菌后存在，则指示剂染料会变色，因为当微生物代谢生长培养基时会形成酸性副产物。已经发现，由于碱性杂质浸入或扩散到生长介质中，染料可以在灭菌完成之后将颜色改变回原色。该方法和装置采用具有一个缓冲液的双缓冲系统，该缓冲液在高pH值下操作以缓解灭菌开始时的pH波动，以及在灭菌完成后使pH波动最小的第二缓冲液。使用比低pH缓冲液低的pH缓冲液以使生物指示剂的速度和灵敏度最大化。

2. 发明授权

US5658529A Method of protecting and sterilizing aluminum surfaces on medical instruments 失效
标题翻译：在医疗器械上保护和消毒铝表面的方法
公开(公告)号：US5658529A
公开(公告)日：1997-08-19
申请号：US614705
申请日：1996-03-13
申请人： Leslie A. Feldman , Henry Hui
发明人： Leslie A. Feldman , Henry Hui
IPC分类号： A61L2/20 , C25D11/22 , C25D11/24 , A61L2/08
CPC分类号： A61L2/20 , C25D11/22 , C25D11/24
摘要： A process for color anodizing and sterilizing aluminum surfaces on medical instruments without fading the anodized color comprises the steps of: anodizing an aluminum surface on a medical instrument to form an oxide film; immersing the surface in a salt bath of a coloring metal and electrolytically depositing the coloring metal onto the oxide film; and repeatedly sterilizing the medical instrument and its surface by exposing it to an oxidizing sterilant, whereby the electrolytically deposited coloring metal remains adhered to the surface and the color of the surface is not adversely affected by the repeated exposure to the oxidizing sterilant. Preferably, the sterilant comprises hydrogen peroxide, the coloring metal comprises tin and the surface remains non-cytotoxic after the anodizing, coloring steps and sterilizing steps.
摘要翻译：用于在医疗仪器上对铝表面进行彩色阳极氧化和灭菌的方法，而不会使阳极化颜色褪色的步骤包括以下步骤：阳极氧化医疗器械上的铝表面以形成氧化膜; 将表面浸渍在着色金属的盐浴中，并将着色金属电解沉积到氧化物膜上; 并通过将其暴露于氧化性灭菌剂而使医疗器械及其表面反复灭菌，由此电解沉积的着色金属保持粘附到表面，并且表面的颜色不会受到反复暴露于氧化消毒剂的不利影响。优选地，灭菌剂包含过氧化氢，着色金属包含锡，并且在阳极氧化，着色步骤和灭菌步骤之后表面保持非细胞毒性。

3. 发明授权

US07229591B2 Lumen sterilization device and method 失效
标题翻译：流明消毒装置及方法
公开(公告)号：US07229591B2
公开(公告)日：2007-06-12
申请号：US10160869
申请日：2002-05-31
申请人： Su-Syin S. Wu , Harold R. Williams , Nancy S. Chu , Hans Strobel , Szu-Min Lin , Henry K. Hui , Leslie A. Feldman
发明人： Su-Syin S. Wu , Harold R. Williams , Nancy S. Chu , Hans Strobel , Szu-Min Lin , Henry K. Hui , Leslie A. Feldman
IPC分类号： A61L2/00
CPC分类号： A61L2/186 , A61L2/208 , A61L2202/24
摘要： Devices and methods for sterilizing lumens involve a booster that is attached to the lumen. In preferred embodiments, the contact area between the lumen and the booster enhances the penetration of an antimicrobial agent to the contact area.
摘要翻译：用于灭菌腔的装置和方法涉及附着于内腔的增压器。在优选实施例中，内腔和助推器之间的接触面积增强了抗微生物剂渗透到接触区域。

4. 发明授权

US06458554B1 Biological indicator for sterilization processes with double buffer system 有权
公开(公告)号：US06458554B1
公开(公告)日：2002-10-01
申请号：US10090057
申请日：2002-02-27
申请人： Henry K. Hui , Leslie A. Feldman , Richard A. Gorham
发明人： Henry K. Hui , Leslie A. Feldman , Richard A. Gorham
IPC分类号： C12Q122
CPC分类号： C12Q1/22 , A61L2/28 , G01N31/226
摘要： A method and an apparatus for preventing reversion of the color of an indicator dye in a biological indicator is disclosed. The indicator dye changes color if viable microorganisms are present after sterilization, because acidic byproducts are formed when the microorganisms metabolize the growth medium. It has been found that the dye can change color back to the original color after the completion of the sterilization due to leaching or diffusion of basic impurities into the growth medium. The method and the apparatus employ a dual buffer system with one buffer which operates at high pH to moderate pH fluctuations at the start of the sterilization and a second buffer which operates at low pH to minimize pH fluctuations after the sterilization is complete. Less high pH buffer than low pH buffer is used in order to maximize the speed and sensitivity of the biological indicator.

5. 发明授权

US5807238A Endoscope pressure equalization system and method 失效
标题翻译：内镜压力均衡系统及方法
公开(公告)号：US5807238A
公开(公告)日：1998-09-15
申请号：US560247
申请日：1995-11-21
申请人： Leslie A. Feldman , Henry Hui , Reinhard Kowatsch , Tsutomu Hayashida , Michael Hahs , Charles Howlett
发明人： Leslie A. Feldman , Henry Hui , Reinhard Kowatsch , Tsutomu Hayashida , Michael Hahs , Charles Howlett
IPC分类号： A61B1/00 , A61B1/12 , F16K17/196 , F16K17/30 , A61B1/30
CPC分类号： A61B1/00057 , A61B1/121 , A61B1/125 , F16K17/196 , F16K17/30
摘要： A pressure equalization device connects to a port on an endoscope and equalizes the pressure within the endoscope to an environment thereabout. An outlet check valve allows flow out of the port and blocks flow into the port. A filter may be provided for preventing known chemical agents from entering the port. If the agent is hydrogen peroxide, the filter preferably comprises a catalyst, such as copper wool, for decomposing the hydrogen peroxide into water and oxygen. An inlet check valve may also be provided to communicate with the endoscope port and allow flow into the port in response to a downstream pressure gradient exceeding a predetermined value.
摘要翻译：压力均衡装置连接到内窥镜上的端口，并将内窥镜内的压力与其周围的环境相平衡。出口止回阀允许从端口流出并阻止流入端口。可以提供过滤器以防止已知的化学试剂进入端口。如果试剂是过氧化氢，则过滤器优选包括用于将过氧化氢分解成水和氧的催化剂，例如铜棉。还可以设置入口止回阀以与内窥镜端口通信，并且响应于超过预定值的下游压力梯度允许流入端口。

6. 发明申请

US20080131342A1 LUMEN STERILIZATION DEVICE AND METHOD 审中-公开
标题翻译：灭菌灭菌装置及方法
公开(公告)号：US20080131342A1
公开(公告)日：2008-06-05
申请号：US11743230
申请日：2007-05-02
申请人： Su-Syin S. Wu , Harold R. Williams , Nancy S. Chu , Hans Strobel , Szu-Min Lin , Henry K. Hui , Leslie A. Feldman
发明人： Su-Syin S. Wu , Harold R. Williams , Nancy S. Chu , Hans Strobel , Szu-Min Lin , Henry K. Hui , Leslie A. Feldman
IPC分类号： A61L2/20
CPC分类号： A61L2/186 , A61L2/208 , A61L2202/24
摘要： Devices and methods for sterilizing lumens involve a booster that is attached to the lumen. In preferred embodiments, the contact area between the lumen and the booster enhances the penetration of an antimicrobial agent to the contact area.
摘要翻译：用于灭菌腔的装置和方法涉及附着于内腔的增压器。在优选实施例中，内腔和助推器之间的接触面积增强了抗微生物剂渗透到接触区域。

7. 发明授权

US5716322A Medical instrument and method for lubrication and sterilization thereof 失效
标题翻译：医疗仪器及其润滑和灭菌方法
公开(公告)号：US5716322A
公开(公告)日：1998-02-10
申请号：US614706
申请日：1996-03-13
申请人： Henry Hui , Leslie A. Feldman , Hung P. Nguyen , Debra Timm , Ron Albers
发明人： Henry Hui , Leslie A. Feldman , Hung P. Nguyen , Debra Timm , Ron Albers
IPC分类号： A61L2/16 , A61B1/00 , A61F2/00 , A61L2/20 , A61L27/30 , A61L27/34 , A61L27/50 , A61B1/04
CPC分类号： A61L27/50 , A61L2/20 , A61L27/303 , A61L27/306 , A61L27/34 , A61F2310/00574
摘要： Medical instruments incorporating solid lubricants are shown to survive an oxidizing sterilization process if they employ solid lubricants free from disulfide and diselenide compounds such as molybdenum disulfide and the instrument is kept free from such compounds. PTFE, powdered graphite and boron nitride are preferred solid lubricants. Of particular importance are flexible endoscope employing solid lubricants on fiber optic bundles encased in elastomeric coverings.
摘要翻译：结合固体润滑剂的医疗仪器如果使用不含二硫化碳的固体润滑剂和二硫化碳化合物如二硫化钼，并且仪器不含此类化合物，则可在氧化灭菌过程中继续存活。 PTFE，粉状石墨和氮化硼是优选的固体润滑剂。特别重要的是在包裹在弹性体覆盖层中的光纤束上采用固体润滑剂的柔性内窥镜。

8. 发明授权

US5634880A Endoscope pressure equalization system and method 失效
标题翻译：内镜压力均衡系统及方法
公开(公告)号：US5634880A
公开(公告)日：1997-06-03
申请号：US446377
申请日：1995-05-22
申请人： Leslie A. Feldman , Henry Hui , Reinhard Kowatsch , Tsutomu Hayashida , Michael Hahs , Charles Howlett
发明人： Leslie A. Feldman , Henry Hui , Reinhard Kowatsch , Tsutomu Hayashida , Michael Hahs , Charles Howlett
IPC分类号： A61B1/00 , A61B1/12 , F16K17/196 , F16K17/30 , A61B1/012
CPC分类号： A61B1/00057 , A61B1/121 , A61B1/125 , F16K17/196 , F16K17/30
摘要： A pressure equalization device connects to a port on an endoscope and equalizes the pressure within the endoscope to an environment thereabout. An outlet check valve allows flow out of the port and blocks flow into the port. A filter may be provided for preventing known chemical agents from entering the port. If the agent is hydrogen peroxide, the filter preferably comprises a catalyst, such as copper wool, for decomposing the hydrogen peroxide into water and oxygen. An inlet check valve may also be provided to communicate with the endoscope port and allow flow into the port in response to a downstream pressure gradient exceeding a predetermined value.
摘要翻译：压力均衡装置连接到内窥镜上的端口，并将内窥镜内的压力与其周围的环境相平衡。出口止回阀允许从端口流出并阻止流入端口。可以提供过滤器以防止已知的化学试剂进入端口。如果试剂是过氧化氢，则过滤器优选包括用于将过氧化氢分解成水和氧的催化剂，例如铜棉。还可以设置入口止回阀以与内窥镜端口通信，并且响应于超过预定值的下游压力梯度允许流入端口。

9. 发明授权

US06451255B1 Dry booster 失效
标题翻译：干加强器
公开(公告)号：US06451255B1
公开(公告)日：2002-09-17
申请号：US09472319
申请日：1999-12-23
申请人： Harold R. Williams , Hans Strobel , Henry K. Hui , Leslie A. Feldman , Szu-Min Lin
发明人： Harold R. Williams , Hans Strobel , Henry K. Hui , Leslie A. Feldman , Szu-Min Lin
IPC分类号： A61L200
CPC分类号： A61L2/186 , A61L2/208 , A61L2202/122 , A61L2202/24
摘要： A method for sterilizing the interior of the lumen, where a dry booster which does not contain liquid and which has a volume at least 2 times the volume of the lumen is attached to the end of the lumen. The lumen and dry booster are placed in a sterilization chamber, and germicide is introduced into the chamber. A higher pressure is created outside the booster than inside the booster. The empty dry booster draws germicide into the lumen, sterilizing the interior of the lumen. The method can be enhanced by reducing the pressure in the chamber before introducing the germicide.
摘要翻译：用于对内腔内部进行灭菌的方法，其中不含液体的干燥助推器具有至少体积的体积的2倍体积的体积附着到管腔的端部。管腔和干增强器放置在灭菌室中，并将杀菌剂引入室中。在增压器外部产生的压力高于助力器。空的干燥助剂将杀菌剂吸入管腔，对内腔内部进行消毒。在引入杀菌剂之前，可以通过降低室内的压力来增强该方法。

10. 发明授权

US5942438A Chemical indicator for oxidation-type sterilization processes using bleachable dyes 失效
标题翻译：使用可漂白染料的氧化型灭菌方法的化学指示剂
公开(公告)号：US5942438A
公开(公告)日：1999-08-24
申请号：US966397
申请日：1997-11-07
申请人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
发明人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
IPC分类号： G01N21/78 , A61L2/28 , C12Q1/22 , G01N31/22 , G01N31/12
CPC分类号： A61L2/28 , C12Q1/22 , G01N31/226
摘要： A method and apparatus for detecting exposure to an oxidation-type sterilant using a chemical indicator comprising bleachable dye is disclosed. Using the method and apparatus disclosed, a bleachable azo dye is incorporated with an anodized aluminum or chromate conversion coated surface and exposed to an oxidation-type sterilant, such as hydrogen peroxide, and inspected upon completion of the sterilization process for color change. If exposed to sterilant for an appropriate amount of time the bleachable dye changes color thereby indicating adequate sterilization. The surface incorporating bleachable dye may be made to change color after a predetermined number of exposures to a oxidation-type sterilant.
摘要翻译：公开了一种使用包含可漂白染料的化学指示剂检测暴露于氧化型杀菌剂的方法和装置。使用所公开的方法和装置，将可漂白的偶氮染料与阳极氧化的铝或铬酸盐转化涂覆的表面结合并暴露于氧化型灭菌剂如过氧化氢，并且在完成用于颜色变化的灭菌过程后检查。如果将杀菌剂暴露于适当的时间，则可漂白染料会改变颜色，从而指示适当的灭菌。包含可漂白染料的表面可以在预定数量的暴露于氧化型杀菌剂之后变色。

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