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1. 发明授权

US08536099B2 Methods of bead manipulation and forming bead arrays 有权
标题翻译：珠粒操作和形成珠粒阵列的方法
公开(公告)号：US08536099B2
公开(公告)日：2013-09-17
申请号：US12872333
申请日：2010-08-31
申请人： Mark Oldham , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
发明人： Mark Oldham , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
IPC分类号： C40B30/00 , C40B30/04 , C40B30/08 , C40B30/10
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.
摘要翻译：根据各种实施方案，提供了一种方法，其包括用洗涤溶液洗涤基底上的DNA包被的珠粒阵列以从基底去除堆叠的珠粒。洗涤溶液可以在载体中包括惰性固体珠。 DNA包被的珠可以具有平均直径，并且洗涤溶液中的固体珠的平均直径可以是DNA包被的珠的直径的至少两倍。洗涤可以形成脱落的DNA包被的珠粒和单层DNA包被的珠粒。在一些实施方案中，用于形成阵列的第一珠粒与包含分子量约350Da或更低的PEG的聚（乙二醇）（PEG）溶液接触。在一些实施例中，用于形成珠阵列的滑块被提供为用于对其进行成像的系统。

2. 发明申请

US20110136677A1 METHODS OF BEAD MANIPULATION AND FORMING BEAD ARRAYS 有权
标题翻译：珠子操纵和形成珠粒阵列的方法
公开(公告)号：US20110136677A1
公开(公告)日：2011-06-09
申请号：US12872333
申请日：2010-08-31
申请人： Mark OLDHAM , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
发明人： Mark OLDHAM , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
IPC分类号： C40B20/08 , C40B50/00 , C40B30/00 , B05D5/00 , B05D7/24
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.
摘要翻译：根据各种实施方案，提供了一种方法，其包括用洗涤溶液洗涤基底上的DNA包被的珠粒阵列以从基底去除堆叠的珠粒。洗涤溶液可以在载体中包括惰性固体珠。 DNA包被的珠可以具有平均直径，并且洗涤溶液中的固体珠的平均直径可以是DNA包被的珠的直径的至少两倍。洗涤可以形成脱落的DNA包被的珠粒和单层DNA包被的珠粒。在一些实施方案中，用于形成阵列的第一珠粒与包含分子量约350Da或更低的PEG的聚（乙二醇）（PEG）溶液接触。在一些实施例中，用于形成珠阵列的滑块被提供为用于对其进行成像的系统。

3. 发明授权

US06956839B2 Method, and associated apparatus, for communicating packet data in a radio communication system 失效
标题翻译：方法和相关装置，用于在无线电通信系统中传送分组数据
公开(公告)号：US06956839B2
公开(公告)日：2005-10-18
申请号：US10133719
申请日：2002-04-26
申请人： Thomas A. Sexton , George Fry
发明人： Thomas A. Sexton , George Fry
IPC分类号： H04W60/04 , H04W74/00 , H04B7/216 , H04J3/24
CPC分类号： H04W60/04 , H04W74/00
摘要： Apparatus, and an associated method, for a radio, such as cellular, communication system to facilitate communications between a mobile station and the network infrastructure. When the mobile station registers in the communication system, a dedicated reverse-link channel is allocated to facilitate communications of packet data between the mobile station and the network infrastructure. By providing dedicated channels, the mobile station becomes functionally connected to the network infrastructure and are analogous to a hard wired connection of a computer in a local area network.
摘要翻译：用于诸如蜂窝式通信系统之类的无线电装置和相关联的方法，以促进移动台与网络基础设施之间的通信。当移动站在通信系统中注册时，分配专用的反向链路信道以促进移动站和网络基础设施之间的分组数据的通信。通过提供专用信道，移动台变得功能上连接到网络基础设施并且类似于局域网中的计算机的硬连线连接。

4. 发明授权

US07747253B2 Apparatus, and associated method, for effectuating a data service designated by a service delivery mode 有权
标题翻译：一种用于实现由服务传递模式指定的数据服务的装置和相关方法
公开(公告)号：US07747253B2
公开(公告)日：2010-06-29
申请号：US10767451
申请日：2004-01-29
申请人： George Fry
发明人： George Fry
IPC分类号： H04W40/00
CPC分类号： H04W40/00 , H04M3/436 , H04M3/54 , H04W4/16 , H04W8/18
摘要： Apparatus, and an associated method, for facilitating routing of a data service call background and foreground service delivery modes are defined. A delivery mode type determiner determines the service delivery mode associated with the data service. If the service delivery mode is a background delivery mode, the data service is effectuated with the intended receiving station instead of being redirected pursuant to a call forwarding, or other service interaction indicia, feature.
摘要翻译：定义了用于促进数据服务呼叫背景和前台服务递送模式的路由的装置和相关联的方法。交付模式类型确定器确定与数据服务相关联的服务递送模式。如果服务传送模式是后台传送模式，则数据服务将通过预期的接收站实现，而不是根据呼叫转移或其他服务交互标记特征被重定向。

5. 发明授权

US06514699B1 Multiplex polynucleotide capture methods and compositions 有权
公开(公告)号：US06514699B1
公开(公告)日：2003-02-04
申请号：US09593312
申请日：2000-06-13
申请人： Roger A. O'Neill , Jer-Kang Chen , Claudia Chiesa , George Fry
发明人： Roger A. O'Neill , Jer-Kang Chen , Claudia Chiesa , George Fry
IPC分类号： C12Q168
CPC分类号： C12Q1/6874 , C12Q2565/514 , C12Q2537/157 , C12Q2525/161 , C12Q2565/629
摘要： The invention relates to methods and compositions for simultaneously generating a plurality of polynucleotide sequencing ladders or PCR amplification products. Each sequencing ladder is generated from a recoverable primer, i.e., an oligonucleotide primer comprising a recovery tag. The recovery tag may be an oligonucleotide. Each sequencing ladder has a unique recovery tag. After the generation of the multiple sequencing ladders, the different sequencing ladders are separated from one another, i.e., purified, by binding to recovery tag binding compounds that have been immobilized on one or more solid supports. The recovery tag binding compounds are immobilized on the solid support in an addressable manner, i.e., the recovery tag binding compounds have distinct locations on the solid support. The binding of the sequencing ladders to the recovery tag binding compounds serves to separate the different polynucleotide sequencing ladders present in a given solution. The separated sequencing ladders may then be released from the immobilized recovery tag binding compounds and subsequently resolved into individual components of the sequencing ladders or PCR products. The subject methods of separating sequencing ladders simultaneously generated in the same vessel may readily be adapted to separate a plurality of simultaneously generated polynucleotide amplification products. Other aspects of the invention are kits for the generation or recovery of a plurality of polynucleotide sequencing ladders or amplification products. The kits comprise a plurality of recoverable primers having unique recovery tags. Preferably, the recovery tags are polynucleotides that have substantially the same denaturation temperature when bound to appropriate recovery tag binding compounds, i.e., the primers comprise an integrated set. The kits may further comprise recovery tag binding compounds. The kits may further comprise labeled chain terminators. Other aspects of the invention include polynucleotide recovery devices.

6. 发明授权

US06697624B2 Apparatus, and associated method, for effectuating a data service designated by a service delivery mode 有权
标题翻译：一种用于实现由服务传递模式指定的数据服务的装置和相关方法
公开(公告)号：US06697624B2
公开(公告)日：2004-02-24
申请号：US09878828
申请日：2001-06-11
申请人： George Fry
发明人： George Fry
IPC分类号： H04Q720
CPC分类号： H04W40/00 , H04M3/436 , H04M3/54 , H04W4/16 , H04W8/18
摘要： Apparatus, and an associated method, for facilitating routing of a data service call background and foreground service delivery modes are defined. A delivery mode type determiner determines the service delivery mode associated with the data service. If the service delivery mode is a background delivery mode, the data service is effectuated with the intended receiving station instead of being redirected pursuant to a call forwarding, or other service interaction indicia, feature.
摘要翻译：定义了用于促进数据服务呼叫背景和前台服务递送模式的路由的装置和相关联的方法。交付模式类型确定器确定与数据服务相关联的服务递送模式。如果服务传送模式是后台传送模式，则数据服务将通过预期的接收站实现，而不是根据呼叫转移或其他服务交互标记特征被重定向。

7. 发明申请

US20050130648A1 Apparatus, and associated method, for effectuating a data service designated by a service delivery mode 有权
标题翻译：一种用于实现由服务传递模式指定的数据服务的装置和相关方法
公开(公告)号：US20050130648A1
公开(公告)日：2005-06-16
申请号：US10767451
申请日：2004-01-29
申请人： George Fry
发明人： George Fry
IPC分类号： H04M3/42 , H04L12/56 , H04M3/436 , H04M3/54 , H04W4/16 , H04W8/18 , H04W40/00 , H04W76/04 , H04Q7/20
CPC分类号： H04W40/00 , H04M3/436 , H04M3/54 , H04W4/16 , H04W8/18
摘要： Apparatus, and an associated method, for facilitating routing of a data service call background and foreground service delivery modes are defined. A delivery mode type determiner determines the service delivery mode associated with the data service. If the service delivery mode is a background delivery mode, the data service is effectuated with the intended receiving station instead of being redirected pursuant to a call forwarding, or other service interaction indicia, feature.
摘要翻译：定义了用于促进数据服务呼叫背景和前台服务递送模式的路由的装置和相关联的方法。交付模式类型确定器确定与数据服务相关联的服务递送模式。如果服务传送模式是后台传送模式，则数据服务将通过预期的接收站实现，而不是根据呼叫转移或其他服务交互标记特征被重定向。

8. 发明授权

US06275712B1 Mobile station control states based on available power 失效
标题翻译：基于可用功率的移动台控制状态
公开(公告)号：US06275712B1
公开(公告)日：2001-08-14
申请号：US09259080
申请日：1999-02-26
申请人： Steven D. Gray , George Fry
发明人： Steven D. Gray , George Fry
IPC分类号： H04Q720
CPC分类号： H04W52/0261 , H04B1/40 , H04W76/27 , Y02D70/40
摘要： A mobile station is transitioned between control states in a telecommunications system based on available power at the mobile station. In an embodiment, a mobile station signals the system to indicate that power available to the mobile station is less than or greater than a predetermined threshold and that timers for controlling transitions between packet data service control states are adjusted accordingly. If power is below the predetermined threshold, the time period durations of transition timers for control states that require higher mobile station power can be reduced. The mobile station will then spend less time in those control states, thereby conserving battery power.
摘要翻译：基于移动站的可用功率，移动站在电信系统中的控制状态之间转换。在一个实施例中，移动站发信号通知系统以指示移动站可用的功率小于或大于预定阈值，并且相应地调整用于控制分组数据业务控制状态之间的转换的定时器。如果功率低于预定阈值，则可以减少需要更高移动台功率的控制状态的转换定时器的时间段持续时间。移动台将在这些控制状态下花费更少的时间，从而节省电池电量。

9. 发明授权

US07797762B2 Cuff clip releasably attaching shoe and garment 失效
标题翻译：袖口夹可释放地连接鞋和服装
公开(公告)号：US07797762B2
公开(公告)日：2010-09-21
申请号：US11446841
申请日：2006-06-05
申请人： Howard Shapiro , Ralph Farias , George Fry
发明人： Howard Shapiro , Ralph Farias , George Fry
IPC分类号： A43B23/24 , A41D13/02
CPC分类号： A41F17/02
摘要： A cuff clip secures a loose trouser leg to a shoe, and support the lower edge of such trouser leg above the ground. A fastener is embedded within a lower portion of the shoe, leaving a coupling head exposed outside the shoe. The cuff clip engages the bottom edge of the trouser leg. The cuff clip includes a snap coupler that mates with the coupling head of the fastener embedded within the shoe. An outwardly-directed exterior wall of the cuff clip includes a bottom lip and opposing side lips to releasably receive a rectangular logo.
摘要翻译：袖口夹将松散的裤腿固定到鞋上，并将这种裤腿的下边缘支撑在地面上方。紧固件嵌入在鞋的下部内，留下一个暴露在鞋外面的联接头。袖口夹与裤腿的底部边缘接合。袖扣包括与嵌入鞋内的紧固件的联接头配合的卡扣联接器。袖口夹具的向外指向的外壁包括底部唇缘和相对的侧唇以可释放地接收矩形徽标。

10. 发明申请

US20070277290A1 Cuff clip releasably attaching shoe and garment 失效
标题翻译：袖口夹可释放地连接鞋和服装
公开(公告)号：US20070277290A1
公开(公告)日：2007-12-06
申请号：US11446841
申请日：2006-06-05
申请人： Howard Shapiro , Ralph Farias , George Fry
发明人： Howard Shapiro , Ralph Farias , George Fry
IPC分类号： A41D1/06
CPC分类号： A41F17/02
摘要： A cuff clip secures a loose trouser leg to a shoe, and supports the lower edge of such trouser leg above the ground. A fastener is secured to a lower portion of the shoe, leaving a coupling head or stud exposed outside the shoe. The cuff clip includes a channel to engage the bottom edge of the trouser leg. The cuff clip includes a snap coupler that mates with the coupling head or stud of the fastener embedded within the shoe. An exterior wall of the cuff clip is used to display a logo or other indicia. Such exterior wall has retaining lips to releasably receive indicia to be displayed thereon.
摘要翻译：袖口夹将松散的裤腿固定到鞋上，并将这种裤腿的下边缘支撑在地面上方。紧固件固定到鞋的下部，留下暴露在鞋外部的联接头或螺栓。袖带夹具有一个通道，用于接合裤腿的底部边缘。袖扣包括与嵌入鞋内的紧固件的联接头或螺柱配合的卡扣联接器。袖口夹的外墙用于显示徽标或其他标记。这种外墙具有保持唇部以可释放地接收要在其上显示的标记。

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