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81. 发明授权

US4560499A Isosolanone and solanone intermediates and organoleptic uses 失效
标题翻译： Isosolanone和solanone中间体和感官用途
公开(公告)号：US4560499A
公开(公告)日：1985-12-24
申请号：US609349
申请日：1984-06-22
申请人： John B. Hall , James M. Sanders , James N. Siano
发明人： John B. Hall , James M. Sanders , James N. Siano
IPC分类号： A24B15/32 , C07C29/40 , C07C33/02 , C07C45/54 , C07C45/67 , C07C45/75 , C07C49/203 , C11D3/50 , C11B9/00
CPC分类号： C11D3/50 , A24B15/32 , C07C29/40 , C07C33/02 , C07C45/54 , C07C45/67 , C07C45/75 , C07C49/203 , C07C67/03
摘要： Described is a novel genus of compounds defined according to the structure: ##STR1## wherein Z represents hydrogen, MgX and the moiety having the structure: ##STR2## and X represents chloro, bromo or iodo; as well as the novel compounds defined according to the structures: ##STR3## and mixtures of same shown according to the structure: ##STR4## wherein the wavy lines indicate both cis and trans juxtaposition of the hydrogen and methallyl moieties about the carbon-carbon double bond; uses of same as intermediates in a process for producing isosolanone which is a mixture of compounds having the structures: ##STR5## or shown by the single structure: ##STR6## and solanone which is a mixture of compounds having the structures: ##STR7## or shown by the structure: ##STR8## wherein the wavy lines are indicative of a cis or trans juxtaposition of the hydrogen or 2-propenyl moieties about the double bond; and organoleptic uses of the compounds having the structures: ##STR9##
摘要翻译：描述了根据以下结构定义的化合物的新颖属性：其中Z表示氢，MgX和具有以下结构的部分：其中X表示氯，溴或碘; 以及根据以下结构定义的新颖化合物：根据以下结构显示的相同的结构：其中波浪线表示氢和甲代烯丙基部分在碳 - 碳双键上的顺式和反式并置键; 在作为制备具有以下结构的化合物的混合物的方法中使用与中间体的相同的化合物：具有以下结构的化合物：或者由单一结构显示：作为化合物的混合物，其具有以下结构：或由以下结构示出：其中波浪线表示在双键上的氢或2-丙烯基部分的顺式或反式并置; 和具有以下结构的化合物的感官用途：

82. 发明授权

US4558148A Fluorinated allylic compounds and a process for preparing these compounds 失效
标题翻译：氟化烯丙基化合物和制备这些化合物的方法
公开(公告)号：US4558148A
公开(公告)日：1985-12-10
申请号：US635682
申请日：1984-07-30
申请人： Nobuo Ishikawa , Tomoya Kitazume
发明人： Nobuo Ishikawa , Tomoya Kitazume
IPC分类号： C07C29/40 , C07C33/42 , C07C33/48 , C07F7/08 , C07F7/18 , C07C33/46
CPC分类号： C07F7/0818 , C07C29/40 , C07C33/423 , C07C33/483
摘要： There are described fluorinated allylic compounds as expressed by the following general formula ##STR1## wherein R.sub.f is a fluorinated aliphatic group and R is a group expressed by a general formula ##STR2## wherein R.sup.1 is an aliphatic or aromatic hydrocarbon group and R.sup.2 and R.sup.3 are the same group or different groups as selected among hydrogen atom, aliphatic and aromatic hydrocarbon groups, and heterocyclic groups. Further, a process of preparing fluorinated allylic compounds is described which includes a process step wherein a silane metal halide as expressed by a general formula(R.sup.1).sub.3 SiCH.sub.2 MX,wherein R.sup.1 is either an aliphatic or aromatic hydrocarbon group, M is an element that belongs to the group IIa, IIIb, or VIIb of the periodic table, and X is a halogen atom, is reacted with a fluorinated carboxylic acid ester as expressed by a general formulaR.sub.f COOR',wherein R.sub.f is a fluorinated aliphatic group and R' is either an aliphatic or aromatic hydrocarbon group, to form a fluorinated carbinol as expressed by a general formula ##STR3## wherein R.sup.1 and R.sub.f are as defined above, and further a molecule of (R.sup.1).sub.3 SiOH, where R.sup.1 is as defined above, is eliminated from this carbinol to produce a fluorinated allylsilane as expressed by a general formula ##STR4## wherein R.sup.1 and R.sub.f are as defined above.
摘要翻译：描述了由以下通式表示的氟化烯丙基化合物，其中Rf是氟化脂族基团，R是由通式表示的基团，其中R 1是脂族或芳族烃基，R 2和R 3是相同的基团或选自氢原子，脂族和芳族烃基和杂环基中的不同基团。此外，描述了制备氟化烯丙基化合物的方法，其包括其中由通式（R1）3SiCH2MX表示的硅烷金属卤化物，其中R 1是脂族或芳族烃基，M是属于元素周期表IIa，IIIb或VIIb族，X为卤原子，与通式RfCOOR'表示的含氟羧酸酯反应，其中Rf为氟化脂族基，R'为脂肪族或芳香族烃基，以形成通式（Ⅰa）所表示的氟化甲醇，其中R 1和R f如上所定义，并且另外分子式（R 1）3 SiOH（其中R 1如上定义）从该甲醇以产生由通式“IMAGE”表示的氟化烯丙基硅烷，其中R 1和R f如上所定义。

83. 发明授权

US4552898A [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties 失效
标题翻译： [3.2.0]具有宝贵治疗性质的双环庚酮肟醚
公开(公告)号：US4552898A
公开(公告)日：1985-11-12
申请号：US524711
申请日：1983-08-19
申请人： Tsung-Tee Li , Michael Marx
发明人： Tsung-Tee Li , Michael Marx
IPC分类号： C07C29/40 , C07C33/042 , C07C45/00 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/65 , C07C49/513 , C07C49/743 , C07C49/747 , C07C49/753 , C07C405/00 , C07D317/72 , C07D493/10 , C07F7/18 , A61K31/19 , A61K31/215 , C07C131/02
CPC分类号： C07D493/10 , C07C405/0083 , C07C45/00 , C07C45/455 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/65 , C07C49/513 , C07C49/743 , C07C49/747 , C07C49/753 , C07D317/72 , C07F7/1804
摘要： Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein:n is an integer from one to four;R.sub.1 is hydroxy;R.sub.2 is hydrogen; orR.sub.1 and R.sub.2 together are an oxo group;R.sub.3 is ##STR2## wherein A is --CH.sub.2 --CH.sub.2 --; trans--CH.dbd.CH--; --C.tbd.C--; andR.sub.4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons, most preferably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or phenylloweralkyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo.
摘要翻译：可用于治疗心血管疾病的化合物是式（1）和（2）中描述的羧酸，以及它们的药学上可接受的无毒盐和酯，其中：n是从1到4的整数; R1是羟基; R2是氢; 或者R 1和R 2一起是氧代基; R3是，其中A是-CH2-CH2-; 反式-CH = CH-; -C 3BOND C-; R4为碳数1〜12，优选碳数1〜10，最优选碳数3-8的直链或支链烷基，碳数为3〜8的环烷基; 任选地被一个或两个相同的取代基取代的苯基，所述取代基选自低级烷基，低级烷氧基，羟基，三氟甲基和卤素; 或任选被一个或两个相同的取代基取代的苯基低级烷基，所述取代基选自低级烷基，低级烷氧基，羟基，三氟甲基和卤素。

84. 发明授权

US4549972A 1,2,3,3,5,6-Hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same 失效
标题翻译： 1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇，其制备方法，可用于所述方法的中间体和其相同的感官用途
公开(公告)号：US4549972A
公开(公告)日：1985-10-29
申请号：US671406
申请日：1984-11-14
申请人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
发明人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
IPC分类号： C07C29/40 , C07C35/31 , C07C45/62 , C07C45/67 , C07C45/69 , C11B9/00 , C11D3/50 , C07C35/22 , C11D9/44
CPC分类号： C11D3/50 , C07C29/40 , C07C35/31 , C07C45/62 , C07C45/673 , C07C45/69 , C11B9/0046 , C07C2102/44
摘要： Described is 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol as a mixture of isomers and in its isomeric forms having the structures: ##STR1## and the uses thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles, and colognes. Also described is a novel process for preparing 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol by first reacting the compound having the structure: ##STR2## with the compound having the structure: ##STR3## in order to produce the ketone defined according to the structure: ##STR4## which is hydrogenated to form the compound having the structure: ##STR5## and further hydrogenated to form the ketone having the structure: ##STR6## This ketone is reacted with CH.sub.3 M wherein M represents Li or MgX and wherein X is chloro, bromo or iodo to form the organometallic intermediate defined according to the structures: ##STR7## These compounds are then hydrolyzed with dilute acid to form the organoleptically useful 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol isomers of our invention defined according to the structures: ##STR8##
摘要翻译：描述为1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇作为异构体的混合物，其异构体具有以下结构：和其用于增强或增强香料组合物，香料制品和古龙水的香气。还描述了制备1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇的新方法，首先使具有以下结构的化合物：＆lt; IMAGE＆gt; 具有以下结构的化合物：为了制备根据以下结构定义的酮：将其氢化形成具有以下结构的化合物：进一步氢化以形成具有以下结构的酮：图像>该酮与CH 3 M反应，其中M表示Li或MgX，并且其中X是氯，溴或碘，以形成根据以下结构定义的有机金属中间体：然后将这些化合物用稀酸水解以形成感官有用的本发明的1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇异构体根据以下结构定义：

85. 发明授权

US4542244A Oxabicycloalkane herbicides 失效
标题翻译：氧杂双环烷烃除草剂
公开(公告)号：US4542244A
公开(公告)日：1985-09-17
申请号：US624552
申请日：1984-06-25
申请人： George B. Payne , Samuel B. Soloway , James E. Powell , Steven A. Roman , Willy D. Kollmeyer
发明人： George B. Payne , Samuel B. Soloway , James E. Powell , Steven A. Roman , Willy D. Kollmeyer
IPC分类号： A01N43/90 , C07C29/00 , C07C29/10 , C07C29/36 , C07C29/40 , C07C33/12 , C07C33/14 , C07C35/08 , C07C35/38 , C07C43/178 , C07C45/51 , C07D493/08 , C07D493/18 , C07C35/18
CPC分类号： C07D493/08 , A01N43/90 , C07C255/00 , C07C29/00 , C07C29/106 , C07C29/36 , C07C29/40 , C07C323/15 , C07C33/12 , C07C33/14 , C07C35/08 , C07C35/38 , C07C43/1781 , C07C45/513 , C07B2200/07 , C07C2101/08 , C07C2101/10 , C07C2101/16
摘要： Certain substituted 3-cyclohexene-1-ol are intermediates to herbicides and plant growth.
摘要翻译：某些取代的3-环己烯-1-醇是除草剂和植物生长的中间体。

86. 发明授权

US4536591A Insecticidal [1,1'-biphenyl]-3-ylmethyl esters 失效
标题翻译：杀虫剂[1,1'-联苯] -3-基甲基酯
公开(公告)号：US4536591A
公开(公告)日：1985-08-20
申请号：US464242
申请日：1983-02-07
申请人： Ernest L. Plummer
发明人： Ernest L. Plummer
IPC分类号： A01N53/00 , C07C17/093 , C07C17/14 , C07C17/26 , C07C29/09 , C07C29/128 , C07C29/147 , C07C29/32 , C07C29/40 , C07C29/62 , C07C33/24 , C07C33/46 , C07C45/56 , C07C45/67 , C07C63/331 , C07C63/72 , C07C205/06 , C07C205/12 , C07C205/19 , C07C205/42 , C07C205/57 , C07D263/10 , C07C69/743 , C07C69/747
CPC分类号： C07C29/095 , A01N53/00 , C07C17/093 , C07C17/14 , C07C17/26 , C07C205/06 , C07C205/12 , C07C205/19 , C07C205/42 , C07C205/57 , C07C29/1285 , C07C29/147 , C07C29/32 , C07C29/40 , C07C29/62 , C07C33/46 , C07C45/565 , C07C45/673 , C07C63/331 , C07C63/72 , C07D263/10
摘要： [1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.
摘要翻译： [1,1'-联苯] -3-基甲基拟除虫菊酯，以及其工艺，用途和中间体。 [1,1'-联苯] -3-基甲基拟除虫菊酯控制广谱的昆虫以及螨类。

87. 发明授权

US4532359A 1,2,3,3,5,6-Hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same 失效
标题翻译： 1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇，其制备方法，可用于所述方法的中间体和其相同的感官用途
公开(公告)号：US4532359A
公开(公告)日：1985-07-30
申请号：US602570
申请日：1984-04-20
申请人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
发明人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
IPC分类号： C07C29/40 , C07C35/31 , C07C45/62 , C07C45/67 , C07C45/69 , C11B9/00 , C11D3/50 , C07C45/61
CPC分类号： C11D3/50 , C07C29/40 , C07C35/31 , C07C45/62 , C07C45/673 , C07C45/69 , C11B9/0046 , C12C11/02 , C07C2102/44
摘要： Described is a novel process for preparing 1,2,3,3,5,6-hexamethyl- bicyclo [2,2,2.] oct-5-en-2-ol by using 2,6,6-trimethylcyclohexa-2,4-diene-1-one as a starting material.
摘要翻译：描述了一种制备1,2,3,3,5,6-六甲基 - 双环[2,2,2]辛-5-烯-2-醇的新方法，其中使用2,6,6-三甲基环己烷-2 ，4-二烯-1-酮作为起始原料。

88. 发明授权

US4515787A Steroids 失效
标题翻译：类固醇
公开(公告)号：US4515787A
公开(公告)日：1985-05-07
申请号：US532739
申请日：1983-09-15
申请人： Jean G. Teutsch , Roger Deraedt , Josette Benzoni
发明人： Jean G. Teutsch , Roger Deraedt , Josette Benzoni
IPC分类号： A61K31/57 , A61P29/00 , C07C29/40 , C07C31/13 , C07C68/02 , C07F7/08 , C07J5/00 , C07J51/00 , A61K31/56
CPC分类号： C07J51/00 , C07C29/40 , C07C31/13 , C07C68/02 , C07F7/0818 , C07J5/0038 , C07C2101/08
摘要： Novel 9.alpha.,11.beta.-dichloro-16.alpha.-methyl-.DELTA..sup.1,4 -pregnadiene 3,20-diones of the formula ##STR1## wherein R is selected from the group consisting of trimethylsilylphenyl, cyclododecyloxy, dicyclopentylmethoxy and cyclohexylmethoxy having a suprising "in loco" anti-inflammatory activity limited to place of inflammation without systemic effects and a process for their preparation.
摘要翻译：新颖的9α，11β-二氯-16α-甲基-TATA1,4-孕二烯3,20-二酮，其具有式Ⅰ的化合物，其中R选自三甲基甲硅烷基苯基，环十二烷氧基，二环戊基甲氧基和环己基甲氧基，其具有令人惊奇的“在loco”抗炎活动限于炎症的地方没有系统的影响及其制备过程。

89. 发明授权

US4514324A 1,2,3,3,5,6-Hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol, and organoleptic uses of same 失效
标题翻译： 1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇及其感官用途
公开(公告)号：US4514324A
公开(公告)日：1985-04-30
申请号：US602569
申请日：1984-04-20
申请人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
发明人： William J. Evers , Braja D. Mookherjee , Anton Van Ouwerkerk , Augustinus G. Van Loveren
IPC分类号： C07C29/40 , C07C35/31 , C07C45/62 , C07C45/67 , C07C45/69 , C11B9/00 , C11D3/50 , A61K7/46
CPC分类号： C11D3/50 , C07C29/40 , C07C35/31 , C07C45/62 , C07C45/673 , C07C45/69 , C11B9/0046 , C07C2102/44
摘要： Described is 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol as a mixture of isomers and in its isomeric forms having the structures: ##STR1## and the uses thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles, and colognes. Also described is a novel process for preparing 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol by first reacting the compound having the structure: ##STR2## with the compound having the structure: ##STR3## in order to produce the ketone defined according to the structure: ##STR4## which is hydrogenated to form the compound having the structure: ##STR5## and further hydrogenated to form the ketone having the structure: ##STR6## This ketone is reacted with CH.sub.3 M wherein M represents Li or MgX and wherein X is chloro, bromo or iodo to form the organometallic intermediate defined according to the structures: ##STR7## These compounds are then hydrolyzed with dilute acid to form the organoleptically useful 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol isomers of our invention defined according to the structures: ##STR8##
摘要翻译：描述为1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇作为异构体的混合物，其异构体具有以下结构：和其用于增强或增强香料组合物，香料制品和古龙水的香气。还描述了制备1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇的新方法，首先使具有以下结构的化合物：＆lt; IMAGE＆gt; 具有以下结构的化合物：为了制备根据以下结构定义的酮：将其氢化形成具有以下结构的化合物：进一步氢化以形成具有以下结构的酮：图像>该酮与CH 3 M反应，其中M表示Li或MgX，其中X为氯，溴或碘，以形成根据以下结构定义的有机金属中间体：然后将这些化合物用稀酸水解以形成感光有用的本发明的1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇异构体根据以下结构定义：

90. 发明授权

US4511751A Process for producing isoprene 失效
标题翻译：生产异戊二烯的方法
公开(公告)号：US4511751A
公开(公告)日：1985-04-16
申请号：US540870
申请日：1983-10-11
申请人： Yoichi Ninagawa , Osamu Yamada , Tsumoru Renge , Sunao Kyo , Takayoshi Osaki , Koichi Kushida
发明人： Yoichi Ninagawa , Osamu Yamada , Tsumoru Renge , Sunao Kyo , Takayoshi Osaki , Koichi Kushida
IPC分类号： C07C1/20 , C07C2/86 , C07C29/40 , C07C45/00 , C07C45/81 , C07C45/82 , C07D309/18 , C07D319/06 , C07C11/18
CPC分类号： C07D319/06 , C07C1/20 , C07C2/867 , C07C29/40 , C07C45/00 , C07C45/81 , C07C45/82 , C07D309/18
摘要： A process for producing isoprene in good yield is provided. The process is characterized in that isobutene and/or tertiary butanol and a formaldehyde source are fed, together with water, into an acidic aqueous solution continuously or intermittently while maintaining the reaction pressure in an adequate range and at the same time distilling off the product isoprene and unreacted starting materials, together with water, from the reaction zone.
摘要翻译：提供了以良好的产率生产异戊二烯的方法。该方法的特征在于将异丁烯和/或叔丁醇和甲醛源与水一起连续或间歇地进料到酸性水溶液中，同时保持反应压力在适当的范围内，同时蒸除产物异戊二烯和来自反应区的未反应的起始原料与水一起。

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