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1. 发明申请

US20180170830A1 CYCLOPROPANATION OF SUBSTITUTED ALKENES 审中-公开
公开(公告)号：US20180170830A1
公开(公告)日：2018-06-21
申请号：US15735712
申请日：2016-08-04
申请人： International Flavors & Fragrances Inc.
发明人： Mohamad GARA , Yigal BECKER
IPC分类号： C07C2/86 , C07C29/44 , C07C45/61 , B01J23/06 , B01J23/72 , B01J35/00 , B01J35/02 , C11B9/00
CPC分类号： C07C2/861 , A23L27/203 , B01J23/06 , B01J23/72 , B01J35/0006 , B01J35/026 , C07C29/32 , C07C29/44 , C07C45/61 , C07C45/69 , C07C2523/06 , C07C2523/72 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2602/18 , C07C2602/20 , C07C2602/32 , C07C2602/40 , C07C2602/50 , C07C2603/08 , C07C2603/62 , C07C2603/96 , C11B9/00 , C11B9/0026 , C11B9/003 , C11B9/0042 , C11B9/0049 , C11B9/0057 , C07C13/605 , C07C13/38 , C07C13/40 , C07C49/427 , C07C31/1333 , C07C33/12 , C07C31/13
摘要： Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.

2. 发明申请

US20170320799A1 METHOD FOR PRODUCING 1-OCTANOL 审中-公开
公开(公告)号：US20170320799A1
公开(公告)日：2017-11-09
申请号：US15525963
申请日：2015-11-12
申请人： Abengoa Bioenergia Nuevas Tecnologias, S.A.
发明人： Avelino Corma Canos , Marcelo Eduardo Domine , Juan Luis Sanz Yague , Francisco Antonio Ladron de Guevara Vidal
IPC分类号： C07C29/34 , B01J37/06 , B01J37/03 , B01J37/02 , B01J23/89 , B01J23/72 , B01J23/648 , B01J23/62 , B01J23/44 , B01J23/08 , B01J37/08 , B01J21/10
CPC分类号： C07C29/34 , B01J21/10 , B01J23/08 , B01J23/44 , B01J23/62 , B01J23/6482 , B01J23/72 , B01J23/898 , B01J37/0213 , B01J37/0236 , B01J37/036 , B01J37/06 , B01J37/08 , B01J37/082 , C07C29/32 , C07C31/125 , C07C31/12
摘要： The present invention relates to a process for obtaining 1-octanol which comprises a contact step between ethanol, n-hexanol and a catalyst, wherein said catalyst comprises: i) a metal oxide that comprises the following metals: M1 is at least one bivalent metal selected from Mg, Zn, Cu, Co, Mn, Fe, Ni and Ca; M2 is at least one trivalent metal selected from Al, La, Fe, Cr, Mn, Co, Ni, and Ga; ii) a noble metal selected from Pd, Pt, Ru, Rh and Re; and iii) optionally, comprises V; with the proviso that the catalyst comprises at least V, Ga or any of their combinations.

3. 发明授权

US09758453B2 One-component reagent for the fluoroalkylation reaction 有权
公开(公告)号：US09758453B2
公开(公告)日：2017-09-12
申请号：US14919557
申请日：2015-10-21
申请人： The Board of Trustees of the University of Illinois
发明人： John F. Hartwig , Hiroyuki Morimoto , Patrick Fier
IPC分类号： B01J31/18 , C07C17/32 , B01J31/02 , C07B39/00 , C07C17/263 , C07C29/32 , C07C41/30 , C07C41/48 , C07C45/68 , C07C67/293 , C07C67/343 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07D209/10 , C07D213/26 , C07D215/18 , C07D239/54 , C07F1/08 , C07C37/11 , C07C45/63 , C07D209/08 , C07D213/61 , C07D239/22 , C07D215/12 , C07C22/08
CPC分类号： C07C17/32 , B01J31/0231 , B01J31/0235 , B01J31/0244 , C07B39/00 , C07C17/263 , C07C22/08 , C07C29/32 , C07C37/11 , C07C41/30 , C07C41/48 , C07C45/63 , C07C45/68 , C07C67/293 , C07C67/343 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07D209/08 , C07D209/10 , C07D213/26 , C07D213/61 , C07D215/12 , C07D215/18 , C07D239/22 , C07D239/54 , C07F1/08 , C07C43/225 , C07C33/46 , C07C47/55 , C07C49/80 , C07C69/63 , C07C43/1742 , C07C69/76 , C07C43/313 , C07C255/50 , C07C25/13 , C07C205/11 , C07C211/52 , C07C233/15
摘要： A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1.

4. 发明授权

US09718754B2 Methyl-iodide-free carbonylation of an alcohol to its homologous aldehyde and/or alcohol 有权
公开(公告)号：US09718754B2
公开(公告)日：2017-08-01
申请号：US15153827
申请日：2016-05-13
申请人： Eastman Chemical Company
发明人： Jonathan Michael Penney , David William Norman , Andrew James Vetter
IPC分类号： C07C45/49 , C07C27/00 , B01J27/128 , B01J31/20 , C07C29/32 , B01J31/02 , C07C51/12
CPC分类号： C07C45/49 , B01J27/128 , B01J31/0239 , B01J31/0268 , B01J31/20 , B01J2231/321 , B01J2531/821 , C07C29/32 , C07C51/12 , C07C31/08 , C07C47/06 , C07C53/08
摘要： Disclosed is a process for the reductive carbonylation of a low molecular weight alcohol to produce the homologous aldehyde and/or alcohol. The process includes conducting the reaction to produce the aldehyde in the presence of a single component catalyst complex composed of cobalt, an onium cation and iodide in a ratio of 1:2:4 without additional promoters. A ruthenium co-catalyst is used in the production of the homologous alcohol. The reductive carbonylation reaction does not require an additional iodide promoter and produces a crude reductive carbonylation product substantially free of methyl iodide.

5. 发明申请

US20170204041A1 PROCESSES FOR PREPARING (R)-1-(5-CHLORO-[1,1`-BIPHENYL]-2-YL)-2,2,2-TRIFLUOROETHANOL AND 1-(5-CHLORO-[1,1`-BIPHENYL]-2-YL)-2,2,2-TRIFLUOROETHANONE 审中-公开
公开(公告)号：US20170204041A1
公开(公告)日：2017-07-20
申请号：US15430786
申请日：2017-02-13
申请人： Karos Pharmaceuticals, Inc.
发明人： Stéphane De Lombaert , Daniel R. Goldberg
IPC分类号： C07C49/80
CPC分类号： C07C29/32 , C07B2200/07 , C07C29/143 , C07C45/455 , C07C49/80 , C07C259/10 , C07C33/46
摘要： The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

6. 发明申请

US20170101366A1 PROCESS FOR MAKING DI-FUNCTIONAL MOLECULES WITH CONCURRENT LIGHT PARAFFIN UPGRADING 审中-公开
公开(公告)号：US20170101366A1
公开(公告)日：2017-04-13
申请号：US15387977
申请日：2016-12-22
申请人： ExxonMobil Research and Engineering Company
发明人： Kun Wang
IPC分类号： C07C253/30 , C07C407/00 , C07C17/281 , C07C51/353 , C07C209/68 , C07C201/12 , C07C29/32 , C07C29/48
CPC分类号： C07C253/30 , C07C17/269 , C07C29/132 , C07C29/32 , C07C29/50 , C07C51/353 , C07C201/12 , C07C209/68 , C07C407/00 , C10G50/02 , C10G69/126 , C10G2300/1025 , C10G2300/1081 , C10G2400/02 , C10G2400/04 , C10G2400/08 , Y02P20/125 , C07C409/04 , C07C409/16 , C07C211/10 , C07C205/02 , C07C255/04 , C07C31/12 , C07C31/202 , C07C55/10 , C07C19/045
摘要： An integrated process for making di-functional or multi-functional molecules with concurrent light paraffin upgrading is disclosed. The process involves three primary steps: (1) oxidation of an iso-paraffin to alkyl hydroperoxide and alcohol; (2) converting the alkyl hydroperoxide and alcohol to dialkyl peroxide; and (3) coupling functional molecules into di-functional or multi-functional molecules using the dialkyl peroxide as a radical initiator, while the dialkyl peroxide is converted to a tertiary alcohol. The functional molecules include any functional molecule R—X, where R is a hydrocarbyl group and X is a functional group such as —OH, —CN, —C(O)OH, —NH—, or the like.

7. 发明授权

US09403860B2 Metathesis catalysts containing onium groups 有权
标题翻译：含有鎓基团的复分解催化剂
公开(公告)号：US09403860B2
公开(公告)日：2016-08-02
申请号：US13779602
申请日：2013-02-27
申请人： Apeiron Synthesis S.A.
发明人： Krzysztof Skowerski , Lukasz Gulajski , Michal Bieniek , Stefan Czarnocki , Grzegorz Szczpaniak , Celina Wierzbicka
IPC分类号： C07F15/00 , B01J31/22 , C07C209/68 , C07D307/28 , C07C29/32 , C07C29/56 , C07C67/333 , C08G61/08
CPC分类号： C07F15/0046 , B01J31/2204 , B01J31/2273 , B01J31/2278 , B01J31/2295 , B01J2231/543 , B01J2531/821 , B01J2531/825 , B01J2531/96 , B01J2540/42 , B01J2540/64 , C07B2200/09 , C07C29/32 , C07C29/56 , C07C67/333 , C07C209/68 , C07C2601/10 , C07D307/28 , C08G61/08 , C08G2261/3324 , C08G2261/418 , C07C211/63 , C07C69/74 , C07C33/035
摘要： Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be represented by formula 1: Methods for the preparation of complexes of formula 1, the preparation of intermediates and the use of complexes of formula 1 in metathesis reactions and a method for conducting an olefin metathesis reaction are also described.
摘要翻译：本文公开了在惰性配体中制备含有季鎓基团的络合物的一般方法。这些配合物中的一些可以由式1表示：还描述了制备式1的络合物的方法，中间体的制备和式1的络合物在复分解反应中的用途和用于进行烯烃复分解反应的方法。

8. 发明申请

US20160090641A1 REMOVING IMPURITIES FROM SUGAR SOLUTIONS 有权
标题翻译：从糖解决方案中移除污染物
公开(公告)号：US20160090641A1
公开(公告)日：2016-03-31
申请号：US14892781
申请日：2013-05-28
申请人： ROHM AND HAAS COMPANY , DOW GLOBAL TECHNOLOGIES LLC
发明人： Yi Shu , Fengshan Luo , Gongwei Pu
IPC分类号： C13K13/00 , B01D15/36 , C07C29/00
CPC分类号： C13K13/007 , B01D15/362 , B01D15/365 , C07C29/00 , C07C29/32 , C07C31/20 , C07H1/06 , C07H3/02
摘要： Provided is a process for removing impurities from a solution (S1), wherein said solution (S1) comprises one or more sugar dissolved in an aqueous solvent, wherein said solution (S1) has conductivity at 25° C. of 500 μS/cm or higher, and wherein said process comprises (a) contacting said solution (S1) with a cation exchange resin (R1) to produce a solution (S2) in which 80% or more of the cations are all of the same element (E); and (b) then contacting said solution (S2) with a cation exchange resin (R2) in which, prior to said contacting, 90% or more of acid groups are in the salt form with said element (E). Also provided is a process for producing glycols comprising providing an extract solution by the process of claim 1, and then contacting said solution (S3) with hydrogen and a metal catalyst.
摘要翻译：提供了从溶液（S1）中除去杂质的方法（S1），其中所述溶液（S1）包含溶解在水性溶剂中的一种或多种糖，其中所述溶液（S1）在25℃下的电导率为500μS/ cm，或并且其中所述方法包括（a）使所述溶液（S1）与阳离子交换树脂（R1）接触以产生其中80％或更多的阳离子全部为相同元素（E）的溶液（S2）; 和（b）然后使所述溶液（S2）与阳离子交换树脂（R2）接触，其中在所述接触之前，90％或更多的酸基与所述元素（E）呈盐形式。还提供了一种生产二醇的方法，其包括通过权利要求1的方法提供提取物溶液，然后使所述溶液（S3）与氢气和金属催化剂接触。

9. 发明申请

US20150368174A1 NONYL ALCOHOLS WITH A LOW DEGREE OF BRANCHING AND THEIR DERIVATIVES 有权
标题翻译：具有低分支的非诺尔酒精及其衍生物
公开(公告)号：US20150368174A1
公开(公告)日：2015-12-24
申请号：US14842076
申请日：2015-09-01
申请人： Shell Oil Company
发明人： Julian Richard BARNES , James Grace CRUMP , Paul Theodore SHARKO
IPC分类号： C07C43/11 , C11D3/20 , C08K5/12 , C07C69/80
CPC分类号： C07C43/11 , C07C29/14 , C07C29/141 , C07C29/16 , C07C29/32 , C07C69/80 , C08K5/12 , C11D3/2068 , C07C31/125 , C08L27/06
摘要： The invention relates to nonyl alcohols with a low degree of branching and derivatives produced using them. In particular the present invention relates to mixture of primary nonyl alcohols in which at least 80% of the alkyl chains are linear and at least 15% of the alkyl chains are branched at the 2-carbon position and its derivatives. The low degree of branching produces derivatives that are more elongated and less bulky that similar derivatives produced with more highly branched alcohols.
摘要翻译：本发明涉及具有低支化度的壬醇和使用它们产生的衍生物。具体地说，本发明涉及初级壬醇的混合物，其中至少80％的烷基链是直链的，并且至少15％的烷基链在2-碳位上是支链的及其衍生物。低分支产生的衍生物更细长，体积较小，相似的衍生物用更高支化的醇生成。

10. 发明授权

US09073829B2 Synthesis of tetracyclines and intermediates thereto 有权
标题翻译：四环素及其中间体的合成
公开(公告)号：US09073829B2
公开(公告)日：2015-07-07
申请号：US13266788
申请日：2010-04-30
申请人： Andrew G. Myers , David A. Kummer , Derun Li , Evan Hecker , Amelie Dion , Peter M. Wright
发明人： Andrew G. Myers , David A. Kummer , Derun Li , Evan Hecker , Amelie Dion , Peter M. Wright
IPC分类号： A61K31/65 , C07C237/26 , C07C311/05 , C07C45/67 , C07C45/69 , C07C49/637 , C07D207/16 , C07D209/58 , C07D213/30 , C07D213/74 , C07D233/61 , C07D261/20 , C07D277/24 , C07D277/64 , C07D295/15 , C07D295/155 , C07D498/04 , C07F7/08
CPC分类号： C07D261/20 , C07B2200/07 , C07C29/32 , C07C45/00 , C07C45/29 , C07C45/67 , C07C45/673 , C07C45/69 , C07C49/637 , C07C237/26 , C07C311/05 , C07C2601/02 , C07C2601/08 , C07C2603/46 , C07C2603/66 , C07D207/16 , C07D209/58 , C07D213/30 , C07D213/74 , C07D233/61 , C07D261/18 , C07D277/24 , C07D277/64 , C07D295/15 , C07D295/155 , C07D498/04 , C07F7/0814 , C07F7/188
摘要： The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously thought susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.
摘要翻译：四环素类抗生素在过去50年的传染病治疗中发挥了重要作用。然而，四环素在人类和兽医药物中的使用量的增加导致了以前认为对四环素抗生素敏感的许多生物体之间的抵抗。通过手性烯酮中间体最近开发的四环素类似物的模块合成使得能够高效合成以前从未制备的新型四环素类似物。本发明提供了更有效的制备烯酮中间体的途径，并允许四环素环体系的4a，5,5a和12a位置的取代基。

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