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1. 发明授权

US10000432B2 Processes for the synthesis of chiral 1-alkanols 有权
公开(公告)号：US10000432B2
公开(公告)日：2018-06-19
申请号：US15111449
申请日：2015-01-09
申请人： PURDUE RESEARCH FOUNDATION
发明人： Ei-ichi Negishi
IPC分类号： C12P17/06 , C07C29/50 , C07C29/44 , C07F5/06 , C07C67/03 , C07C29/62 , C07C67/317 , C07C67/343 , C07C69/734 , C07C41/26 , C07C51/295 , C07C29/09 , C07C29/10 , C07D319/06 , C12P7/62
CPC分类号： C07C29/50 , C07B2200/05 , C07B2200/07 , C07C29/095 , C07C29/10 , C07C29/44 , C07C29/62 , C07C41/26 , C07C51/295 , C07C67/03 , C07C67/317 , C07C67/343 , C07C69/734 , C07C2601/14 , C07D319/06 , C07F5/06 , C12P7/62 , C07C31/125 , C07C31/12 , C07C69/14 , C07C53/128 , C07C33/18 , C07C69/732 , C07C31/1355 , C07C43/13 , C07C31/36
摘要： The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

2. 发明授权

US09744391B2 Use of metal-accumulating plants for implementing chemical reactions 有权
公开(公告)号：US09744391B2
公开(公告)日：2017-08-29
申请号：US14831987
申请日：2015-08-21
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
发明人： Claude Grison , Jose Escarre
IPC分类号： C07C321/00 , A62D3/35 , B01J23/06 , B01J23/72 , B01J23/755 , C07C29/62 , C07C2/86 , C07C17/16 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07D239/22 , C07F1/08 , A62D101/04
CPC分类号： A62D3/35 , A62D2101/04 , B01J23/06 , B01J23/72 , B01J23/755 , C07C2/861 , C07C17/16 , C07C29/62 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07C2523/04 , C07C2527/122 , C07C2527/128 , C07C2527/138 , C07D239/22 , C07F1/08 , C07C31/36
摘要： A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

3. 发明申请

US20170174593A1 PROCESS FOR PREPARING DICHLOROPROPANOL 有权
公开(公告)号：US20170174593A1
公开(公告)日：2017-06-22
申请号：US15263727
申请日：2016-09-13
申请人： CHANG CHUN PLASTICS CO., LTD.
发明人： Chien-Fu Huang , Cheng-Hui Chan
IPC分类号： C07C29/62 , C07C29/80
CPC分类号： C07C29/62 , C07C29/80 , C07C29/86 , C07C31/42 , C07C31/36
摘要： Provided is a process of preparing dichloropropanol, DCP. The process includes the step of: subjecting a three-carbon material to a first chlorination reaction with an aqueous hydrochloric acid solution in the presence of a carboxylic acid catalyst; adding the three-carbon material into the first mixture solution to undergo a second chlorination reaction and obtain a second mixture solution containing less than 13 wt % of hydrochloric acid; distilling the second mixture solution; and purifying the overhead product by oil-water separation to obtain DCP from the oil phase. By lowering the concentration of the hydrochloric acid contained in the mixture to be distilled, the DCP product can be straightly obtained via distillation and oil-water separation, thereby effectively simplifying the process of preparing DCP.

4. 发明申请

US20170166679A1 POLYURETHANE MATERIALS FORMED FROM UNSATURATED PLANT OILS VIA AN ALKYNE ZIPPER REACTION 有权
公开(公告)号：US20170166679A1
公开(公告)日：2017-06-15
申请号：US14965263
申请日：2015-12-10
申请人： International Business Machines Corporation
发明人： Scott B. King , Brandon M. Kobilka , Joseph Kuczynski , Jason T. Wertz
IPC分类号： C08G18/32 , C08G18/72 , G10K11/162 , C07C29/147
CPC分类号： C08G18/3206 , C07C29/14 , C07C29/143 , C07C29/147 , C07C29/56 , C07C29/58 , C07C29/62 , C07C45/26 , C08G18/72 , C08G2101/00 , C08G2350/00 , G10K11/162 , C07C33/025 , C07C33/02 , C07C31/36 , C07C33/042 , C07C33/04 , C07C47/19 , C07C49/185 , C07C31/20 , C07C31/22 , C07C31/24
摘要： A process of forming a polyurethane material includes forming an unsaturated alcohol from an unsaturated plant oil via a reduction reaction. The process includes forming an alkyne-terminated alcohol from the unsaturated alcohol and forming a polyol having two primary hydroxyl groups from the alkyne-terminated alcohol. The process further includes polymerizing a mixture that includes the polyol having the two primary hydroxyl groups to form a polyurethane material.

5. 发明申请

US20170036981A1 PROCESS FOR PREPARING ARYL KETONE 审中-公开
标题翻译：制备ARYL KETONE的方法
公开(公告)号：US20170036981A1
公开(公告)日：2017-02-09
申请号：US15229204
申请日：2016-08-05
申请人： ETERNAL MATERIALS CO., LTD.
发明人： Sheng-Yao HSUEH , Chih-An CHEN , You-Han LIN , Hao-Tien BAI
IPC分类号： C07C45/28 , C07C45/27 , C07C67/313
CPC分类号： C07C45/28 , C07C29/62 , C07C45/27 , C07C67/313 , C07C2601/14 , C07C33/46 , C07C49/82 , C07C49/83 , C07C49/76 , C07C69/738 , C07C49/84 , C07C49/792
摘要： A process for preparing aryl ketones is disclosed. The process includes photo-oxidizing a compound of formula (V), (VI), (VII) or (VIII): in the presence of an oxidative system comprising at least one bromide compound to form aryl ketones. X1, X2, R1, R2, R3, L1, L2, L3, L4, t, n, m and p have the meanings as described in the specification and claims.
摘要翻译：在包含至少一种溴化物化合物的氧化体系的存在下形成芳基酮。 X1，X2，R1，R2，R3，L1，L2，L3，L4，t，n，m和p具有说明书和权利要求书中所述的含义。

6. 发明授权

US09518074B2 Method for producing fluorine-containing substituted compound and fluorine-containing substituted compound 有权
公开(公告)号：US09518074B2
公开(公告)日：2016-12-13
申请号：US14986238
申请日：2015-12-31
申请人： Kyoto University , Taiyo Nippon Sanso Corporation
发明人： Junichi Yoshida , Aiichiro Nagaki
IPC分类号： C07F7/22 , C07C231/10 , C07F9/50 , C07C29/40 , C07C45/45 , C07F7/08 , C07C29/62 , C07C33/20 , C07C45/00 , C07C49/80 , C07C231/00 , C07C233/13 , C07C233/15 , C07F7/12 , C07F9/28 , C07C33/46 , C07C33/48
CPC分类号： C07F7/2208 , C07C29/40 , C07C29/62 , C07C33/20 , C07C33/46 , C07C33/483 , C07C45/00 , C07C45/455 , C07C49/80 , C07C231/00 , C07C231/10 , C07C233/13 , C07C233/15 , C07F7/0805 , C07F7/12 , C07F7/122 , C07F9/28 , C07F9/5022 , C07F9/5068 , C07C233/07 , C07C233/05 , C07C49/233
摘要： A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.

7. 发明授权

US09222940B2 Fused cyclooctyne compounds and their use in metal-free click reactions 有权
标题翻译：熔融环辛烯化合物及其在无金属点击反应中的应用
公开(公告)号：US09222940B2
公开(公告)日：2015-12-29
申请号：US14512324
申请日：2014-10-10
申请人： SynAffix B.V.
发明人： Floris Louis Van Delft , Floris Petrus Johannes Theodorus Rutjes , Frederik Jan Dommerholt
IPC分类号： C07C33/16 , C07C271/10 , C07C271/20 , C07C29/147 , C07C29/58 , C07C29/62 , C07C269/04 , C07C67/347 , A61K47/48 , A61K49/00 , G01N33/58 , G01N33/532 , C07C271/12 , C07C62/30 , C07C269/06 , C07D311/82 , C07D495/04 , C07K14/47
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
摘要： The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
摘要翻译：本发明涉及稠合环辛烯化合物及其制备方法。本发明还涉及缀合物，其中根据本发明的稠合环辛炔化合物与标记缀合，以及这些缀合物在靶分子的生物正交标记，成像和/或修饰，例如表面改性中的用途。本发明还涉及一种用于修饰靶分子的方法，其中根据本发明的缀合物与包含1,3-偶极或1,3-（杂）二烯的化合物反应。

8. 发明申请

US20150329511A1 METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL 有权
标题翻译：合成替代HEXITOLS等作为二氢吡咯烷酮的方法
公开(公告)号：US20150329511A1
公开(公告)日：2015-11-19
申请号：US14550131
申请日：2014-11-21
申请人： DEL MAR PHARMACEUTICALS
发明人： Dennis M. BROWN , Mike Tso-Ping LI
IPC分类号： C07D301/24 , C07D303/14 , C07C29/62
CPC分类号： C07D301/24 , C07C29/62 , C07D303/14 , C07D493/04
摘要： The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C. to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t-butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. Another method produces dianhydrogalactitol from dulcitol; this method comprises: (1) reacting dulcitol with a reactant to convert the 1,6-hydroxy groups of dulcitol to an effective leaving group to generate an intermediate; and (2) reacting the intermediate with an inorganic weak base to produce dianhydrogalactitol through an intramolecular SN2 reaction. Other methods for the synthesis of dianhydrogalactitol from dulcitol are described.
摘要翻译：本发明提供了合成和纯化二脱水己糖醇如二脱水半乳糖醇的有效方法。通常，应用于二氢半乳糖醇时，该方法包括：（1）在约80℃的温度下使糊精与氢溴酸的浓缩溶液反应，生产二溴乳糖醇; （2）使二溴乳糖醇与碳酸钾在叔丁醇中反应，生成二脱水半乳糖; 和（3）使用乙醚的浆液纯化二脱水半乳糖醇以产生纯化的二脱水半乳糖醇。另一种方法由二糖醇制得二脱水半乳糖醇; 该方法包括：（1）使杜仲醇与反应物反应，以将曲奇醇的1,6-羟基转化为有效的离去基团以产生中间体; 和（2）使中间体与无机弱碱反应，通过分子内SN2反应产生二脱水半乳糖。描述了从杜尔醇醇合成二脱水半乳糖醇的其它方法。

9. 发明授权

US08969630B2 Method for preparing chlorohydrins and method for preparing epichlorohydrin using chlorohydrins prepared thereby 有权
标题翻译：氯氢化物的制备方法和由此制备的氯代醇制备表氯醇的方法
公开(公告)号：US08969630B2
公开(公告)日：2015-03-03
申请号：US13805750
申请日：2011-06-08
申请人： Won Seob Song , Sung Yul Woo , Boo Weon Song , Seong Han Park , Myoung Suk Kwon
发明人： Won Seob Song , Sung Yul Woo , Boo Weon Song , Seong Han Park , Myoung Suk Kwon
IPC分类号： C07C31/34 , C07D301/02 , C07C29/62 , C07D303/08
CPC分类号： C07C29/62 , C07D303/08 , C07C31/36
摘要： A method of preparing chlorohydrins and a method of preparing epichlorohydrin by using chlorohydrins prepared using the method are provided. The method of preparing chlorohydrins by reacting polyhydroxy aliphatic hydrocarbon with a chlorination agent in the presence of a catalyst includes at least one combination of a series of unit operations including a first reaction step, a water removal step, and a second reaction step, in that respective order, wherein the method further includes purifying chlorohydrins from a reaction mixture discharged from a final reaction step of the plurality of reaction steps. The method of preparing epichlorohydrin includes reacting chlorohydrins prepared using the method of preparing chlorohydrins, with an alkaline agent.
摘要翻译：提供了一种制备氯代醇的方法和一种使用该方法制备的使用氯代醇制备表氯醇的方法。通过在催化剂存在下使多羟基脂族烃与氯化剂反应制备氯代醇的方法包括一系列单元操作的组合，包括第一反应步骤，除水步骤和第二反应步骤，其中其中所述方法还包括从多个反应步骤的最终反应步骤排出的反应混合物中纯化氯代醇。制备表氯醇的方法包括使用制备氯代醇的方法制备的氯代醇与碱性试剂反应。

10. 发明授权

US08420871B2 Process for producing an organic compound 失效
标题翻译：生产有机化合物的方法
公开(公告)号：US08420871B2
公开(公告)日：2013-04-16
申请号：US13238206
申请日：2011-09-21
申请人： Patrick Gilbeau , Ivan De Andolenko , Philippe Krafft , Freddy Gielen
发明人： Patrick Gilbeau , Ivan De Andolenko , Philippe Krafft , Freddy Gielen
IPC分类号： C07C31/34 , C08F16/02 , C08F283/00 , C07D301/24
CPC分类号： C07C29/62 , C07C29/76 , C07C29/82 , C07D301/02 , C07D301/26 , C07D303/08 , C07C31/36
摘要： Process for producing a chlorohydrin by reaction between a multihydroxylated-aliphatic hydrocarbon, an ester of a multihydroxylated-aliphatic hydrocarbon, or a mixture thereof, and a chlorinating agent, according to which the multihydroxylated-aliphatic hydrocarbon, the ester of a multihydroxylated-aliphatic hydrocarbon, or the mixture thereof used contains at least one solid or dissolved metal salt, the process comprising a separation operation to remove at least part of the metal salt.
摘要翻译：多羟基化脂肪族烃，多羟基化脂肪族烃或其混合物的酯与氯化剂反应生成氯代醇的方法，根据该方法，多羟基化脂肪族烃，多羟基化脂肪族烃，或其使用的混合物含有至少一种固体或溶解的金属盐，该方法包括去除至少部分金属盐的分离操作。

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