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1. 发明授权

US09550797B2 Preparation of Grignard reagents using a fluidized bed 有权
标题翻译：使用流化床制备格氏试剂
公开(公告)号：US09550797B2
公开(公告)日：2017-01-24
申请号：US14899445
申请日：2014-06-27
申请人： DPX Holdings B.V.
发明人： Mehul Thathagar , Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Michel Goldbach
IPC分类号： C07F3/02 , C07D257/02 , C07F15/00 , C07C29/40 , C07C67/30
CPC分类号： C07F3/02 , C07C29/40 , C07C67/30 , C07D257/02 , C07F15/0046
摘要： The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.
摘要翻译：本发明涉及一种制备格氏试剂的方法，包括使镁颗粒在流化床反应器中反应。本发明还涉及一种连续方法，包括在反应器中流化镁颗粒，连续形成格氏试剂，并使格利雅试剂与底物反应。

2. 发明授权

US09334253B2 Direct trifluoromethylations using trifluoromethane 有权
标题翻译：使用三氟甲烷进行直接三氟甲基化
公开(公告)号：US09334253B2
公开(公告)日：2016-05-10
申请号：US14113482
申请日：2012-04-19
申请人： G. K. Surya Prakash , Parag V. Jog , Patrice. T. D Batamack , George Olah
发明人： G. K. Surya Prakash , Parag V. Jog , Patrice. T. D Batamack , George Olah
IPC分类号： C07D307/44 , C07C29/62 , C07C41/01 , C07F7/08 , C07C29/40 , C07C303/16 , C07C41/30 , C07C41/50 , C07C201/12 , C07C45/45 , C07D213/26 , C07D307/42 , C07C17/269 , C07C17/32 , C07B39/00
CPC分类号： C07D307/44 , C07B39/00 , C07C17/269 , C07C17/32 , C07C29/40 , C07C29/62 , C07C41/01 , C07C41/30 , C07C41/50 , C07C45/455 , C07C201/12 , C07C303/16 , C07C2603/24 , C07D213/26 , C07D307/42 , C07F7/081 , C07F7/0896 , C07C22/08 , C07C205/26 , C07C205/11 , C07C205/37 , C07C309/06 , C07C33/46 , C07C43/23 , C07C33/486 , C07C49/80 , C07C43/317 , C07C43/225
摘要： A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.
摘要翻译：直接三氟甲基化方法优选使用三氟甲烷作为氟代甲基化物质。特别地，本发明的方法用于通过使氟可甲基底物与三氟甲基化试剂在硅烷的醇盐或金属盐的存在下在足以使底物三氟甲基化的条件下反应制备三氟甲基化底物; 其中所述氟甲基基材包括氯硅烷，羰基化合物如酯，芳基卤化物，醛，酮，查尔酮，甲酸烷基酯，烷基卤，芳基卤，烷基硼酸盐，二氧化碳或硫。

3. 发明申请

US20080004351A1 Hydrogenation of imine intermediates of sertraline with catalysts 审中-公开
公开(公告)号：US20080004351A1
公开(公告)日：2008-01-03
申请号：US11645081
申请日：2006-12-21
申请人： Mordechay Herskowitz , Mark Kaliya
发明人： Mordechay Herskowitz , Mark Kaliya
IPC分类号： A61K31/136 , A61P25/24 , B01J23/75 , C07C29/40
CPC分类号： C07C209/52 , B01J23/75 , B01J35/10 , B01J35/1014 , B01J35/1061 , C07C211/42
摘要： Provided are hydrogenation processes of sertraline imine intermediates with catalysts in various reactors.

4. 发明申请

US20050218532A1 Method of preparing organomagnesium compounds 有权
标题翻译：制备有机镁化合物的方法
公开(公告)号：US20050218532A1
公开(公告)日：2005-10-06
申请号：US11097707
申请日：2005-04-01
申请人： Paul Knochel , Arkady Krasovskiy
发明人： Paul Knochel , Arkady Krasovskiy
IPC分类号： C07D333/16 , C07B49/00 , C07C1/32 , C07C15/58 , C07C17/263 , C07C25/24 , C07C29/40 , C07C33/18 , C07C33/24 , C07C33/46 , C07C41/26 , C07C43/23 , C07C45/45 , C07C45/68 , C07C49/697 , C07C49/813 , C07C49/84 , C07C67/343 , C07C69/616 , C07C69/76 , C07C253/30 , C07C255/50 , C07C255/53 , C07C255/56 , C07C319/14 , C07C323/20 , C07D213/16 , C07D213/61 , C07D277/24 , C07D333/56 , C07F3/02 , C07F3/04 , C07F9/53
CPC分类号： C07B49/00 , C07F3/02
摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.
摘要翻译：本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

5. 发明授权

US06906230B1 Method for producing alcohol surfactants and alcohol ether surfactants, the products obtained and their use 失效
标题翻译：制备醇类表面活性剂和醇醚表面活性剂的方法，获得的产品及其用途
公开(公告)号：US06906230B1
公开(公告)日：2005-06-14
申请号：US09926168
申请日：2000-03-17
申请人： Heiko Maas , Michael Röper , Marc Walter , Ralf Schulz , Jürgen Tropsch , Hans-Ulrich Jäger
发明人： Heiko Maas , Michael Röper , Marc Walter , Ralf Schulz , Jürgen Tropsch , Hans-Ulrich Jäger
IPC分类号： C07H15/04 , C07B61/00 , C07C2/06 , C07C2/08 , C07C2/10 , C07C11/00 , C07C11/02 , C07C27/22 , C07C29/132 , C07C29/16 , C07C29/36 , C07C29/38 , C07C29/40 , C07C29/44 , C07C29/46 , C07C31/02 , C07C31/125 , C07C41/03 , C07C43/13 , C07C45/50 , C07C303/24 , C07C305/06 , C07C305/10 , C07F9/09 , C07F9/11 , C07H1/00 , C07H13/04 , C08B1/00 , C08B37/00 , C11D1/72
CPC分类号： C07C45/50 , C07C2/10 , C07C11/02 , C07C29/141 , C07C41/03 , C07C43/11 , C07C303/24 , C07C2521/04 , C07C2521/06 , C07C2521/08 , C07C2523/755 , C07F9/091 , C07C31/125 , C07C305/10 , C07C305/06 , C07C47/02
摘要： The invention describes a process for the preparation of surfactant alcohols and surfactant alcohol ethers which are, inter alia, highly suitable as surfactants or for the preparation of surfactants. The process, starting from olefin mixtures having a defined minimum content of linear hexenes, gives mixtures having a predominant fraction of branched dodecenes, which are subsequently derivatized to give surfactant alcohols and then optionally alkoxylated.The surfactant alcohol mixture obtained in the process has a degree of branching of from 2.0 to 3.0 and in particular exhibits advantageous properties as regards ecotoxicity and biodegradability.A description is also given of the use of the surfactant alcohols and surfactant alcohol ethers as surfactants by glycosidation or polyglycosidation, sulfation or phosphation.
摘要翻译：本发明描述了制备表面活性剂醇和表面活性剂醇醚的方法，其特别是非常适合作为表面活性剂或用于制备表面活性剂。该方法从具有确定的最小含量的线性己烯的烯烃混合物开始，得到具有主要部分的支化十二碳烯的混合物，随后将其衍生化得到表面活性剂醇然后任选烷氧基化。本方法得到的表面活性剂醇混合物的支化度为2.0〜3.0，特别是在生态毒性和生物降解性方面表现出有利的特性。还给出了表面活性剂醇和表面活性剂醇醚通过糖基化或多糖苷化，硫酸化或磷酸化作为表面活性剂的用途。

6. 发明申请

US20050075473A1 Telechelic emissive oligiomers and polymers derived therefrom 审中-公开
标题翻译：从其衍生的远端电子发射性低聚物和聚合物
公开(公告)号：US20050075473A1
公开(公告)日：2005-04-07
申请号：US10680470
申请日：2003-10-07
申请人： James Cella
发明人： James Cella
IPC分类号： C07C29/40 , C07C29/44 , C07C39/17 , C08G61/02 , C08G61/12 , C09K11/06 , H01L51/00 , H05B33/14 , C08G2/00
CPC分类号： H01L51/0039 , C07C29/40 , C07C29/44 , C07C39/17 , C07C2603/18 , C08G61/02 , C09K11/06 , C09K2211/1011 , C09K2211/1416 , H01L51/0058 , H05B33/14 , Y02E10/549 , Y02P70/521 , C07C35/52
摘要： The present invention is directed to a telechelic emissive, semi-conductive end-functionalized oligomers which can be polymerized by a variety of conventional techniques to afford emissive polymers. The polymers are useful as active layers in light emitting as well as photovoltaic devices.
摘要翻译：本发明涉及可以通过各种常规技术聚合以提供发射聚合物的遥爪发射半导电端官能化低聚物。聚合物可用作发光和光伏器件中的有源层。

7. 发明申请

US20030065223A1 Process for preparing vanillylamine hydrochloride 审中-公开
标题翻译：香草胺盐酸盐的制备方法
公开(公告)号：US20030065223A1
公开(公告)日：2003-04-03
申请号：US10259120
申请日：2002-09-27
申请人： Boehringer Ingelheim Pharma KG
发明人： Oliver Meyer , Ingo Heddesheimer
IPC分类号： C07C29/40 , C07C249/08
CPC分类号： C07C217/58
摘要： Process for preparing vanillylamine or one of the salts thereof by reacting vanillin with hydroxylamine or the salts thereof in the presence of an organic salt, which may optionally be produced in situ, wherein the reaction is carried out in an inorganic or organic acid as diluent, and subsequently hydrogenating the resulting vanillyloxime with hydrogen in the presence of a suitable catalyst and an organic and/or inorganic acid.
摘要翻译：通过香草醛与羟胺或其盐在有机盐存在下反应来制备香兰胺或其盐之一的方法，所述有机盐可以任意地原位制备，其中反应在无机或有机酸中作为稀释剂进行，随后在合适的催化剂和有机和/或无机酸的存在下用氢氢化所得的钒酸肟。

8. 发明申请

US20020013500A1 Process for producing trifluoromethylbenzylamines 失效
标题翻译：制备三氟甲基苄胺的方法
公开(公告)号：US20020013500A1
公开(公告)日：2002-01-31
申请号：US09833211
申请日：2001-04-12
发明人： Satoru Narizuka , Eri Tsukada , Takashi Kume
IPC分类号： C07C29/40
CPC分类号： C07C209/40 , C07C211/29
摘要： The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1), 1 where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group. This process includes the step of reducing an oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia. The oxime is represented by the general formula (2), 2 where R1 is defined as above, and R2 represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high yield.
摘要翻译：本发明涉及由通式（1）表示的三氟甲基苄胺的制备方法，其中R1表示氢原子，选自氟，氯，溴和碘的卤素原子或三氟甲基。该方法包括在催化剂和氨的存在下，通过有机溶剂中的氢还原肟的步骤。肟由通式（2）表示，其中R 1如上定义，R 2表示氢原子，烷基或芳烷基。通过该方法，可以高产率制备三氟甲基苄胺。

9. 发明授权

US5292929A Asymmetric synthesis of chiral secondary alcohols 失效
标题翻译：手性仲醇的不对称合成
公开(公告)号：US5292929A
公开(公告)日：1994-03-08
申请号：US51994
申请日：1993-04-26
申请人： Jeffrey M. Sullivan
发明人： Jeffrey M. Sullivan
IPC分类号： C07C29/38 , C07C29/40 , C07C69/63 , C07C69/02
CPC分类号： C07C45/30 , C07C29/40 , C07C67/08
摘要： A process for producing (R)-2-hydroxy-6-haloalkane is disclosed. In the first step, a cyclic alkanol is photohalogenated. In the second step, the photohalogenation product is reacted with a chiral catalyst and dialkyl zinc to produce (R)-2-hydroxy-6-haloalkane.
摘要翻译：公开了制备（R）-2-羟基-6-卤代烷烃的方法。在第一步中，环烷醇被光卤化。在第二步中，使光卤化产物与手性催化剂和二烷基锌反应生成（R）-2-羟基-6-卤代烷烃。

10. 发明授权

US5091400A Clathrate compound 失效
标题翻译：复合化合物
公开(公告)号：US5091400A
公开(公告)日：1992-02-25
申请号：US563945
申请日：1990-08-07
申请人： Minoru Yagi , Fumio Toda
发明人： Minoru Yagi , Fumio Toda
IPC分类号： A01N25/22 , A01N43/80 , C07C29/40 , C07C33/26
CPC分类号： C07C33/26
摘要： 2,2'-Bis(.alpha.-hydroxydiphenylemthyl)biphenyl of formula: ##STR1## Clathrate compound is composed of the above compound as the host compound and a microbicide, 5-chloro-2-methyl-4-isothiazolin-3-one as the guest compound. The compound is formed such that, where diphenic acid is reacted with an alcohol for diesterification and then reacted with a Grignard reagent comprising a phenylmagnesium halide.

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