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    • 3. 发明授权
    • Alpha- and chi-diketone reactants for charge transfer reactions in mass spectrometers
    • 用于质谱仪中电荷转移反应的α-和二 - 二酮反应物
    • US09557297B2
    • 2017-01-31
    • US13667018
    • 2012-11-02
    • Bruker Daltonik GmbH
    • Ralf Hartmer
    • G01N24/00G01N27/62H01J49/00C07C49/12C07C49/203C07C49/403C07C49/437
    • G01N27/62C07C49/12C07C49/203C07C49/403C07C49/437C07C2601/14C07C2602/42H01J49/0072Y10T436/24
    • The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers.
    • 本发明涉及用于生产适用于质谱仪中的电荷转移反应的阴离子的物质的用途,特别是通过电子转移或通过质子转移进行电荷还原的多重带正电荷的生物聚合物离子的断裂。 Diketones,特别是α-二酮被提出作为新发现的一类物质,可以用于生产具有高产率碎片离子的电子转移离解(ETD)的自由基阴离子,并且用于生成非自由基 通过质子转移反应(PTR)对多重电荷的分析物离子进行电荷还原的阴离子。 这些物质在其处理和相关分析方法方面具有良好的性质:它们在很大程度上是无毒的,涵盖了有利的分子量范围,并且它们的挥发性意味着它们可以储存在真空系统外的未加热的容器中,这便于 重新填充容器。