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1. 发明授权

US09828324B2 Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom 有权
公开(公告)号：US09828324B2
公开(公告)日：2017-11-28
申请号：US14868795
申请日：2015-09-29
申请人： Sirrus, Inc.
发明人： Jeffrey M. Sullivan , Adam G. Malofsky , Bernard M. Malofsky , Tanmoy Dey
IPC分类号： C07C45/00 , C07C49/00 , C08L27/12 , B03D1/016 , C08F214/06 , C08L27/00 , C07C49/84 , C07C45/75 , C07C49/203 , C07C49/794 , C07C49/796 , C07D333/22 , C07C49/557 , C07C49/227 , C07D307/46 , C07C49/80
CPC分类号： C07C49/84 , C07C45/75 , C07C49/203 , C07C49/227 , C07C49/557 , C07C49/794 , C07C49/796 , C07C49/80 , C07C2601/14 , C07D307/46 , C07D333/22
摘要： The present teachings are directed at 1,1-disubstituted alkene monomers (e.g., methylene beta-diketone monomers), methods for producing the same, and compositions and products formed therefrom. In the method for producing the monomer, a beta-diketone is preferably reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to vaporization in order to isolate the monomer. The monomer(s) may be employed in compositions and products, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

2. 发明授权

US09557297B2 Alpha- and chi-diketone reactants for charge transfer reactions in mass spectrometers 有权
标题翻译：用于质谱仪中电荷转移反应的α-和二 - 二酮反应物
公开(公告)号：US09557297B2
公开(公告)日：2017-01-31
申请号：US13667018
申请日：2012-11-02
申请人： Bruker Daltonik GmbH
发明人： Ralf Hartmer
IPC分类号： G01N24/00 , G01N27/62 , H01J49/00 , C07C49/12 , C07C49/203 , C07C49/403 , C07C49/437
CPC分类号： G01N27/62 , C07C49/12 , C07C49/203 , C07C49/403 , C07C49/437 , C07C2601/14 , C07C2602/42 , H01J49/0072 , Y10T436/24
摘要： The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers.
摘要翻译：本发明涉及用于生产适用于质谱仪中的电荷转移反应的阴离子的物质的用途，特别是通过电子转移或通过质子转移进行电荷还原的多重带正电荷的生物聚合物离子的断裂。 Diketones，特别是α-二酮被提出作为新发现的一类物质，可以用于生产具有高产率碎片离子的电子转移离解（ETD）的自由基阴离子，并且用于生成非自由基通过质子转移反应（PTR）对多重电荷的分析物离子进行电荷还原的阴离子。这些物质在其处理和相关分析方法方面具有良好的性质：它们在很大程度上是无毒的，涵盖了有利的分子量范围，并且它们的挥发性意味着它们可以储存在真空系统外的未加热的容器中，这便于重新填充容器。

3. 发明申请

US20160340285A1 FLAVOR AND FRAGRANCE FORMULATION (VII) 审中-公开
标题翻译：风味和香料制剂（VII）
公开(公告)号：US20160340285A1
公开(公告)日：2016-11-24
申请号：US15116525
申请日：2015-01-30
申请人： DSM IP ASSETS B.V.
发明人： Ralf PROPLESCH , Johannes TSCHUMI , Raphael BEUMER
IPC分类号： C07C49/203 , A23L27/20 , C11B9/00 , C11D3/50 , A61K8/35 , A61Q13/00
CPC分类号： C07C49/203 , A23L27/2024 , A23V2002/00 , A61K8/35 , A61Q13/00 , C07B2200/09 , C11B9/0015 , C11D3/50
摘要： The present invention relates to the use of a specific organic compound as flavor and fragrance material. Furthermore the invention relates to flavor and fragrance formulations comprising such a specific organic compound of formula (I).

4. 发明授权

US09468594B2 Flavor and fragrance formulation (II) 有权
标题翻译：香精和香料配方（II）
公开(公告)号：US09468594B2
公开(公告)日：2016-10-18
申请号：US14430345
申请日：2013-10-07
申请人： DSM IP ASSETS B.V.
发明人： Raphael Beumer , Johannes Tschumi , Michael Gressly
IPC分类号： C08F2/46 , C08F2/50 , C08G61/04 , A61K8/00 , A61K8/35 , A23L1/226 , A61Q13/00 , C07C49/175 , C11B9/00 , C11D3/50 , A61Q19/00 , A61L9/01 , A61Q5/02 , A61Q15/00 , A61Q19/10 , C07C49/04 , C07C49/203 , C11D3/20
CPC分类号： A61K8/35 , A23L27/2024 , A61K2800/10 , A61L9/01 , A61Q5/02 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C49/04 , C07C49/175 , C07C49/203 , C11B9/0015 , C11D3/2072 , C11D3/50
摘要： The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to a new specific organic compound, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds.
摘要翻译：本发明涉及特定有机化合物作为香料和香料的用途。此外，本发明涉及新的特定有机化合物，以及包含至少一种特定有机化合物的风味和香料制剂。

5. 发明授权

US09447364B2 Fragrance compounds 有权
标题翻译：香料化合物
公开(公告)号：US09447364B2
公开(公告)日：2016-09-20
申请号：US14714693
申请日：2015-05-18
申请人： Givaudan, S.A.
发明人： Felix Flachsmann
IPC分类号： C11D3/50 , C07C69/533 , C07C45/74 , C07C49/203 , C07C49/255 , C07C49/84 , C07C69/602 , C07C69/738 , C07C233/09 , C11B9/00 , C11D3/00 , C11D3/20 , C11D3/32
CPC分类号： A01K1/0155 , A01K1/0152 , C07C45/74 , C07C49/203 , C07C49/255 , C07C49/84 , C07C69/533 , C07C69/602 , C07C69/738 , C07C233/09 , C07C2601/14 , C11B9/0007 , C11B9/0015 , C11B9/0019 , C11B9/0061 , C11D3/001 , C11D3/2072 , C11D3/2093 , C11D3/32 , C11D3/50 , C11D3/507
摘要： A method of providing a fragrant odor to an application, comprising the addition thereto of at least one compound of the formula I wherein X and Y are independently selected from the group consisting of —CR1R2R3, —NR4R5 and —OR6, wherein R1 to R5 are selected from H and essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom, and R6 is selected from essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom; and, A is an essentially hydrocarbon moiety that optionally comprises at least one oxygen, sulphur, nitrogen or silicon atom, with the proviso that the compound A-CHO is a fragrant aldehyde. The use of these compounds in laundry, household and personal care products confers a long-lasting freshness.

6. 发明申请

US20150321987A1 NITROGEN MONOXIDE AS CIS/TRANS ISOMERIZATION CATALYSTS FOR UNSATURATED COMPOUNDS 有权
标题翻译：不饱和化合物的硝基一氧化碳/转异构化催化剂
公开(公告)号：US20150321987A1
公开(公告)日：2015-11-12
申请号：US14652286
申请日：2013-12-18
申请人： DSM IP ASSETS B.V.
发明人： René Tobias STEMMLER , Nadine GREINER , Angela WILDERMANN
IPC分类号： C07C45/67 , C07C29/56 , C07C33/02 , C07C49/203
CPC分类号： C07C43/313 , C07B2200/09 , C07C29/56 , C07C33/02 , C07C45/67 , C07C49/203
摘要： The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsaturated carboxylic acids, esters of an unsaturated carboxylic acid and amides of an unsaturated carboxylic acid using nitrogen monoxide as cis/trans isomerization catalyst. It has been observed that the isomerization is very efficient and fast.
摘要翻译：本发明涉及不饱和化合物A的顺式/反式异构化方法，其选自不饱和酮，不饱和缩酮，不饱和醛，不饱和缩醛，不饱和羧酸，不饱和羧酸的酯和酰胺的酰胺使用一氧化氮作为顺/反异构化催化剂的不饱和羧酸。已经观察到异构化非常有效和快速。

7. 发明授权

US09023884B2 Polymorphs and amorphous forms of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile 有权
标题翻译： 5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -4 - [（三氟甲基）亚硫酰基] -1H-吡唑-3-甲腈的多晶型物和无定形形式
公开(公告)号：US09023884B2
公开(公告)日：2015-05-05
申请号：US13893045
申请日：2013-05-13
申请人： Makhteshim Chemical Works Ltd.
发明人： Sharona Zamir
IPC分类号： A61K31/415 , C07D231/00 , A01N43/56 , A01N47/02 , C07C15/06 , C07C49/203 , C07D231/44
CPC分类号： C07D231/44 , A01N43/56 , A01N47/02 , C07B2200/13 , C07C15/06 , C07C49/203
摘要： The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.
摘要翻译：本发明涉及5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -4 - [（三氟甲基）亚硫酰基] -1H-吡唑-3的新型结晶多晶型物，溶剂化物假晶体和无定形形式（氟虫腈）。本发明还提供了制备新型多晶型物，假晶体和无定形形式的方法，以及包含其的杀虫剂或杀虫剂组合物的方法及其作为杀虫剂的使用方法。

8. 发明申请

US20130296323A1 GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM 有权
公开(公告)号：US20130296323A1
公开(公告)日：2013-11-07
申请号：US13779568
申请日：2013-02-27
申请人： COYOTE PHARMACEUTICALS, INC.
发明人： Hiroaki Serizawa , Ankush B. Argade , Akash Datwani , Natalie Spencer , Yonghua Pan , Florian Ermini
IPC分类号： C07C49/203 , C07C69/02 , C07C69/24 , C07C69/743 , C07C69/74 , C07D295/13 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07D211/26 , C07C69/145 , C07C69/75
CPC分类号： C07C49/203 , C07C33/02 , C07C33/14 , C07C47/21 , C07C49/21 , C07C49/255 , C07C49/557 , C07C49/647 , C07C57/03 , C07C57/66 , C07C69/007 , C07C69/02 , C07C69/145 , C07C69/24 , C07C69/587 , C07C69/608 , C07C69/738 , C07C69/74 , C07C69/743 , C07C69/75 , C07C69/757 , C07C69/76 , C07C69/92 , C07C205/57 , C07C211/08 , C07C211/35 , C07C211/38 , C07C217/08 , C07C251/40 , C07C251/60 , C07C271/12 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/30 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D211/26 , C07D213/75 , C07D263/32 , C07D263/38 , C07D271/10 , C07D295/13 , C07D307/46 , C07D307/52 , C07D413/04
摘要： This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.

9. 发明授权

US08481789B2 Method for producing natural 9-decen-2-one by bioconverting undecylenic acid using a mold, and use in the perfume and food flavoring fields 有权
标题翻译：使用模具生物转化十一碳烯酸生产天然9-癸烯-2-酮的方法，用于香水和食品香料领域
公开(公告)号：US08481789B2
公开(公告)日：2013-07-09
申请号：US12995289
申请日：2009-06-03
申请人： Jean Mane , Joseph Zucca
发明人： Jean Mane , Joseph Zucca
IPC分类号： C07C49/203 , A23L1/23
CPC分类号： C12P7/26 , A23L27/2024 , A23L27/24 , A23L27/29 , C11B9/0015
摘要： The present invention relates to a process for producing 9-decen-2-one, characterized by the bioconversion of undecylenic acid using a mold, and to its use in perfumery, cosmetics and food flavoring.
摘要翻译：本发明涉及一种生产9-癸烯-2-酮的方法，其特征在于使用模具对十一碳烯酸进行生物转化，以及其用于香料，化妆品和食品香料中的用途。

10. 发明申请

US20110311583A1 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS 有权
标题翻译：用于输送治疗药物的新型脂肪和组合物
公开(公告)号：US20110311583A1
公开(公告)日：2011-12-22
申请号：US13128287
申请日：2009-11-10
申请人： Muthiah Manoharan , kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
发明人： Muthiah Manoharan , kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
IPC分类号： A61K39/12 , A61K47/08 , C07J41/00 , A61K47/28 , C07C211/22 , A61K47/16 , C07C211/21 , C07D211/72 , A61K47/22 , C07C251/78 , C07C279/12 , C07C271/12 , A61K48/00 , A61K31/713 , C12N5/00 , A61K39/39 , A61K39/00 , A61K39/02 , A61P37/04 , A61P31/12 , A61P31/04 , A61P33/00 , C07C49/203
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
摘要： (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(0)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ?-aminoalkyl, ?-(substituted)aminoalky, ?-phosphoalkyl or ?-thiophosphoalkyl.
摘要翻译：（A1）翻译本发明本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3是H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代磷酸烷基酯，硫代磷酸烷基酯，磷酸二烷基酯，烷基膦酸酯，烷基胺，羟烷基，α-氨基烷基，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q）），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，α-氨基烷基，β-（取代）氨基烷基，α-磷酸烷基或α-硫代磷酰烷基。

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