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81. 发明申请

US20010018216A1 Apparatus and method for transfering small volumes of substances 有权
标题翻译：用于转移少量物质的装置和方法
公开(公告)号：US20010018216A1
公开(公告)日：2001-08-30
申请号：US09846467
申请日：2001-04-30
申请人： PE Corporation (NY)
发明人： Reid B. Kowallis
IPC分类号： G01N021/00
CPC分类号： B01L3/0244 , B01J2219/00367 , B01J2219/00459 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01L3/0262 , B01L2300/0838 , C40B60/14 , G01N35/00009 , G01N35/10 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/114998 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.
摘要翻译：本发明提供了用于将小体积的选定物质（例如生物试剂或样品）分配到基底上的方法和装置。根据一个一般实施例，沿着沿着试剂供应位置延伸的输送路径，例如通过输送机前进的多个间隔开的串列布置的基板，例如支撑在基座中的固定位置处的储存器。从试剂供应位置和路径上的位置，试剂转移仪器或尖端沿着轴线延伸穿过中间区域，例如由输送机的表面限定的开口，分离相邻的一对前进接触试剂供应位置的接触试剂的底物。然后将试剂转移仪器连同一部分这种试剂一起通过中间区域排出到输送通道上方的位置。一旦输送机将所选择的基板在中间区域的上游推进到与试剂转移仪器的轴线对准的位置，则将选定量的试剂从仪器转移到基板的选定位置。有利地，该装置和方法容易适用于生产具有大量紧密间隔的点的微阵列。

82. 发明申请

US20010016631A1 Methods for parallel semi-continuous or continuous reactions 失效
标题翻译：平行半连续或连续反应的方法
公开(公告)号：US20010016631A1
公开(公告)日：2001-08-23
申请号：US09755388
申请日：2001-01-04
发明人： J. Christopher Freitag , Damian Hajduk , Ralph B. Nielsen , Adam Safir , Richard Tiede
IPC分类号： C08F002/00
CPC分类号： B01J19/0046 , B01J2219/0029 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00319 , B01J2219/00351 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00691 , B01J2219/0072 , B01J2219/00722 , C40B40/14 , C40B60/14 , Y10S526/92 , Y10T436/11 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.
摘要翻译：提供了以半批或连续模式并行地进行多种不同混合物的方法和装置。每个反应都包含在反应器容器中，反应器容器组合成反应器块。在反应过程中加入的反应物保持在集管筒中，其具有柱塞，以通过输送管将反应物从集管筒送入反应器容器。柱塞使用驱动系统移动。标题桶可选地组合在标题块中。集管块被密封到含有输送管线的板上，转移管路又与反应器块密封。提供了一种闭锁机构，用于容易地将反应堆和集管块密封到板上。当反应进行时，整个装置可以放置在摇臂或旋转板上用于混合。

83. 发明申请

US20010010936A1 System and method of aspirating and dispensing reagent 有权
标题翻译：抽吸和分配试剂的系统和方法
公开(公告)号：US20010010936A1
公开(公告)日：2001-08-02
申请号：US09825596
申请日：2001-04-04
发明人： William Richards , Anthony Ford , Vince Rizzo , Darin McDaniel , Kurt Reinhardt , Wayne Showalter
IPC分类号： G01N001/10 , G01N035/10
CPC分类号： G01N35/1002 , G01N1/31 , G01N1/312 , Y10T436/114998 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： Apparatus and methods for aspirating and dispensing reagents are provided. Aspirating of reagents is accomplished by a probe, a vial insert and reagent vial according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the vial insert. Dispensing of reagents is accomplished by a probe and a probe dispense and wash station according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the probe dispense and wash station.
摘要翻译：提供了用于抽吸和分配试剂的装置和方法。通过根据本发明的探针，小瓶插入物和试剂小瓶实现试剂的吸入，其中当探针接合小瓶插入物时，在探针和小瓶插入物之间形成密封。试剂的分配是通过根据本发明的探针和探针分配和洗涤台实现的，其中当探头接合探针分配和洗涤站时，在探针和小瓶插入物之间形成密封。

84. 发明申请

US20010000723A1 Multi-well rotary synthesizer 有权
标题翻译：多孔旋转合成器
公开(公告)号：US20010000723A1
公开(公告)日：2001-05-03
申请号：US09742261
申请日：2000-12-19
发明人： Gary R. McLuen , Richard J. Hanney , Daniel W. Hugens
IPC分类号： B01J019/24
CPC分类号： B01J19/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00326 , B01J2219/00351 , B01J2219/00353 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , C40B60/14 , G01N35/025 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The multiple banks of valves provide an additional number of reagent choices while operating in a serial mode and faster reagent distribution while operating in a parallel mode. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system. The controller rotates the cartridge and operates the banks of valves and the waste tube system in response to the required sequence of dispensing various reagent solutions and flushing appropriate vials in order to form the desired polymer chain within each vial.
摘要翻译：一种用于合成聚合物链的装置包括一个控制器，多个精确配合的小瓶，圆形布置在药筒上的多个组中，对应于每一组小瓶的排水口，室碗，用于将试剂输送到选择性小瓶的多个阀以及用于从小瓶中清除材料的废物管系统。清洗操作可以选择性地在一个或多个小瓶组上执行。当以并行模式运行时，多组阀门在串行模式下运行，并提供更快的试剂分配，可提供额外的试剂选择。多个小瓶被存储在盒中并且被划分成各个组，其中每一组小瓶具有相应的排水管。当废物管系统耦合到相应的排水管时，存在至少一个废物管系统，用于将试剂溶液从小瓶中的小瓶中排出。保持多个小瓶的盒相对于静止的阀组和废物管系统旋转。响应于分配各种试剂溶液所需的顺序并且冲洗合适的小瓶以便在每个小瓶中形成所需的聚合物链，控制器旋转墨盒并操作阀组和废液管系统。

85. 发明授权

US06218193B1 Precision small volume fluid processing apparatus and method 失效
标题翻译：精密小体积流体处理设备及方法
公开(公告)号：US06218193B1
公开(公告)日：2001-04-17
申请号：US09107242
申请日：1998-06-30
申请人： Ray Kraft , Neal A. Friedman , Deirdre Meldrum , Ronald Seubert
发明人： Ray Kraft , Neal A. Friedman , Deirdre Meldrum , Ronald Seubert
IPC分类号： B01L302
CPC分类号： B01F13/0071 , B01F11/0071 , B01F13/0059 , B01F13/0084 , B01F15/0201 , B01F15/0232 , B01F2215/0409 , B01L3/02 , B01L3/022 , B01L3/0262 , B01L3/0268 , B01L3/06 , B01L9/065 , B01L2200/0605 , B01L2200/143 , B01L2300/0838 , B01L2300/18 , B01L2400/0478 , G01N2035/00237 , Y10T436/118339 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： A high precision, small volume fluid processing system employs open ended capillary tubes to meter, aliquot and mix small volumes of sample fluid and reagents. The system has an automatic mechanism for moving the capillary tubes as well as automated sub-systems for incubating and mixing fluids within the capillary tubes.
摘要翻译：高精度，小体积的流体处理系统采用开放式毛细管来计量，等分和混合少量的样品液和试剂。该系统具有用于移动毛细管的自动机构以及用于在毛细管内孵育和混合流体的自动子系统。

86. 发明授权

US06200819B1 Method and apparatus for providing diluent gas to exhaust emission analyzer 失效
标题翻译：用于向废气排放分析仪提供稀释气体的方法和装置
公开(公告)号：US06200819B1
公开(公告)日：2001-03-13
申请号：US08606242
申请日：1996-02-23
申请人： R. Neal Harvey , Allen F. Dageforde
发明人： R. Neal Harvey , Allen F. Dageforde
IPC分类号： G01N114
CPC分类号： G01N1/2252 , G01N33/0006 , G01N33/0018 , G01N2001/2264 , G01N2001/244 , Y10T436/205831 , Y10T436/25625 , Y10T436/25875
摘要： An apparatus adapted for analyzing exhaust emissions by using a small fraction of a continuously-extracted exhaust sample combined with a pollutant-free diluent through a system of critical flow orifices at a predetermined and precisely controlled flow ratio. A small quantity of gas is extracted from the diluted exhaust gas available which is diluted with the contaminant-free air or nitrogen to produce a mixture having a dew point below ambient air temperature and satisfying the flow requirements of the analysis system. The diluted sample may then be analyzed to obtain the total mass of pollutants through identification of the instantaneous exhaust concentration rate and the exhaust mass flow rate or through identification of the concentration of pollutants collected in a sample bag and the total exhaust volume.
摘要翻译：一种适于通过使用一小部分连续抽取的排气样品与无污染物的稀释剂组合的分析废气排放物的装置，其通过临时流量孔系统以预定且精确控制的流量比。从可用的稀释废气中提取少量气体，用无污染的空气或氮气稀释，以产生露点低于环境空气温度并满足分析系统的流量要求的混合物。然后可以分析稀释的样品，以通过识别瞬时排放浓度率和废气质量流量或通过识别样品袋中收集的污染物浓度和总排气量来获得污染物的总质量。

87. 发明授权

US6103196A Flow detection apparatus and method 失效
标题翻译：流量检测装置及方法
公开(公告)号：US6103196A
公开(公告)日：2000-08-15
申请号：US53195
申请日：1998-04-01
申请人： Zia Yassinzadeh , Paul J. Lingane
发明人： Zia Yassinzadeh , Paul J. Lingane
IPC分类号： G01N11/04 , G01N33/49 , G01N35/00 , G01N33/86 , G01N21/03
CPC分类号： G01N11/04 , G01N33/4905 , G01N2035/00425 , Y10T436/117497 , Y10T436/25 , Y10T436/25625
摘要： Fluid sample tester assembly (12) comprises a cartridge (6) having a pressure chamber (22) and entrance port (20) connected by a passageway (24). An analyte reagent (36) is positioned along the fluid passageway so that when a liquid sample (28) is drawn through the entrance port into the passageway, the analyte reagent mixes with the sample. The sample is preferably drawn into the cartridge by temporarily reducing the volume of the pressure chamber, applying the sample to the entrance port and then returning the pressure chamber to its initial volume; this can also be done by heating the chamber, contacting the sample and then cooling the chamber. The end of the sample defines a boundary surface (30) along the fluid passageway. Positive and negative pressure is applied to the sample to cause the boundary surface to oscillate within the passageway. The position of the boundary surface is continuously monitored so that continuous boundary position data is obtained and is analyzed to obtain a flow-related characteristic, typically speed of coagulation, of the sample.
摘要翻译：流体样品测试器组件（12）包括具有通过通道（24）连接的压力室（22）和入口（20）的盒（6）。分析物试剂（36）沿着流体通道定位，使得当液体样品（28）通过入口进入通道时，分析物试剂与样品混合。样品优选通过临时减小压力室的体积，将样品施加到入口端口，然后使压力室返回到其初始体积而被吸入筒中; 这也可以通过加热室，接触样品然后冷却室完成。样品的末端限定沿着流体通道的边界表面（30）。对样品施加正压和负压，使得边界面在通道内振荡。连续监测边界面的位置，以获得连续的边界位置数据并进行分析，以获得样品的流动相关特性，即凝固速度。

88. 发明授权

US6086824A Automatic sample testing machine 有权
标题翻译：自动样品检测机
公开(公告)号：US6086824A
公开(公告)日：2000-07-11
申请号：US327110
申请日：1999-06-07
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

89. 发明授权

US6033914A Electrochemical analytical cartridge 失效
标题翻译：电化学分析盒
公开(公告)号：US6033914A
公开(公告)日：2000-03-07
申请号：US275856
申请日：1999-03-24
申请人： Douglas E. Boyd , Jan B. Yates , Ronald K. Coleman
发明人： Douglas E. Boyd , Jan B. Yates , Ronald K. Coleman
IPC分类号： G01N1/36 , B01L3/00 , G01N21/07 , G01N27/07 , G01N27/28 , G01N27/416 , G01N33/487 , G01N1/38 , G01N35/10
CPC分类号： G01N21/07 , B01L3/502 , B01L3/5027 , G01N27/416 , G01N33/48707 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： An electro-analytical cartridge adapted for use in analyzing fluids. The cartridge includes an electrochemical device that measures ionic activity using ion-specific electrodes. The cartridge further includes a plumbing system composed of the electrochemical device and various wells or chambers which are interconnected by passageways. After introduction into the cartridge, liquid samples are measured out and transported to the electrochemical device utilizing a sequential application of centrifugal force followed by pressurization of the system. Reference fluid is transported from a reference fluid well or reservoir to the electrochemical device for use in measuring ionic activity. The cartridge may be used to measure the ionic activity of a wide variety of ions in fluids including bodily fluids.
摘要翻译：适用于分析流体的电解分析筒。该盒包括使用离子特异性电极测量离子活性的电化学装置。墨盒还包括由电化学装置和通过通道互连的各种井或室组成的管道系统。在引入到盒中之后，利用离心力的顺序施加随后对系统进行加压，测量出液体样品并将其输送到电化学装置。参考流体从参考流体井或储存器输送到用于测量离子活性的电化学装置。筒可以用于测量包括体液在内的流体中的各种离子的离子活性。

90. 发明授权

US5965090A Vacuum loading of test sample cards in an analytical instrument 失效
标题翻译：测试样品卡在分析仪器中的真空加载
公开(公告)号：US5965090A
公开(公告)日：1999-10-12
申请号：US6623
申请日：1998-01-13
申请人： Mark Joseph Fanning , Clifford W. Karl , Donald Meyer , William Ernest Seaton , Paul Springer , Craig Drager
发明人： Mark Joseph Fanning , Clifford W. Karl , Donald Meyer , William Ernest Seaton , Paul Springer , Craig Drager
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

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