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1. 发明授权

US6086824A Automatic sample testing machine 有权
标题翻译：自动样品检测机
公开(公告)号：US6086824A
公开(公告)日：2000-07-11
申请号：US327110
申请日：1999-06-07
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

2. 发明授权

US5856193A Automatic sample testing method 失效
标题翻译：自动样品测试方法
公开(公告)号：US5856193A
公开(公告)日：1999-01-05
申请号：US838983
申请日：1997-04-23
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

3. 发明授权

US5762873A Automatic sample testing machine 失效
公开(公告)号：US5762873A
公开(公告)日：1998-06-09
申请号：US604672
申请日：1996-02-21
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.

4. 发明授权

US5853667A Test sample positioning system 失效
标题翻译：测试样品定位系统
公开(公告)号：US5853667A
公开(公告)日：1998-12-29
申请号：US934934
申请日：1997-09-22
申请人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
发明人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
IPC分类号： G01N21/13 , G01N35/00 , G01N35/04
CPC分类号： G01N21/13 , G01N35/00029 , G01N35/04 , G01N2035/00039 , G01N2035/00148 , G01N2035/0415 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： A positioning system for a sample testing machine incudes a base pan and a set of independent drive systems for sliding a sample tray across the base pan. Each of the drive systems incudes a paddle that engages a side of the sample tray. The paddle is slideably mounted to a shaft with a collar that slides over the shaft. A motor and drive belt is provided to move the collar along the shaft, causing the paddle to engage the side of the sample tray and slide the sample tray across the base pan. Track sections are provided in the base pan to prevent the sample tray from rotating as the paddle slides the sample tray across the base pan.
摘要翻译：用于样品测试机的定位系统包括底盘和一组独立的驱动系统，用于将样品盘滑过底盘。每个驱动系统包括一个接合样品盘侧面的桨叶。桨叶可滑动地安装到轴上，其轴环在轴上滑动。提供电动机和传动带以沿着轴移动套环，使得桨接合样品托盘的侧面，并将样品托盘滑过底盘。轨道部分设置在底盘中，以防止样品盘旋转，因为桨将样品盘滑过底盘。

5. 发明授权

US5762874A Drive system for test sample positioning system 失效
标题翻译：驱动系统用于测试样品定位系统
公开(公告)号：US5762874A
公开(公告)日：1998-06-09
申请号：US818632
申请日：1997-03-14
申请人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
发明人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
IPC分类号： G01N21/13 , G01N35/00 , G01N35/04
CPC分类号： G01N21/13 , G01N35/00029 , G01N35/04 , G01N2035/00039 , G01N2035/00148 , G01N2035/0415 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： A positioning system for a sample testing machine includes a base pan and a set of independent drive systems for sliding a sample tray across the base pan. Each of the drive systems includes a paddle that engages a side of the sample tray. The paddle is slideably mounted to a shaft with a collar that slides over the shaft. A motor and drive belt is provided to move the collar along the shaft, causing the paddle to engage the side of the sample tray and slide the sample tray across the base pan. Track sections are provided in the base pan to prevent the sample tray from rotating as the paddle slides the sample tray across the base pan.
摘要翻译：用于样品测试机的定位系统包括底盘和一组独立的驱动系统，用于将样品盘滑过底盘。每个驱动系统包括接合样品托盘一侧的桨叶。桨叶可滑动地安装到轴上，其轴环在轴上滑动。提供电动机和传动带以沿着轴移动套环，使得桨接合样品托盘的侧面，并将样品托盘滑过底盘。轨道部分设置在底盘中，以防止样品盘旋转，因为桨将样品盘滑过底盘。

6. 发明授权

US5798084A Test sample positioning system 失效
标题翻译：测试样品定位系统
公开(公告)号：US5798084A
公开(公告)日：1998-08-25
申请号：US818507
申请日：1997-03-14
申请人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral
发明人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral
IPC分类号： G01N21/13 , G01N35/00 , G01N35/04
CPC分类号： G01N21/13 , G01N35/00029 , G01N35/04 , G01N2035/00039 , G01N2035/00148 , G01N2035/0415 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： A positioning system for a sample testing machine includes a base pan and a set of independent drive systems for sliding a sample tray across the base pan. Each of the drive systems includes a paddle that engages a side of the sample tray. The paddle is slideably mounted to a shaft with a collar that slides over the shaft. A motor and drive belt is provided to move the collar along the shaft, causing the paddle to engage the side of the sample tray and slide the sample tray across the base pan. Track sections are provided in the base pan to prevent the sample tray from rotating as the paddle slides the sample tray across the base pan.
摘要翻译：用于样品测试机的定位系统包括底盘和一组独立的驱动系统，用于将样品盘滑过底盘。每个驱动系统包括接合样品托盘一侧的桨叶。桨叶可滑动地安装到轴上，其轴环在轴上滑动。提供电动机和传动带以沿着轴移动套环，使得桨接合样品托盘的侧面，并将样品托盘滑过底盘。轨道部分设置在底盘中，以防止样品盘旋转，因为桨将样品盘滑过底盘。

7. 发明授权

US5736102A Test sample positioning system 失效
公开(公告)号：US5736102A
公开(公告)日：1998-04-07
申请号：US604725
申请日：1996-02-21
申请人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
发明人： William Ernest Seaton , Mark Joseph Fanning , Craig Drager , Ron Robinson , Roger James Morris , Jean-Pierre Bernard Gayral , JoAnne T. Gerst
IPC分类号： G01N21/13 , G01N35/00 , G01N35/04
CPC分类号： G01N21/13 , G01N35/00029 , G01N35/04 , G01N2035/00039 , G01N2035/00148 , G01N2035/0415 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： A positioning system for a sample testing machine includes a base pan and a set of independent drive systems for sliding a sample tray across the base pan. Each of the drive systems includes a paddle that engages a side of the sample tray. The paddle is slideably mounted to a shaft with a collar that slides over the shaft. A motor and drive belt is provided to move the collar along the shaft, causing the paddle to engage the side of the sample tray and slide the sample tray across the base pan. Track sections are provided in the base pan to prevent the sample tray from rotating as the paddle slides the sample tray across the base pan.

8. 发明授权

US5888455A Optical reader and sample card transport stations for biological sample testing machine 失效
标题翻译：光学读卡器和样品卡运输站用于生物样品测试机
公开(公告)号：US5888455A
公开(公告)日：1999-03-30
申请号：US886090
申请日：1997-07-02
申请人： William Ernest Seaton , Mark Joseph Fanning , Ron Robinson , David B. Shine , Craig Drager , Richard James Ryall , Erik William Anthon
发明人： William Ernest Seaton , Mark Joseph Fanning , Ron Robinson , David B. Shine , Craig Drager , Richard James Ryall , Erik William Anthon
IPC分类号： G01N21/27 , G01N21/64 , G01N35/00 , G01N35/02
CPC分类号： G01N21/6452 , G01N21/276 , G01N21/6428 , G01N35/00029 , G01N2035/00049 , G01N2035/00099 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： A sample card transport station moves a test sample card from an incubation station for the card to a transmittance and fluorescence optical station in a sample testing machine. The sample card transport station has a drive belt and an associated stepper motor. The belt supports the card from one side of the card. A ledge having a card slot is disposed above the belt. The card is snugly received within the card slot, and supported from below by the drive belt and rollers for the belt. When the motor turns the belt, the belt grips the card and slides the card along the slot to the optical stations, without any slippage between the belt and the card. This construction provides for precise control over the movement of the card.The fluorescence station has a linear flash lamp that illuminates a column of the wells of the cards simultaneously. A reference detector and dichromatic beam splitter design is used to insure that the fluorescence measurements are independent of lamp output changes over time. A solid reference is mounted to an optical shuttle and moved into the optical path to calibrate the fluorescence photodiode detectors.
摘要翻译：样本卡运送站将测试样本卡从卡的孵化站移动到样品测试机中的透射率和荧光光学站。样品卡传送站具有传动带和相关的步进电机。皮带从卡的一侧支持卡。具有卡槽的凸缘设置在带上方。卡片紧贴在卡槽内，并由传动带和传送带的滚筒从下方支撑。当电机转动皮带时，皮带夹住卡片，将卡片沿着插槽滑动到光学工作站，皮带和卡片之间没有任何滑动。这种结构提供了对卡的移动的精确控制。荧光站具有线性闪光灯，同时照亮卡的孔的列。使用参考检测器和二色分束器设计来确保荧光测量与时间上的灯输出变化无关。将固体参考安装到光梭上并移动到光路中以校准荧光光电二极管检测器。

9. 发明授权

US5869006A Identification system for test sample cards in an analytical instrument 失效
标题翻译：分析仪器中测试样本卡的识别系统
公开(公告)号：US5869006A
公开(公告)日：1999-02-09
申请号：US6313
申请日：1998-01-13
申请人： Mark Joseph Fanning , Roger James Morris , Ron Robinson , William Ernest Seaton , Daniel Ray Williams , Craig Drager
发明人： Mark Joseph Fanning , Roger James Morris , Ron Robinson , William Ernest Seaton , Daniel Ray Williams , Craig Drager
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/02 , G06F17/00
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

10. 发明授权

US5853666A Optical reader and sample card transport stations for biological sample testing machine 失效
公开(公告)号：US5853666A
公开(公告)日：1998-12-29
申请号：US798093
申请日：1997-02-12
申请人： William Ernest Seaton , Mark Joseph Fanning , David B. Shine , Craig Drager
发明人： William Ernest Seaton , Mark Joseph Fanning , David B. Shine , Craig Drager
IPC分类号： G01N35/00 , G01N35/02
CPC分类号： G01N35/00029 , G01N2035/00039 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10S435/808 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： A sample card transport station moves a test sample card from an incubation station for the card to a transmittance and fluorescence optical station in a sample testing machine. The sample card transport station has a drive belt and an associated stepper motor. The belt supports the card from one side of the card. A ledge having a card slot is disposed above the belt. The card is snugly received within the card slot, and supported from below by the drive belt and rollers for the belt. When the motor turns the belt, the belt grips the card and slides the card along the slot to the optical stations, without any slippage between the belt and the card. This construction provides for precise control over the movement of the card. The fluorescence station has a linear flash lamp that illuminates a column of the wells of the cards simultaneously. A reference detector and dichromatic beam splitter design is used to insure that the fluorescence measurements are independent of lamp output changes over time. A solid reference is mounted to an optical shuttle and moved into the optical path to calibrate the fluorescence photodiode detectors.

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