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1. 发明授权

US06827904B2 Liquid dispensing apparatus and an automatic analyzing apparatus using the same 失效
标题翻译：液体分配装置和使用该装置的自动分析装置
公开(公告)号：US06827904B2
公开(公告)日：2004-12-07
申请号：US09820684
申请日：2001-03-30
申请人： Nobuhiro Kitagawa
发明人： Nobuhiro Kitagawa
IPC分类号： B01L302
CPC分类号： B65D21/0204 , G01N35/00 , G01N35/1002 , G01N2035/0405
摘要： A liquid dispensing apparatus, includes a container for containing a liquid, a container setting part for setting the container, a dispensing mechanism part having a pipette for drawing and dispensing the liquid, a raising/lowering part for raising and lowering the pipette, a base for holding the raising/lowering part and provided with a projecting part, and a base driving part for moving the base. A lid capable of being opened/closed with an opening/closing pivot part is coupled to the container, and the lid is provided with a hook part projecting upward from the lid for engaging with the projecting part, which opens the lid by abutting against the hook part and moving the hook part toward the pivot part side of the container as the base moves relatively to the container and retains the state of the lid opened.
摘要翻译：一种液体分配装置，包括用于容纳液体的容器，用于设置容器的容器设置部分，具有用于抽取和分配液体的移液管的分配机构部分，用于升高和降低移液管的升降部分，基部用于保持升降部分并且设置有突出部分，以及用于移动基座的基部驱动部分。能够用打开/关闭枢转部分打开/关闭的盖子联接到容器，并且盖子设置有从盖子向上突出的钩部分，用于与突出部分接合，该突出部分通过抵靠钩部分，并且当基座相对于容器移动时将钩部朝向容器的枢转部分侧移动并保持盖打开的状态。

2. 发明授权

US06814938B2 Non-planar microfluidic devices and methods for their manufacture 失效
标题翻译：非平面微流体装置及其制造方法
公开(公告)号：US06814938B2
公开(公告)日：2004-11-09
申请号：US09864610
申请日：2001-05-23
申请人： Christoph D. Karp , Stephen D. O'Connor , Vincent K. Gustafson
发明人： Christoph D. Karp , Stephen D. O'Connor , Vincent K. Gustafson
IPC分类号： B01L302
CPC分类号： B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： Non-planar microfluidic devices and methods for transferring fluids between vessels and microfluidic devices are provided. The devices may be contoured to physically contact non-planar vessels, such as pipes, tubes, vials, or syringes to establish fluid communication between a vessel and a microfluidic device. Devices according to the invention may be constructed from flexible, rigid, or combinations of flexible and rigid materials. In certain embodiments, microfluidic devices are composed of sandwiched stencils, and self-adhesive tapes may be used for one or more layers. A microfluidic device may be removably attached to a vessel with a non-permanent adhesive or adhesive layer. Continuously wrapped microfluidic devices fashioned from a single layer, in addition to rewindable microfluidic devices constructed from multiple layers, are provided. A multi-plunger syringe permits a microfluidic device or other reservoir coupled to the vessel to be filled on the draw stroke of the syringe plunger.

3. 发明授权

US06808935B2 System and method for dispensing solution to a multi-well container 失效
标题翻译：将溶液分配到多孔容器的系统和方法
公开(公告)号：US06808935B2
公开(公告)日：2004-10-26
申请号：US10058380
申请日：2002-01-28
申请人： Robert Levin , Rob Neeper , John Bridwell
发明人： Robert Levin , Rob Neeper , John Bridwell
IPC分类号： B01L302
CPC分类号： G01N35/028 , Y10T436/2575
摘要： An automated sample-on-solid-support processing system includes a treatment solution supply subsystem which feeds solvent to a dispenser to dispense a measured amount of treatment solution to each well of a multi-well plate. The dispenser measures the solution within a fill container having a plurality of reservoir wells corresponding to the number of wells in the multi-well plate. The fill container is contained within a reservoir chamber that is filled with an excess of solution. Each reservoir well is surrounded by a plurality of bores which drains excess solution from the top of the fill container so that a precise amount of solution is left in the reservoir wells when solution is drained out of the reservoir chamber. Gas pressure is introduced into the reservoir chamber to force the solution out of the reservoir well through a bundle of tubes, with one tube per well, and into the wells of the multi-well plate.
摘要翻译：自动化固体样本固体支持处理系统包括处理溶液供应子系统，其将溶剂供给到分配器以将测量量的处理溶液分配给多孔板的每个孔。分配器测量在具有对应于多孔板中的孔的数量的多个储层孔的填充容器内的溶液。填充容器容纳在填充有过量溶液的储存室中。每个储存井被多个孔围绕，从而从填充容器的顶部排出多余的溶液，使得当溶液从储存室排出时，储存器孔中留有精确量的溶液。将气体压力引入储存室以迫使溶液从储存器中穿过一束管，每个孔具有一个管，并进入多孔板的孔中。

4. 发明授权

US06759012B2 Pin holder for a microarraying apparatus 有权
标题翻译：微阵列装置的针架
公开(公告)号：US06759012B2
公开(公告)日：2004-07-06
申请号：US09985555
申请日：2001-11-05
申请人： James Keith Haslam , John Richard Andrews
发明人： James Keith Haslam , John Richard Andrews
IPC分类号： B01L302
CPC分类号： G01N35/10 , B01J19/0046 , B01J2219/00274 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00691 , B01L3/0244 , C40B60/14 , G01N35/1074 , G01N2035/1037 , Y10T436/25 , Y10T436/2575
摘要： A pin holder for a microarraying apparatus comprising at least one group of bodies of circular cross-section packed together to form a network of pathways in gaps between the bodies; and an array of pins slidably arranged in the pathways. The pins are held in parallel to each other automatically as a result of the self organized packing of the circular cross-section bodies, which may be spheres, for example ball bearings, or cylindrical, for example needle roller bearings. The pin holder provides for very accurate parallel alignment of the pins, low pin friction, as well as low cost and complexity of manufacture.
摘要翻译：一种用于微阵列装置的针座，包括至少一组包装在一起的圆形横截面的主体，以在所述主体之间的间隙中形成路径网络; 以及可滑动地布置在路径中的销的阵列。由于可以是球体的圆形横截面体（例如，球轴承）或圆柱形的滚针轴承（例如滚针轴承）的自组织的填充，自动地将销彼此平行地保持。引脚支架提供了非常精确的引脚平行对准，低引脚摩擦，以及低成本和复杂的制造。

5. 发明授权

US06758106B2 Liquid proportioning method and apparatus for implementing the method 有权
标题翻译：液体配比方法及其实施方法
公开(公告)号：US06758106B2
公开(公告)日：2004-07-06
申请号：US10199605
申请日：2002-07-18
申请人： Jorg Richter , Boris Von Beichmann , Gerhard Salje
发明人： Jorg Richter , Boris Von Beichmann , Gerhard Salje
IPC分类号： B01L302
CPC分类号： G01F11/28 , B01L3/021 , G01F11/029
摘要： A liquid proportioning method using a chamber for a gas and a reception volume connectable thereto for a liquid with an aperture to the environment, wherein a desired volume is predetermined for the liquid to be taken up by the reception volume, a chamber negative pressure is determined which has to exist in the chamber to cause the desired liquid volume to be taken up in the reception volume after the aperture is dipped into the liquid and the chamber is connected to the reception volume, the chamber negative pressure is produced in the chamber, the reception volume dips its aperture into the liquid, and the chamber is connected to the reception volume and the desired volume of the liquid is taken up in the reception volume.
摘要翻译：一种液体配比方法，使用气体室和可连接到其上的接收体积用于具有环境的孔的液体，其中对于被接收体积吸收的液体预定的期望体积，确定室负压其必须存在于腔室中，以便在孔被浸入液体中并且室连接到接收体积之后，在接收体积中吸收所需的液体体积，在室中产生室负压，接收体积将其孔径浸入液体中，并且室连接到接收体积，并且所需体积的液体被吸收在接收体积中。

6. 发明授权

US06716396B1 Penetrable cap 有权
标题翻译：可穿透帽
公开(公告)号：US06716396B1
公开(公告)日：2004-04-06
申请号：US09704210
申请日：2000-11-01
申请人： Bruce W. Anderson , Nick M. Carter , Mordi I. Iheme , Shirley J. Johnson , Daniel L. Kacian , James P. Light , Gus G. Tseo
发明人： Bruce W. Anderson , Nick M. Carter , Mordi I. Iheme , Shirley J. Johnson , Daniel L. Kacian , James P. Light , Gus G. Tseo
IPC分类号： B01L302
CPC分类号： G01N35/1079 , B01L3/0275 , B01L3/5029 , B01L3/50825 , B01L2200/026 , B01L2200/0684 , B01L2200/141 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/069 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention relates to a cap which can form an essentially leak-proof seal with a vessel capable of receiving fluid specimens for clinical analysis and diagnosis. To minimize potentially contaminating contact between the fluid specimen and humans or the environment, the present invention features a cap which is penetrable by a plastic pipette tip or other fluid transfer device, and may include a plurality of striations which were discovered to further improve penetrability of the cap. In this way, substances can be dispensed into or withdrawn from the vessel without having to physically separate the cap from the vessel. Also featured are fluid transfer devices and caps having surface ribs and/or grooves which aid in creating passageways for venting displaced air from a penetrated collection device.
摘要翻译：本发明涉及一种能够与能够接收用于临床分析和诊断的流体标本的容器形成基本上防漏密封的盖。为了最小化流体样品与人类或环境之间的潜在的污染接触，本发明的特征在于一种可由塑料移液管尖端或其它流体转移装置穿透的帽，并且可以包括多个条纹，这些条纹被发现以进一步提高流体样本的渗透性这顶帽子。以这种方式，可以将物质分配到容器中或从容器中取出，而不必将容器从容器物理上分开。还具有流体输送装置和帽，其具有表面肋和/或凹槽，其有助于形成通道，用于从穿透的收集装置排出置换的空气。

7. 发明授权

US06709870B2 Sample extracting device and adding device 失效
标题翻译：样品提取装置和添加装置
公开(公告)号：US06709870B2
公开(公告)日：2004-03-23
申请号：US09739327
申请日：2000-12-19
申请人： Motoo Suzuki , Takashi Ishikawa , Hirokazu Saito
发明人： Motoo Suzuki , Takashi Ishikawa , Hirokazu Saito
IPC分类号： B01L302
CPC分类号： G01N1/14 , G01N35/1004 , Y10T436/114998 , Y10T436/2575
摘要： A sample tube of a sampling valve is moved up and down by a cylinder. When the sample tube is moved downward, a sample inlet opposes a stored sample, and the sample can be extracted. When the sample tube is moved upward, the sample inlet opposes a cleaning liquid path. Thus, cleaning liquid is fed into the cleaning liquid path from a cleaning liquid supply port of a cleaning pipe. The cleaning liquid flows within the sample tube from the sample inlet, and flows out from a sample discharge port. Thus, an entire interior of the sample tube can be cleaned. In a sample extracting device using the sampling valve, a state in which no air or impurities are mixed in the sample can always be maintained, such that stable extraction can be carried out.
摘要翻译：采样阀的样品管由气缸上下移动。当样品管向下移动时，样品入口与存储的样品相对，并且可以提取样品。当样品管向上移动时，样品入口与清洁液体路径相反。因此，清洗液从清洗管的清洗液供给口送入清洗液路径。清洗液从样品入口在样品管内流动，从样品排出口流出。因此，可以清洁样品管的整个内部。在使用采样阀的样品提取装置中，可以始终保持在样品中不混合空气或杂质的状态，从而可以进行稳定的提取。

8. 发明授权

US06627160B2 Multiple channel pipetting device 有权
标题翻译：多通道移液装置
公开(公告)号：US06627160B2
公开(公告)日：2003-09-30
申请号：US09811820
申请日：2001-03-20
申请人： Jurgen Wanner
发明人： Jurgen Wanner
IPC分类号： B01L302
CPC分类号： B01L3/0231 , G01N35/1065
摘要： A multiple channel pipetting device and pipette shaft, in which each pipette shaft has a circumferential seal receptacle inside, at its upper end in which the circumferential plunger seal is positioned and in which the circumferential plunger seal, at least in the case of a pulled back pipette plunger, definitely remains in the seal receptacle when the pipetted shaft is removed from the shaft carrier.
摘要翻译：多通道移液装置和移液管轴，其中每个移液管轴在其上端具有圆周密封容器，其中圆周柱塞密封件定位在其上端，并且周向柱塞密封件至少在拉回的情况下移液管柱塞，当吸管轴从轴承架上取下时，绝对保留在密封容器中。

9. 发明授权

US06589791B1 State-variable control system 失效
标题翻译：状态变量控制系统
公开(公告)号：US06589791B1
公开(公告)日：2003-07-08
申请号：US09575395
申请日：2000-05-22
申请人： Edward V. LaBudde , Paul J. Queeney, Jr.
发明人： Edward V. LaBudde , Paul J. Queeney, Jr.
IPC分类号： B01L302
CPC分类号： B01L3/0268 , B01L3/0265 , B01L2200/146 , B01L2400/0478 , B01L2400/0487 , B01L2400/0633 , G01N35/1016 , Y10T137/0352 , Y10T436/115831 , Y10T436/12 , Y10T436/2575
摘要： The invention relates to a state-variable feedback control system for monitoring and optimally controlling the operation of a microfluidic aspirate dispense-system. A steady state operating pressure is determined from the fluid, flow and/or operational characteristics of the system. Measurements from one or more pressure sensors are part of the control strategy to derive information for active feedback control and/or to achieve the desired operating pressure. Advantageously, the control system adds to the versatility of the aspirate-dispense system, for example, by permitting rapid dispensing of drops of different size. The control system also desirably facilitates efficient, repeatable and accurate performance and reduces wastage of valuable reagents or fluid.
摘要翻译：本发明涉及一种状态变量反馈控制系统，用于监测和最佳地控制微流体吸出物分配系统的操作。稳态工作压力由系统的流体，流量和/或操作特性确定。来自一个或多个压力传感器的测量是用于获得用于主动反馈控制和/或实现期望的操作压力的信息的控制策略的一部分。有利地，控制系统增加了吸气分配系统的通用性，例如通过允许快速分配不同尺寸的液滴。控制系统还期望地促进了有效的，可重复的和准确的性能，并且减少了有价值的试剂或流体的浪费。

10. 发明授权

US06551558B1 Method and device for liquid transfer with an analysis apparatus 失效
标题翻译：用分析仪器进行液体转移的方法和装置
公开(公告)号：US06551558B1
公开(公告)日：2003-04-22
申请号：US09559191
申请日：2000-04-27
申请人： Karl-Heinz Mann , Stephan Sattler
发明人： Karl-Heinz Mann , Stephan Sattler
IPC分类号： B01L302
CPC分类号： G01N35/1016 , G01F23/24 , G01F23/245 , G01F23/263 , G01N2035/1018 , G01N2035/1025
摘要： The invention concerns a liquid transfer device for an analysis apparatus with a liquid transfer cannula (5) and a capacitive liquid level detector to detect the immersion of the liquid transfer cannula (5) in an analysis liquid contained in a vessel. To reliably check if the liquid transfer cannula (5) is submerged in the analysis liquid or immersed for example in foam it is proposed additionally that resistance is measured by a measurement section (16) in the liquid transfer cannula (5).
摘要翻译：本发明涉及一种用于具有液体转移插管（5）和电容液位检测器的分析装置的液体转移装置，用于检测液体转移插管（5）浸入容纳在容器中的分析液体中。为了可靠地检查液体转移插管（5）是否浸没在分析液体中或浸没在例如泡沫中，另外还提出了通过液体输送套管（5）中的测量部分（16）测量电阻。

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