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1. 发明授权

US5965090A Vacuum loading of test sample cards in an analytical instrument 失效
标题翻译：测试样品卡在分析仪器中的真空加载
公开(公告)号：US5965090A
公开(公告)日：1999-10-12
申请号：US6623
申请日：1998-01-13
申请人： Mark Joseph Fanning , Clifford W. Karl , Donald Meyer , William Ernest Seaton , Paul Springer , Craig Drager
发明人： Mark Joseph Fanning , Clifford W. Karl , Donald Meyer , William Ernest Seaton , Paul Springer , Craig Drager
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

2. 发明授权

US5998201A Incubation station for test sample cards 失效
公开(公告)号：US5998201A
公开(公告)日：1999-12-07
申请号：US905374
申请日：1997-08-04
申请人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
发明人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
摘要： An incubation station has a carousel for receiving a plurality of test sample cards. An even temperature and air flow distribution inside the carousel and incubation of the cards over time at the proper temperature was found to be critically dependent upon air flow characteristics within the incubation station. To optimize air flow, the carousel was given an open rear side that is exposed to an air distribution table having a cover plate placed adjacent to the rear surface of the carousel. The cover plate has a plurality of elongate slots positioned in a symmetrical ring-shaped pattern in registry with the carousel. The elongate slots are positioned at an angle relative to the slots in the carousel such that each carousel slot receives air from more than one slot. An extra fan was also added to the system to increase the flow of air into the air table. Scallop features on the carousel walls also promote even distribution of air flow over the cards. The carousel may be divided into a plurality of carousel segments to increase ease of removal and insertion of the carousel into the incubation station and manufacturability of the carousel.

3. 发明授权

US5674454A Stacking disposal system for test sample cards or other similarly shaped objects 失效
标题翻译：用于测试样品卡或其他类似形状的物体的堆放处理系统
公开(公告)号：US5674454A
公开(公告)日：1997-10-07
申请号：US604475
申请日：1996-02-21
申请人： Clifford W. Karl , Kent Smith , Arthur Rousmaniere , David Porat , Thomas Burchard , Gregg Flender
发明人： Clifford W. Karl , Kent Smith , Arthur Rousmaniere , David Porat , Thomas Burchard , Gregg Flender
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/00029 , Y10S206/817 , Y10T436/11 , Y10T436/112499 , Y10T436/114165
摘要： A disposal system for stacking card-like objects neatly in a magazine. The cards enter the disposal system via a card entrance slot. A push plate located adjacent the slot pushes the cards past a pair of resilient snap elements in the sides of the magazine. A pressure plate is located behind the snap elements and biases the cards that have been pushed over the snap elements forward towards the rear of the snap elements. The cards are maintained in a stacked condition between the snap elements and the pressure plate. When a card is inserted into the card slot, the push plate is operated to an extended position, in which it pushes the card past the snap elements against the cards stacked between the snap elements and the pressure plate. The push plate then retracts, so as to enable another card to enter into the card slot. The user of the machine removes the magazine from the machine when the need arises or when the magazine is fully loaded with cards.
摘要翻译：一种处理系统，用于将卡状物体整齐地堆放在杂志中。卡通过卡片入口插槽进入处理系统。位于狭槽附近的推板推动卡通过盒的侧面中的一对弹性卡扣元件。压板位于卡扣元件后面并且偏压已经被推到卡扣元件上的卡片朝向卡扣元件的后部。这些卡在卡扣元件和压力板之间保持堆叠状态。当卡插入卡槽中时，推板被操作到延伸位置，在该延伸位置，卡将卡通过卡扣元件抵靠堆叠在卡扣元件和压板之间的卡片。推板然后缩回，以使另一张卡进入卡槽。当需要时或当杂志完全装满卡时，机器的用户将机器从机器上移除。

4. 发明授权

US6156565A Incubation station for test sample cards 失效
标题翻译：孵化站用于测试样品卡
公开(公告)号：US6156565A
公开(公告)日：2000-12-05
申请号：US905374
申请日：1997-08-04
申请人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
发明人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
IPC分类号： C12M1/38 , B01L3/00 , C12M1/18 , G01N1/00 , G01N1/38 , G01N35/00 , C12M3/00
CPC分类号： G01N35/00029 , B01L3/50 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , G01N2035/00356 , G01N2035/0441 , G01N2035/0465 , Y10S435/809 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831
摘要： An incubation station has a carousel for receiving a plurality of test sample cards. An even temperature and air flow distribution inside the carousel and incubation of the cards over time at the proper temperature was found to be critically dependent upon air flow characteristics within the incubation station. To optimize air flow, the carousel was given an open rear side that is exposed to an air distribution table having a cover plate placed adjacent to the rear surface of the carousel. The cover plate has a plurality of elongate slots positioned in a symmetrical ring-shaped pattern in registry with the carousel. The elongate slots are positioned at an angle relative to the slots in the carousel such that each carousel slot receives air from more than one slot. An extra fan was also added to the system to increase the flow of air into the air table. Scallop features on the carousel walls also promote even distribution of air flow over the cards. The carousel may be divided into a plurality of carousel segments to increase ease of removal and insertion of the carousel into the incubation station and manufacturability of the carousel.
摘要翻译：孵化站具有用于接收多个测试样本卡的转盘。转盘内均匀的温度和空气流量分布以及随时间推移的适当温度下卡的温度和空气流分布被认为严重依赖于孵化站内的气流特性。为了优化空气流动，旋转盘被给予敞开的后侧，暴露于具有邻近转盘的后表面放置的盖板的空气分配台。盖板具有多个细长槽，其以对称的环形图案定位，与转盘对准。细长槽相对于转盘中的狭槽成角度定位，使得每个转盘槽从多于一个槽接收空气。还向系统添加了额外的风扇，以增加进入空气台的空气流。旋转木马墙上的扇贝特征也促进了气流在卡上的均匀分布。旋转木马可以分成多个转盘段，以增加转盘进入孵化站的移除和插入的便利性以及转盘的可制造性。

5. 发明授权

US5856193A Automatic sample testing method 失效
标题翻译：自动样品测试方法
公开(公告)号：US5856193A
公开(公告)日：1999-01-05
申请号：US838983
申请日：1997-04-23
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

6. 发明授权

US5762873A Automatic sample testing machine 失效
公开(公告)号：US5762873A
公开(公告)日：1998-06-09
申请号：US604672
申请日：1996-02-21
申请人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人： Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.

7. 发明授权

US6136270A Carousel for incubation station 有权
标题翻译：旋转木马为孵化站
公开(公告)号：US6136270A
公开(公告)日：2000-10-24
申请号：US300751
申请日：1999-04-26
申请人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
发明人： Gregory R. Maes , Dennis M. Connor , Brent D. Freiner , Clifford W. Karl , Ron Robinson , Raymond M. Shelton , Garry R. Tegeler , Michael James Justin
IPC分类号： C12M1/38 , B01L3/00 , C12M1/18 , G01N1/00 , G01N1/38 , G01N35/00
CPC分类号： G01N35/00029 , B01L3/50 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , G01N2035/00356 , G01N2035/0441 , G01N2035/0465 , Y10S435/809 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831
摘要： An incubation station has a carousel for receiving a plurality of test sample cards. An even temperature and air flow distribution inside the carousel and incubation of the cards over time at the proper temperature was found to be critically dependent upon air flow characteristics within the incubation station. To optimize air flow, the carousel was given an open rear side that is exposed to an air distribution table having a cover plate placed adjacent to the rear surface of the carousel. The cover plate has a plurality of elongate slots positioned in a symmetrical ring-shaped pattern in registry with the carousel. The elongate slots are positioned at an angle relative to the slots in the carousel such that each carousel slot receives air from more than one slot. An extra fan was also added to the system to increase the flow of air into the air table. Scallop features on the carousel walls also promote even distribution of air flow over the cards. The carousel may be divided into a plurality of carousel segments to increase ease of removal and insertion of the carousel into the incubation station and manufacturability of the carousel.
摘要翻译：孵化站具有用于接收多个测试样本卡的转盘。转盘内均匀的温度和空气流量分布以及随时间推移的适当温度下卡的温度和空气流分布被认为严重依赖于孵化站内的气流特性。为了优化空气流动，旋转盘被给予敞开的后侧，暴露于具有邻近转盘的后表面放置的盖板的空气分配台。盖板具有多个细长槽，其以对称的环形图案定位，与转盘对准。细长槽相对于转盘中的狭槽成角度定位，使得每个转盘槽从多于一个槽接收空气。还向系统添加了额外的风扇，以增加进入空气台的空气流。旋转木马墙上的扇贝特征也促进了气流在卡上的均匀分布。旋转木马可以分成多个转盘段，以增加转盘进入孵化站的移除和插入的便利性以及转盘的可制造性。

8. 发明授权

US5891396A Cutting and sealing station for test sample cards in an automated analytical system 失效
标题翻译：自动分析系统中测试样品卡的切割和封口站
公开(公告)号：US5891396A
公开(公告)日：1999-04-06
申请号：US6617
申请日：1998-01-13
申请人： Clifford W. Karl , Ron Robinson
发明人： Clifford W. Karl , Ron Robinson
IPC分类号： B01L3/00 , G01N1/38 , G01N35/00 , G01N35/02
CPC分类号： B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译：用于测试存储在测试卡中的样品的自动样品测试机。该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。移液站将流体从一个容器传送到另一个容器。设置真空站，其具有可在上位置和下位置之间相对于托盘移动的真空室。当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。真空发生器为腔室提供真空。当从室释放真空时，将流体样品从容器装载到卡中。测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

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