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71. 发明申请

US20060032816A1 Monolithic structures comprising polymeric fibers for chemical separation by liquid chromatography 有权
标题翻译：包含用于通过液相色谱进行化学分离的聚合物纤维的单片结构
公开(公告)号：US20060032816A1
公开(公告)日：2006-02-16
申请号：US10915735
申请日：2004-08-10
申请人： Richard Marcus , Rayman Stanelle
发明人： Richard Marcus , Rayman Stanelle
IPC分类号： B01D11/04
CPC分类号： B01D15/08 , B01D15/22 , B01J20/261 , B01J20/262 , B01J20/28014 , B01J20/28023 , B01J20/28042 , B01J20/28095 , B01J20/285 , B01J2220/54 , B01J2220/62 , B01J2220/82 , G01N30/6043 , G01N30/6078 , G01N30/6091 , G01N2030/528
摘要： Monolithic cartridges including a plurality of nominally aligned polymer fibers can be used as stationary phase materials for liquid chromatography separations. Bundles of fibers are packed together so as to form capillary channels between the fibers. Different polymer compositions permit the “chemical tuning” of the separation process. The fibers can be physically or chemically bonded at spaced locations throughout the cartridge or can be packed together under pressure by use of an encasing wrap to form the capillary channels. Use of fibers allows a wide range of liquid flow rates with very low backpressures. Applications in HPLC, cap-LC, prep-scale separations, analytical separations, waste remediation/immobilization, extraction of selected organic molecules/ions from solution, purification of liquid streams (process waste, drinking water, pure solvents), selective extraction of cell matter and bacteria from growth media, and immobilization of cell matter and bacteria are envisioned.
摘要翻译：包括多个名义上排列的聚合物纤维的单片墨盒可用作液相色谱分离的固定相材料。纤维束被包装在一起，以在纤维之间形成毛细通道。不同的聚合物组合物允许分离过程的“化学调节”。纤维可以在整个药筒的间隔位置物理地或化学地结合，或者可以通过使用包裹包装在压力下包装在一起以形成毛细通道。纤维的使用允许具有非常低的背压的宽范围的液体流速。应用于HPLC，cap-LC，预分离分离，分析分离，废物修复/固定，从溶液中萃取选定的有机分子/离子，液体流净化（工艺废物，饮用水，纯溶剂），细胞的选择性提取生长介质中的物质和细菌，以及细胞和细菌的固定化。

72. 发明申请

US20050126914A1 Materials classifier, method of using, and method of making 有权
标题翻译：材料分类，使用方法和制作方法
公开(公告)号：US20050126914A1
公开(公告)日：2005-06-16
申请号：US10868702
申请日：2004-06-14
申请人： Scott Sibbett
发明人： Scott Sibbett
IPC分类号： G01N27/447 , G01N30/00 , G01N30/02 , G01N30/52 , G01N27/453
CPC分类号： G01N30/0005 , G01N27/44773 , G01N30/02 , G01N2030/0035 , G01N2030/528 , B01D15/34
摘要： The present invention relates to a method of classifying charged molecules such as proteins for quantitative analysis. An analyte solution of the molecules is subjected to separational forces may be fluid drag and electrophoretic force in opposition. The analyte solution may be subjected to a two-phase process. The two-phase process may add both electrophoretic force based upon molecule charge, and differential mobility resistance based upon molecule mass and/or size.
摘要翻译：本发明涉及用于定量分析的带电分子如蛋白质的分类方法。分子的分析物溶液经受分离力可能是相反的流体阻力和电泳力。分析物溶液可以进行两相处理。两相方法可以基于分子电荷增加电泳力，并且基于分子质量和/或尺寸增加差动迁移率。

73. 发明授权

US06863820B2 Monolithic sorbents with fibre-reinforced plastic coating 有权
标题翻译：具有纤维增强塑料涂层的单片吸附剂
公开(公告)号：US06863820B2
公开(公告)日：2005-03-08
申请号：US10240921
申请日：2001-03-13
申请人： Karin Cabrera , Alexander Kraus , Willi Neuroth , Dieter Lubda
发明人： Karin Cabrera , Alexander Kraus , Willi Neuroth , Dieter Lubda
IPC分类号： B01D15/08 , B01J20/28 , B01J20/281 , B01J20/283 , C02F1/28 , G01N30/00 , G01N30/52 , G01N30/60 , G01N30/88
CPC分类号： B01J20/281 , B01J20/28042 , B01J2220/54 , B01J2220/82 , G01N30/60 , G01N2030/528
摘要： The invention relates to monolithic sorbents with a casing of fiber-reinforced plastic. Through the use of fiber-reinforced plastic having a viscosity of between 40 and 100 ml/10 min by the MVI method, the casing can be applied to the moulding leaving just a small dead space and has adequate mechanical stability.
摘要翻译：本发明涉及具有纤维增强塑料外壳的整体吸附剂。通过使用通过MVI方法粘度为40-100ml / 10分钟的纤维增强塑料，可以将外壳施加到模制件上，只留下较小的死空间并具有足够的机械稳定性。

74. 发明授权

US06830717B2 Cast membrane structures for sample preparation 有权
标题翻译：用于样品制备的铸膜结构
公开(公告)号：US06830717B2
公开(公告)日：2004-12-14
申请号：US10209390
申请日：2002-07-31
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B29C6500
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads' and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

75. 发明授权

US06818259B1 Porous article with surface functionality and method for preparing same 失效
标题翻译：具有表面功能的多孔制品及其制备方法
公开(公告)号：US06818259B1
公开(公告)日：2004-11-16
申请号：US09166457
申请日：1998-11-23
申请人： Steven L. Koontz
发明人： Steven L. Koontz
IPC分类号： H05H146
CPC分类号： B01D67/009 , A61L27/28 , A61L33/0076 , A61L33/0094 , B01D15/08 , B01D39/1692 , B01D67/0093 , B01J20/261 , B01J20/28033 , B01J20/28069 , B01J20/28078 , B01J20/286 , B01J20/3085 , B01J20/321 , B01J20/3217 , B01J20/3248 , B01J20/3268 , B01J20/3272 , B01J37/14 , B01J2219/0894 , B01J2220/54 , B29C59/14 , B29K2023/00 , B29K2105/04 , B29K2105/041 , B29L2031/755 , C08J9/36 , C08J2205/05 , C12N5/0068 , C12N2533/30 , C12P21/00 , G01N30/482 , G01N33/54306 , G01N33/54393 , G01N33/545 , G01N2030/525 , G01N2030/528
摘要： Porous organic articles having no surface functionality may be treated by remote plasma discharge to thereby introduce functionality to the surface of the article. The functionality is introduced throughout the article's surface, including the exterior surface and the surfaces of the pores. Little or no degradation of the porous organic article occurs as a result of the functionalization. Amino, hydroxyl, carbonyl and carboxyl groups may be introduced to the article. In this way, an essentially inert hydrophobic porous article, made from, for example, polyethylene, can have its surface modified so that the surface becomes hydrophilic. The remote plasma discharge process causes essentially no change in the bulk properties of the organic article. The remote plasma discharge process is preferably conducted so that no photons, and particularly no ultraviolet radiation, is transmitted from the plasma glow to the porous article. The surface-functionalized article may be used, for example, as a solid support in organic synthesis or in the chromatographic purification of organic or biochemicals
摘要翻译：可以通过远程等离子体放电来处理没有表面官能团的多孔有机制品，从而将功能性引入制品的表面。在整个制品的表面上引入了功能，包括外表面和孔的表面。作为官能化的结果，发生多孔有机物的很少或没有劣化。可以将氨基，羟基，羰基和羧基引入制品中。以这种方式，由例如聚乙烯制成的基本上惰性的疏水性多孔体可以使其表面改性，使得表面变得亲水。远程等离子体放电过程基本上不引起有机制品的体积性质的变化。优选进行远程等离子体放电处理，使得不会将光子，特别是没有紫外线辐射从等离子体辉光传输到多孔制品。表面官能化制品可用于例如有机合成中的固体载体或有机或生物化学品的色谱纯化

76. 发明授权

US06814870B2 Microchip electrospray device and column with affinity adsorbents and use of the same 有权
标题翻译： Microchip电喷雾装置和具有亲和吸附剂的柱和使用它们
公开(公告)号：US06814870B2
公开(公告)日：2004-11-09
申请号：US10658008
申请日：2003-09-09
申请人： Sheng Zhang , Xian Huang , Thomas N. Corso , Gary A. Schultz , Simon J. Prosser
发明人： Sheng Zhang , Xian Huang , Thomas N. Corso , Gary A. Schultz , Simon J. Prosser
IPC分类号： B01D1508
CPC分类号： G01N30/6095 , B01D15/3804 , B01J20/28042 , B01J20/285 , B01J20/286 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3244 , B01J20/3251 , B01J20/3274 , B01J45/00 , B01J2220/52 , B01J2220/54 , B01J2220/58 , B01J2220/82 , G01N30/463 , G01N30/466 , G01N30/482 , G01N30/7266 , G01N2030/528 , H01J49/0018 , H01J49/167
摘要： A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination. At least a portion of the device or column has immobilized affinity adsorbents. Methods for using the device are provided as well for affinity capture of biomolecules to meet the needs for the modem life sciences such as proteomics and drug discover.
摘要翻译：公开了一种基于微芯片的电喷雾离子化装置和具有亲和吸附剂的柱。本发明包括微芯片阵列和毛细管，或单独或组合连接。装置或柱的至少一部分具有固定的亲和吸附剂。还提供了使用该装置的方法用于亲和捕获生物分子以满足现代生命科学如蛋白质组学和药物发现的需要。

77. 发明授权

US06693159B1 Manufacturing porous cross-linked polymer monoliths 失效
标题翻译：制造多孔交联聚合物整料
公开(公告)号：US06693159B1
公开(公告)日：2004-02-17
申请号：US09890630
申请日：2001-09-28
申请人： Andrew Bruce Holmes , Andrew Ian Cooper
发明人： Andrew Bruce Holmes , Andrew Ian Cooper
IPC分类号： C08F12010
CPC分类号： B01J20/28042 , B01J20/26 , B01J20/261 , B01J20/28057 , B01J20/28083 , B01J20/28085 , B01J20/2809 , B01J20/281 , B01J20/285 , B01J2220/52 , B01J2220/54 , C08J9/122 , C08J9/20 , G01N27/44747 , G01N30/48 , G01N2030/528 , Y02P20/544 , Y10S526/942
摘要： Highly cross-linked, maroporous/mesoporous polymer monoliths are prepard using supercritical carbon dioxide (scCO2) as the solvent and porogen for the polymerisation of monomers having more than one polymerisable group, at a monomer concentration in CO2 of more than 40 vol %. The procedure allows the direct formation of dry, solvent-free, macroporous/mesoporous cross-linked monoliths with large surface area and well-controlled pore size distribution.
摘要翻译：以高于40体积％的CO 2的单体浓度，使用超临界二氧化碳（scCO2）作为溶剂和致孔剂用于聚合具有多于一个可聚合基团的单体的高度交联的大孔/介孔聚合物整料。该程序允许直接形成具有大表面积和良好控制的孔径分布的干燥，无溶剂，大孔/介孔交联的整料。

78. 发明申请

US20030201390A1 Separation media, multiple electrospray nozzle system and method 有权
公开(公告)号：US20030201390A1
公开(公告)日：2003-10-30
申请号：US10405689
申请日：2003-04-01
发明人： Thomas N. Corso , Gary A. Schultz , Simon J. Prosser , Xian Huang
IPC分类号： H01J049/00 , B01D059/44
CPC分类号： G01N30/466 , B01J20/261 , B01J20/267 , B01J20/281 , B01J20/285 , B01J2220/54 , B01J2220/82 , G01N27/44717 , G01N30/463 , G01N30/467 , G01N30/48 , G01N30/6095 , G01N30/7266 , G01N2030/285 , G01N2030/528 , H01J49/0018 , H01J49/167
摘要： A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods. The silicon chip having the packed microchannels disclosed herein finds application in coupling with mass spectrometry for sample analysis. Also disclosed is a separation block having multiple through-substrate channels filled with a separation material such as polymer monolith which can be stacked in multiple blocks for sequential two-dimensional chromatographic separation and integrated with the electrospray device.

79. 发明申请

US20030062309A1 Bonded phase photopolymerized sol-gel column and associated methods 有权
标题翻译：粘结相光聚合溶胶 - 凝胶柱及相关方法
公开(公告)号：US20030062309A1
公开(公告)日：2003-04-03
申请号：US09978515
申请日：2001-10-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： Richard N. Zare , Maria T. Dulay , Joselito P. Quirino , Bryson D. Bennett
IPC分类号： B01D015/08
CPC分类号： G01N30/48 , B01J20/281 , B01J2220/54 , G01N2030/528
摘要： A separation column and a method of making the separation column are provided. The separation column includes a separation channel and a separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a support and a stationary phase. The support includes a metal organic polymer, such as a photopolymer, and the stationary phase includes a bonded phase. The separation medium can be used to separate a sample of analytes.
摘要翻译：提供分离塔和制造分离塔的方法。分离塔包括通道中的分离通道和分离介质。分离介质包括多孔基质，多孔基质包括载体和固定相。载体包括金属有机聚合物，例如光聚合物，并且固定相包括键合相。分离介质可用于分离样品的分析物。

80. 发明申请

US20020185428A1 Cast membrane structures for sample preparation 有权
标题翻译：用于样品制备的铸膜结构
公开(公告)号：US20020185428A1
公开(公告)日：2002-12-12
申请号：US10209390
申请日：2002-07-31
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B01D063/00
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads' and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

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