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1. 发明授权

US11648490B2 Valve manifolds for simulated moving bed chromatography 有权
公开(公告)号：US11648490B2
公开(公告)日：2023-05-16
申请号：US17113311
申请日：2020-12-07
申请人： Cytiva Sweden AB
发明人： Klaus Gebauer , Bjorn Markus Olovsson
IPC分类号： B01D15/18 , G01N30/20 , G01N30/42 , G01N30/46 , G01N30/88
CPC分类号： B01D15/1842 , G01N30/20 , G01N30/461 , G01N30/466 , G01N30/467 , G01N30/88 , G01N30/42 , G01N30/468 , G01N2030/205 , G01N2030/8881
摘要： Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.

2. 发明授权

US08624599B2 Analysis system with GPC and NMR spectroscopy coupling, in particular for the analysis of samples having polymers 有权
标题翻译：具有GPC和NMR光谱耦合的分析系统，特别是用于分析具有聚合物的样品
公开(公告)号：US08624599B2
公开(公告)日：2014-01-07
申请号：US12929748
申请日：2011-02-14
申请人： Andreas Kamlowski , Thorsten Hofe , Markus Cudaj , Manfred Wilhelm , Gisela Guthausen
发明人： Andreas Kamlowski , Thorsten Hofe , Markus Cudaj , Manfred Wilhelm , Gisela Guthausen
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N30/467 , G01N30/62 , G01N30/78 , G01R33/46
摘要： An analysis system (1) for the analysis of a sample, comprises a gel permeation chromatograph (14) that is coupled with a nuclear magnetic resonance (=NMR) spectrometer. The chromatograph (14) has a gel permeation chromatography (=GPC) separating column system (6a) that is filled with porous particles (21). The NMR spectrometer is configured as a low-field NMR spectrometer (8) with a permanent magnet system (9) for generating a B0 field of the NMR spectrometer. The low-field NMR spectrometer (8) comprises a shim system (10) with which homogeneity of the B0 field of at least 0.5 ppm can be achieved in a right circular cylindrical sample volume (27) having a diameter of at least 5 mm and a length of at least 15 mm. The system permits the quantitative and qualitative chemical analysis of samples containing substances of different molecular size using a less expensive apparatus.
摘要翻译：用于分析样品的分析系统（1）包括与核磁共振（= NMR）光谱仪耦合的凝胶渗透色谱仪（14）。色谱仪（14）具有填充有多孔颗粒（21）的凝胶渗透色谱（= GPC）分离柱系统（6a）。 NMR光谱仪被配置为具有用于产生NMR光谱仪的B0场的永磁体系统（9）的低场NMR光谱仪（8）。低场NMR光谱仪（8）包括垫片系统（10），其直径为至少5mm的右圆形圆柱形样品体积（27）可以实现至少0.5ppm的B0场的均匀性，长度至少为15毫米。该系统允许使用较便宜的装置对含有不同分子尺寸的物质的样品进行定量和定性化学分析。

3. 发明申请

US20110108485A1 DEVICE FOR CHROMATOGRAPHIC SEPARATIONS 有权
标题翻译：用于色谱分离的装置
公开(公告)号：US20110108485A1
公开(公告)日：2011-05-12
申请号：US12962488
申请日：2010-12-07
申请人： Marc Antonius T. Bisschops , Jozef Anton M. Pennings , Jacob Arthur Tijsterman
发明人： Marc Antonius T. Bisschops , Jozef Anton M. Pennings , Jacob Arthur Tijsterman
IPC分类号： B01D15/18 , B01D15/10
CPC分类号： G01N30/468 , B01D15/14 , B01D15/1821 , B01D15/1842 , B01D15/1864 , B01D15/1885 , G01N30/20 , G01N30/461 , G01N30/466 , G01N30/467 , G01N30/6034 , G01N2030/205
摘要： A device is provided for chromatographic separations comprising a manifold comprising a plurality of connectors for connecting to one or more chromatographic separation columns and/or feed or extraction tubing. At least one central duct is formed between at least two connectors forming an inlet and an outlet respectively. The central duct comprises a closable duct valve; and a plurality of branch ducts branching from the central duct to a branch connector. The branch duct comprises a closable branch valve, wherein at least one branch duct is positioned between the inlet and the central duct valve and wherein at least one branch duct is positioned between the outlet and the central duct valve. The device is arranged for carrying out single-column and (continuous) multicolumn chromatographic separations. This allows the purification of biopharmaceutical products without having to develop, demonstrate and validate cleaning procedures for the valves.
摘要翻译：提供了用于色谱分离的装置，其包括歧管，该歧管包括用于连接到一个或多个色谱分离柱和/或进料或提取管道的多个连接器。在形成入口和出口的至少两个连接器之间形成至少一个中心管道。中央管道包括可关闭的管道阀; 以及从中央管道分支到分支连接器的多个分支管道。分支管道包括可关闭的分支阀，其中至少一个分支管道位于入口和中心管道阀之间，并且其中至少一个分支管道位于出口和中心管道阀之间。该装置用于进行单柱和（连续）多色谱色谱分离。这允许净化生物制药产品，而不必开发，证明和验证阀门的清洁程序。

4. 发明申请

US20050196823A1 Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore 审中-公开
公开(公告)号：US20050196823A1
公开(公告)日：2005-09-08
申请号：US10952557
申请日：2004-09-28
申请人： Joel Vandekerckhove , Kris Gevaert
发明人： Joel Vandekerckhove , Kris Gevaert
IPC分类号： G01N27/62 , C07K1/16 , C07K1/20 , C07K1/36 , C12P21/02 , G01N30/02 , G01N30/06 , G01N30/34 , G01N30/46 , G01N30/72 , G01N30/80 , G01N30/84 , G01N30/88 , G01N33/48 , G01N33/50 , G01N33/68 , C12Q1/37 , G01N33/00
CPC分类号： G01N30/461 , B01D15/1871 , C07K1/36 , G01N30/467 , G01N30/468 , G01N30/7233 , G01N30/80 , G01N33/6842 , G01N33/6848 , G01N2030/8411 , Y10S435/803
摘要： Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alteration of one or more types of peptides. This alteration modifies the biophysical, chemical or any other biochemical property of the affected types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way that the altered peptides can be separated from the unaltered peptides.

5. 发明申请

US20040005633A1 Methods and apparatuses for gel-free qualitative and quantitative proteome analysis, and uses therefore 有权
标题翻译：用于无凝胶定性和定量蛋白质组分析的方法和装置，因此
公开(公告)号：US20040005633A1
公开(公告)日：2004-01-08
申请号：US10394980
申请日：2003-03-21
发明人： Joel Vandekerckhove , Kris Gevaert
IPC分类号： G01N033/53 , C12P021/06 , C12M001/34 , C07K001/16
CPC分类号： G01N30/461 , B01D15/1871 , C07K1/36 , G01N30/467 , G01N30/468 , G01N30/7233 , G01N30/80 , G01N33/6842 , G01N33/6848 , G01N2030/8411 , Y10S435/803
摘要： Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alteration of one or more types of peptides. This alteration modifies the biophysical, chemical or any other biochemical property of the affected types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way that the altered peptides can be separated from the unaltered peptides.
摘要翻译：提供了定性和定量蛋白质组分析的方法和装置。所述方法和装置允许从肽的复杂混合物中分离肽的子集。分离基于一种或多种类型的肽的特定化学和/或酶促改变。这种改变改变受影响类型的肽的生物物理，化学或任何其它生物化学性质（例如，净电荷和/或疏水性），使得改变的肽可以与未改变的肽分离。

6. 发明授权

US06197198B1 Method and device for parallel chromatography 失效
标题翻译：并行色谱法的方法和装置
公开(公告)号：US06197198B1
公开(公告)日：2001-03-06
申请号：US09367056
申请日：1999-10-28
申请人： Josef Messinger , Frank Gundlach , Ernst Sinner
发明人： Josef Messinger , Frank Gundlach , Ernst Sinner
IPC分类号： B01D1508
CPC分类号： G01N30/467 , B01D15/1885 , G01N30/80 , G01N30/82
摘要： The invention relates to a device or equipment as well as to a method for the simultaneous, fractionating operation of a plurality of parallel chromatographic columns. It is particularly advantageous to apply this equipment and method in research, in the framework of organic synthesis for simultaneous, parallel separation, isolation and purification of a plurality of chemical compounds, e.g. of potential new active ingredients for medicaments, particularly also on the semi-preparative scale.
摘要翻译：本发明涉及一种装置或设备以及用于同时分馏多个平行色谱柱的操作的方法。在用于多个化合物的同时，平行分离，分离和纯化的有机合成的框架中，将该设备和方法应用于研究中是特别有利的。潜在的新药物活性成分，特别是半制备规模。

7. 发明授权

US08828234B2 Device for chromatographic separations 有权
标题翻译：色谱分离装置
公开(公告)号：US08828234B2
公开(公告)日：2014-09-09
申请号：US12962488
申请日：2010-12-07
申请人： Marc Abtonius Theodorus Bisschops , Jozef Anton Mari Pennings , Jacob Arthur Tijsterman
发明人： Marc Abtonius Theodorus Bisschops , Jozef Anton Mari Pennings , Jacob Arthur Tijsterman
IPC分类号： B01D15/14 , B01D15/18 , G01N30/46 , G01N30/60
CPC分类号： G01N30/468 , B01D15/14 , B01D15/1821 , B01D15/1842 , B01D15/1864 , B01D15/1885 , G01N30/20 , G01N30/461 , G01N30/466 , G01N30/467 , G01N30/6034 , G01N2030/205
摘要： A device is provided for chromatographic separations comprising a manifold comprising a plurality of connectors for connecting to one or more chromatographic separation columns and/or feed or extraction tubing. At least one central duct is formed between at least two connectors forming an inlet and an outlet respectively. The central duct comprises a closable duct valve; and a plurality of branch ducts branching from the central duct to a branch connector. The branch duct comprises a closable branch valve, wherein at least one branch duct is positioned between the inlet and the central duct valve and wherein at least one branch duct is positioned between the outlet and the central duct valve. The device is arranged for carrying out single-column and (continuous) multicolumn chromatographic separations. This allows the purification of biopharmaceutical products without having to develop, demonstrate and validate cleaning procedures for the valves.
摘要翻译：提供了用于色谱分离的装置，其包括歧管，该歧管包括用于连接到一个或多个色谱分离柱和/或进料或提取管道的多个连接器。在形成入口和出口的至少两个连接器之间形成至少一个中心管道。中央管道包括可关闭的管道阀; 以及从中央管道分支到分支连接器的多个分支管道。分支管道包括可关闭的分支阀，其中至少一个分支管道位于入口和中心管道阀之间，并且其中至少一个分支管道位于出口和中心管道阀之间。该装置用于进行单柱和（连续）多色谱色谱分离。这允许净化生物制药产品，而不必开发，证明和验证阀门的清洁程序。

8. 发明申请

US20140165841A1 PLATE-TYPE CAPILLARY COLUMN, CAPILLARY COLUMN UNIT, AND CHROMATOGRAPH USING SAME 有权
标题翻译：板式毛细管柱，毛细管柱单元和使用其的色谱图
公开(公告)号：US20140165841A1
公开(公告)日：2014-06-19
申请号：US14233490
申请日：2012-08-03
申请人： Takahiro Otsuka
发明人： Takahiro Otsuka
IPC分类号： B01D53/02
CPC分类号： G01N30/606 , B01D53/025 , G01N30/467 , G01N30/468 , G01N30/6039 , G01N30/6095 , G01N2030/8881
摘要： A plate-type capillary column has extensibility that enables a capillary to be extended as a whole to improve resolution of a chromatograph by stacking respective plate-type capillary columns. The capillary column is provided with a plate having first and second face plate parts that face each other; a capillary that is formed inside the plate; a first bottom-equipped hole connected to one end part of the capillary and formed to open in the first face plate part; and a second bottom-equipped hole connected to the other end part and formed to open in the second face plate part, wherein as viewed from a direction vertical to the first face plate part or the second face plate part, on a capillary column first virtual circle, passing through the second bottom-equipped hole, one or more through-holes penetrating through the first face plate part and the second face plate part are formed.
摘要翻译：板式毛细管柱具有伸长性，使毛细管作为整体延伸，以通过堆叠相应的板式毛细管柱来提高色谱分离度。毛细管柱设置有具有彼此相对的第一和第二面板部分的板; 形成在板内的毛细管; 连接到毛细管的一个端部并形成为在第一面板部分中打开的第一底部设有孔; 以及与所述另一端部连接并形成为在所述第二面板部开口的第二底部配置孔，其中，从垂直于所述第一面板部或所述第二面板部的方向观察，在毛细管柱上，圆通过第二底部设置的孔，形成穿过第一面板部和第二面板部的一个或多个通孔。

9. 发明授权

US07846335B2 Device for chromatographic separations 有权
标题翻译：色谱分离装置
公开(公告)号：US07846335B2
公开(公告)日：2010-12-07
申请号：US12090086
申请日：2006-10-13
申请人： Marc Antonius T. Bisschops , Jozef Anton M. Pennings , Jacob Arthur Tijsterman
发明人： Marc Antonius T. Bisschops , Jozef Anton M. Pennings , Jacob Arthur Tijsterman
IPC分类号： B01D15/08
CPC分类号： G01N30/468 , B01D15/14 , B01D15/1821 , B01D15/1842 , B01D15/1864 , B01D15/1885 , G01N30/20 , G01N30/461 , G01N30/466 , G01N30/467 , G01N30/6034 , G01N2030/205
摘要： A device is provided for chromatographic separations comprising a manifold comprising a plurality of connectors for connecting to one or more chromatographic separation columns and/or feed or extraction tubing. At least one central duct is formed between at least two connectors forming an inlet and an outlet respectively. The central duct comprises a closable duct valve; and a plurality of branch ducts branching from the central duct to a branch connector. The branch duct comprises a closable branch valve, wherein at least one branch duct is positioned between the inlet and the central duct valve and wherein at least one branch duct is positioned between the outlet and the central duct valve. The device is arranged for carrying out single-column and (continuous) multicolumn chromatographic separations. This allows the purification of biopharmaceutical products without having to develop, demonstrate and validate cleaning procedures for the valves.
摘要翻译：提供了用于色谱分离的装置，其包括歧管，该歧管包括用于连接到一个或多个色谱分离柱和/或进料或提取管道的多个连接器。在形成入口和出口的至少两个连接器之间形成至少一个中心管道。中央管道包括可关闭的管道阀; 以及从中央管道分支到分支连接器的多个分支管道。分支管道包括可关闭的分支阀，其中至少一个分支管道位于入口和中心管道阀之间，并且其中至少一个分支管道位于出口和中心管道阀之间。该装置用于进行单柱和（连续）多色谱色谱分离。这允许净化生物制药产品，而不必开发，证明和验证阀门的清洁程序。

10. 发明申请

US20090308137A1 GAS CHROMATOGRAPHY CAPILLARY DEVICES AND METHODS 有权
标题翻译：气体色谱法毛细管装置和方法
公开(公告)号：US20090308137A1
公开(公告)日：2009-12-17
申请号：US12138124
申请日：2008-06-12
申请人： RON W. CURRIE , DAVID CHRISTIANSEN
发明人： RON W. CURRIE , DAVID CHRISTIANSEN
IPC分类号： G01N30/02 , D01D5/24 , B01D53/02 , B29C47/02
CPC分类号： G01N30/56 , B29C47/0014 , B29C47/0026 , B29C47/06 , B29L2023/00 , G01N30/467 , G01N30/6043 , G01N30/6078 , G01N2030/025 , G01N2030/3061 , G01N2030/567
摘要： A multicapillary bundle for use in a gas chromatograph. Each of the capillaries in the bundle is formed using a coating solution containing a stationary phase and a solvent. The capillaries are coated with stationary phase by reducing pressure at a vacuum end of the capillary and creating a moving interface between the coating solution and a film of stationary phase deposited on each of the capillaries. The reducing pressure at the vacuum end of the capillary and the temperature of the capillary are controlled to maintain motion of the moving interface away from the vacuum end of the capillary. Maintained movement of the interface prevents recoating of the stationary phase. A heating wire and capillaries are embedded in a thermally conductive polymer to create a highly responsive method of heating the multicapillary column. An electronic control device controls the feedback temperature of the multicapillary column using the heating wire.
摘要翻译：用于气相色谱仪的多毛细管束。束中的每个毛细管是使用含有固定相和溶剂的涂布溶液形成的。通过在毛细管的真空端减小压力并在涂覆溶液和沉积在每个毛细管上的固定相的膜之间产生移动界面，毛细管被固定相涂覆。控制毛细管真空端的减压和毛细管的温度，以保持移动界面的运动远离毛细管的真空端。维护接口的运动可防止固定相重新涂覆。将加热丝和毛细管嵌入导热聚合物中以产生加热多毛细管柱的高反应性方法。电子控制装置使用加热丝来控制多毛柱的反馈温度。

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