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1. 发明授权

US06998047B1 Cast membrane structures for sample preparation 有权
公开(公告)号：US06998047B1
公开(公告)日：2006-02-14
申请号：US09698378
申请日：2000-10-27
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B01D63/00
CPC分类号： B01L3/0275 , B01J20/28026 , B01J20/28033 , B01J2220/64 , B01L3/50255 , B01L2300/0681 , B01L2300/0829
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.

2. 发明授权

US6048457A Cast membrane structures for sample preparation 失效
标题翻译：用于样品制备的铸膜结构
公开(公告)号：US6048457A
公开(公告)日：2000-04-11
申请号：US7320
申请日：1998-01-15
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： G01N1/10 , B01D61/00 , B01D61/18 , B01D63/00 , B01D63/16 , B01D67/00 , B01D69/10 , B01D69/14 , B01J20/28 , B01L3/02 , C12M1/00 , C12M1/12 , C12M1/26 , G01N1/36 , G01N30/46 , G01N30/52 , G01N30/60 , G01N35/10
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01L3/0275 , G01N30/6065 , B01J2220/64 , G01N2030/528 , G01N2035/1053 , G01N2035/1055 , G01N30/466 , G01N30/6004 , G01N30/6052
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量的吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

3. 发明授权

US06830717B2 Cast membrane structures for sample preparation 有权
标题翻译：用于样品制备的铸膜结构
公开(公告)号：US06830717B2
公开(公告)日：2004-12-14
申请号：US10209390
申请日：2002-07-31
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B29C6500
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads' and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

4. 发明授权

US06635201B1 Cast membrane structures for sample preparation 有权
标题翻译：用于样品制备的铸膜结构
公开(公告)号：US06635201B1
公开(公告)日：2003-10-21
申请号：US09291355
申请日：1999-04-14
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B29C6500
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二结构中，在合适的壳体中原位铸造，并且可以用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

5. 发明授权

US06200474B1 Cast membrane structures for sample prepartion 有权
标题翻译：铸造膜结构用于样品制备
公开(公告)号：US06200474B1
公开(公告)日：2001-03-13
申请号：US09366134
申请日：1999-08-02
申请人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
发明人： William Kopaciewicz , Donald G. Sheer , Todd E. Arnold , Vinay Goel
IPC分类号： B01D6300
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译：用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。本发明还包括复合结构以及含有该结构的样品制备装置。在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。本发明还包括这些结构以及包含这些结构的壳体。

6. 发明申请

US20120232790A1 SYSTEM AND METHOD FOR STORING AND PROVIDING ROUTES 有权
标题翻译：用于存储和提供路由的系统和方法
公开(公告)号：US20120232790A1
公开(公告)日：2012-09-13
申请号：US13479443
申请日：2012-05-24
申请人： Vinay Goel
发明人： Vinay Goel
IPC分类号： G01C21/30
CPC分类号： G01C21/3484 , G01C21/34 , G01C21/3476 , G01C21/3492 , H04W4/02
摘要： In one aspect, a system and method is provided whereby map-related requests from mobile devices are used to store and aggregate routes. The routes are then used to determine optimum directions in response to subsequent requests.
摘要翻译：一方面，提供一种系统和方法，其中使用来自移动设备的地图相关请求来存储和聚合路由。然后，这些路由用于响应于后续请求来确定最佳方向。

7. 发明授权

US08612459B1 Lead generation system and methods 有权
标题翻译：铅代系统和方法
公开(公告)号：US08612459B1
公开(公告)日：2013-12-17
申请号：US13182256
申请日：2011-07-13
申请人： Vinay Goel , Kiran S. Panesar
发明人： Vinay Goel , Kiran S. Panesar
IPC分类号： G06F17/30
CPC分类号： G06F17/30699 , G06F17/3064 , G06F17/30864 , G06F17/30867 , G06Q30/0241 , G06Q30/0275
摘要： Methods, systems, and computer program products are provided for providing matching resources. One example method includes identifying example resources, evaluating query logs to determine queries including query terms that resolved to a given example resource, identifying matching resources other than the example resources that also were provided as a solution to the determined queries, filtering the matching resources based on one or more criteria to identify matching resources that are relevant to a consumer, and providing the filtered matching resources for output to the consumer.
摘要翻译：提供了方法，系统和计算机程序产品来提供匹配的资源。一个示例性方法包括识别示例资源，评估查询日志以确定包括解析给给定示例资源的查询项的查询，识别除了被提供为所确定的查询的解决方案的示例资源之外的匹配资源，基于匹配资源过滤用于识别与消费者相关的匹配资源的一个或多个标准，以及提供用于向消费者输出的过滤的匹配资源。

8. 发明授权

US08433513B2 System and method for storing and providing routes 有权
标题翻译：用于存储和提供路线的系统和方法
公开(公告)号：US08433513B2
公开(公告)日：2013-04-30
申请号：US13479443
申请日：2012-05-24
申请人： Vinay Goel
发明人： Vinay Goel
IPC分类号： G01C21/00
CPC分类号： G01C21/3484 , G01C21/34 , G01C21/3476 , G01C21/3492 , H04W4/02
摘要： In one aspect, a system and method is provided whereby map-related requests from mobile devices are used to store and aggregate routes. The routes are then used to determine optimum directions in response to subsequent requests.
摘要翻译：一方面，提供一种系统和方法，其中使用来自移动设备的地图相关请求来存储和聚合路由。然后，这些路由用于响应于后续请求来确定最佳方向。

9. 发明授权

US08219316B2 System and method for storing and providing routes 有权
标题翻译：用于存储和提供路线的系统和方法
公开(公告)号：US08219316B2
公开(公告)日：2012-07-10
申请号：US12291852
申请日：2008-11-14
申请人： Vinay Goel
发明人： Vinay Goel
IPC分类号： G01C21/32
CPC分类号： G01C21/3484 , G01C21/34 , G01C21/3476 , G01C21/3492 , H04W4/02
摘要： In one aspect, a system and method is provided whereby map-related requests from mobile devices are used to store and aggregate routes. The routes are then used to determine optimum directions in response to subsequent requests.
摘要翻译：一方面，提供一种系统和方法，其中使用来自移动设备的地图相关请求来存储和聚合路由。然后，这些路由用于响应于后续请求来确定最佳方向。

10. 发明授权

US08218741B2 Telephone number-based advertising 有权
标题翻译：电话号码广告
公开(公告)号：US08218741B2
公开(公告)日：2012-07-10
申请号：US11948171
申请日：2007-11-30
申请人： Vinay Goel
发明人： Vinay Goel
IPC分类号： H04M15/00 , H04M3/00 , G06Q30/00
CPC分类号： H04M17/00 , G06Q30/0242 , G06Q30/0255 , G06Q30/0264 , G06Q30/0275 , G06Q30/0601 , H04M3/54 , H04M7/003
摘要： Methods, systems, and apparatus, including computer program products, in which a first telephone number is associated with a second telephone number, and a web-based advertisement is served for an advertiser that includes the first telephone number. A call placed to the first telephone number is received, and the call is routed to the second telephone number based on the association of the second telephone number with the first telephone number. A determination as to whether a call-through event in response to receiving the call placed to the first telephone number has occurred, and an advertiser associated with the second telephone number is charged a cost-per-call amount if the call-through event is determined to have occurred.
摘要翻译：包括第一电话号码与第二电话号码相关联的计算机程序产品和基于网络的广告的方法，系统和装置被服务于包括第一电话号码的广告商。接收到第一电话号码的呼叫，并且基于第二电话号码与第一电话号码的关联将呼叫路由到第二电话号码。关于是否已经发生响应于接收到第一电话号码的呼叫的通话事件的确定，并且如果呼叫事件是第二电话号码，则与第二电话号码相关联的广告商被收取每次呼叫费用确定已经发生。

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