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1. 发明授权

US09482651B2 Chip produced at wafer level for liquid chromatography and method for the production thereof 有权
标题翻译：用于液相色谱的晶片级生产的芯片及其制造方法
公开(公告)号：US09482651B2
公开(公告)日：2016-11-01
申请号：US13508196
申请日：2010-11-05
申请人： Gundula Piechotta , Hans-Joachim Quenzer
发明人： Gundula Piechotta , Hans-Joachim Quenzer
IPC分类号： G01N30/56 , G01N30/60 , G01N30/52
CPC分类号： G01N30/6095 , G01N2030/528
摘要： The present invention relates to a method for producing a miniaturized separation column for chromatographic purposes including a porous stationary phase anchored in the column, including the following steps: (a) preparing a flat substrate of silicon, glass, glass ceramic or ceramic; (b) etching at least one channel structure into the flat substrate; (c) introducing a non-porous precursor material for the porous stationary phase into at least one portion of the channel structure (s); (d) forming a porous, three-dimensional network from the precursor material; and (e) fluid-tight covering of the channel structure(s) on the top side of the flat substrate.

2. 发明授权

US09260362B2 Hydrophilic activated sorbent extraction disk 有权
标题翻译：亲水性活化吸附剂萃取盘
公开(公告)号：US09260362B2
公开(公告)日：2016-02-16
申请号：US13961241
申请日：2013-08-07
申请人： Joseph M. Boyd , Edward J. Kim
发明人： Joseph M. Boyd , Edward J. Kim
IPC分类号： C07C7/12 , B01D15/00 , B01D15/08 , B01J20/28 , B01J20/26 , B01D15/32 , G01N30/52
CPC分类号： C07C7/12 , B01D15/00 , B01D15/08 , B01D15/322 , B01J20/261 , B01J20/264 , B01J20/28026 , B01J20/28035 , B01J20/28042 , B01J20/28047 , B01J20/2805 , B01J20/28085 , G01N2030/528
摘要： A one-piece solid phase extraction article to be used in solid phase extraction analysis, a filtration funnel comprising the one piece solid phase extraction article, and a method of use of the article. The article, device and method provide for improved analysis of hexane extractable material by eliminating the standard use of polar solvents to pre-condition the sorbent materials. The one-piece solid phase extraction article comprises water wettable monomeric phase type sorptive material embedded within a porous matrix. The water wettable monolithic polymeric sorptive material may be a hydrophilic polymeric gel, such as functionalized C-18 sorbent material, and the porous matrix may be fibrous matric, such as a glass fiber. The one-piece solid phase extraction article may further comprise one or more pre-filtration layers which do not contain the sorptive particles.
摘要翻译：用于固相萃取分析的单片固相萃取制品，包括一件固相萃取制品的过滤漏斗以及该制品的使用方法。该物品，装置和方法通过消除极性溶剂的标准用途来预先吸附吸附剂材料来提供对己烷可萃取材料的改进分析。一体式固相萃取制品包括嵌入多孔基体内的可湿润水溶性单体型吸附材料。水可湿性整体聚合物吸附材料可以是亲水性聚合物凝胶，例如官能化的C-18吸附剂材料，并且多孔基质可以是纤维基质，例如玻璃纤维。一体式固相萃取制品还可以包含一个或多个不含有吸附颗粒的预过滤层。

3. 发明授权

US08935941B2 Method of cladding monolithic silica body and separation medium 有权
标题翻译：包层整体二氧化硅体和分离介质的方法
公开(公告)号：US08935941B2
公开(公告)日：2015-01-20
申请号：US12865815
申请日：2008-02-01
申请人： Shota Miyazaki , Hiroyuki Terashima , Masahiko Nyudo , Masayoshi Ohira , Kei Morisato , Masahiro Furuno
发明人： Shota Miyazaki , Hiroyuki Terashima , Masahiko Nyudo , Masayoshi Ohira , Kei Morisato , Masahiro Furuno
IPC分类号： B01J20/283 , B01D15/22 , B01J20/10 , B01J20/28 , G01N30/60 , B01J20/32 , B01D15/20 , G01N30/50 , G01N30/52
CPC分类号： B01D15/22 , B01D15/20 , B01J20/103 , B01J20/28042 , B01J20/283 , B01J20/3257 , B01J2220/54 , B01J2220/82 , B01J2220/825 , G01N30/50 , G01N30/6052 , G01N2030/528
摘要： To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.
摘要翻译：为了在使用HPLC柱或GC色谱柱的色谱法中使用整体二氧化硅体，并且为了简化其作为分离介质的用途，旨在提供一种用玻璃包覆整体式吸附剂或分离剂的主体的方法，以便以保护外表面，并提供通过该方法制备的分离介质。为此，通过模制单独形成整体式二氧化硅体，并且模塑被玻璃体涂覆; 然后玻璃体和整体式二氧化硅体在玻璃体的熔融温度下以适当的压力熔融并整合。用玻璃覆盖的所得整体二氧化硅体的表面被玻璃强烈保护，并且保持了整体二氧化硅体内部的均匀性，因此样品溶液的均匀流动确保了分析精度。

4. 发明授权

US08795529B2 Disposable monolithic column 有权
标题翻译：一次性整体柱
公开(公告)号：US08795529B2
公开(公告)日：2014-08-05
申请号：US11932526
申请日：2007-10-31
申请人： Shaofeng Xie
发明人： Shaofeng Xie
IPC分类号： B01J20/30 , B01J20/283 , B01J20/285 , B01D15/20 , G01N30/52
CPC分类号： B01J20/3064 , B01D15/206 , B01J8/0005 , B01J19/0013 , B01J19/18 , B01J20/283 , B01J20/285 , B01J2219/00162 , B01J2220/54 , B01J2220/82 , G01N30/56 , G01N2030/522 , G01N2030/528 , G01N2030/567 , G01N30/30
摘要： Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.
摘要翻译：在塑料柱套管中制备可渗透的聚合物整体材料。在一个实施方案中，可透过的聚合物整体材料通过根据柱的混合物和尺寸从外部源起始于低温（例如40℃）进行聚合，并在较高温度下继续进行，例如 60摄氏度。聚合开始时的温度足够低，从而不会引起放热的脱离条件，并避免高度的反应热，从而阻止整个塔的截面上的基本恒定的温度。在发生足够的单体消耗并且空间干扰增加之后使用较高的温度，因此聚合反应足够慢，以避免足够高的反应产生热，导致孔径的均匀性显着降低。

5. 发明授权

US08597508B2 Sol-gel monolithic column with optical window and method of making 有权
标题翻译：具有光学窗口的溶胶 - 凝胶整体柱和制造方法
公开(公告)号：US08597508B2
公开(公告)日：2013-12-03
申请号：US13102651
申请日：2011-05-06
申请人： Abdul Malik , James D. Hayes
发明人： Abdul Malik , James D. Hayes
IPC分类号： B01D15/08
CPC分类号： B01J20/291 , B01D15/08 , B01D15/206 , B01J20/28042 , B01J20/282 , B01J2220/52 , B01J2220/54 , B01J2220/82 , G01N27/44721 , G01N27/44747 , G01N30/6082 , G01N2030/528
摘要： A method of preparing a sol-gel monolithic column includes the step of forming a separation bed (14) from a sol-gel solution in a single process step. This column has improved characteristics for CEC based on its incorporated surface charge and ease of operation due to a lack of or need for end frits. Also, a second type of column includes an optical window (30) for on-column detection.
摘要翻译：制备溶胶 - 凝胶整体柱的方法包括在单一工艺步骤中从溶胶 - 凝胶溶液形成分离床（14）的步骤。由于缺少或需要末端玻璃料，该色谱柱基于其结合的表面电荷和易于操作，具有改进的CEC特性。此外，第二类型的列包括用于列列检测的光学窗口（30）。

6. 发明授权

US08435410B2 Surfactant-based monolithic columns, methods for making the same, and method for using the same 有权
标题翻译：基于表面活性剂的整体柱，其制备方法及其使用方法
公开(公告)号：US08435410B2
公开(公告)日：2013-05-07
申请号：US12922357
申请日：2009-03-30
申请人： Shahab Ahmed Shamsi , Congying Gu , Jun He
发明人： Shahab Ahmed Shamsi , Congying Gu , Jun He
IPC分类号： B01D15/08
CPC分类号： C08J9/127 , B01J20/261 , B01J20/267 , B01J20/28042 , B01J20/285 , B01J2220/82 , G01N2030/528
摘要： A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.
摘要翻译：提供了制备基于表面活性剂的整体柱的方法。该方法包括提供包含至少一种表面活性剂单体，至少一种交联剂，至少一种引发剂和至少一种致孔剂的混合物，并使混合物聚合以形成基于表面活性剂的整体柱。本公开还提供了一种基于表面活性剂的整体柱，分离分子的方法和制备表面活性剂单体的方法。

7. 发明授权

US08076152B2 Microfluidic devices comprising fluid flow paths having monolithic chromatographic material 有权
标题翻译：微流体装置包括具有整体色谱材料的流体流动路径
公开(公告)号：US08076152B2
公开(公告)日：2011-12-13
申请号：US12902008
申请日：2010-10-11
申请人： Karla M. Robotti
发明人： Karla M. Robotti
IPC分类号： C08F20/06 , C08F112/08
CPC分类号： G01N30/6095 , G01N2030/528 , Y10T29/494 , Y10T156/10
摘要： Aspects of the invention include a microfluidic device having a fluid flow path and a monolithic chromatographic material covalently bound to at least a portion of a polymeric surface of the fluid flow path. Aspects of the invention further include methods of making and using such devices.
摘要翻译：本发明的方面包括具有流体流动路径和共价结合到流体流动路径的聚合物表面的至少一部分的整体色谱材料的微流体装置。本发明的方面还包括制造和使用这些装置的方法。

8. 发明申请

US20110290999A1 MONOLITHIC COLUMN CHROMATOGRAPHY 审中-公开
标题翻译：单色柱色谱
公开(公告)号：US20110290999A1
公开(公告)日：2011-12-01
申请号：US13204529
申请日：2011-08-05
申请人： Nigel Clarke , Mildred M. Goldman
发明人： Nigel Clarke , Mildred M. Goldman
IPC分类号： B01D15/42 , H01J49/26 , B01D15/08 , G01N30/00 , B82Y30/00
CPC分类号： G01N30/60 , B01D15/1814 , B01D15/1864 , B01D15/1871 , B01D15/34 , B01J20/28083 , B01J20/28085 , B01J2220/82 , G01N30/40 , G01N30/461 , G01N30/48 , G01N30/52 , G01N30/72 , G01N30/88 , G01N2030/407 , G01N2030/528 , G01N2030/8813
摘要： Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column. In other aspects, a single monolithic column is used to perform both the preparative chromatography and analytical chromatography steps in succession. In another aspect, a chromatography system is provided to perform preparative and analytical chromatography using a single monolithic column.
摘要翻译：本文提供了液相柱色谱法，其中制备色谱与分析色谱同步进行。在特定方面，整体式制备柱用于通过将混合物施加到柱上来净化来自其它物质的混合物的感兴趣分析物，逆转通过柱的流动以洗脱分析物，将分析物施加到分析柱上，与制备柱一致。在其他方面，使用单个整体柱连续进行制备色谱和分析色谱步骤。在另一方面，提供色谱系统以使用单个整体柱进行制备和分析色谱。

9. 发明申请

US20110108522A1 MICROSTRUCTURED SEPARATION ELEMENT WITH A POROUS SURFACE COATING 审中-公开
标题翻译：具有多孔表面涂层的微结构分离元件
公开(公告)号：US20110108522A1
公开(公告)日：2011-05-12
申请号：US12989076
申请日：2008-04-23
申请人： Gerard Rozing
发明人： Gerard Rozing
IPC分类号： C03C25/68 , G01N27/26 , G01N1/10 , G01N30/02 , H01J49/00 , B05D5/00 , B28B11/08 , B29C35/08
CPC分类号： G01N30/6095 , B01J2220/54 , B01L3/502753 , B01L2200/0631 , B01L2300/0681 , B01L2400/0421 , G01N30/6069 , G01N2030/528
摘要： A fluidic device for separating different components of a sample, the fluidic device comprising a microstructured body and porous material covering at least a portion of a surface of the microstructured body.
摘要翻译：用于分离样品的不同组分的流体装置，所述流体装置包括微结构体和覆盖所述微结构体的表面的至少一部分的多孔材料。

10. 发明授权

US07915318B2 Aqueous ROMP-based monolith materials and methods for making 有权
标题翻译：基于水性ROMP的整料材料及其制备方法
公开(公告)号：US07915318B2
公开(公告)日：2011-03-29
申请号：US12207055
申请日：2008-09-09
申请人： Su Lu , Liangliang Qiang , Yanrong Zhu , Zhida Pan
发明人： Su Lu , Liangliang Qiang , Yanrong Zhu , Zhida Pan
IPC分类号： C08F2/44 , B01J20/26 , C08F4/80
CPC分类号： C08F290/00 , B01J20/28042 , B01J20/286 , B01J20/288 , C08F255/00 , C08F255/08 , C08F277/00 , C08F290/06 , C08F291/00 , C08G61/08 , C08L51/003 , C08L51/06 , G01N2030/528 , C08L2666/02
摘要： A water soluble ROMP catalyst, which has high catalytic efficiency for ring opening metathesis is use in the preparation of polymeric blends for use in monolithic columns. In one embodiments a method for making a polymeric blend is discolosed comprising reaction of a water-soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor, and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support. In another embodiment a monolithic bed is disclosed comprising the water-soluble ROMP catalyst immobilized on a surface of a solid support. Also disclosed is a monolithic bed comprising: a polymer blend, the polymer blend produced from contacting a water soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor; and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support.
摘要翻译：对于开环复分解具有高催化效率的水溶性ROMP催化剂用于制备用于整体柱的聚合物共混物。在一个实施方案中，制造聚合物共混物的方法被解开，包括水溶性ROMP催化剂与降冰片烯取代的环烯烃聚合物或聚降冰片烯聚合物前体的反应，并且其中所述接触在水溶液或极性溶剂中，在坚实的支持。在另一个实施方案中，公开了一种整体床，其包含固定在固体载体表面上的水溶性ROMP催化剂。还公开了一种整体床，包括：聚合物共混物，通过使水溶性ROMP催化剂与降冰片烯取代的环烯烃聚合物或聚降冰片烯聚合物前体接触而制备的聚合物共混物; 并且其中所述接触在固体载体存在下在水性或极性溶剂中进行。

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