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71. 发明授权

US5804684A Method for isolating nucleic acids 失效
标题翻译：分离核酸的方法
公开(公告)号：US5804684A
公开(公告)日：1998-09-08
申请号：US519039
申请日：1995-08-24
申请人： Xing Su
发明人： Xing Su
IPC分类号： B01L3/00 , C12N15/10 , C07H21/00
CPC分类号： B01L3/502753 , C12N15/1006 , C12N15/1013 , B01L2200/0631 , B01L2300/069 , B01L2400/0406
摘要： The invention features a method of isolating nucleic acid in a substantially purified form, including the steps of: a) contacting a biological sample which contains aggregated nucleic acid with a matrix comprising a solid hydrophilic organic polymer without an effective positive charge under conditions which permit the nucleic acid to bind to the matrix; and b) recovering nucleic acid from the matrix.
摘要翻译：本发明的特征在于以基本纯化的形式分离核酸的方法，包括以下步骤：a）使含有聚集核酸的生物样品与包含固体亲水性有机聚合物的基质在没有有效正电荷的条件下接触，条件允许核酸结合基质; 和b）从基质中回收核酸。

72. 发明授权

US08962279B2 Solid-phase chelators and electronic biosensors 有权
标题翻译：固相螯合剂和电子生物传感器
公开(公告)号：US08962279B2
公开(公告)日：2015-02-24
申请号：US12655459
申请日：2009-12-30
申请人： David J. Liu , Xing Su , Kai Wu
发明人： David J. Liu , Xing Su , Kai Wu
IPC分类号： C12P19/34 , C12M1/00 , C12Q1/48 , C12Q1/68 , G01N27/414
CPC分类号： C12Q1/48 , C12Q1/6837 , C12Q1/6869 , G01N27/4145 , G01N2333/9125 , C12Q2565/607 , C12Q2565/507 , C12Q2565/301
摘要： Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions.
摘要翻译：介绍了核酸测序方法。通过化学扩增DNA合成产物和化学扩增产物的检测来完成测序。在本发明的实施方案中，提供了具有多个待测序的DNA分子的底物和能够螯合连接的焦磷酸根离子的多个分子，引入待测序的DNA分子，并且掺入下一个互补核苷酸，切除多次导致待测序的DNA分子局部周围的焦磷酸盐离子的积聚。焦磷酸根离子被底物连接的螯合剂捕获并电子检测以确定待测序的DNA分子中下一个互补核酸的同一性。另外，提供了通过检测焦磷酸根离子来检测生物分子的装置和方法。

73. 发明申请

US20140342470A1 DEVICE AND METHOD FOR PARTICLE COMPLEX HANDLING 有权
标题翻译：用于粒子复杂处理的装置和方法
公开(公告)号：US20140342470A1
公开(公告)日：2014-11-20
申请号：US14448141
申请日：2014-07-31
申请人： Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
发明人： Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
IPC分类号： G01N1/40
CPC分类号： G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

74. 发明申请

US20140299485A1 DEVICE AND METHOD FOR DETECTING REDOX REACTIONS IN SOLUTIONS 有权
标题翻译：用于检测解决方案中的氧化还原反应的装置和方法
公开(公告)号：US20140299485A1
公开(公告)日：2014-10-09
申请号：US14267327
申请日：2014-05-01
申请人： Jonathan S. Daniels , Oguz H. Elibol , Grace M. Credo , Xing Su
发明人： Jonathan S. Daniels , Oguz H. Elibol , Grace M. Credo , Xing Su
IPC分类号： G01N27/22
CPC分类号： G01N27/3277 , B82Y30/00 , C12Q1/68 , G01D5/24 , G01K7/34 , G01L1/14 , G01N27/22 , G01R27/26 , G06K7/08
摘要： Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.
摘要翻译：这里描述的是一种装置，其包括排列成阵列的多个第一反应电极，多个第一反应电极构造为暴露于溶液并具有电容; 第一电路，被配置为将多个第一反应电极可控地连接到偏置源并且可控制地将多个第一反应电极与偏置源分离; 以及第二电路，被配置为测量电容的充电或放电速率。本文还描述了使用该装置来对DNA进行序列化的方法。

75. 发明授权

US08715932B2 Nucleic acid sequencing 有权
标题翻译：核酸测序
公开(公告)号：US08715932B2
公开(公告)日：2014-05-06
申请号：US12860462
申请日：2010-08-20
申请人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
发明人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2531/125 , C12Q2535/122 , C12Q2565/301 , C12Q2565/607
摘要： Nucleic acid sequencing using concatemers of DNA is provided. Optionally, amplified reaction products from the repeated incorporation and excision of a nucleoside complementary to a nucleoside of the DNA to be sequenced onto primer molecules hybridized to the concatemers of DNA are detected. Nucleic acid sequencing using concatemers of DNA and non-natural oligonucleotides is also provided. Nucleic acid sequencing reactions are detected electronically and or optically using arrays of detectors.
摘要翻译：提供使用DNA连接子的核酸测序。任选地，检测来自重复掺入和切除与待测序的DNA的核苷互补的核苷酸的扩增反应产物与DNA连接体杂交的引物分子上。还提供了使用DNA和非天然寡核苷酸的并联体的核酸测序。使用检测器阵列电子和/或光学检测核酸测序反应。

76. 发明授权

US08674086B2 Nucleotides and oligonucleotides for nucleic acid sequencing 有权
标题翻译：用于核酸测序的核苷酸和寡核苷酸
公开(公告)号：US08674086B2
公开(公告)日：2014-03-18
申请号：US12823995
申请日：2010-06-25
申请人： Jianquan Liu , Xing Su , Kai Wu
发明人： Jianquan Liu , Xing Su , Kai Wu
IPC分类号： C07H19/20 , C07H19/00 , C07H19/04
CPC分类号： C07H19/10 , C12Q1/6874 , C12Q2521/101 , C12Q2521/319 , C12Q2521/525 , C12Q2525/186 , C12Q2537/157 , C12Q2565/537 , C12Q2565/607
摘要： Embodiments of the invention provide non-natural bifunctional nucleotides having both nuclease resistance and nucleic acid synthesis blocking properties and methods of sequencing nucleic acids that employ non-natural bifunctional nucleic acids. Additional embodiments provide non-natural oligonucleotides and methods for sequencing nucleic acids using the non-natural oligonucleotides. Methods according to embodiments of the invention employ electronic detection and fluorescent detection of nucleic acid sequencing reactions.
摘要翻译：本发明的实施方案提供具有核酸酶抗性和核酸合成阻断性质的非天然双功能核苷酸，以及使用非天然双功能核酸测序核酸的方法。另外的实施方案提供非天然寡核苷酸和使用非天然寡核苷酸测序核酸的方法。根据本发明的实施方案的方法使用核酸测序反应的电子检测和荧光检测。

77. 发明授权

US08438099B2 Periodic reset total return index futures contracts 有权
标题翻译：期货复盘总回报指数期货合约
公开(公告)号：US08438099B2
公开(公告)日：2013-05-07
申请号：US12914639
申请日：2010-10-28
申请人： Richard Co , TuenTuen Wang , Xing Su , John Labuszewski
发明人： Richard Co , TuenTuen Wang , Xing Su , John Labuszewski
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/06
摘要： A periodic reset total return index may be based on a standard index, such as an equity index. The value of the periodic reset total return index may be the sum of the standard index plus the income flow generated by the index, such as dividends generated by stocks. The periodic reset total return index valuation may be deployed as the basis for a futures contract. On a periodic basis, the income flow accrued for the preceding period are passed from the short to the long position holder, with a corresponding adjustment of the settlement price of the contract. The expiration of the contract may be settled at the sum of the underlying index quotation plus the income flow accrual for the previous period. A buyer of a futures contract based on a periodic reset total return index receives the performance of the index plus the intervening income flow accrual.
摘要翻译：定期复位总回报指数可以基于标准指数，如权益指数。定期复位总回报指数的价值可以是标准指数加上指数产生的收入流量之和，如股票产生的股息。周期性复位总回报指数估值可以部署为期货合约的基础。定期按照上期计入当期损益，由短仓转为长期持有人，并对合同结算价格进行相应调整。合同到期可以按照相关指数报价加上一个期间的应计利润总额来结算。根据定期重置总回报指数的期货合约的买方收到指数的表现加上间接收入流动应计利润。

78. 发明授权

US08278055B2 Methods and device for analyte characterization 有权
标题翻译：用于分析物表征的方法和装置
公开(公告)号：US08278055B2
公开(公告)日：2012-10-02
申请号：US10697682
申请日：2003-10-29
申请人： Xing Su , Andrew A. Berlin
发明人： Xing Su , Andrew A. Berlin
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/48721 , G01N33/582 , G01N33/6803 , G01N33/6818
摘要： The methods and apparatus, disclosed herein are of use for sequencing and/or identifying proteins, polypeptides and/or peptides. Proteins containing labeled amino acid residues may be synthesized and passed through nanopores. A detector operably coupled to a nanopore may detect labeled amino acid residues as they pass through the nanopore. Distance maps for each type of labeled amino acid residue may be compiled. The distance maps may be used to sequence and/or identify the protein. Apparatus of use for protein sequencing and/or identification is also disclosed herein. In alternative methods, other types of analytes may be analyzed by the same techniques.
摘要翻译：本文公开的方法和装置可用于测序和/或鉴定蛋白质，多肽和/或肽。含有标记氨基酸残基的蛋白质可以合成并通过纳米孔。可操作地耦合到纳米孔的检测器可以在通过纳米孔时检测标记的氨基酸残基。可以编制每种类型的标记氨基酸残基的距离图。距离图可以用于序列和/或鉴定蛋白质。本文还公开了用于蛋白质测序和/或鉴定的装置。在替代方法中，可以通过相同的技术分析其它类型的分析物。

79. 发明申请

US20120109808A1 PERIODIC RESET TOTAL RETURN INDEX FUTURES CONTRACTS 有权
标题翻译：定期复位总回报指数期货合约
公开(公告)号：US20120109808A1
公开(公告)日：2012-05-03
申请号：US12914639
申请日：2010-10-28
申请人： Richard Co , Tuen Tuen Wang , Xing Su , John Labuszewski
发明人： Richard Co , Tuen Tuen Wang , Xing Su , John Labuszewski
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/06
摘要： A periodic reset total return index may be based on a standard index, such as an equity index. The value of the periodic reset total return index may be the sum of the standard index plus the income flow generated by the index, such as dividends generated by stocks. The periodic reset total return index valuation may be deployed as the basis for a futures contract. On a periodic basis, the income flow accrued for the preceding period are passed from the short to the long position holder, with a corresponding adjustment of the settlement price of the contract. The expiration of the contract may be settled at the sum of the underlying index quotation plus the income flow accrual for the previous period. A buyer of a futures contract based on a periodic reset total return index receives the performance of the index plus the intervening income flow accrual.
摘要翻译：定期复位总回报指数可以基于标准指数，如权益指数。定期复位总回报指数的价值可以是标准指数加上指数产生的收入流量之和，如股票产生的股息。周期性复位总回报指数估值可以部署为期货合约的基础。定期按照上期计入当期损益，由短仓转为长期持有人，并对合同结算价格进行相应调整。合同到期可以按照相关指数报价加上一个期间的应计利润总额来结算。根据定期重置总回报指数的期货合约的买方收到指数的表现加上间接收入流动应计利润。

80. 发明申请

US20120031758A1 Nanofabricated Structures for Electric Field-Assisted Nucleic Acid Extraction 有权
标题翻译：电场辅助核酸提取的纳米结构
公开(公告)号：US20120031758A1
公开(公告)日：2012-02-09
申请号：US13273934
申请日：2011-10-14
申请人： Steven A. Sundberg , Xing Su , Grace Credo
发明人： Steven A. Sundberg , Xing Su , Grace Credo
IPC分类号： C25B7/00 , G01N27/447
CPC分类号： C12N15/1006
摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.
摘要翻译：本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

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