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1. 发明授权

US08795523B2 Device and method for particle complex handling 有权
标题翻译：用于粒子复合物处理的装置和方法
公开(公告)号：US08795523B2
公开(公告)日：2014-08-05
申请号：US13430171
申请日：2012-03-26
申请人： Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
发明人： Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
IPC分类号： H05K13/04 , G01N33/53 , G01N33/553
CPC分类号： G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

2. 发明授权

US08563240B2 Nucleic acid sequencing and electronic detection 有权
标题翻译：核酸测序和电子检测
公开(公告)号：US08563240B2
公开(公告)日：2013-10-22
申请号：US12319168
申请日：2008-12-31
申请人： Xing Su , Kai Wu , David J. Liu
发明人： Xing Su , Kai Wu , David J. Liu
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： C12Q1/6874 , C12Q1/6837 , C12Q2565/607 , C12Q2565/518 , C12Q2525/117 , C12Q2537/149 , C12Q2525/113 , C12Q2521/319
摘要： Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing sensors to monitor changes in solutions or bound molecules contained in the reaction regions. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction regions that allow for optical monitoring of solutions in the reaction regions. Chemical amplification schemes that allow DNA to be sequenced in which multiple nucleotide addition reactions are performed to detect the incorporation of a base are disclosed. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
摘要翻译：本发明的实施方案提供了使用包含传感器的反应区域的阵列来测序DNA的装置方法，以监测反应区域中包含的溶液或结合分子的变化。另外的实施方案提供了使用允许对反应区域中的溶液进行光学监测的反应区域阵列来测序DNA的装置和方法。公开了允许进行多核苷酸加成反应进行DNA测序以检测碱基掺入的化学扩增方案。通过使用大阵列中包含的平行反应测序DNA，可以快速测序DNA。

3. 发明授权

US08158008B2 Device and method for particle complex handling 有权
标题翻译：用于粒子复合物处理的装置和方法
公开(公告)号：US08158008B2
公开(公告)日：2012-04-17
申请号：US13197918
申请日：2011-08-04
申请人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
发明人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC分类号： G01N1/00 , G01N21/00 , G01N33/48 , G01N33/53 , G01N33/553
CPC分类号： G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

4. 发明申请

US20120322683A1 ENZYMATIC SIGNAL GENERATION AND DETECTION OF BINDING COMPLEXES IN STATIONARY FLUIDIC CHIP 有权
标题翻译：固定信号生成和检测固定液流芯片中的结合复合物
公开(公告)号：US20120322683A1
公开(公告)日：2012-12-20
申请号：US13543488
申请日：2012-07-06
申请人： David J. Liu , Kai Wu , Xing Su
发明人： David J. Liu , Kai Wu , Xing Su
IPC分类号： G01N33/558 , G01N33/53 , C40B30/04 , G01N33/573 , G01N21/78 , G01N27/26 , G01N21/00 , G01N21/76 , C12Q1/70 , B82Y15/00
CPC分类号： G01N21/658 , B01L3/50273 , B01L3/502761 , B01L2300/0654 , B01L2400/043 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N21/255 , G01N21/6428 , G01N21/645 , G01N21/76 , G01N33/54333 , G01N33/587
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

5. 发明授权

US07993525B2 Device and method for particle complex handling 有权
标题翻译：用于粒子复合物处理的装置和方法
公开(公告)号：US07993525B2
公开(公告)日：2011-08-09
申请号：US11647566
申请日：2006-12-29
申请人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
发明人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC分类号： G01N1/00 , G01N21/00 , G01N33/48 , G01N33/53 , G01N33/553
CPC分类号： G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微机架阵列机械可移动的永磁体在功能上耦合到流体网络，其可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

6. 发明授权

US08586385B2 Method and device for biomolecule preparation and detection using magnetic array 有权
标题翻译：使用磁阵列进行生物分子制备和检测的方法和装置
公开(公告)号：US08586385B2
公开(公告)日：2013-11-19
申请号：US11646601
申请日：2006-12-28
申请人： Xing Su , Kai Wu , David J. Liu
发明人： Xing Su , Kai Wu , David J. Liu
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N27/74 , B01J2219/00576 , B01J2219/00648 , B01J2219/00655 , B01J2219/00725 , B01J2219/0074 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0439 , B03C1/032 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01R33/1269
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括多个区域，例如样品区域，清洁区域和检测区域。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

7. 发明申请

US20120035084A1 DEVICE AND METHOD FOR PARTICLE COMPLEX HANDLING 有权
公开(公告)号：US20120035084A1
公开(公告)日：2012-02-09
申请号：US13197918
申请日：2011-08-04
申请人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
发明人： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC分类号： C40B60/12 , G01N33/48 , B01L3/00
CPC分类号： G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

8. 发明授权

US08664008B2 Enzymatic signal generation and detection of binding complexes in stationary fluidic chip 有权
标题翻译：在固定流体芯片中的酶信号产生和结合复合物的检测
公开(公告)号：US08664008B2
公开(公告)日：2014-03-04
申请号：US13543488
申请日：2012-07-06
申请人： David J. Liu , Kai Wu , Xing Su
发明人： David J. Liu , Kai Wu , Xing Su
IPC分类号： G01N33/553 , C12Q1/00
CPC分类号： G01N21/658 , B01L3/50273 , B01L3/502761 , B01L2300/0654 , B01L2400/043 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N21/255 , G01N21/6428 , G01N21/645 , G01N21/76 , G01N33/54333 , G01N33/587
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

9. 发明授权

US08409877B2 Enzymatic signal generation and detection of binding complexes in stationary fluidic chip 有权
标题翻译：在固定流体芯片中的酶信号产生和结合复合物的检测
公开(公告)号：US08409877B2
公开(公告)日：2013-04-02
申请号：US11647565
申请日：2006-12-29
申请人： David J. Liu , Kai Wu , Xing Su
发明人： David J. Liu , Kai Wu , Xing Su
IPC分类号： G01N33/553 , C12Q1/00
CPC分类号： G01N21/658 , B01L3/50273 , B01L3/502761 , B01L2300/0654 , B01L2400/043 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N21/255 , G01N21/6428 , G01N21/645 , G01N21/76 , G01N33/54333 , G01N33/587
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

10. 发明申请

US20110159481A1 Solid-phase chelators and electronic biosensors 有权
标题翻译：固相螯合剂和电子生物传感器
公开(公告)号：US20110159481A1
公开(公告)日：2011-06-30
申请号：US12655459
申请日：2009-12-30
申请人： David J. Liu , Xing Su , Kai Wu
发明人： David J. Liu , Xing Su , Kai Wu
IPC分类号： C12Q1/68 , G01N33/50 , G01N27/26
CPC分类号： C12Q1/48 , C12Q1/6837 , C12Q1/6869 , G01N27/4145 , G01N2333/9125 , C12Q2565/607 , C12Q2565/507 , C12Q2565/301
摘要： Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions.
摘要翻译：介绍了核酸测序方法。通过化学扩增DNA合成产物和化学扩增产物的检测来完成测序。在本发明的实施方案中，提供了具有多个待测序的DNA分子的底物和能够螯合连接的焦磷酸根离子的多个分子，引入待测序的DNA分子，并且掺入下一个互补核苷酸，切除多次导致待测序的DNA分子局部周围的焦磷酸盐离子的积聚。焦磷酸根离子被底物连接的螯合剂捕获并电子检测以确定待测序的DNA分子中下一个互补核酸的同一性。另外，提供了通过检测焦磷酸根离子来检测生物分子的装置和方法。

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