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11. 发明申请

US20110188035A1 VIBRATING TIP SURFACE ENHANCED RAMAN SPECTROSCOPY 有权
标题翻译：振动提示表面增强拉曼光谱
公开(公告)号：US20110188035A1
公开(公告)日：2011-08-04
申请号：US12697156
申请日：2010-01-29
申请人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
发明人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。尖端构造成吸附分析物。该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。该系统还包括配置为与纳米针的振动协同地选通的同步检测器。该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

12. 发明申请

US20090280478A1 GENE METHYLATION AND EXPRESSION 有权
标题翻译：基因甲基化和表达
公开(公告)号：US20090280478A1
公开(公告)日：2009-11-12
申请号：US11915645
申请日：2006-05-30
申请人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
发明人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
IPC分类号： C12Q1/68 , C40B50/06 , C40B30/00 , C07H21/04
CPC分类号： C12N15/1093 , C12Q1/6855 , C12Q1/6881 , C12Q2600/154 , C12Q2600/158 , C12Q2521/331
摘要： The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer.
摘要翻译：本发明提供了分析全部或部分整个基因组的甲基化状态的方法。此外，本发明的特征在于含有易于甲基化的DNA的生物细胞的表征方法和试剂。这些方法包括诊断癌症的方法，例如乳腺癌。

13. 发明授权

US5939251A Apparatus and method for simplifying the processes in creating a sealed space on slides to conduct molecular biological reactions therein 失效
标题翻译：用于简化在载玻片上形成密封空间以在其中进行分子生物反应的过程的装置和方法
公开(公告)号：US5939251A
公开(公告)日：1999-08-17
申请号：US680324
申请日：1996-07-12
申请人： Min Hu
发明人： Min Hu
IPC分类号： B01L3/00 , G02B21/34 , C12Q1/00
CPC分类号： B01L3/508 , G02B21/34 , B01L2300/0822 , Y10T436/25
摘要： The present invention includes an enclosure dam for defining an sealed space between a slide and a covering means for containing a mixture of target samples and reagents for carrying out a molecular biological reaction therein. The enclosure dam a surrounding wall disposed on the slide wherein the surrounding wall composed of resin type of materials sustainable over a range of reaction conditions for the molecular biological reaction, the surrounding wall defining a securely sealed space on the slide in combination with the covering means provided for covering the surrounding wall whereby the molecular biological reaction can be flexibly and conveniently conducted in the sealed space in situ on the slide.
摘要翻译：本发明包括用于限定载玻片和覆盖装置之间的密封空间的封闭坝，用于容纳用于在其中进行分子生物反应的目标样品和试剂的混合物。外壳围绕设置在载玻片上的周围壁，其中由树脂类型的材料组成的周围壁在分子生物反应的一系列反应条件下可持续，围绕壁与覆盖装置组合在滑动件上限定牢固的密封空间提供用于覆盖周围壁，由此分子生物反应可以在滑动件上原位在密封空间中灵活方便地进行。

14. 发明授权

US09556430B2 Gene methylation and expression 有权
标题翻译：基因甲基化和表达
公开(公告)号：US09556430B2
公开(公告)日：2017-01-31
申请号：US11915645
申请日：2006-05-30
申请人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
发明人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1093 , C12Q1/6855 , C12Q1/6881 , C12Q2600/154 , C12Q2600/158 , C12Q2521/331
摘要： The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer.
摘要翻译：本发明提供了分析全部或部分整个基因组的甲基化状态的方法。此外，本发明的特征在于含有易于甲基化的DNA的生物细胞的表征方法和试剂。这些方法包括诊断癌症的方法，例如乳腺癌。

15. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

16. 发明授权

US08558788B2 Diffusing light of a laser 有权
标题翻译：扩散激光的光
公开(公告)号：US08558788B2
公开(公告)日：2013-10-15
申请号：US13066994
申请日：2011-04-29
申请人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
发明人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
IPC分类号： G02B27/20
CPC分类号： G02B27/20 , G02B5/0278 , G02B6/04 , G06F3/0421
摘要： Embodiments disclosed herein relate to diffusing light of a multi-mode laser. In one embodiment, the multi-mode laser projects a plurality of modes of light and a diffuser reflects the plurality of modes of light to output a single lobe of light.
摘要翻译：本文公开的实施例涉及漫射多模激光器的光。在一个实施例中，多模激光器投射多种模式的光，扩散器反射多种模式的光以输出单个光。

17. 发明授权

US08462333B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08462333B2
公开(公告)日：2013-06-11
申请号：US12905891
申请日：2010-10-15
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.
摘要翻译：用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中纳米手指以阵列排列在基板上。该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层，手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

18. 发明授权

US08390804B2 Surface enhanced Raman spectroscopy employing vibrating nanorods 有权
标题翻译：使用振动纳米棒的表面增强拉曼光谱
公开(公告)号：US08390804B2
公开(公告)日：2013-03-05
申请号：US12697136
申请日：2010-01-29
申请人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
发明人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。尖端被配置为吸附分析物并以振动频率振动。该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

19. 发明申请

US20130040862A1 MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS 审中-公开
标题翻译：用于分子分析的多支架结构
公开(公告)号：US20130040862A1
公开(公告)日：2013-02-14
申请号：US13636799
申请日：2010-04-20
申请人： Zhiyong Li , Min Hu , Fung Suong Ou , Wei Wu , R. Stanley Williams
发明人： Zhiyong Li , Min Hu , Fung Suong Ou , Wei Wu , R. Stanley Williams
IPC分类号： C40B40/14 , C40B50/14 , C40B40/18 , C40B40/04 , B82Y15/00
CPC分类号： G01N21/658
摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.
摘要翻译：提供了一种用于分子分析的多支柱结构。该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。每个纳米孔涂有金属涂层。还提供了这种多支柱结构的阵列。还提供了一种制备多支柱结构的方法。

20. 发明授权

US08314932B2 Surface-enhanced Raman spectroscopy device and a mold for creating and a method for making the same 有权
标题翻译：表面增强拉曼光谱装置及其制造用模具及其制造方法
公开(公告)号：US08314932B2
公开(公告)日：2012-11-20
申请号：US12771440
申请日：2010-04-30
申请人： Fung Suong Ou , Zhiyong Li , Min Hu , Wei Wu
发明人： Fung Suong Ou , Zhiyong Li , Min Hu , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G02B1/12 , G01N21/658
摘要： A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.
摘要翻译：表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。拉曼信号增强材料设置在每个锥形突起上。

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