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1. 发明授权

US08390804B2 Surface enhanced Raman spectroscopy employing vibrating nanorods 有权
标题翻译：使用振动纳米棒的表面增强拉曼光谱
公开(公告)号：US08390804B2
公开(公告)日：2013-03-05
申请号：US12697136
申请日：2010-01-29
申请人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
发明人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。尖端被配置为吸附分析物并以振动频率振动。该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

2. 发明申请

US20110188035A1 VIBRATING TIP SURFACE ENHANCED RAMAN SPECTROSCOPY 有权
标题翻译：振动提示表面增强拉曼光谱
公开(公告)号：US20110188035A1
公开(公告)日：2011-08-04
申请号：US12697156
申请日：2010-01-29
申请人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
发明人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。尖端构造成吸附分析物。该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。该系统还包括配置为与纳米针的振动协同地选通的同步检测器。该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

3. 发明申请

US20110188034A1 SURFACE ENHANCED RAMAN SPECTROSCOPY EMPLOYING VIBRATING NANORODS 有权
标题翻译：表面增强拉曼光谱仪采用振动纳米级
公开(公告)号：US20110188034A1
公开(公告)日：2011-08-04
申请号：US12697136
申请日：2010-01-29
申请人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
发明人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。尖端被配置为吸附分析物并以振动频率振动。该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

4. 发明授权

US08243270B2 Vibrating tip surface enhanced Raman spectroscopy 有权
标题翻译：振动尖端表面增强拉曼光谱
公开(公告)号：US08243270B2
公开(公告)日：2012-08-14
申请号：US12697156
申请日：2010-01-29
申请人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
发明人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。尖端构造成吸附分析物。该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。该系统还包括配置为与纳米针的振动协同地选通的同步检测器。该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

5. 发明授权

US08472018B2 Grating for multiple discrete wavelengths of Raman scattering 有权
标题翻译：用于多个离散波长的拉曼散射的光栅
公开(公告)号：US08472018B2
公开(公告)日：2013-06-25
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

6. 发明申请

US20120026493A1 GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING 有权
标题翻译：用于拉曼散射的多个分辨波长的光刻
公开(公告)号：US20120026493A1
公开(公告)日：2012-02-02
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

7. 发明申请

US20120188539A1 NANOROD SURFACE ENHANCED RAMAN SPECTROSCOPY APPARATUS, SYSTEM AND METHOD 审中-公开
标题翻译： NANOROD表面增强拉曼光谱仪器，系统和方法
公开(公告)号：US20120188539A1
公开(公告)日：2012-07-26
申请号：US13014683
申请日：2011-01-26
申请人： Michael J. Stuke , Shih-Yuan (SY) Wang , Zhiyong Li , Min Hu , Fung Suong Ou , Huei Pei Kuo
发明人： Michael J. Stuke , Shih-Yuan (SY) Wang , Zhiyong Li , Min Hu , Fung Suong Ou , Huei Pei Kuo
IPC分类号： G01J3/44 , B82Y20/00
CPC分类号： B82Y20/00 , G01N21/658
摘要： A nanorod surface enhanced Raman spectroscopy (SERS) apparatus, system and method of SERS using nanorods that are activated with a key. The nanorod SERS apparatus includes a plurality of nanorods, an activator to move the nanorods from an inactive to an active configuration and the key to trigger the activator. The nanorod SERS system further includes a Raman signal detector and an illumination source. The method of SERS using nanorods includes activating a plurality of nanorods with the key, illuminating the activated plurality of nanorods, and detecting a Raman scattering signal when the nanorods are in the active configuration.
摘要翻译：纳米棒表面增强拉曼光谱（SERS）装置，使用由键激活的纳米棒的SERS的系统和方法。纳米棒SERS装置包括多个纳米棒，激活剂将纳米棒从非活性构型移动到活性构型，以及触发激活剂的键。纳米棒SERS系统还包括拉曼信号检测器和照明源。使用纳米棒的SERS的方法包括用键激活多个纳米棒，照亮激活的多个纳米棒，以及当纳米棒处于活动配置时检测拉曼散射信号。

8. 发明申请

US20110188033A1 MOLECULE DETECTION USING RAMAN LIGHT DETECTION 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US20110188033A1
公开(公告)日：2011-08-04
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

9. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

10. 发明申请

US20120013902A1 MULTI-WAVELENGTH RAMAN LIGHT DETECTION FOR DETECTING A SPECIES 有权
标题翻译：用于检测物种的多波长拉曼光检测
公开(公告)号：US20120013902A1
公开(公告)日：2012-01-19
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译：用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

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