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1. 发明授权

US08472018B2 Grating for multiple discrete wavelengths of Raman scattering 有权
标题翻译：用于多个离散波长的拉曼散射的光栅
公开(公告)号：US08472018B2
公开(公告)日：2013-06-25
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

2. 发明授权

US08358407B2 Enhancing signals in Surface Enhanced Raman Spectroscopy (SERS) 有权
标题翻译：增强表面增强拉曼光谱（SERS）信号
公开(公告)号：US08358407B2
公开(公告)日：2013-01-22
申请号：US12771753
申请日：2010-04-30
申请人： Min Hu , Wei Wu , Fung Suong Ou , Zhiyong Li , R. Stanley Williams
发明人： Min Hu , Wei Wu , Fung Suong Ou , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/40
CPC分类号： G01N21/658 , B82Y15/00
摘要： An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.
摘要翻译：一种用于增强表面增强拉曼光谱（SERS）信号的集成器件。所述集成器件包括纳米结构的阵列，其包括材料，其中所述材料被配置为允许光通过。该集成装置还包括设置在纳米结构阵列的至少一部分上的SERS活性纳米颗粒和集成在纳米结构阵列的基底下方的反射镜。镜子被配置为将通过材料的光反射到纳米结构阵列中。

3. 发明授权

US08319963B2 Compact sensor system 有权
标题翻译：紧凑型传感器系统
公开(公告)号：US08319963B2
公开(公告)日：2012-11-27
申请号：US12772063
申请日：2010-04-30
申请人： Min Hu , Wei Wu , Fung Suong Ou , Zhen Peng , Zhiyong Li , R. Stanley Williams
发明人： Min Hu , Wei Wu , Fung Suong Ou , Zhen Peng , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N21/7746
摘要： A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.
摘要翻译：一种紧凑的传感器系统，包括：配置用于光子 - 物质相互作用的分析单元，其中从光源接收光子; 所述集成光谱分析仪包括：与所述分析单元耦合的波导，所述波导被配置为通过所述波导传播一组频率;以及波导，其被配置为用于识别一组频率。一个或多个与所述波导耦合的环形谐振器，所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器，所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。

4. 发明申请

US20120236298A1 TUNABLE APPARATUS FOR PERFORMING SERS 审中-公开
标题翻译：用于执行人员的装置
公开(公告)号：US20120236298A1
公开(公告)日：2012-09-20
申请号：US13048594
申请日：2011-03-15
申请人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
发明人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable substrate and a plurality of SERS-active nanoparticles disposed at a plurality of locations on the deformable substrate. The plurality of SERS-active nanoparticles are to enhance Raman scattered light emission from an analyte molecule located in close proximity to the SERS-active nanoparticles. In addition, the deformable substrate is to be deformed to vary distances between the SERS-active nanoparticles, in which varying distances between the SERS-active nanoparticles varies enhancement of an intensity of Raman scattered light emission from the analyte molecule.
摘要翻译：用于执行表面增强拉曼光谱（SERS）的可调谐装置包括可变形基板和设置在可变形基板上的多个位置处的多个SERS活性纳米颗粒。多个SERS活性纳米颗粒是增强来自位于紧邻SERS活性纳米颗粒的分析物分子的拉曼散射光发射。此外，可变形基底将变形以改变SERS活性纳米粒子之间的距离，其中SERS-活性纳米粒子之间的变化距离改变了来自分析物分子的拉曼散射光发射强度的增强。

5. 发明授权

US08243270B2 Vibrating tip surface enhanced Raman spectroscopy 有权
标题翻译：振动尖端表面增强拉曼光谱
公开(公告)号：US08243270B2
公开(公告)日：2012-08-14
申请号：US12697156
申请日：2010-01-29
申请人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
发明人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。尖端构造成吸附分析物。该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。该系统还包括配置为与纳米针的振动协同地选通的同步检测器。该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

6. 发明申请

US20120026493A1 GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING 有权
标题翻译：用于拉曼散射的多个分辨波长的光刻
公开(公告)号：US20120026493A1
公开(公告)日：2012-02-02
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

7. 发明申请

US20110267608A1 TUNABLE APPARATUS FOR PERFORMING SERS 有权
标题翻译：用于执行人员的装置
公开(公告)号：US20110267608A1
公开(公告)日：2011-11-03
申请号：US12771779
申请日：2010-04-30
申请人： Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li , R. Stanley Williams
发明人： Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的可调谐装置包括可变形层和设置在可变形层上的一个或多个位置处的多个SERS活性纳米颗粒，其中所述一个或多个位置被配置为用泵浦波长以使拉曼激发光与纳米颗粒相互作用，并从靠近纳米颗粒的分子产生增强的拉曼散射光。此外，可变形层的形态被配置为可控地改变以改变由分子产生的拉曼散射光的强度。

8. 发明授权

US08462333B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08462333B2
公开(公告)日：2013-06-11
申请号：US12905891
申请日：2010-10-15
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.
摘要翻译：用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中纳米手指以阵列排列在基板上。该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层，手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

9. 发明授权

US08390804B2 Surface enhanced Raman spectroscopy employing vibrating nanorods 有权
标题翻译：使用振动纳米棒的表面增强拉曼光谱
公开(公告)号：US08390804B2
公开(公告)日：2013-03-05
申请号：US12697136
申请日：2010-01-29
申请人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
发明人： Michael J. Stuke , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan (Sy) Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译：表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。尖端被配置为吸附分析物并以振动频率振动。该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

10. 发明申请

US20130040862A1 MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS 审中-公开
标题翻译：用于分子分析的多支架结构
公开(公告)号：US20130040862A1
公开(公告)日：2013-02-14
申请号：US13636799
申请日：2010-04-20
申请人： Zhiyong Li , Min Hu , Fung Suong Ou , Wei Wu , R. Stanley Williams
发明人： Zhiyong Li , Min Hu , Fung Suong Ou , Wei Wu , R. Stanley Williams
IPC分类号： C40B40/14 , C40B50/14 , C40B40/18 , C40B40/04 , B82Y15/00
CPC分类号： G01N21/658
摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.
摘要翻译：提供了一种用于分子分析的多支柱结构。该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。每个纳米孔涂有金属涂层。还提供了这种多支柱结构的阵列。还提供了一种制备多支柱结构的方法。

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