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1. 发明授权

US09352283B2 Tubular fiber membrane with nanoporous skin 有权
标题翻译：管状纤维膜与纳米多孔皮肤
公开(公告)号：US09352283B2
公开(公告)日：2016-05-31
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , B01D63/06 , B01D71/68 , A61M1/16 , B01D67/00 , B01D69/08 , D01D5/06 , D01D5/247 , A61M1/36
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。表皮层中的孔可具有小于约7nm的平均孔径，并且管腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

2. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

3. 发明申请

US20110006453A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 有权
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：US20110006453A1
公开(公告)日：2011-01-13
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

4. 发明申请

US20130206673A1 TUBULAR FIBER MEMBRANE WITH NANOPOROUS SKIN 有权
标题翻译：管状纤维膜与纳米皮肤
公开(公告)号：US20130206673A1
公开(公告)日：2013-08-15
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , D01D5/06 , D01D5/247
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。皮肤层中的孔可以具有小于约7nm的平均孔径，并且内腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

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