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1. 发明授权

US08373854B2 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US08373854B2
公开(公告)日：2013-02-12
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
IPC分类号： G01N1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

2. 发明授权

US07742164B1 Luminescence reference standards 失效
标题翻译：发光参考标准
公开(公告)号：US07742164B1
公开(公告)日：2010-06-22
申请号：US12338778
申请日：2008-12-18
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

3. 发明授权

US07480042B1 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US07480042B1
公开(公告)日：2009-01-20
申请号：US11173609
申请日：2005-06-30
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：系统及其组件，用于检测和/或分析光。样品分析之前，期间和/或之后，这些系统可以包括用于校准，验证和/或监测光检测系统的光学参考标准。

4. 发明申请

US20110085168A1 Luminescence Reference Standards 有权
标题翻译：发光参考标准
公开(公告)号：US20110085168A1
公开(公告)日：2011-04-14
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10 , G01B11/00 , B82Y99/00
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

5. 发明授权

US06419827B1 Purification apparatus and method 失效
标题翻译：净化装置及方法
公开(公告)号：US06419827B1
公开(公告)日：2002-07-16
申请号：US09552301
申请日：2000-04-18
申请人： Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： B01D6300
CPC分类号： B01L3/50255 , B01D61/18 , B01L3/5025 , B01L2400/049 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102
摘要： The invention includes a filtration apparatus for processing a plurality of fluid samples into sample wells is provided. In one embodiment, the filtration apparatus includes a purification tray and a sample well tray with a plurality of sample wells. The purification tray includes a filter plate having a plurality of columns with discharge openings at the bottom thereof, at least one filter positioned in the columns of the filter plate for filtering the fluid samples as they pass therethrough, a heat plate positioned adjacent the columns of the filter plate, and a vent plate positioned below the heat plate. The heat plate is configured for transferring heat to the columns of the filter plate. The vent plate includes vents for permitting aerosols from the sample wells of the sample well tray to escape. A sample well tray with a plurality of the sample wells is positioned so that the sample wells align with the discharge openings of the filter plate columns to receive the liquid sample therein.
摘要翻译：本发明提供了一种用于将多个流体样品加工成样品孔的过滤装置。在一个实施例中，过滤装置包括净化盘和具有多个样品孔的样品井托盘。净化盘包括一个过滤板，该过滤板具有多个在其底部具有排放口的柱，至少一个过滤器，定位在过滤板的列中，用于在流体样品通过过滤器时对其进行过滤，过滤板和位于加热板下方的通风板。加热板被配置为将热量传递到过滤板的列。通风板包括用于允许来自样品井托盘的样品井的气溶胶逸出的通风口。定位具有多个样品孔的样品孔盘，使得样品孔与过滤板柱的排出口对准以在其中接收液体样品。

6. 发明授权

US07452510B2 Manually-operable multi-well microfiltration apparatus and method 有权
标题翻译：手动操作的多孔微滤装置及方法
公开(公告)号：US07452510B2
公开(公告)日：2008-11-18
申请号：US11338254
申请日：2006-01-24
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： B01L11/00 , B01L3/00 , B01D63/00 , B65B43/42
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A multi-well microfiltration apparatus and method are provided and feature a manual touch-off system for transferring pendent drops hanging from discharge-conduits of a discharge-conduit array to respective receiving wells or receiving holes of a corresponding receiving array, with minimum or no cross-contamination between the discharge conduits, or the receiving wells or receiving holes. The manual touch-off is achieved by manually shifting a carriage that supports one of the arrays, into a position whereat pendent drops of fluid hanging from the distal ends of the discharge conduits contact the inner sidewalls of the corresponding receiving wells or receiving holes of the receiving array.
摘要翻译：提供了一种多孔微滤装置和方法，其特征在于一种手动触发系统，用于将从排放管阵列的排放管道悬挂的悬挂液滴转移到相应接收孔的相应接收孔或接收孔的最小或不排放管道或接收井或接收孔之间的交叉污染。手动触发是通过将支撑其中一个阵列的托架手动地移动到从排出管道的远端悬挂的悬挂液滴与相应的接收井的内侧壁接触的位置或接收孔的接收孔接收阵列。

7. 发明授权

US06906292B2 Sample tray heater module 有权
标题翻译：样品盘加热器模块
公开(公告)号：US06906292B2
公开(公告)日：2005-06-14
申请号：US10359665
申请日：2003-02-06
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： B01L99/00 , B01D61/18 , B01L3/00 , B01L7/00 , G01N35/00 , G01N35/02 , G01N35/10 , C12M1/38 , H05B3/22
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.
摘要翻译：描述了一种加热器模块，其包括配热板，该散热板包括具有第一和第二侧面的底部以及远离其中一个侧面延伸的多个突起。提供了用于加热分布板的热源，并且可选地，加热盘可以用于接收热源和散热板。加热器模块适于接合具有多个净化和/或排出柱的样品净化盘，其可以延伸穿过加热器模块中的开口并将样品引导到样品接收托盘中。还描述了使用加热器模块加热样品的方法。

8. 发明授权

US07019267B2 Sample tray heater module 失效
标题翻译：样品盘加热器模块
公开(公告)号：US07019267B2
公开(公告)日：2006-03-28
申请号：US11120797
申请日：2005-05-03
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： H05B3/22 , C12M1/38 , B01L7/00
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.
摘要翻译：描述了一种加热器模块，其包括配热板，该散热板包括具有第一和第二侧面的底部以及远离其中一个侧面延伸的多个突起。提供了用于加热分布板的热源，并且可选地，加热盘可以用于接收热源和散热板。加热器模块适于接合具有多个净化和/或排出柱的样品净化盘，其可以延伸穿过加热器模块中的开口并将样品引导到样品接收托盘中。还描述了使用加热器模块加热样品的方法。

9. 发明授权

US08945481B1 Microfluidic devices and method for their use 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US08945481B1
公开(公告)日：2015-02-03
申请号：US12145333
申请日：2008-06-24
申请人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
发明人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
IPC分类号： B01L3/00
CPC分类号： B01J19/0046 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0867 , B01L2300/185 , B01L2400/0655 , G01N21/17 , G01N2201/0407
摘要： Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
摘要翻译：示例性实施例提供了用于它们的微流体装置和方法。微流体装置可以包括通过与流动层的第一和第二多个流体通道相交形成的M×N反应位点的阵列。流层可以具有矩阵设计和/或盲通道设计，以在有限数量的条件下分析大量样品。微流体装置还可以包括控制层，其包括用于调节通过流体通道的溶液流动的阀门系统。此外，通过使控制层与流体通道对准，可以通过向/从反应位置的管道灯来改善微流体装置的检测，例如光学信号收集。在示例性实施例中，保护通道可以包括在微流体装置中用于热循环和/或减少从反应位置的蒸发。

10. 发明申请

US20090000690A1 Diffusion-aided loading system for microfluidic devices 审中-公开
标题翻译：用于微流体装置的扩散辅助加载系统
公开(公告)号：US20090000690A1
公开(公告)日：2009-01-01
申请号：US12156584
申请日：2008-06-03
申请人： Mark F. Oldham , Ian A. Harding , Kevin S. Bodner
发明人： Mark F. Oldham , Ian A. Harding , Kevin S. Bodner
IPC分类号： B65B31/00
CPC分类号： B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/049 , B01L2400/06
摘要： Microfluidic devices having a diffusion-aided system for loading samples into the microfluidic device are provided. Methods of gas-venting a microfluidic device through a non-porous, gas permeable material sealing cover layer, for example, during liquid sample loading, are also provided. The non-porous, gas-permeable material can be, for example, a polysiloxane, for example, polydimethylsiloxane.
摘要翻译：提供具有用于将样品加载到微流体装置中的扩散辅助系统的微流体装置。还提供了例如在液体样品加载期间通过非多孔，透气材料密封覆盖层气体排出微流体装置的方法。无孔透气材料可以是例如聚硅氧烷，例如聚二甲基硅氧烷。

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