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    • 5. 发明申请
    • ENHANCED TRANS-KERATIN DRUG DELIVERY
    • 增强转基因药物递送
    • US20100021530A1
    • 2010-01-28
    • US12510237
    • 2009-07-27
    • Todd A. WEINFIELD
    • Todd A. WEINFIELD
    • A61K31/4402A61K9/00A61K9/70A61Q3/00
    • A61K31/4402A61F7/02A61F2007/0037A61F2007/0046A61K9/0014A61K9/70A61M37/00A61M2210/086
    • The teachings provided herein are directed to a system and method for delivering an anti-infective agent through the nail of a subject having a nail infection. The system can comprise a drug delivery mechanism comprising an anti-infective agent and a heating element and a holding mechanism for releasably attaching the drug delivery mechanism to the digit having the infected nail. The drug delivery mechanism does not comprise a nail-infection-agent-containing member or sponge for receiving and delivering the anti-infective agent to the infected nail. In addition, the holding mechanism comprises a substantially open structure that covers the infected nail and does not enclose the digit. The system facilitates an enhanced trans-keratin drug delivery of the anti-infective agent through the infected nail in a dark, warm, and moist environment that prevents the growth of fungi in the infected nail. The teachings also include a heatable bandage for treating an infected nail.
    • 本文提供的教导涉及用于通过具有指甲感染的受试者的指甲递送抗感染剂的系统和方法。 该系统可以包括药物递送机构,其包括抗感染剂和加热元件以及用于将药物递送机构可释放地附接到具有感染指甲的数字的保持机构。 药物递送机制不包括用于接受并将感染剂递送到感染的指甲的含有感染剂的构件或海绵。 此外,保持机构包括覆盖受感染的钉并且不包围数字的基本上开放的结构。 该系统促进抗感染剂通过感染的指甲在黑暗,温暖和潮湿的环境中增强的转角蛋白药物递送,其防止感染指甲中的真菌生长。 该教导还包括用于治疗感染的指甲的可加热绷带。