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1. 发明申请

US20090000690A1 Diffusion-aided loading system for microfluidic devices 审中-公开
标题翻译：用于微流体装置的扩散辅助加载系统
公开(公告)号：US20090000690A1
公开(公告)日：2009-01-01
申请号：US12156584
申请日：2008-06-03
申请人： Mark F. Oldham , Ian A. Harding , Kevin S. Bodner
发明人： Mark F. Oldham , Ian A. Harding , Kevin S. Bodner
IPC分类号： B65B31/00
CPC分类号： B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/049 , B01L2400/06
摘要： Microfluidic devices having a diffusion-aided system for loading samples into the microfluidic device are provided. Methods of gas-venting a microfluidic device through a non-porous, gas permeable material sealing cover layer, for example, during liquid sample loading, are also provided. The non-porous, gas-permeable material can be, for example, a polysiloxane, for example, polydimethylsiloxane.
摘要翻译：提供具有用于将样品加载到微流体装置中的扩散辅助系统的微流体装置。还提供了例如在液体样品加载期间通过非多孔，透气材料密封覆盖层气体排出微流体装置的方法。无孔透气材料可以是例如聚硅氧烷，例如聚二甲基硅氧烷。

2. 发明授权

US08945481B1 Microfluidic devices and method for their use 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US08945481B1
公开(公告)日：2015-02-03
申请号：US12145333
申请日：2008-06-24
申请人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
发明人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
IPC分类号： B01L3/00
CPC分类号： B01J19/0046 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0867 , B01L2300/185 , B01L2400/0655 , G01N21/17 , G01N2201/0407
摘要： Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
摘要翻译：示例性实施例提供了用于它们的微流体装置和方法。微流体装置可以包括通过与流动层的第一和第二多个流体通道相交形成的M×N反应位点的阵列。流层可以具有矩阵设计和/或盲通道设计，以在有限数量的条件下分析大量样品。微流体装置还可以包括控制层，其包括用于调节通过流体通道的溶液流动的阀门系统。此外，通过使控制层与流体通道对准，可以通过向/从反应位置的管道灯来改善微流体装置的检测，例如光学信号收集。在示例性实施例中，保护通道可以包括在微流体装置中用于热循环和/或减少从反应位置的蒸发。

3. 发明授权

US08373854B2 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US08373854B2
公开(公告)日：2013-02-12
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
IPC分类号： G01N1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

4. 发明授权

US06451261B1 Multi-well microfiltration apparatus 失效
公开(公告)号：US06451261B1
公开(公告)日：2002-09-17
申请号：US09565673
申请日：2000-05-04
申请人： Kevin S. Bodner , Alfred P. Madden , Joseph Jackson , Jason H. Halsey , Mark T. Reed , Ward Frye , Mark F. Oldham , Stephen E. Moring , Jon Hoshizaki
发明人： Kevin S. Bodner , Alfred P. Madden , Joseph Jackson , Jason H. Halsey , Mark T. Reed , Ward Frye , Mark F. Oldham , Stephen E. Moring , Jon Hoshizaki
IPC分类号： B01L300
CPC分类号： B01L3/5025 , B01D61/18 , B01L3/50255 , B01L2400/049 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25
摘要： The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.

5. 发明授权

US6159368A Multi-well microfiltration apparatus 有权
标题翻译：多孔微滤装置
公开(公告)号：US6159368A
公开(公告)日：2000-12-12
申请号：US182946
申请日：1998-10-29
申请人： Stephen E. Moring , Kevin S. Bodner , Jason H. Halsey , Jon Hoshizaki , Joseph Jackson , Alfred P. Madden , Mark F. Oldham , Mark T. Reed
发明人： Stephen E. Moring , Kevin S. Bodner , Jason H. Halsey , Jon Hoshizaki , Joseph Jackson , Alfred P. Madden , Mark F. Oldham , Mark T. Reed
IPC分类号： G01N1/00 , B01D29/00 , B01D35/02 , B01D53/22 , B01D61/18 , B01L3/00 , C12N15/09 , G01N35/00 , G01N35/02 , G01N35/10 , B01D63/00
CPC分类号： B01L3/5025 , B01D61/18 , B01L3/50255 , G01N35/0099 , B01L2400/049 , G01N2035/00485 , G01N2035/102 , G01N35/028 , G01N35/1074 , Y10T436/25
摘要： The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with is the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要翻译：本发明提供了多孔板和柱阵列，其中可以分析和/或处理样品（例如，含有目标核酸的细胞裂解物，例如RNA）。在一个实施方案中，微滤装置是多层结构，包括（i）具有可以放置样品的小柱阵列的柱板，（ii）设置在每个小柱中的离散过滤元件，（iii）滴液导向器板具有相应的滴液导向器阵列，滤液可以通过其排出;以及（iv）接收孔板，其具有滤液能够流过的相应阵列的接收孔。本发明提供了相对简单的多孔微过滤装置，并且克服了许多与以下问题有关的问题：（i）由于穿过公共过滤片芯线而引起的交叉污染或（ii）单个过滤元件在大量死体积内捕获样品成分。此外，本发明提供了多孔微过滤装置，其充分地支撑设置在井中的分立的过滤元件，而不产生实质的优先流动。另外，本发明提供了多孔微量过滤装置，其避免了由于气溶胶形成，悬挂液滴和/或飞溅而导致的交叉污染。本发明的其它公开的特征提供了分别收集在孔阵列中的滤液样品的自动覆盖或热封。

6. 发明授权

US07480042B1 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US07480042B1
公开(公告)日：2009-01-20
申请号：US11173609
申请日：2005-06-30
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：系统及其组件，用于检测和/或分析光。样品分析之前，期间和/或之后，这些系统可以包括用于校准，验证和/或监测光检测系统的光学参考标准。

7. 发明授权

US06783732B2 Apparatus and method for avoiding cross-contamination due to pendent drops of fluid hanging from discharge conduits 有权
标题翻译：用于避免由排放管道悬挂的流体悬垂液滴引起的交叉污染的装置和方法
公开(公告)号：US06783732B2
公开(公告)日：2004-08-31
申请号：US10199743
申请日：2002-07-19
申请人： Alfred P Madden , Jon Hoshizaki , Jason H. Halsey , Stephen E. Moring , Mark F. Oldham , Kevin S. Bodner
发明人： Alfred P Madden , Jon Hoshizaki , Jason H. Halsey , Stephen E. Moring , Mark F. Oldham , Kevin S. Bodner
IPC分类号： G01N3500
CPC分类号： B01L3/5025 , B01D61/18 , B01L3/50255 , B01L2400/049 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25
摘要： The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要翻译：本发明提供了多孔板和柱阵列，其中可以分析和/或处理样品（例如，含有目标核酸的细胞裂解物，例如RNA）。在一个实施方案中，微滤装置是多层结构，包括（i）具有可以放置样品的小柱阵列的柱板，（ii）设置在每个小柱中的离散过滤元件，（iii）滴液导向器板具有相应的滴液导向器阵列，滤液可以通过其排出;以及（iv）接收孔板，其具有滤液能够流过的相应阵列的接收孔。本发明提供了相对简单的多孔微量过滤装置，并且克服了许多与先前布置有关的问题，这些问题涉及（i）由于芯毛穿过公共过滤片引起的交叉污染或（ii）截留的单个过滤器元件大量死体积的样品成分。此外，本发明提供了多孔微过滤装置，其充分地支撑设置在井中的分立的过滤元件，而不产生实质的优先流动。此外，本发明提供了多孔微滤装置，其避免了由于气溶胶形成，悬垂滴和/或飞溅而导致的交叉污染。本发明的其它公开的特征提供了分别收集在孔阵列中的滤液样品的自动覆盖或热封。

8. 发明授权

US06506343B1 Multi-well microfiltration apparatus and method for avoiding cross-contamination 有权
标题翻译：多孔微滤装置及避免交叉污染的方法
公开(公告)号：US06506343B1
公开(公告)日：2003-01-14
申请号：US09565202
申请日：2000-05-04
申请人： Kevin S. Bodner , Alfred P. Madden , Jason H. Halsey , Mark F. Oldham , Stephen E. Moring , Jon Hoshizaki
发明人： Kevin S. Bodner , Alfred P. Madden , Jason H. Halsey , Mark F. Oldham , Stephen E. Moring , Jon Hoshizaki
IPC分类号： B01D3500
CPC分类号： B01L3/5025 , B01D61/18 , B01L3/50255 , B01L2400/049 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25
摘要： The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要翻译：本发明提供了多孔板和柱阵列，其中可以分析和/或处理样品（例如，含有目标核酸的细胞裂解物，例如RNA）。在一个实施方案中，微滤装置是多层结构，包括（i）具有可以放置样品的小柱阵列的柱板，（ii）设置在每个小柱中的离散过滤元件，（iii）滴液导向器板具有相应的滴液导向器阵列，滤液可以通过其排出;以及（iv）接收孔板，其具有滤液能够流过的相应阵列的接收孔。本发明提供了相对简单的多孔微量过滤装置，并且克服了许多与先前布置有关的问题，这些问题涉及（i）由于芯毛穿过公共过滤片引起的交叉污染或（ii）截留的单个过滤器元件大量死体积的样品成分。此外，本发明提供了多孔微过滤装置，其充分地支撑设置在井中的分立的过滤元件，而不产生实质的优先流动。此外，本发明提供了多孔微滤装置，其避免了由于气溶胶形成，悬垂滴和/或飞溅而导致的交叉污染。本发明的其它公开的特征提供了分别收集在孔阵列中的滤液样品的自动覆盖或热封。

9. 发明申请

US20110085168A1 Luminescence Reference Standards 有权
标题翻译：发光参考标准
公开(公告)号：US20110085168A1
公开(公告)日：2011-04-14
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10 , G01B11/00 , B82Y99/00
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

10. 发明授权

US07742164B1 Luminescence reference standards 失效
标题翻译：发光参考标准
公开(公告)号：US07742164B1
公开(公告)日：2010-06-22
申请号：US12338778
申请日：2008-12-18
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

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