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1. 发明申请

US20190201889A1 ASPIRATION-FREE WELL PLATE APPARATUS AND METHODS 审中-公开
公开(公告)号：US20190201889A1
公开(公告)日：2019-07-04
申请号：US16139317
申请日：2018-09-24
申请人： CytoSaver LLC
发明人： Matthew B. HALE
IPC分类号： B01L3/00 , G01N1/40 , B01J8/00 , G01N1/34
CPC分类号： B01L3/50255 , B01D61/18 , B01D63/16 , B01D2315/02 , B01J8/006 , B01L2200/028 , B01L2200/0631 , B01L2200/0652 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , G01N1/34 , G01N1/40 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , G01N2035/00495 , Y10T436/255
摘要： A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir.

2. 发明申请

US20180003602A1 PROCESS AND DEVICE FOR SEPARATING BIOLOGICAL PARTICLES CONTAINED IN A FLUID BY MEANS OF FILTRATION 审中-公开
公开(公告)号：US20180003602A1
公开(公告)日：2018-01-04
申请号：US15707993
申请日：2017-09-18
申请人： Patrizia PATERLINI-BRECHOT
发明人： Patrizia PATERLINI-BRECHOT
IPC分类号： G01N1/40 , B01L3/00 , B01L9/00
CPC分类号： G01N1/4077 , B01L3/50255 , B01L9/523 , B01L2200/0631 , B01L2400/049 , G01N2001/4088
摘要： The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterised in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.

3. 发明申请

US20170320055A1 LOADING TOOL FOR A MULTI-WELL CHROMATOGRAPHY FILTER PLATE 审中-公开
公开(公告)号：US20170320055A1
公开(公告)日：2017-11-09
申请号：US15520373
申请日：2014-11-19
申请人： Halliburton Energy Services, Inc.
发明人： Jody Marie Burks , Christopher Ray Bell
IPC分类号： B01L3/00 , G01N35/10
CPC分类号： B01L3/50255 , B01D15/14 , B01L3/502707 , B01L3/52 , B01L2200/02 , B01L2200/025 , B01L2300/069 , B01L2300/0829 , B01L2400/0493 , G01N30/16 , G01N35/1011 , G01N2030/8854
摘要： In accordance with some embodiments of the present disclosure, a loading tool for a multi-well chromatography filter plate is disclosed. The loading tool may include a top plate and a bottom plate slidably coupled to the top plate. The top plate may include a plurality of wells for holding a material, a rail located along a side of the top plate, and a notch formed in the rail. The bottom plate may include a plurality of funnels extending from the bottom plate, each of the plurality of funnels corresponding to one of the plurality of wells, a track located along a side of the bottom plate to receive the rail located on the top plate, and a pathway formed in the track to receive the notch such that the notch and the pathway limit movement of the top plate relative to the bottom plate.

4. 发明申请

US20170266663A1 MULTIWELL PLATE 审中-公开
公开(公告)号：US20170266663A1
公开(公告)日：2017-09-21
申请号：US15613004
申请日：2017-06-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： JON A. KIRSCHHOFFER , ANDREW H. TILSTRA , WENSHENG XIA
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L2200/025 , B01L2200/028 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851
摘要： An assembly for processing a sample is provided. The assembly comprises a first body having a plurality of spaced-apart conduits and a second body having a plurality of chambers wherein each conduit is fluidically connected to a separate chamber. The assembly forms a plurality of liquid flow paths, each flow path comprising a conduit and a chamber. An analyte capture element is detachably attached to a conduit and is in fluidic communication with the liquid flow path of the conduit. Optionally, the assembly further may comprise a third body comprising a plurality of reservoirs. The assembly can be used to process a liquid sample for detecting an analyte.

5. 发明授权

US09677981B2 Sample concentrator and method of use 有权
公开(公告)号：US09677981B2
公开(公告)日：2017-06-13
申请号：US14774149
申请日：2014-03-13
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Gregory W. Sitton , Andrew H. Tilstra , Wensheng Xia , Jon A. Kirschhoffer
IPC分类号： G01N1/40 , C12Q1/04 , B01L3/00 , C12Q1/24 , G01N33/569 , C12Q1/68 , G01N15/06
CPC分类号： G01N1/4077 , B01L3/50255 , B01L3/508 , B01L2200/0647 , B01L2200/0689 , B01L2300/045 , B01L2300/0681 , B01L2300/0832 , B01L2400/0475 , B01L2400/0478 , C12Q1/04 , C12Q1/24 , C12Q1/6844 , G01N1/40 , G01N15/0618 , G01N33/56911 , G01N2001/4088 , G01N2333/00 , G01N2333/195
摘要： The present disclosure provides an assembly for preparing a sample for analysis. The assembly comprises a hollow body comprising first opening, an outlet with a second opening, and a fluid pathway extending therebetween; a filter element operatively interposed in the fluid pathway; and a closure comprising a third opening and a chamber, the closure being slideably engaged with the outlet. The chamber and the outlet are dimensioned so that the outlet is sealingly engaged with the chamber. A method of using the assembly to detect a microorganism is also provided.

6. 发明授权

US09662649B2 Devices and methods for capturing target molecules 有权
公开(公告)号：US09662649B2
公开(公告)日：2017-05-30
申请号：US14889131
申请日：2013-10-02
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL CO. AMERICA LTD.
发明人： Masato Mitsuhashi , Mieko Ogura
IPC分类号： G01N15/06 , G01N1/18 , G01N33/00 , G01N33/48 , B01L3/00 , B04B3/00
CPC分类号： C12Q1/6806 , B01L3/502 , B01L3/5021 , B01L3/50255 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2300/021 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , B04B3/00 , G01N1/405 , G01N1/4077 , G01N2001/4088
摘要： Provided herein are devices and methods for the capture or isolation of a biomarker from a biological sample. In several embodiments, the device comprises a loading region, a filter material, and a receiving region. In particular, in several embodiments, biological fluid is passed from the loading region through the filter material and into the receiving region, thereby resulting in capture or isolation of a biomarker.

7. 发明申请

US20170120244A1 Modular Well Plates 审中-公开
公开(公告)号：US20170120244A1
公开(公告)日：2017-05-04
申请号：US14928666
申请日：2015-10-30
申请人： Lonza Limited
发明人： Matthias Johannes FORSCHNER
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L3/50255 , B01L3/50853 , B01L2200/028 , B01L2300/041 , B01L2300/0681 , B01L2300/0829 , B01L2300/12
摘要： A filter plate with a flexible modular design. The filter plate has removable and completely closable rows and columns of wells, as well as removable and completely closable single or groups of wells.

8. 发明授权

US09457359B2 Device for insertion into a rotor of a centrifuge, centrifuge and method for the fluidic coupling of cavities 有权
标题翻译：用于插入离心机转子的设备，离心机和腔体流体耦合的方法
公开(公告)号：US09457359B2
公开(公告)日：2016-10-04
申请号：US13624079
申请日：2012-09-21
申请人： Albert-Ludwigs-Universitaet Freiburg , Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.
发明人： Felix Von Stetten , Marion Finkbeiner , Roland Zengerle , Nils Paust , Guenter Roth
IPC分类号： B04B7/08 , B01L3/00 , B04B5/04
CPC分类号： B04B7/08 , B01L3/502 , B01L3/5021 , B01L3/5025 , B01L3/50255 , B01L2300/044 , B01L2300/047 , B01L2300/049 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , B01L2400/065 , B01L2400/0683 , B04B5/0407 , B04B5/0421 , B04B2005/0435
摘要： A device for insertion into a rotor of a centrifuge has at least two bodies stacked one above the other in a stacking direction inside a housing insertable into a holder of the rotor of the centrifuge. The two bodies are movably disposed in relation to each other inside the housing in order to fluidically couple, in a first phase, responding to a rotation of the rotor, a first cavity of the first body to a first cavity of the second body and to fluidically couple in a second phase a second cavity of the first body to the first cavity of the second body.
摘要翻译：用于插入到离心机的转子中的装置具有在可插入离心机的转子的保持器的壳体内的堆叠方向上彼此层叠的至少两个主体。这两个主体在壳体内相对于彼此可移动地设置，以便在第一阶段中响应于转子的旋转，第一主体的第一腔体与第二主体的第一腔体流体耦合，并且在第二阶段中将第一体的第二腔流体耦合到第二体的第一腔。

9. 发明申请

US20160202277A1 SAMPLE PREPARATION WORKSTATION 有权
标题翻译：样品制备工作站
公开(公告)号：US20160202277A1
公开(公告)日：2016-07-14
申请号：US14913078
申请日：2014-08-19
申请人： BIOTAGE AB
发明人： Lars ANDERSSON
IPC分类号： G01N35/00
CPC分类号： G01N35/00 , B01L3/50255 , B01L3/5085 , B01L9/523 , B01L2400/0409 , G01N35/0099 , G01N35/04 , G01N2001/4061 , G01N2035/0418 , G01N2035/0467
摘要： The present invention relates to laboratory instruments, in particular to instruments for automated preparation of liquid samples like Solid Phase Extraction (SPE), Supported Liquid Extraction (SLE) or liquid-liquid extraction (LLE). The instrument reduces the risk of cross-contamination between sample collection containers by lifting the sample collection containers to the level of the outlet of the sample processing containers, or slightly above. The instrument further comprises a movable table positioning the liquid collection containers directly beneath said sample processing containers and a waste collection container directly beneath the sample processing containers, wherein said waste collection container is vertically movable from a position below the movable table to a position above the movable table.
摘要翻译：本发明涉及实验室仪器，特别涉及用于液体样品如固相萃取（SPE），支持液体萃取（SLE）或液 - 液萃取（LLE）的自动化制备的仪器。该仪器通过将样品收集容器提升到样品处理容器出口的水平或略高于样品收集容器，从而降低了交叉污染的风险。仪器还包括一个可移动的工作台，将液体收集容器直接放置在样品处理容器的正下方，以及在样品处理容器正下方的废物收集容器，其中所述废物收集容器可从活动台下方的位置垂直移动至活动桌。

10. 发明申请

US20160074860A1 DEVICES AND METHODS FOR CAPTURING TARGET MOLECULES 有权
标题翻译：用于捕获目标分子的装置和方法
公开(公告)号：US20160074860A1
公开(公告)日：2016-03-17
申请号：US14889131
申请日：2013-10-02
申请人： HITACHI CHEMICAL COMPANY LTD , HITACHI CHEMICAL CO. AMERICA, LTD.
发明人： Masato Mitsuhashi , Mieko Ogura
IPC分类号： B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502 , B01L3/5021 , B01L3/50255 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2300/021 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , B04B3/00 , G01N1/405 , G01N1/4077 , G01N2001/4088
摘要： Provided herein are devices and methods for the capture or isolation of a biomarker from a biological sample. In several embodiments, the device comprises a loading region, a filter material, and a receiving region. In particular, in several embodiments, biological fluid is passed from the loading region through the filter material and into the receiving region, thereby resulting in capture or isolation of a biomarker.
摘要翻译：本文提供了用于从生物样品捕获或分离生物标志物的装置和方法。在几个实施例中，该装置包括加载区域，过滤材料和接收区域。特别地，在几个实施例中，生物流体从装载区域通过过滤材料并进入接收区域，从而导致捕获或分离生物标志物。

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