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1. 发明授权

US08945481B1 Microfluidic devices and method for their use 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US08945481B1
公开(公告)日：2015-02-03
申请号：US12145333
申请日：2008-06-24
申请人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
发明人： Mark F. Oldham , Kenneth J. Livak , Jason E. Babcoke , H. Pin Kao , Stephen J. Gunstream , Kevin S. Bodner , Douglas P. Greiner , Nigel P. Beard , Dar Bahatt
IPC分类号： B01L3/00
CPC分类号： B01J19/0046 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0867 , B01L2300/185 , B01L2400/0655 , G01N21/17 , G01N2201/0407
摘要： Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
摘要翻译：示例性实施例提供了用于它们的微流体装置和方法。微流体装置可以包括通过与流动层的第一和第二多个流体通道相交形成的M×N反应位点的阵列。流层可以具有矩阵设计和/或盲通道设计，以在有限数量的条件下分析大量样品。微流体装置还可以包括控制层，其包括用于调节通过流体通道的溶液流动的阀门系统。此外，通过使控制层与流体通道对准，可以通过向/从反应位置的管道灯来改善微流体装置的检测，例如光学信号收集。在示例性实施例中，保护通道可以包括在微流体装置中用于热循环和/或减少从反应位置的蒸发。

2. 发明授权

US07494819B2 Electrochemiluminescence electrode 失效
标题翻译：电化学发光电极
公开(公告)号：US07494819B2
公开(公告)日：2009-02-24
申请号：US10866624
申请日：2004-06-12
申请人： Dar Bahatt , Timothy Z. Liu , Zbignew Bryning
发明人： Dar Bahatt , Timothy Z. Liu , Zbignew Bryning
IPC分类号： G01N21/66 , G01N21/76
CPC分类号： G01N21/76 , G01N21/66
摘要： Disclosed is a bipolar electrode useful for ECL assays and a method for using the same.
摘要翻译：公开了可用于ECL测定的双极电极及其使用方法。

3. 发明申请

US20070035819A1 Two-dimensional spectral imaging system 有权
公开(公告)号：US20070035819A1
公开(公告)日：2007-02-15
申请号：US11480287
申请日：2006-06-30
申请人： Dar Bahatt , Chirag Patel , Roy Tan , Derek Prothro
发明人： Dar Bahatt , Chirag Patel , Roy Tan , Derek Prothro
IPC分类号： G02B23/00
CPC分类号： G01N21/31 , G01J3/10 , G01J3/12 , G01J3/18 , G01J3/189 , G01J3/2803 , G01J3/2823 , G01J3/4406 , G01J2003/1204 , G01J2003/1208 , G01J2003/1213 , G01J2003/1226 , G01N21/0332 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/76 , G01N2021/6421 , G01N2021/6432 , G01N2201/06113 , G01N2201/0621 , G01N2201/0697
摘要： Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.

4. 发明申请

US20050069895A1 Compositions, methods, and kits for fabricating coded molecular tags 审中-公开
标题翻译：用于制作编码分子标签的组合物，方法和试剂盒
公开(公告)号：US20050069895A1
公开(公告)日：2005-03-31
申请号：US10651561
申请日：2003-08-29
申请人： Timothy Woudenberg , Dar Bahatt , Muhammad Sharaf , Timothy Liu , Serguei Ermakov , Charles Connell , Jens Hyldig-Nielsen , Benjamin Schroeder , Paolo Vatta
发明人： Timothy Woudenberg , Dar Bahatt , Muhammad Sharaf , Timothy Liu , Serguei Ermakov , Charles Connell , Jens Hyldig-Nielsen , Benjamin Schroeder , Paolo Vatta
IPC分类号： C12Q1/68 , G01N33/532 , G01N33/533 , G01N35/00 , G01N33/543
CPC分类号： G01N33/533 , C12Q1/6816 , G01N33/532 , G01N2035/00158 , C12Q2565/102 , C12Q2563/179
摘要： The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern.
摘要翻译：本文的教导通常涉及包含用于检测分析物的制造的编码分子标签的探针。该教导还涉及用于制造编码分子标签的组合物，方法和试剂盒，其包含有序图案中的多个或报告基团。

5. 发明授权

US06797139B2 Detection cell for guiding excitation light therein and method for using same 有权
标题翻译：用于引导激发光的检测单元及其使用方法
公开(公告)号：US06797139B2
公开(公告)日：2004-09-28
申请号：US09812750
申请日：2001-03-19
申请人： Dar Bahatt , Richard T. Reel
发明人： Dar Bahatt , Richard T. Reel
IPC分类号： B01D5702
CPC分类号： G01N21/05 , G01N21/645 , G01N27/44721 , G01N2021/0346 , G01N2021/6482
摘要： The present invention provides a detection cell that comprises a body having a first end that defines a first opening, a second end that defines a second opening, and an internal surface that defines an interior cavity that fluidly connects the first opening and the second opening; wherein the interior cavity is capable of holding a support matrix for receiving a chemical species through the first opening, passing the chemical species through the interior cavity, and discharging the chemical species through the second opening; and wherein at least two portions of the body are capable of providing a first and a second guiding region each having an index of refraction less than that of the support matrix. A system utilizing the detection cell of the present invention is also provided. In another embodiment, the present invention provides a method for guiding light through a support matrix through which a chemical species is passing.
摘要翻译：本发明提供了一种检测单元，其包括具有限定第一开口的第一端，限定第二开口的第二端和限定使第一开口和第二开口流体连接的内部空腔的内表面的主体; 其中所述内部空腔能够保持用于通过所述第一开口接收化学物质的支撑矩阵，使所述化学物质通过所述内部空腔，并且通过所述第二开口排出所述化学物质; 并且其中所述主体的至少两个部分能够提供每个具有小于所述支撑矩阵的折射率的折射率的第一和第二引导区域。还提供了利用本发明的检测单元的系统。在另一个实施方案中，本发明提供一种用于引导光通过化学物质通过的载体基质的方法。

6. 发明授权

US08202479B1 Light collection system 有权
标题翻译：集光系统
公开(公告)号：US08202479B1
公开(公告)日：2012-06-19
申请号：US11270263
申请日：2005-11-09
申请人： Dar Bahatt , Konrad Faulstich
发明人： Dar Bahatt , Konrad Faulstich
IPC分类号： C12M1/34
CPC分类号： C12Q1/66 , G01N21/6428 , G01N21/645 , G01N21/66 , G01N21/763 , G01N33/581 , G01N2021/6439 , G01N2021/6469
摘要： The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.
摘要翻译：本教导提供了用于生物材料的检测单元和用于检测生物材料的方法，所述生物材料包括与包含生物材料的内部空间光学耦合的感光材料，以避免光学部件或外部光源。

7. 发明授权

US07663750B2 Two-dimensional spectral imaging system 有权
标题翻译：二维光谱成像系统
公开(公告)号：US07663750B2
公开(公告)日：2010-02-16
申请号：US11480287
申请日：2006-06-30
申请人： Dar Bahatt , Chirag Patel , Roy H. Tan , Derek Prothro
发明人： Dar Bahatt , Chirag Patel , Roy H. Tan , Derek Prothro
IPC分类号： G01J3/28
CPC分类号： G01N21/31 , G01J3/10 , G01J3/12 , G01J3/18 , G01J3/189 , G01J3/2803 , G01J3/2823 , G01J3/4406 , G01J2003/1204 , G01J2003/1208 , G01J2003/1213 , G01J2003/1226 , G01N21/0332 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/76 , G01N2021/6421 , G01N2021/6432 , G01N2201/06113 , G01N2201/0621 , G01N2201/0697
摘要： Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.
摘要翻译：用于对二维样本阵列进行光谱成像的系统，包括方法，装置和算法。

8. 发明申请

US20060013742A1 Fluid processing device 有权
标题翻译：流体处理装置
公开(公告)号：US20060013742A1
公开(公告)日：2006-01-19
申请号：US10891650
申请日：2004-07-15
申请人： Dar Bahatt , Debjyoti Banerjee
发明人： Dar Bahatt , Debjyoti Banerjee
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0636 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , Y10T436/11 , Y10T436/143333
摘要： A fluid processing device and method of using the device are provided. The fluid processing device can include a substrate with a fluid processing pathway at least partially formed in or on the substrate. The fluid processing pathway can include an input end, at least one output end, a first input opening, a plurality of reaction sites each in fluid communication with the first input opening and arranged between the first input opening and the at least one output end. The fluid processing pathway can include a plurality of second input openings including two or more in fluid communication respectively with each of the reaction sites, the second input openings being arranged with the reaction site disposed between the at least one output end and the second input openings. The fluid processing device can include one or more output openings in fluid communication with one or more of the plurality of reaction sites and arranged at the at least one output end of the fluid processing pathway.
摘要翻译：提供一种使用该装置的流体处理装置和方法。流体处理装置可以包括具有至少部分地形成在基底中或基底上的流体处理通路的基底。流体处理通道可以包括输入端，至少一个输出端，第一输入开口，多个反应位置，每个反应位置与第一输入开口流体连通并且布置在第一输入开口和至少一个输出端之间。流体处理路径可以包括多个第二输入开口，包括两个或更多个分别与每个反应位置流体连通的第二输入开口，第二输入开口被布置成使反应部位设置在至少一个输出端和第二输入开口。流体处理装置可以包括与多个反应部位中的一个或多个处于流体连通并且布置在流体处理通路的至少一个输出端处的一个或多个输出开口。

9. 发明申请

US20050019802A1 Electrochemiluminescence electrode 失效
标题翻译：电化学发光电极
公开(公告)号：US20050019802A1
公开(公告)日：2005-01-27
申请号：US10866624
申请日：2004-06-12
申请人： Dar Bahatt , Timothy Liu , Zbignew Bryning
发明人： Dar Bahatt , Timothy Liu , Zbignew Bryning
IPC分类号： G01N21/66 , G01N21/76 , C12Q1/68
CPC分类号： G01N21/76 , G01N21/66
摘要： Disclosed is a bipolar electrode useful for ECL assays and a method for using the same.
摘要翻译：公开了可用于ECL测定的双极电极及其使用方法。

10. 发明申请

US20120212738A1 Two-Dimensional Spectral Imaging System 有权
标题翻译：二维光谱成像系统
公开(公告)号：US20120212738A1
公开(公告)日：2012-08-23
申请号：US13364226
申请日：2012-02-01
申请人： Dar Bahatt , Chirag Patel , Roy H. Tan , Derek Prothro
发明人： Dar Bahatt , Chirag Patel , Roy H. Tan , Derek Prothro
IPC分类号： G01J3/28
CPC分类号： G01N21/31 , G01J3/10 , G01J3/12 , G01J3/18 , G01J3/189 , G01J3/2803 , G01J3/2823 , G01J3/4406 , G01J2003/1204 , G01J2003/1208 , G01J2003/1213 , G01J2003/1226 , G01N21/0332 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/76 , G01N2021/6421 , G01N2021/6432 , G01N2201/06113 , G01N2201/0621 , G01N2201/0697
摘要： Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.
摘要翻译：用于对二维样本阵列进行光谱成像的系统，包括方法，装置和算法。

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