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1. 发明专利

JP2013085822A Liquid chemical set and liquid chemical administration method 有权
标题翻译：液体化学和液体化学管理方法
公开(公告)号：JP2013085822A
公开(公告)日：2013-05-13
申请号：JP2011230817
申请日：2011-10-20
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： SUMIYOSHI NOBUAKI , OTANI SHINGO
IPC分类号： A61M5/14 , A61M5/165 , A61M39/00
摘要： PROBLEM TO BE SOLVED: To provide a liquid chemical set and a liquid chemical administration method, capable of easily and quickly switching a liquid chemical supply part and not exposing a liquid chemical.SOLUTION: The liquid chemical set includes: a plurality of liquid chemical supply parts, each of which has a bottle needle to be punctured to a liquid chemical discharge part of a liquid chemical bag and a liquid supply tube whose one end is connected to a connection part; a liquid chemical integration part connected to all the other ends of liquid supply tubes and provided with a liquid discharge port; and a liquid discharge tube whose one end is connected to the liquid discharge port and other end is connected to an indwelling device. Each of the liquid chemical supply parts includes a flow path opening/closing part provided in the middle of the liquid supply tube to open and close the distribution of the liquid chemical, the liquid chemical integration part includes a plurality of liquid supply ports to which the other ends of the respective liquid supply tubes of the plurality of liquid chemical supply parts are connected, and one liquid discharge port, and a filter unit having an air vent filter and a liquid chemical filter is provided integrally with the liquid chemical integration part or in the middle of the liquid discharge tube.
摘要翻译：要解决的问题：提供一种能够容易且快速地切换液体化学物质供应部分而不暴露液体化学品的液体化学品和液体化学品给药方法。液体化学品包括：多个液体化学品供应部件，每个液体化学品供应部件具有要刺穿液体化学药品袋的液体化学物质排出部分的瓶针和一端连接的液体供应管连接部分; 连接到液体供给管的所有另一端并具有液体排出口的液体化学整合部分; 以及其一端连接到液体排出口并且另一端连接到留置装置的液体排出管。每个液体化学品供应部分包括设置在液体供应管的中间以打开和关闭液体化学品分布的流动通道开/关部分，液体化学整合部分包括多个液体供应口，连接多个液体化学品供应部件的各个液体供给管的另一端，并且一个液体排出口和具有排气过滤器和液体化学过滤器的过滤器单元与液体化学整合部一体地设置液体放电管的中间。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2008132317A Dissolved oxygen-reducing liquid agent 有权
标题翻译：溶解氧化还原液体试剂
公开(公告)号：JP2008132317A
公开(公告)日：2008-06-12
申请号：JP2007276806
申请日：2007-10-24
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： SUMIYOSHI NOBUAKI , TATEISHI ISAMU , MORI HITOSHI , MORIMOTO YASUSHI
IPC分类号： A61J1/10 , A61K9/08
摘要： PROBLEM TO BE SOLVED: To provide a dissolved oxygen reducing liquid agent for reducing the amount of dissolved oxygen, hardly deteriorated by oxidation and excellent in stability with the elapse of time. SOLUTION: The dissolved oxygen reducing liquid agent is housed in a chemical liquid container comprising a plastic of which the oxygen permeability under the condition of a temperature of 25°C and humidity RH of 60% within 12 hr after steam or hot water sterilization treatment is 200 cm 3 /m 2 *24h*atm or above and the oxygen permeability under the condition of a temperature of 25°C and humidity RH of 60% within 12 hr when the oxygen permeability is in a steady state, is 100 cm 3 /m 2 *24h*atm or below. After the container is hermetically sealed and subjected to steam or hot water sterilization treatment, the chemical liquid container is preserved under an environment equipped with a deoxidation means to adjust the concentration of dissolved oxygen of the liquid agent when the oxygen permeability of the plastic reaches the steady state becomes 2 ppm or below. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种溶解氧还原液剂，用于减少溶解氧的量，几乎不会因氧化而劣化，并且随着时间的推移稳定性优异。解决方案：将溶解的氧还原液剂容纳在包含塑料的药液容器中，该蒸汽或热水在12小时内在25℃的温度和湿度RH为60％的条件下具有氧气渗透性灭菌处理是在25℃的温度和湿度RH为60％的条件下的200cm 3 / SP 2 / SP 2 * / 24h * atm以上的氧气渗透性当氧气渗透率处于稳定状态时，为12小时，为100厘米3 /小时* 24小时*大气压以下。在将容器密封并进行蒸汽或热水杀菌处理之后，将化学液容器在具有脱氧装置的环境下保存，以在塑料的透氧性达到时调节液体剂的溶解氧浓度稳态变为2ppm以下。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2006117586A Complex infusion preparation 有权
标题翻译：复杂的输液制剂
公开(公告)号：JP2006117586A
公开(公告)日：2006-05-11
申请号：JP2004307382
申请日：2004-10-21
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： SUMIYOSHI NOBUAKI , TANI HARUHITO , IZUI SEIJI , ARITA SHIGEAKI , KAWAKAMI KEIICHI
IPC分类号： A61K31/70 , A61J1/05 , A61K9/08 , A61K31/198 , A61K31/375 , A61K31/7004 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34
摘要： PROBLEM TO BE SOLVED: To provide a complex infusion preparation free from risk of incorrect administration though an amino acid, a reducing sugar, a fat-soluble vitamin, vitamin B 2 , vitamin C, etc., are formulated therein. SOLUTION: The complex infusion preparation has a reducing sugar solution (A) and an amino acid solution (B) separately stored in each chamber of a container having two chambers partitioned by communicable diaphragm and a fat-soluble vitamin liquid (C) stored in a small container which is communicable to either one of the two chambers, and vitamin B 2 is formulated in the fat-soluble vitamin liquid (C) and vitamin C is formulated in the reducing sugar solution (A) or the amino acid solution (B). COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种复合的输液制剂，其不含有氨基酸，还原糖，脂溶性维生素，维生素B，维生素C等的不正确给药的风险。在其中配制。复方输液制剂具有还原糖溶液（A）和氨基酸溶液（B），该氨基酸溶液（B）分别储存在容器的每个腔室中，该容器具有由可连通隔膜和脂溶性维生素液体（C）隔开的两个腔室，储存在可容纳两个腔室之一的小容器中，维生素B 2 配制在脂溶性维生素液体（C）中，维生素C配制在还原糖溶液 A）或氨基酸溶液（B）。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005035962A Iron-formulated infusion preparation 审中-公开
标题翻译：铁配制输液制剂
公开(公告)号：JP2005035962A
公开(公告)日：2005-02-10
申请号：JP2003277151
申请日：2003-07-18
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： SUMIYOSHI NOBUAKI , ARITA SHIGEAKI , TANI HARUHITO , MITSUMOTO YASUHIRO
IPC分类号： A61J3/00 , A61K9/08 , A61K31/198 , A61K31/51 , A61K31/7004 , A61K33/06 , A61K33/18 , A61K33/20 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61P3/02
摘要： PROBLEM TO BE SOLVED: To provide an iron-formulated complex infusion preparation free from contamination by bacterium when a plurality of solutions are mixed when needed. SOLUTION: In an infusion container having a plurality of chambers partitioned by a partition wall means which is communicable by pressure from the outside, an amino acid solution is housed in one chamber and a sugar solution are housed in other chamber and iron is formulated in at least either one of the amino acid solution and the sugar solution. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：当需要时混合多种溶液时，提供不受细菌污染的铁配制的复合体输液制剂。解决方案：在具有由分隔壁装置分隔的多个室的输液容器中，该分隔壁装置可通过外部压力而连通，氨基酸溶液容纳在一个室中，糖溶液容纳在另一个室中，铁是配制在氨基酸溶液和糖溶液中的至少一种中。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2013212333A Mixer, mixing support device and mixing method 有权
标题翻译：混合器，混合支持装置和混合方法
公开(公告)号：JP2013212333A
公开(公告)日：2013-10-17
申请号：JP2012093810
申请日：2012-04-17
申请人： Otsuka Techno Kk , 大塚テクノ株式会社 , Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： NISHIOKA MASAKI , TAKIGUCHI OSAMU , HAMAI KATSUYOSHI , MASUDA TETSUYA , INOUE FUJIO , SUMIYOSHI NOBUAKI , YOSHINARI TAKASHI
IPC分类号： A61J3/00
摘要： PROBLEM TO BE SOLVED: To provide a mixer for mixing a medical agent and a mixture liquid which blocks the medical agent within a closed space even when the medical agent leaks or volatilizes from a vessel, and prevents exposure of the medical agent from extending outward.SOLUTION: A mixer 1 mixes a medical agent stored in at least one medical agent vessel 50 and a mixture liquid stored in at least one mixture liquid vessel 60 using a syringe, and includes: a body part 10 having a closed space S1; a syringe-holding part 20 by which a communication part and the closed space can communicate with each other; a medical agent vessel-holding part 30 capable of holding the medical agent vessel while the insides of the medical agent vessel and the closed space can communicate with each other; and a mixture liquid vessel-holding part 40 capable of holding the mixture liquid vessel at the outside of the closed space while the inside of the mixture liquid vessel and the closed space can communicate with each other. The syringe-holding part can hold the syringe while the communication part is relatively movable in the closed space with respect to the insides of the medical agent vessel and the mixture liquid vessel so that the communication part communicates with the insides of the medical agent vessel and the mixture liquid vessel after the communication part communicates with the closed space.
摘要翻译：要解决的问题：即使当药剂从容器泄漏或挥发而使药剂和混合液混合在封闭空间内时，也提供了混合器，并且防止药剂向外延伸。解决方案：混合器1使用注射器将存储在至少一个药剂容器50中的药剂和存储在至少一个混合液体容器60中的混合液混合，并且包括：具有封闭空间S1的主体部分10; 注射器保持部20，其中连通部和封闭空间可以彼此连通; 能够在药剂容器的内部和封闭空间能够相互连通的状态下容纳医药容器的药剂容器保持部30; 以及混合液容器保持部40，其能够将混合液容器保持在封闭空间的外部，同时混合液容器和封闭空间的内部可以彼此连通。注射器保持部可以保持注射器，同时连通部相对于药剂容器和混合液体容器的内部在封闭空间中相对移动，使得连通部与药剂容器的内部和通信部之后的混合液容器与封闭空间连通。

6. 发明专利

JP2013132241A Cell separation device 审中-公开
标题翻译：细胞分离装置
公开(公告)号：JP2013132241A
公开(公告)日：2013-07-08
申请号：JP2011284382
申请日：2011-12-26
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場 , National Cerebral & Cardiovascular Center , 独立行政法人国立循環器病研究センター
发明人： TAGUCHI AKIHIKO , YAMAHARA KENICHI , SUMIYOSHI NOBUAKI , OTANI SHINGO , WADA KEIKI , ARATA TOMOHIRO
IPC分类号： C12M1/10
CPC分类号： C12M47/02
摘要： PROBLEM TO BE SOLVED: To provide a cell separation device which can easily stratify without disarranging the interface of sample on stratification, and can prevent the mixing of a separated target substance to recover the target substance in good purity.SOLUTION: The cell separation device has the first container 11 having the first liquid-receiving portion 51, the second container 12 having the second liquid-receiving portion 52 and disposed under the first container 11, and a communication member 20 disposed between the first container 11 and the second container 12 and having the first needle 72 extended toward the first liquid-receiving portion 51 and the second needle 73 communicating with the first needle 72 and extended toward the second liquid-receiving portion 52. The cell separation device further has a switch mechanism 55 which can switch into a communication state for communicating the first liquid-receiving portion 51 with the second liquid-receiving portion 52 through the communication member 20 or into an interception state for intercepting the communication, by the approach of the first container 11 to the second container 12 or the separation of the first container 11 from the second container 12.
摘要翻译：要解决的问题：提供一种细胞分离装置，其可以容易地分层而不使分层的样品界面混乱，并且可以防止分离的目标物质的混合以高纯度回收目标物质。解决方案：细胞分离装置具有第一容器11具有第一液体接收部分51，第二容器12具有第二液体接收部分52并且设置在第一容器11下方;以及连通构件20，设置在第一容器11和第二容器12之间，第一针72朝向第一液体接收部51延伸，第二针73与第一针72连通并朝向第二液体接收部52延伸。细胞分离装置还具有切换到用于使第一液体接收部分51与第二液体接收部分52通过的连通状态通过第一容器11到第二容器12的接近或将第一容器11与第二容器12分离的方式，进入用于截取通信的拦截状态。

7. 发明专利

JP2012125436A Vial 审中-公开
标题翻译： VIAL
公开(公告)号：JP2012125436A
公开(公告)日：2012-07-05
申请号：JP2010280086
申请日：2010-12-16
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： FUJIMURA TAKASHI , SUMIYOSHI NOBUAKI , OTANI SHINGO
IPC分类号： A61J1/05 , B65D39/04 , B65D51/18
摘要： PROBLEM TO BE SOLVED: To provide a vial that reliably prevents a solution from dispersing outside a container.SOLUTION: The vial includes: a cylindrical container body 2 having openings in the upper and lower ends thereof; a sealing member 3 for sealing the upper end of the container body 2; and a sliding member 4 slidably arranged in the container body 2 in the longitudinal direction of the container body 2, and for sealing a medical agent in the container body 2 between the sealing member 3 and the sliding member.
摘要翻译：要解决的问题：提供可靠地防止溶液分散在容器外部的小瓶。解决方案：小瓶包括：在其上端和下端具有开口的圆柱形容器主体2; 用于密封容器主体2的上端的密封构件3; 以及滑动构件4，其沿着容器主体2的长度方向可滑动地布置在容器主体2中，并且用于将容器主体2中的药剂密封在密封构件3和滑动构件之间。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2006187429A Manufacturing method of medical double-packaged pharmaceutical and medical double packaged pharmaceutical 有权
标题翻译：医药双包装药物和医药双包装药物的制造方法
公开(公告)号：JP2006187429A
公开(公告)日：2006-07-20
申请号：JP2005000994
申请日：2005-01-05
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： TANI HARUHITO , SUMIYOSHI NOBUAKI , ARITA SHIGEAKI , KAWAKAMI KEIICHI , NAGAO KATSUMI
IPC分类号： A61J1/00 , A61J1/10
摘要： PROBLEM TO BE SOLVED: To provide a medical double-packaged pharmaceutical having superior quality stability, a preservation safety and handling property. SOLUTION: This manufacturing method of a medical double-packaged pharmaceutical includes a process for tightly sealing a pharmaceutical storage container 1, which is made of oxygen easily-permeable plastic and is provided with a small container 2 sealed with easily-oxidizing pharmaceutical 22 in a storage chamber 3 and the storage chamber 3 filled with liquid, along with deoxidizer 6 in an oxygen-barrier external bag 5; and a process for retaining the double-packaged body with the small container non-exposed to a headspace 7 in the storage chamber till the oxygen is substantially non-existed in the headspace in the storage chamber. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有优异的质量稳定性，保存安全性和处理性的医用双重包装药物。解决方案：医药性双重包装药物的制造方法包括密封由易透氧塑料制成的药物储藏容器1的方法，并且设置有用容易氧化的药物密封的小容器2 22和储存室3中，以及在氧隔离外袋5中与脱氧剂6一起填充液体; 以及将储存室中没有暴露于顶部空间7的小容器保持双重包装体的方法，直到氧气基本上不存在于储存室的顶部空间中。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2006124286A Multiple infusion preparation 审中-公开
标题翻译：多种输注制剂
公开(公告)号：JP2006124286A
公开(公告)日：2006-05-18
申请号：JP2004311375
申请日：2004-10-26
申请人： Otsuka Pharmaceut Factory Inc , 株式会社大塚製薬工場
发明人： SUMIYOSHI NOBUAKI , TANI HARUHITO , IZUI SEIJI , ARITA SHIGEAKI , KAWAKAMI KEIICHI
IPC分类号： A61K31/047 , A61J1/05 , A61K31/07 , A61K31/122 , A61K31/195 , A61K31/355 , A61K31/409 , A61K31/51 , A61K31/59 , A61K33/24 , A61P3/02 , B65D30/22 , B65D81/32
摘要： PROBLEM TO BE SOLVED: To provide a multiple infusion preparation excellent in stability of vitamin B 1 . SOLUTION: The multiple infusion preparation comprises (A) a reducing sugar solution and (B) an amino acid solution separately stored in each chamber of a container having two chambers partitioned by a communication-free partition wall and (C) a vitamin B 1 solution stored in a small container which is capable of communicating with either one of the two chambers. COPYRIGHT: (C)2006,JPO&NCIPI

10. 发明专利

JP2011147720A Bag for liquid and method of manufacturing the same 有权
标题翻译：用于液体的袋及其制造方法
公开(公告)号：JP2011147720A
公开(公告)日：2011-08-04
申请号：JP2010013253
申请日：2010-01-25
申请人： Mitsui Chemicals Inc , Otsuka Pharmaceut Factory Inc , 三井化学株式会社 , 株式会社大塚製薬工場
发明人： HITOMI MITSUO , SHIBA EIJI , MIHIRA KEITA , SUMIYOSHI NOBUAKI , DENPO TAKAYUKI , MORI HITOSHI , SHOJI HIDEO
IPC分类号： A61J1/10 , B65D30/10 , B65D33/38
摘要： PROBLEM TO BE SOLVED: To provide a bag for a liquid, restraining variation in the capacity of a head space after the liquid is injected by applying a point seal where a flexible film is locally stuck, and further simply changing the position of the point seal according to the capacity of the bag, and provide a method of manufacturing the same. SOLUTION: In the medical liquid bag 1, the point seal 18 where a pair of flexible films 5 are locally stuck is applied at a predetermined position along the longitudinal direction of a pair of vertical seals 7 on the inside of a storing chamber 2 spaced with a fixed clearance 19 from the inner edge 9 of each vertical seal 7 to thereby restrain the storing chamber 2 from being swollen when the medical liquid is stored in the storing chamber 2. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供液体袋，通过施加局部粘贴柔性膜的点密封来限制液体注入之后的顶部空间的容量的变化，并且进一步简单地改变位置根据袋的容量进行点密封，并提供其制造方法。解决方案：在药液袋1中，将一对柔性膜5局部粘贴的点密封18沿着一对垂直密封件7的长度方向的预定位置施加在储存室 2与每个垂直密封件7的内边缘9间隔开固定的间隙19，从而当医用液体储存在储存室2中时，可以抑制储存室2膨胀。（C）2011，JPO＆INPIT

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