会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明授权
    • VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN DIAMANTANEN
    • VERFAHREN ZUR HERSTELLUNG VON替代品DIAMANTANEN
    • EP1960330B1
    • 2011-11-02
    • EP06828601.2
    • 2006-12-04
    • Justus-Liebig-Universität Gießen
    • SCHREINER, Peter R., Prof. Dr.FOKIN, Andrey, A.
    • C07C13/615C07C23/46
    • C07C203/08C07C29/12C07C51/353C07C67/11C07C2603/90C07C35/44C07C61/135C07C69/013C07C69/14
    • The invention relates to at least dinitroxylated diamantanes, and to methods by which means a high yield and selectivity of substituted diamantanes can be produced. According to the invention, dinitroxylated diamantanes can be reacted with nucleophiles to form the corresponding disubstituted diamantanes. Surprisingly, it was discovered that at least dinitroxylated or hydroxylated diamantanes are rearranged in the presence of a strong acid, creating at least 4,9-nitroxylated or hydroxylated diamantanes. On the basis of this, 4,9-substituted diamantanes can be produced in a targeted manner by reaction with other nucleophiles. The inventive methods for producing at least disubstituted diamantanes consist of the following steps: a) at least dinitroxylation, followed by substitution of all of the nitroxy groups with a nucleophile, or b) at least dinitroxylation, then rearrangement in the presence of a strong acid, all nitroxy groups being replaced by a nucleophile in the event of a successful rearrangement, or c) at least dinitroxylation, followed by a reaction with water (as nucleophile), and rearrangement of the at least dihydroxylated compound in the presence of a strong acid, all hydroxy groups being replaced by another nucleophile in the event of a successful rearrangement.
    • 二硝基甲酰基二金刚烷适合与亲核试剂反应形成相应的二取代二金刚烷。 令人惊讶的是,至少在强酸存在下重新排列二硝基氧化或羟基化的金刚烷,并且产生至少4,9-硝酰氧基化或羟基化的二金刚烷。 在此基础上,能够通过与另外的亲核试剂反应,以目标方式制备4,9-取代的二金刚烷。 至少生成二取代二金刚烷的方法包括:(a)至少二硝基甲酰化,然后用亲核试剂代替全部硝基; 或(b)至少二硝基甲基化,随后在强酸存在下的重排,在实现重排之后,所有的硝酰基被亲核试剂代替; 或(c)至少二硝基甲酰化,然后随后与水(作为亲核试剂)反应,并在强酸存在下重排至少二羟基化合物,则在重新排列的情况下,所有羟基被另一个亲核试剂取代。
    • 5. 发明公开
    • METHOD FOR PRODUCING NORBORNENE DERIVATIVE
    • 用于生产降冰片烯衍生物
    • EP2174922A1
    • 2010-04-14
    • EP08791783.7
    • 2008-07-29
    • Nippon Oil Corporation
    • KOMATSU, ShinichiSHOKO, ToshikatsuKAMINADE, Tadahiro
    • C07C2/86C07C13/605C07B61/00
    • C07C13/605C07C2/86C07C2/861C07C17/266C07C2531/24C07C2602/42C07C2603/86C07C2603/90C07C13/42C07C13/68C07C13/64C07C25/24
    • A method for producing a norbornene derivative wherein,
      in the presence of palladium and at least one selected from phosphorus compounds represented by the following General Formulae (1) and (2):

      [in Formula (1), R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom or the like, and R 5 and R 6 each independently represent a branched chain saturated hydrocarbon group having 3 to 10 carbon atoms or the like], and

      [in Formula (2), R 7 represents a branched chain saturated hydrocarbon group having 3 to 10 carbon atoms],
      a norbornadiene derivative represented by the following General Formula (3):

      [in Formula (3), R 8 , R 9 , R 10 , R 11 and R 12 each independently represent a hydrogen atom or the like, 1 represents an integer of 0 or 1, m represents an integer of 0 or 1, and n represents an integer of 0 or 1], and a bromine compound represented by the following General Formula (4):

              [Chemical Formula 4] Br-Z-R 13      (4)

      [in Formula (4), Z represents a phenylene group or the like, and R 13 represents a hydrogen atom or the like] are reacted with each other, to thereby obtain a norbornene derivative represented by the following General Formula(5):


      [in Formula (5), R 14 , R 15 , R 16 , R 17 and R 18 each independently represent a hydrogen atom or the like, Z represents a phenylene group or the like, R 19 represents a hydrogen atom or the like, 1 represents an integer of 0 or 1, m represents an integer of 0 or 1, and n represents an integer of 0 or 1], the norbornene derivative having a configuration of a substituent represented by Z in General Formula (5) that is an exo configuration.