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1. 发明公开

EP1382591A4 NOVEL ATISANE COMPOUND AND USE THEREOF 审中-公开
标题翻译： NEER ATISANVERBINDUNG UND DEREN VERWENDUNG
公开(公告)号：EP1382591A4
公开(公告)日：2006-01-18
申请号：EP02720602
申请日：2002-04-25
申请人： EISAI CO LTD
发明人： AKAIKE AKINORI , SUGIMOTO HACHIRO , NISHIZAWA YUKIO , YONAGA MASAHIRO , ASAKAWA NAOKI , ASAI NAOKI , MANO NARIYASU , TERAUCHI TARO , DOKO TAKASHI
IPC分类号： A61P17/00 , C07C43/13 , C07C43/315 , C07C47/36 , C07C47/37 , C07C47/46 , C07C62/06 , C07C62/14 , C07C69/00 , C07C229/46 , C07C235/26 , C07C247/12 , C07C255/31 , C07C271/22 , C07C309/66 , C07C309/73 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/13 , C07C323/22 , C07C323/26 , C07C323/43 , C07C323/53 , C07C323/55 , C07C323/58 , C07C323/60 , C07C327/32 , C07C35/44
CPC分类号： C07C69/757 , C07C43/13 , C07C43/315 , C07C47/36 , C07C47/37 , C07C47/46 , C07C62/06 , C07C62/14 , C07C229/46 , C07C235/26 , C07C247/12 , C07C255/31 , C07C271/22 , C07C309/66 , C07C309/73 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/13 , C07C323/22 , C07C323/26 , C07C323/43 , C07C323/53 , C07C323/55 , C07C323/58 , C07C323/60 , C07C327/32 , C07C2603/90 , C07C2603/95
摘要： A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the following formula, a salt thereof, or a hydrate of either. (I) In the formula, Z means an optionally substituted, divalent, C2-3 organic group, etc., and R3 represents carboxyl, etc.
摘要翻译：本发明提供一种新兴化合物，其表现出对自由基引起的细胞损伤的抑制作用以及由兴奋性输尿管如谷氨酸诱导的神经毒性。具体地，它提供由下式表示的化合物，其盐或它们的水合物。其中Z表示2〜3个可具有取代基的碳原子的二价有机基团等; R 3表示羧基等。

2. 发明公开

EP0915825A2 SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY 失效
标题翻译： WITH A维甲酸和/或类似类视黄醇拮抗剂生物活性的取代四氢化萘和二氢萘衍生物，
公开(公告)号：EP0915825A2
公开(公告)日：1999-05-19
申请号：EP97933997.0
申请日：1997-06-19
申请人： Allergan Sales, Inc.
发明人： VULIGONDA, Vidyasagar , TENG, Min , BEARD, Richard, L. , JOHNSON, Alan, T. , LIN, Yuan , CHANDRARATNA, Roshantha, A. , SONG, Tae, K. , WONG, Harold, N. , DUONG, Tien, T. , GILLETT, Samuel, J.
IPC分类号： A61K31 , A61P43 , C07C69 , C07C233 , C07C245 , C07C251 , C07C309 , C07C317 , C07C323 , C07D213 , C07D263 , C07D277 , C07D309 , C07D317 , C07D333 , C07D339 , C07D409 , C07F7
CPC分类号： C07C251/44 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of formulas (1-6) where the symbols have the meaning described in the specification, have retinoid and/or retinoid antagonist-like biological acitivity.
摘要翻译：式（1-6）其中各符号具有说明书中所描述的含义，化合物具有类视黄醇和/或类视黄醇拮抗剂样生物活性。

3. 发明授权

EP0270843B1 4-Hydroxy-4-(substituted alkenyl)-cyclohexane carboxylic acid 有权转让
标题翻译： 4-羟基-4-（取代的烷基） - 环己基羧酸
公开(公告)号：EP0270843B1
公开(公告)日：1991-03-06
申请号：EP87116316.8
申请日：1987-11-05
申请人： MERRELL DOW PHARMACEUTICALS INC.
发明人： Cregge, Robert J. , Lentz, Nelsen L.
IPC分类号： C07C323/22 , A61K31/19 , A61K31/16 , A61K31/215
CPC分类号： C07C323/55 , A61K31/16 , A61K31/19 , A61K31/215 , C07C2601/14 , Y02P20/582 , Y10S514/826

4. 发明公开

EP0419905A2 Quinone derivatives and pharmacological use 失效
标题翻译： Chinonderivate und ihre pharmakologische Verwendung。
公开(公告)号：EP0419905A2
公开(公告)日：1991-04-03
申请号：EP90117119.9
申请日：1990-09-05
申请人： Eisai Co., Ltd.
发明人： Abe, Shinya , Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Nagakawa, Junichi , Hirota, Kazuo , Hishinuma, Ieharu , Miyamoto, Kaname , Yamanaka, Takashi , Yokohama, Hiromitsu , Yoshimura, Tsutomu , Horie, Tohru , Akita, Yasunori , Katayama, Koichi , Yamatsu, Isao
IPC分类号： C07C66/00 , A61K31/19 , C07C59/90 , C07C59/68 , C07C65/21 , C07C69/736 , C07C255/38 , C07D309/00
CPC分类号： C07D295/185 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C2601/14 , C07C2601/16 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24
摘要： The quinone compound is useful to treat hepatic disease and defined by the formula:
wherein A is a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula
(wherein n is 0 or 1 and R 6 is a lower alkyl group), or an acyl group),

R 1 is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula
(wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula
{wherein q is an integer of 1 to 6 and B is a group represented by the formula:
(wherein r is 0 or an integer of 1 to 2, R 7 is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R 8 (wherein R 8 is a lower alkyl group or an aryl group)}, or a group represented by the formula
(wherein s is an integer of 1 to 3),
R 2 is a group represented by the formula -OR 8 (wherein R 8 is a hydrogen atom or a lower alkyl group) or a group represented by the formula:
(wherein R 9 and R 10 which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R 9 and R 10 may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).
摘要翻译：醌化合物可用于治疗肝病并由下式定义：其中A是由下式表示的基团：其中R 3，R 4和R 5可以是相同或不同的是氢原子，低级烷基或低级烷氧基）或由下式表示的基团：其中R 3，R 4和R 5如下：可以相同或不同的是氢原子，低级烷基或低级烷氧基，可以相同或不同的X和Y各自为羟基，由（其中n为0或1，R 6为低级烷基）或酰基），R 1为碳原子数2〜20的烷基，芳基环烷基，环烷基烷基，烯基，炔基，芳基烷基，由式表示的基团，其中p为1〜10的整数，杂芳基烷基基团 p为由式＆lparstr＆CH 2＆rparstr＆B B表示的基团，其中q为1〜6的整数，B为下式所示的基团：其中r为0或1〜2的整数，R 或者由式-OR 8表示的基团（其中R 8为低级烷基或芳基）}，或者式由式＆lparstr＆CH2-CH2-O）@ CH3表示的基团（其中s为1至3的整数），R 2为由式-OR 8表示的基团（其中R 8为氢原子或低级烷基）或由下式表示的基团：其中可以彼此不同的（其中R 9和R 1 各自为氢原子，低级烷基，羟基烷基或杂芳基，条件是R 9和R 1可以彼此结合形成与其键合的氮原子一起形成的环，其还可含有氮原子和/或氧原子并且可以被取代）。

5. 发明公开

EP0270843A1 4-Hydroxy-4-(substituted alkenyl)-cyclohexane carboxylic acid 有权转让
标题翻译： 4-羟基-4-（取代的烯基） - 环己烷烃。
公开(公告)号：EP0270843A1
公开(公告)日：1988-06-15
申请号：EP87116316.8
申请日：1987-11-05
申请人： MERRELL DOW PHARMACEUTICALS INC.
发明人： Cregge, Robert J. , Lentz, Nelsen L.
IPC分类号： C07C323/22 , A61K31/19 , A61K31/16 , A61K31/215
CPC分类号： C07C323/55 , A61K31/16 , A61K31/19 , A61K31/215 , C07C2601/14 , Y02P20/582 , Y10S514/826
摘要： Compounds of the formula:
wherein n is an integer from 0 to 2; R is straight-chain alkyl containing from 6 to 15 carbon atoms: X is hydrogen or, when n is 1 or 2, X can be -NH 2 ; Y is hydroxy, -0-(C 1 -C 4 )alkyl, -NH 2 , -NH(C 1 -C 4 )alkyl, -N-(C 1 -C 4 )alkyl) 2 or
wherein R' is hydrogen, alkyl of 1 to 4 carbon atoms, or benzyl; and Z is hydroxy, -O-(C 1 -C 4 )alkyl), -NH 2 , -NH-(C 1 -C 4 )alkyl , or -N-(C 1 -C 4 )alkyl) 2 , can be used in pharmaceutical composition. They may be prepared by reacting
with:
摘要翻译：下式的化合物：其中n是0-2的整数; R为含有6至15个碳原子的直链烷基; X是氢或当n是1或2时X可以是-NH 2; Y是羟基，-O-（C 1 -C 4）烷基，-NH 2，-NH（C 1 -C 4）烷基，-N-（C 1 -C 4）烷基）2或-NH- ，1至4个碳原子的烷基或苄基; Z为羟基，-O-（C 1 -C 4）烷基），-NH 2，-NH-（C 1 -C 4）烷基或-N-（C 1 -C 4）烷基）2可用于药物组合物。它们可以通过与：HS-（CH2）n - @@ - @ - Y'f反应来制备

6. 发明授权

EP2313090B1 NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT 无效转让
标题翻译：新型含S脂类食物补充剂或药物
公开(公告)号：EP2313090B1
公开(公告)日：2016-03-30
申请号：EP09798181.5
申请日：2009-07-13
申请人： Pronova BioPharma Norge AS
发明人： HOLMEIDE, Anne, Kristin , HOVLAND, Ragnar , BRÆNDVANG, Morten
IPC分类号： C07C323/52 , C07C317/44 , C07C323/54 , C07C323/56 , C07C323/61 , A23L33/12 , A61K31/19 , A61P3/04 , A61P3/10
CPC分类号： C07C323/54 , A23L33/12 , C07C317/44 , C07C323/52 , C07C323/55 , C07C323/56 , C07C323/61 , C07C2601/04

7. 发明公开

EP2069295A2 SUBSTITUTED CYCLOPENTANE DERIVATIVES AS THERAPEUTIC AGENTS 有权
标题翻译：替代品CYCLOPENTAN-DERIVATE ALS THERAPEUTISCHE MITTEL
公开(公告)号：EP2069295A2
公开(公告)日：2009-06-17
申请号：EP07812665.3
申请日：2007-07-06
申请人： ALLERGAN, INC.
发明人： OLD, David, W. , NGO, Vinh, X.
IPC分类号： C07C323/55 , C07C229/32 , C07C233/47 , C07D333/38 , A61K31/192 , A61K31/196 , A61K31/381 , A61P27/02
CPC分类号： C07C323/55 , C07C229/32 , C07C233/50 , C07C2601/08 , C07D213/70 , C07D213/74 , C07D215/26 , C07D215/40 , C07D217/04 , C07D257/04 , C07D277/56 , C07D307/64 , C07D307/68 , C07D307/79 , C07D333/34 , C07D333/38 , C07D333/62
摘要： Disclosed herein are compounds of formula (I); methods of reducing intraocular pressure and treating glaucoma by administering these compounds and medicaments related thereto.
摘要翻译：本文公开了下式的化合物，还公开了与之相关的治疗方法，组合物和药物。

8. 发明公开

EP2313090A1 NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT 无效转让
标题翻译：新型含S脂类食物补充剂或药物
公开(公告)号：EP2313090A1
公开(公告)日：2011-04-27
申请号：EP09798181.5
申请日：2009-07-13
申请人： Pronova BioPharma Norge AS
发明人： HOLMEIDE, Anne, Kristin , HOVLAND, Ragnar , BRÆNDVANG, Morten
IPC分类号： A61K31/10 , A23L1/29 , A61K31/22 , C07C317/04 , C07C317/06 , C07C317/12 , C07C321/14 , C07C321/18 , C07C321/22 , A61P3/04 , A61P9/10
CPC分类号： C07C323/54 , A23L33/12 , C07C317/44 , C07C323/52 , C07C323/55 , C07C323/56 , C07C323/61 , C07C2601/04
摘要： The present invention relates to lipid compounds of the general formula (I): (I) wherein R
1 is selected from a C
10 -C
22 alkyl, a C
10 -C
22 alkenyl having 1-6 double bonds, and a C
10 -C
22 alkynyl having 1-6 triple bonds;R
2 and R
3 are the same or different and may be selected from a group of different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.

9. 发明公开

EP2147910A1 Novel lipid compounds 审中-公开
标题翻译： Neue Lipid-Verbindungen
公开(公告)号：EP2147910A1
公开(公告)日：2010-01-27
申请号：EP08160450.6
申请日：2008-07-15
申请人： Pronova BioPharma Norge AS
发明人： Holmeide, Anne Kristin , Hovland, Ragnar , Brændvang, Morten
IPC分类号： C07C323/52 , C07C323/60 , C07C323/61 , A23L1/30 , A61K31/19 , A61P3/04 , A61P3/10
CPC分类号： C07C323/54 , A23L33/12 , C07C317/44 , C07C323/52 , C07C323/55 , C07C323/56 , C07C323/61 , C07C2601/04
摘要： The present invention relates to lipid compounds of the general formula (I):

wherein R 1 is selected from a C 10 -C 22 alkyl, a C 10 -C 22 alkenyl having 1-6 double bonds, and a C 10 -C 22 alkynyl having 1-6 triple bonds;R 2 and R 3 are the same or different and may be selected from a group of different substituents; Y is selected from suphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof.
The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.
摘要翻译：本发明涉及通式（I）的脂质化合物：其中R 1选自C 10 -C 22烷基，具有1-6个双键的C 10 -C 22烯基和C 10 -C 22 具有1-6个三键的炔基; R 2和R 3相同或不同，并且可以选自不同取代基的基团; Y选自suphur，亚砜和砜; X表示羧酸或其衍生物，羧酸酯，羧酸酐或羧酰胺; 或其药学上可接受的盐，络合物或溶剂合物。本发明还涉及包含这些化合物的药物组合物和脂质组合物以及用作药物或用于治疗，特别是用于治疗与心血管，代谢和炎性疾病区域有关的疾病的化合物。

10. 发明公开

EP1382591A1 NOVEL ATISANE COMPOUND AND USE THEREOF 审中-公开
标题翻译：新ATISANVERBINDUNG及其用途
公开(公告)号：EP1382591A1
公开(公告)日：2004-01-21
申请号：EP02720602.8
申请日：2002-04-25
申请人： Eisai Co., Ltd.
发明人： AKAIKE, Akinori , SUGIMOTO, Hachiro , NISHIZAWA, Yukio , YONAGA, Masahiro , ASAKAWA, Naoki , ASAI, Naoki , MANO, Nariyasu , TERAUCHI, Taro , DOKO, Takashi
IPC分类号： C07C35/44
CPC分类号： C07C69/757 , C07C43/13 , C07C43/315 , C07C47/36 , C07C47/37 , C07C47/46 , C07C62/06 , C07C62/14 , C07C229/46 , C07C235/26 , C07C247/12 , C07C255/31 , C07C271/22 , C07C309/66 , C07C309/73 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/13 , C07C323/22 , C07C323/26 , C07C323/43 , C07C323/53 , C07C323/55 , C07C323/58 , C07C323/60 , C07C327/32 , C07C2603/90 , C07C2603/95
摘要： The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury causedby radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.
Wherein Z represents a bivalent organic group and the like of from 2 to 3 carbon atom(s) which may have a substituent; and R 3 represents a carboxyl group and the like.

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