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1. 发明公开

EP3394020A1 INTERMOLECULAR REACTION OF PROPARGYL ETHERS WITH DIMETHYLFURAN IN THE PRESENCE OF GOLD(I) COMPLEXES 有权
公开(公告)号：EP3394020A1
公开(公告)日：2018-10-31
申请号：EP16801530.3
申请日：2016-11-28
申请人： DSM IP Assets B.V.
发明人： ACKERMANN, Stephan , LEHMANN, Hajo , LETINOIS, Ulla , MEDLOCK, Jonathan
IPC分类号： C07C37/14 , C07C39/07
CPC分类号： C07C41/30 , C07C37/07 , C07C37/50 , C07C41/36 , C07C43/1783 , C07C46/08 , C07D311/72 , C07C50/02 , C07C39/08 , C07C39/07
摘要： The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.

2. 发明公开

EP3392228A1 METHOD FOR PRODUCING PERFLUOROALKYLATED COMPOUND 无效
公开(公告)号：EP3392228A1
公开(公告)日：2018-10-24
申请号：EP16875566.8
申请日：2016-12-12
申请人： RIKEN
发明人： SODEOKA, Mikiko , KAWAMURA, Shintaro
IPC分类号： C07B37/04 , C07B37/08 , C07B47/00 , C07C17/263 , C07C21/18 , C07C22/00 , C07C22/08 , C07C29/32 , C07C31/38 , C07C41/30 , C07C43/205 , C07C45/68 , C07C49/167 , C07C67/293 , C07C69/78 , C07C303/40 , C07C311/16 , C07D203/24
CPC分类号： C07B37/04 , C07B37/08 , C07B47/00 , C07B61/00 , C07C17/263 , C07C21/18 , C07C22/00 , C07C22/08 , C07C29/32 , C07C31/38 , C07C41/30 , C07C43/205 , C07C45/68 , C07C49/167 , C07C67/293 , C07C69/78 , C07C303/40 , C07C311/16 , C07D203/24 , C07D207/444 , C07D209/34 , C07D279/02
摘要： Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl) peroxide with a compound having a carbon-carbon unsaturated bond and/or an aromatic ring having a hydrogen atom bonded thereto in the presence of a copper catalyst.

3. 发明授权

EP3004120B1 SPIRO-1,1'-BIINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALLADIUM-CATALYZED ASYMMETRIC HECK REACTION 有权
公开(公告)号：EP3004120B1
公开(公告)日：2018-08-29
申请号：EP14807914.8
申请日：2014-06-05
申请人： Nanyang Technological University
发明人： ZHOU, Jianrong, Steve , HU, Jian , WU, Chunlin
IPC分类号： C07B37/04 , C07C17/266 , C07C2/86 , C07D207/20 , C07D209/08 , C07D277/64 , C07D307/28 , C07D307/80 , C07D309/18 , C07D311/58 , C07D321/06 , C07D333/54 , C07D409/04 , C07D417/04 , C07F15/00 , C07F9/50 , C07F9/6558 , B01J31/24 , C07F9/53
CPC分类号： B01J31/2495 , B01J2231/4261 , B01J2531/824 , C07B37/04 , C07C2/861 , C07C2/868 , C07C17/263 , C07C17/266 , C07C41/30 , C07C45/68 , C07C67/343 , C07C2531/24 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/08 , C07D207/20 , C07D209/08 , C07D277/64 , C07D307/28 , C07D307/80 , C07D309/18 , C07D311/58 , C07D321/06 , C07D333/54 , C07D409/04 , C07D417/04 , C07F9/5027 , C07F9/5325 , C07F9/65586 , C07F15/006 , C07F15/0066 , C07C13/28 , C07C25/24 , C07C43/21 , C07C49/798 , C07C69/76
摘要： The present invention relates to catalyst complexes comprising palladium (Pd) and at least one spiro-1,1′-biindane-7,7′-bisphosphine oxide ligand as disclosed herein, and their use. The present invention is further directed to the asymmetric catalyzed covalent carbon-carbon single bond formation from aryl, heteroaryl and alkenyl triflates and halides and olefins utilising the said catalyst complexes.

4. 发明授权

EP1833605B1 PALLADIUM-CATALYZED CARBON-NITROGEN AND CARBON-CARBON BOND-FORMING REACTIONS 有权
公开(公告)号：EP1833605B1
公开(公告)日：2018-08-15
申请号：EP06733627.1
申请日：2006-01-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： BUCHWALD, Stephen, L. , ANDERSON, Kevin, W.
IPC分类号： B01J31/24 , C07F9/50 , C07C303/22 , C07C41/30 , C07C303/40 , C07B37/04 , C07B43/04 , C07D409/06 , C07C227/16 , C07C231/12 , C07C51/353 , C07C51/363 , C07C51/367
CPC分类号： C07C51/367 , B01J31/2404 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2531/0266 , B01J2531/824 , B01J2531/847 , B01J2531/96 , C07B37/04 , C07B43/04 , C07C41/30 , C07C51/353 , C07C51/363 , C07C227/16 , C07C231/12 , C07C303/22 , C07C303/40 , C07D409/06 , C07F9/5022 , C07C65/105 , C07C63/331 , C07C63/72 , C07C311/16 , C07C229/60 , C07C233/65 , C07C309/30 , C07C43/215
摘要： One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

6. 发明授权

EP2890672B1 PROCESSES FOR PREPARING INTERMEDIATES FOR THE MANUFACTURE OF NEP INHIBITORS 有权
公开(公告)号：EP2890672B1
公开(公告)日：2018-05-30
申请号：EP13832514.7
申请日：2013-09-02
申请人： Novartis AG
发明人： ZHU, Guoliang , YE, Wenfa , ZHENG, Hui , QIAN, Lingfeng , WEI, Junhui , YANG, Lijun , LI, Yunguang , LUO, Lijun
IPC分类号： C07C213/00 , C07C215/28 , C07C269/04 , C07C269/06 , C07C271/16 , C07C271/22 , C07C29/36 , C07C33/46 , C07C41/30 , C07C43/178
CPC分类号： C07C269/04 , C07B2200/07 , C07C29/36 , C07C41/30 , C07C213/00 , C07C213/02 , C07C269/06 , C07C215/28 , C07C271/16 , C07C271/22 , C07C33/46 , C07C43/1782
摘要： The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

7. 发明公开

EP3320107A1 ELECTROCHEMICALLY ACTIVE AGENTS FOR PH MODULATION IN BIOLOGICAL BUFFERS 审中-公开
标题翻译：电化学活性剂用于生物缓冲液PH调节
公开(公告)号：EP3320107A1
公开(公告)日：2018-05-16
申请号：EP16733550.4
申请日：2016-06-30
申请人： Robert Bosch GmbH
发明人： MARUNIAK, Autumn , AHMAD, Habib , RAGHUNATHAN, Ashwin , JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda , LANG, Christoph
IPC分类号： C12Q1/00 , G01N33/543 , C07C37/00
CPC分类号： G01N27/4167 , C07C37/00 , C07C37/07 , C07C39/10 , C07C39/11 , C07C41/01 , C07C41/24 , C07C41/30 , C07C43/1783 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C45/42 , C07C46/06 , C07C49/82 , C07C49/84 , C12Q1/001 , C12Q1/004 , G01N27/302 , G01N27/327 , G01N27/3275 , G01N27/4163 , G01N33/5438
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

8. 发明公开

EP3317320A1 MATÉRIAUX RÉTICULÉS THERMODURCISSABLES À BASSE TG ET THERMOSTABLES À BASE D'UNITÉS FLUOROÉTHERS 有权
标题翻译：基于FLUOROETHERS单位的低TG热固性和热稳定性交联材料
公开(公告)号：EP3317320A1
公开(公告)日：2018-05-09
申请号：EP16750916.5
申请日：2016-07-01
申请人： Safran Electrical & Power , Universite De Montpellier (Universite Montpellier 2 Sciences Et Techniques) , Centre National de la Recherche Scientifique (CNRS)
发明人： CHARLAS, Mathieu , MARTINEAU, Donatien, Henri, Edouard , LOPEZ, Gérald Pierre Maurice , HABAS, Jean-Pierre , AMEDURI, Bruno
IPC分类号： C08G65/00 , C08G65/333 , C08G65/337 , C08L71/00
CPC分类号： C08G73/08 , C07C41/30 , C07C247/04 , C08G65/007 , C08G65/333 , C08G65/33365 , C08G65/337 , C08G2650/20 , C08G2650/60 , C08K5/0025 , C08K5/28 , C08L71/00
摘要： The present invention relates to a cross-linkable composition comprising: i) a fluorinated α,ω-bis(propargyl) oligomer of formula (I): in which m is 1 to 100, e.g. 1 to 93, n is 2 to 150, e.g. 1 to 128, p is 0 to 2, preferably 0 or 1.75, and n, m and p are selected such that the fluorinated α,ω-bis(propargyl) oligomer of formula (I) has a number average molar mass Mn of 400 to 25000; ii) a cross-linking agent comprising at least three azide-N
3 groups; and iii) optionally, a fluorinated oligomer comprising two terminal azide-N3 or fluorinated α,ω-bis(azide) oligomer groups. The invention also relates to a material comprising the click chemistry reaction product of the cross-linkable composition of the invention, to a method for preparing said material and to the uses thereof.

9. 发明公开

EP3315486A1 METHOD FOR PRODUCING AROMATIC COMPOUND 有权转让
标题翻译：生产芳香化合物的方法
公开(公告)号：EP3315486A1
公开(公告)日：2018-05-02
申请号：EP17198805.8
申请日：2017-10-27
申请人： Tosoh Corporation , KYOTO UNIVERSITY
发明人： EGUCHI, Hisao , MIYAZAKI, Takanori , NAKAO, Yoshiaki
IPC分类号： C07C41/18 , C07C67/343 , C07B37/04 , C07C1/32 , C07C315/04 , C07C45/45 , C07C45/49 , C07C45/59 , C07D215/06 , C07D409/04 , C07D295/033 , C07D213/16 , C07D213/64 , C07C17/263
CPC分类号： C07C41/30 , C07B37/04 , C07C1/321 , C07C1/323 , C07C17/263 , C07C41/18 , C07C45/45 , C07C45/49 , C07C45/59 , C07C45/61 , C07C67/28 , C07C67/343 , C07C303/30 , C07C315/04 , C07C2527/12 , C07C2603/24 , C07D213/16 , C07D213/64 , C07D215/06 , C07D217/04 , C07D295/033 , C07D409/04 , C07C43/205 , C07C43/225 , C07C15/14 , C07C15/24 , C07C15/28 , C07C22/08 , C07C25/13 , C07C69/78 , C07C69/94 , C07C47/575 , C07C49/78 , C07C317/14
摘要： In a cross coupling reaction, in a case where a halogen atom is selected as the leaving group of the raw material compound, a harmful halogen waste forms as a by-product after the reaction, and disposal of the waste liquid is complicated and environmental burden is high. In a carbon-hydrogen activation cross coupling reaction which requires no halogen atom as the leaving group, although no halogen waste forms as a by-product, the reaction substrate is considerably restricted, and the reaction remains a limited molecular construction method.
A method for producing an aromatic compound, which comprises subjecting an aromatic nitro compound and a boronic acid compound to a cross coupling reaction in the presence of a metal catalyst, is hereby provided.
摘要翻译：在交叉偶联反应中，在选择卤素原子作为原料化合物的离去基团的情况下，反应后形成有害的卤素废物作为副产物，并且废液的处理复杂且环境负担高。在不需要卤素原子作为离去基团的碳氢激活交叉偶联反应中，尽管没有卤素废物作为副产物形成，但反应底物受到相当大的限制，并且反应仍然是有限的分子构建方法。本发明提供一种芳香族化合物的制造方法，其特征在于，在金属催化剂的存在下，使芳香族硝基化合物与硼酸化合物交叉偶联反应。

10. 发明公开

EP3301098A1 PROCESS FOR THE PREPARATION OF A LIGAND FOR A CATALYST 有权
标题翻译：制备催化剂配体的方法
公开(公告)号：EP3301098A1
公开(公告)日：2018-04-04
申请号：EP17195336.7
申请日：2013-12-19
申请人： Borealis AG
发明人： RESCONI, Luigi , VIRKKUNEN, Ville , AJELLAL, Noureddine , CASTRO, Pascal , IZMER, Vyatcheslav , KONONOVICH, Dmitry , VOSKOBOYNIKOV, Alexander
IPC分类号： C07F7/08 , C07C13/465 , C07F17/00 , C08F10/06 , C08F4/6592 , C07C1/32 , C07C25/18
CPC分类号： C07C1/326 , C07C1/20 , C07C41/30 , C07C2531/04 , C07C2531/18 , C07C2531/24 , C07C2602/24 , C07F7/081 , C07F17/00 , C08F4/65912 , C08F4/65916 , C08F4/65927 , C08F10/06 , C08F110/06 , C08F4/02 , C08F2500/03 , C08F2500/12 , C08F2500/15 , C07C13/465 , C07C43/188
摘要： A catalyst in solid particulate form free from an external carrier material comprising (i) a complex of formula (I)

wherein
M is zirconium or hafnium;
each X is a sigma ligand;
L is a divalent bridge selected from -R' 2 C-, -R' 2 C-CR' 2 -, -R' 2 Si-, -R' 2 Si-SiR' 2 -,-R' 2 Ge-, wherein each R' is independently a hydrogen atom, C 1-20 -alkyl, tri(C 1-20 -alkyl)silyl, C 6-20 -aryl, C 7-20 -arylalkyl or C 7-20 -alkylaryl;
R 2 is a C 1-20 -hydrocarbyl radical;
R 2' is a C 1-20 -hydrocarbyl radical;
R 5 is a linear or branched aliphatic C 1-20 -hydrocarbyl group, SR 9 or OR 9 ;
R 6' is a linear or branched aliphatic C 1-20 -hydrocarbyl group, SR 9' or OR 9' ;
with the proviso that neither R 6 or R 6' represents a group having a quaternary carbon atom directly attached to the indenyl ring;
R 9 is a C 1-20 -hydrocarbyl group;
R 9' is a C 1-20 -hydrocarbyl group;
Ar is a C 6-12 -aryl or C 5-12 -heteroaryl group optionally carrying one or more substituents R 8 ;
Ar' is a C 6-12 -aryl or C 5-12 -heteroaryl group optionally carrying one or more substituents R 8' ;
each R 8 is a C 1-20 -hydrocarbyl group;
each R 8' is a C 1-20 -hydrocarbyl group;
wherein at least two of R 2 and R 2' ; R 6 and R 6' ; or Ar and Ar' are the same;
and (ii) a cocatalyst comprising a compound of a group 13 metal, e.g. A1 or boron.
摘要翻译：一种不含外部载体材料的固体颗粒形式的催化剂，其包含（i）其中M为锆或铪的式（I）的络合物; 每个X是σ配体; L是选自-R'2C - ， - R'2C-CR'2 - ， - R'2Si-，-R'2Si-SiR'2 - ， - R'2Ge-的二价桥，其中每个R'是独立地为氢原子，C 1-20 - 烷基，三（C 1-20 - 烷基）甲硅烷基，C 6-20 - 芳基，C 7-20 - 芳基烷基或C 7-20 - 烷基芳基; R2是C1-20-烃基; R2'是C1-20-烃基; R5是直链或支链的脂族C1-20-烃基，SR9或OR9; R6'是直链或支链的脂族C1-20-烃基，SR9'或OR9'; 条件是R6或R6'都不代表具有直接连接到茚基环上的季碳原子的基团; R9是C1-20-烃基; R9'是C1-20-烃基; Ar是任选带有一个或多个取代基R8的C6-12-芳基或C5-12-杂芳基; Ar'是任选带有一个或多个取代基R8'的C6-12芳基或C5-12杂芳基; 每个R 8是C 1-20 - 烃基; 每个R8'是C1-20-烃基; 其中R2和R2'中的至少两个; R6和R6'; 或Ar和Ar'相同; 和（ii）包含13族金属化合物的助催化剂，例如， A1或硼。

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